{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T13:16:18Z","timestamp":1761311778319,"version":"3.44.0"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.ejphar.2021.174206","type":"journal-article","created":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T11:46:43Z","timestamp":1621943203000},"page":"174206","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["The proarrhythmic effects of hypothermia in atria isolated from 5-HT4-receptor-overexpressing mice"],"prefix":"10.1016","volume":"906","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6986-485X","authenticated-orcid":false,"given":"Ulrich","family":"Gergs","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Br\u00fcckner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Britt","family":"Hofmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5018-3851","authenticated-orcid":false,"given":"Joachim","family":"Neumann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.ejphar.2021.174206_bib1","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.hrthm.2009.12.006","article-title":"J wave syndromes","volume":"7","author":"Antzelevitch","year":"2010","journal-title":"Heart Rhythm"},{"issue":"6","key":"10.1016\/j.ejphar.2021.174206_bib2","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1113\/jphysiol.2014.279893","article-title":"Hypokalaemia induces Ca2\u207a overload and Ca2\u207a waves in ventricular myocytes by reducing Na\u207a,K\u207a-ATPase \u03b1\u2082 activity","volume":"593","author":"Aronsen","year":"2015","journal-title":"J. Physiol."},{"key":"10.1016\/j.ejphar.2021.174206_bib53","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3389\/fphar.2018.00013","article-title":"Phenotyping of mice with heart specific overexpression of A2A-adenosine receptors: evidence for cardioprotective effects of A2A-adenosine receptors","volume":"9","author":"Boknik","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejphar.2021.174206_bib3","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.3389\/fphar.2019.01051","article-title":"Evidence for arrhythmogenic effects of A2A-adenosine receptors","volume":"10","author":"Boknik","year":"2019","journal-title":"Front. Pharmacol."},{"issue":"5","key":"10.1016\/j.ejphar.2021.174206_bib4","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/0002-9149(70)90708-3","article-title":"Depression of cardiac function by streptomycin and other antimicrobial agents","volume":"26","author":"Cohen","year":"1970","journal-title":"Am. J. Cardiol."},{"issue":"6","key":"10.1016\/j.ejphar.2021.174206_bib56","doi-asserted-by":"crossref","DOI":"10.1096\/fasebj.12.6.451","article-title":"Overexpression of HSP-70 inhibits the phosphorylation of HSF1 by activating protein phosphatase and inhibiting protein kinase C activity","volume":"12","author":"Ding","year":"1998","journal-title":"FASEB J."},{"issue":"1","key":"10.1016\/j.ejphar.2021.174206_bib5","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s00395-003-0386-y","article-title":"Prolonged action potential durations, increased dispersion of repolarization, and polymorphic ventricular tachycardia in a mouse model of proarrhythmia","volume":"98","author":"Fabritz","year":"2003","journal-title":"Basic Res. Cardiol."},{"issue":"15","key":"10.1016\/j.ejphar.2021.174206_bib6","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1161\/CIRCULATIONAHA.115.018874","article-title":"Arrhythmia protection in hypokalemia: a novel role of Ca2+-activated K+ currents in the ventricle","volume":"132","author":"Faggioni","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2021.174206_bib7","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1093\/europace\/eux221","article-title":"Broad antiarrhythmic effect of mexiletine in different arrhythmia models","volume":"20","author":"Frommeyer","year":"2018","journal-title":"Europace"},{"issue":"1","key":"10.1016\/j.ejphar.2021.174206_bib55","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1093\/jnci\/56.1.189","article-title":"Stimulatory effect of 3\u2019, 5\u2019-adenosine monophosphate on protein synthesis in heat-shocked murine leukemia lymphoblasts","volume":"56","author":"Fuhr","year":"1976","journal-title":"J. Natl. Cancer Inst."},{"issue":"1","key":"10.1016\/j.ejphar.2021.174206_bib8","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1253\/circj.CJ-17-0145","article-title":"Arrhythmogenic delayed afterdepolarizations are promoted by severe hypothermia but not therapeutic hypothermia","volume":"82","author":"Fukaya","year":"2017","journal-title":"Circ. J."},{"issue":"3","key":"10.1016\/j.ejphar.2021.174206_bib9","doi-asserted-by":"crossref","first-page":"H788","DOI":"10.1152\/ajpheart.00691.2009","article-title":"Cardiac overexpression of the human 5-HT4 receptor in mice","volume":"299","author":"Gergs","year":"2010","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"2","key":"10.1016\/j.ejphar.2021.174206_bib10","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.ijcard.2010.09.009","article-title":"Modulation of cardiac contractility by serine\/threonine protein phosphatase type 5","volume":"154","author":"Gergs","year":"2012","journal-title":"Int. J. Cardiol."