{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T16:50:20Z","timestamp":1777567820069,"version":"3.51.4"},"reference-count":70,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,26]],"date-time":"2022-06-26T00:00:00Z","timestamp":1656201600000},"content-version":"vor","delay-in-days":298,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015068","name":"University of Santiago de Compostela","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015068","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"publisher","award":["88881.198095\/2018-01"],"award-info":[{"award-number":["88881.198095\/2018-01"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018942","name":"Centro Singular de Investigaci\u00f3n de Galicia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018942","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010801","name":"Xunta de Galicia","doi-asserted-by":"publisher","award":["2019-2022"],"award-info":[{"award-number":["2019-2022"]}],"id":[{"id":"10.13039\/501100010801","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010801","name":"Xunta de Galicia","doi-asserted-by":"publisher","award":["ED431G 2019\/02"],"award-info":[{"award-number":["ED431G 2019\/02"]}],"id":[{"id":"10.13039\/501100010801","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.ejphar.2021.174276","type":"journal-article","created":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T10:38:30Z","timestamp":1624444710000},"page":"174276","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Gamma-decanolactone: Preliminary evaluation as potential antiparkinsonian drug"],"prefix":"10.1016","volume":"906","author":[{"given":"Pricila","family":"Pfl\u00fcger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7987-1359","authenticated-orcid":false,"given":"Patr\u00edcia","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda I.","family":"Loza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Brea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dolores","family":"Vi\u00f1a","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2547-0071","authenticated-orcid":false,"given":"Amit","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 A.","family":"Fontenla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2021.174276_bib1","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.neuint.2019.104612","article-title":"Neuroprotective potential of chrysin in Parkinson's disease: molecular mechanisms and clinical implications","volume":"132","author":"Angelopoulou","year":"2020","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.ejphar.2021.174276_bib2","doi-asserted-by":"crossref","first-page":"5648","DOI":"10.1063\/1.464913","article-title":"Density-functional thermochemistry. III. The role of exact exchange","volume":"98","author":"Becke","year":"1993","journal-title":"J. Chem. Phys."},{"key":"10.1016\/j.ejphar.2021.174276_bib3","doi-asserted-by":"crossref","first-page":"5848","DOI":"10.1021\/jm070677y","article-title":"Structures of human monoamine oxidase b complexes with selective noncovalent inhibitors: Safinamide and coumarin analogs","volume":"50","author":"Binda","year":"2007","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejphar.2021.174276_bib4","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s40263-017-0408-1","article-title":"Safinamide: a review in Parkinson's disease","volume":"31","author":"Blair","year":"2017","journal-title":"CNS Drugs"},{"key":"10.1016\/j.ejphar.2021.174276_bib5","author":"Blood-brain barrier predictor"},{"key":"10.1016\/j.ejphar.2021.174276_bib6","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/nrn3887","article-title":"Spreading of pathology in neurodegenerative diseases: a focus on human studies","volume":"16","author":"Brettschneider","year":"2015","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.ejphar.2021.174276_bib7","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1073\/pnas.0707684105","article-title":"A threading-based method (FINDSITE) for ligand-binding site prediction and functional annotation","volume":"105","author":"Brylinski","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ejphar.2021.174276_bib8","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.3892\/mmr.2014.2040","article-title":"Monoamine oxidase inhibitors: promising therapeutic agents for Alzheimer's disease (Review)","volume":"9","author":"Cai","year":"2014","journal-title":"Mol. Med. Rep."},{"issue":"12","key":"10.1016\/j.ejphar.2021.174276_bib9","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1000585","article-title":"Predicting protein ligand binding sites by combining evolutionary sequence conservation and 3D structure","volume":"5","author":"Capra","year":"2009","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.ejphar.2021.174276_bib10","first-page":"1","article-title":"Evaluation of enzyme inhibitors in drug discovery. A guide for medicinal chemists and pharmacologists","volume":"46","author":"Copeland","year":"2005","journal-title":"Methods Biochem. Anal."},{"key":"10.1016\/j.ejphar.2021.174276_bib11","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0378-8741(97)00102-5","article-title":"Anticonvulsant properties of gamma-decanolactone in mice","volume":"58","author":"Coelho de Souza","year":"1997","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.ejphar.2021.174276_bib12","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1039\/C7MD00311K","article-title":"MAO inhibitory activity of bromo-2-phenylbenzofurans: synthesis, in vitro study, and docking calculations","volume":"8","author":"Delogu","year":"2017","journal-title":"Medchemcomm"},{"key":"10.1016\/j.ejphar.2021.174276_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2020.104616","article-title":"Synthesis and in vitro study of nitro- and methoxy-2-phenylbenzofurans as human monoamine oxidase inhibitors","volume":"107","author":"Delogu","year":"2021","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejphar.2021.174276_bib14","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1212\/WNL.0000000000008171","article-title":"Dravet syndrome and parkinsonism: a case report investigating the dopaminergic system","volume":"93","author":"Deuel","year":"2019","journal-title":"Neurology"},{"key":"10.1016\/j.ejphar.2021.174276_bib15","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s00221-008-1295-y","article-title":"Effects of gamma-decanolactone on seizures induced by PTZ-kindling in mice","volume":"187","author":"De Oliveira","year":"2008","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.ejphar.2021.174276_bib16","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1002\/jps.3030460322","article-title":"A note on a simple apparatus for detecting neurological deficits in rats and mice","volume":"46","author":"Dunham","year":"1957","journal-