},{"issue":"1","key":"10.1016\/j.ejphar.2021.174206_bib51","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1124\/jpet.118.255711","article-title":"Initial characterization of transgenic mice overexpressing human histamine H2 receptors","volume":"369","author":"Gergs","year":"2019","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"5","key":"10.1016\/j.ejphar.2021.174206_bib11","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/s00210-013-0831-x","article-title":"Human 5-HT4 receptor stimulation in atria of transgenic mice","volume":"386","author":"Gergs","year":"2013","journal-title":"Naunyn-Schmiedeberg\u2019s Arch. Pharmacol."},{"issue":"10","key":"10.1016\/j.ejphar.2021.174206_bib12","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1007\/s00210-017-1403-2","article-title":"Desensitization of the human 5-HT4 receptor in isolated atria of transgenic mice","volume":"390","author":"Gergs","year":"2017","journal-title":"Naunyn-Schmiedeberg\u2019s Arch. Pharmacol."},{"issue":"6","key":"10.1016\/j.ejphar.2021.174206_bib13","doi-asserted-by":"crossref","first-page":"H1087","DOI":"10.1152\/ajpheart.00350.2017","article-title":"Pharmacological and physiological assessment of serotonin formation and degradation in isolated preparations from mouse and human heart","volume":"313","author":"Gergs","year":"2017","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"1","key":"10.1016\/j.ejphar.2021.174206_bib52","doi-asserted-by":"crossref","first-page":"5610","DOI":"10.1038\/s41598-019-42141-w","article-title":"Alterations of protein expression of phospholamban, ZASP and plakoglobin in human atria in subgroups of seniors","volume":"9","author":"Gergs","year":"2019","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.ejphar.2021.174206_bib50","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s00210-008-0371-y","article-title":"Phosphorylation of phospholamban and troponin I through 5-HT4 receptors in the isolated human atrium","volume":"379","author":"Gergs","year":"2009","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"issue":"6","key":"10.1016\/j.ejphar.2021.174206_bib14","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1067\/mtc.2001.113934","article-title":"Cold cardioplegic arrest enhances heat shock protein 70 in the heat-shocked rat heart","volume":"121","author":"Gray","year":"2001","journal-title":"J. Thorac. Cardiovasc. Surg."},{"issue":"6 Pt 1","key":"10.1016\/j.ejphar.2021.174206_bib15","doi-asserted-by":"crossref","first-page":"C1250","DOI":"10.1152\/ajpcell.1989.256.6.C1250","article-title":"Correction of proton and Ca association constants of EGTA for temperature and ionic strength","volume":"256","author":"Harrison","year":"1989","journal-title":"Am. J. Physiol."},{"issue":"5","key":"10.1016\/j.ejphar.2021.174206_bib18","doi-asserted-by":"crossref","first-page":"H1137","DOI":"10.1152\/ajpheart.00208.2018","article-title":"Hypothermia elongates the contraction-relaxation cycle in explanted human failing heart decreasing the time for ventricular filling during diastole","volume":"315","author":"Hiis","year":"2018","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"2","key":"10.1016\/j.ejphar.2021.174206_bib19","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1097\/SHK.0000000000000272","article-title":"Impaired heart rate regulation and depression of cardiac chronotropic and dromotropic function in polymicrobial sepsis","volume":"43","author":"Hoover","year":"2015","journal-title":"Shock"},{"issue":"5","key":"10.1016\/j.ejphar.2021.174206_bib20","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1007\/BF00169055","article-title":"Piglet sinoatrial 5-HT receptors resemble human atrial 5-HT4-like receptors","volume":"342","author":"Kaumann","year":"1990","journal-title":"Naunyn-Schmiedeberg\u2019s Arch. Pharmacol."},{"issue":"3","key":"10.1016\/j.ejphar.2021.174206_bib21","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.pharmthera.2005.12.004","article-title":"5-hydroxytryptamine receptors in the human cardiovascular system","volume":"111","author":"Kaumann","year":"2006","journal-title":"Pharmacol. Ther."},{"issue":"9","key":"10.1016\/j.ejphar.2021.174206_bib22","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1007\/s00210-018-1519-z","article-title":"Cardiovascular effects of cisapride and prucalopride on human 5-HT4 receptors in transgenic mice","volume":"391","author":"Keller","year":"2018","journal-title":"Naunyn-Schmiedeberg\u2019s Arch. Pharmacol."},{"issue":"5","key":"10.1016\/j.ejphar.2021.174206_bib23","doi-asserted-by":"crossref","first-page":"H2216","DOI":"10.1152\/ajpheart.00137.2004","article-title":"Age-dependent biochemical and contractile properties in atrium of transgenic mice overexpressing junctin","volume":"287","author":"Kirchhefer","year":"2004","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"1","key":"10.1016\/j.ejphar.2021.174206_bib24","first-page":"3","article-title":"Temperature dependent contribution of Ca2+ transporters to relaxation in cardiac myocytes: important role of sarcolemmal Ca2+-ATPase","volume":"57","author":"Mackiewicz","year":"2006","journal-title":"J. Physiol. Pharmacol."},{"issue":"4","key":"10.1016\/j.ejphar.2021.174206_bib25","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1172\/JCI117815","article-title":"Overexpression of the rat inducible70-kD heat stress protein in a transgenic mouse increases the resistance of the heart to ischemic injury","volume":"95","author":"Marber","year":"1995","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.ejphar.2021.174206_bib26","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0014-2999(73)90181-7","article-title":"Temperature-dependent supersensitivity to isoprenaline in mouse atria","volume":"22","author":"Mu\u00f1oz-Ram\u00edrez","year":"1973","journal-title":"Eur. J. Pharmacol."},{"issue":"10","key":"10.1016\/j.ejphar.2021.174206_bib27","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1006\/jmcc.1998.0760","article-title":"Targeted overexpression of phospholamban to mouse atrium depresses Ca2+ transport and contractility","volume":"30","author":"Neumann","year":"1998","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"1","key":"10.1016\/j.ejphar.2021.174206_bib28","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/sj.bjp.0705012","article-title":"Pertussis toxin sensitive and insensitive effects of adenosine and carbachol in murine atria overexpressing A1\u2013adenosine receptors","volume":"138","author":"Neumann","year":"2003","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2021.174206_bib29","series-title":"Serotonin - A Chemical Messenger between All Types of Living Cells","isbn-type":"print","doi-asserted-by":"crossref","first-page":"271","DOI":"10.5772\/intechopen.69111","article-title":"Production and function of serotonin in cardiac cells","author":"Neumann","year":"2017","ISBN":"https:\/\/id.crossref.org\/isbn\/9789535133612"},{"issue":"8","key":"10.1016\/j.ejphar.2021.174206_bib30","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1007\/s00210-019-01653-y","article-title":"Which phosphodiesterase can decrease cardiac effects of 5-HT4 receptor activation in transgenic mice?","volume":"392","author":"Neumann","year":"2019","journal-title":"Naunyn-Schmiedeberg\u2019s Arch. Pharmacol."},{"key":"10.1016\/j.ejphar.2021.174206_bib32","doi-asserted-by":"crossref","DOI":"10.1007\/s00210-021-02065-7","article-title":"Amitryptiline functionally antagonizes H2 receptors in transgenic mice and human atria","author":"Neumann","year":"2021","journal-title":"N. Schmied. Arch. Pharmacol."},{"issue":"4","key":"10.1016\/j.ejphar.2021.174206_bib57","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1007\/s12576-019-00684-7","article-title":"Overexpression of the HCN2 channel increases the arrhythmogenicity induced by hypokalemia","volume":"69","author":"Oshita","year":"2019","journal-title":"J. Physiol. Sci."},{"issue":"628","key":"10.1016\/j.ejphar.2021.174206_bib33","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1136\/pgmj.54.628.68","article-title":"Plasma concentration\/time curve of erythromycin after a 12-hour intravenous infusion of erythromycin lactobionate in man","volume":"54","author":"Parsons","year":"1978","journal-title":"Postgrad. Med."},{"issue":"16","key":"10.1016\/j.ejphar.2021.174206_bib58","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1161\/CIRCULATIONAHA.115.016217","article-title":"Molecular basis of hypokalemia-induced ventricular fibrillation","volume":"132","author":"Pezhouman","year":"2015","journal-title":"Circulation"},{"issue":"5 Pt 2","key":"10.1016\/j.ejphar.2021.174206_bib34","first-page":"H1772","article-title":"Temperature and relative contributions of Ca transport systems in cardiac myocyte relaxation","volume":"270","author":"Puglisi","year":"1996","journal-title":"Am. J. Physiol."},{"issue":"1","key":"10.1016\/j.ejphar.2021.174206_bib35","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0014-2999(78)90048-1","article-title":"The role of cyclic AMP in temperature-dependent changes of contractile force and sensitivity ot isoprenaline and papaverine in Guinea-pig atria","volume":"48","author":"Reinhardt","year":"1978","journal-title":"Eur. J. Pharmacol."},{"issue":"6","key":"10.1016\/j.ejphar.2021.174206_bib36","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1161\/01.RES.61.6.761","article-title":"Inotropic response to hypothermia and the temperature-dependence of ryanodine action in isolated rabbit and rat ventricular muscle: implications for excitation-contraction coupling","volume":"61","author":"Shattock","year":"1987","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2021.174206_bib37","doi-asserted-by":"crossref","first-page":"C692","DOI":"10.1152\/ajpcell.00287.2008","article-title":"Hypothermia increases the gain of excitation-contraction coupling in Guinea pig ventricular myocytes","volume":"295","author":"Shutt","year":"2008","journal-title":"Am. J. Physiol. Cell Physiol."},{"issue":"3","key":"10.1016\/j.ejphar.2021.174206_bib38","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1007\/s15010-007-7211-8","article-title":"Proarrhythmic potential of antimicrobial agents","volume":"36","author":"Simk\u00f3","year":"2008","journal-title":"Infection"},{"issue":"3","key":"10.1016\/j.ejphar.2021.174206_bib39","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1111\/j.1476-5381.1995.tb17191.x","article-title":"Sustained negative inotropism mediated by alpha-adrenoceptors in adult mouse myocardia: developmental conversion from positive response in the neonate","volume":"114","author":"Tanaka","year":"1995","journal-title":"Br. J. Pharmacol."},{"issue":"4","key":"10.1016\/j.ejphar.2021.174206_bib40","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/0014-2999(82)90073-5","article-title":"A comparison of josamycin with macrolides and related antibiotics on isolated rat atria","volume":"80","author":"Tamargo","year":"1982","journal-title":"Eur. J. Pharmacol."},{"issue":"7","key":"10.1016\/j.ejphar.2021.174206_bib41","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1161\/CIRCRESAHA.119.315641","article-title":"Hypokalemia promotes arrhythmia by distinct mechanisms in atrial and ventricular myocytes","volume":"126","author":"Tazmini","year":"2020","journal-title":"Circ. Res."},{"issue":"6","key":"10.1016\/j.ejphar.2021.174206_bib42","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1139\/y78-147","article-title":"Characterization of the inotropic response induced by stimulation of beta-adrenergic and H1 histaminergic receptors in Guinea pig left atria","volume":"56","author":"Tenner","year":"1978","journal-title":"Can. J. Physiol. Pharmacol."},{"issue":"1","key":"10.1016\/j.ejphar.2021.174206_bib44","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1124\/jpet.113.207001","article-title":"Dopamine and lipophilic derivates protect cardiomyocytes against cold preservation injury","volume":"348","author":"Vettel","year":"2014","journal-title":"J. Pharmacol. Exp. Therapeut."},{"issue":"4","key":"10.1016\/j.ejphar.2021.174206_bib45","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1111\/j.1476-5381.1990.tb14073.x","article-title":"Mediation of 5-hydroxytryptamine-induced tachycardia in the pig by the putative 5-HT4 receptor","volume":"100","author":"Villal\u00f3n","year":"1990","journal-title":"Br. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.ejphar.2021.174206_bib46","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1161\/01.RES.79.1.79","article-title":"Developmental changes in the delayed rectifier K+ channels in mouse heart","volume":"79","author":"Wang","year":"1996","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2021.174206_bib47","first-page":"1439","article-title":"K+-free induced early afterdepolarization in cardiac ventricular fibers of Guinea pig after cold treatment","volume":"31","author":"Wang","year":"1988","journal-title":"Sci. Sin B"},{"issue":"5","key":"10.1016\/j.ejphar.2021.174206_bib48","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.yjmcc.2007.08.005","article-title":"Hyperthermia treatment prevents angiotensin II-mediated atrial fibrosis and fibrillation via induction of heat-shock protein 72","volume":"43","author":"Wakisaka","year":"2007","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"3","key":"10.1016\/j.ejphar.2021.174206_bib49","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1161\/CIRCULATIONAHA.113.007765","article-title":"Screening for acute IKr block is insufficient to detect torsades de pointes liability: role of late sodium current","volume":"130","author":"Yang","year":"2014","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.ejphar.2021.174206_bib54","first-page":"379","article-title":"Interactions between sympathomimetic amines and blocking agents on the rat ventricle strip","volume":"160","author":"Wenzel","year":"1966","journal-title":"Arch. Int. Pharmacodyn. Ther."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299921003599?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299921003599?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T22:50:42Z","timestamp":1757976642000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299921003599"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":54,"alternative-id":["S0014299921003599"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2021.174206","relation":{},"ISSN":["0014-2999"],"issn-type":[{"type":"print","value":"0014-2999"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The proarrhythmic effects of hypothermia in atria isolated from 5-HT4-receptor-overexpressing mice","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2021.174206","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"174206"}}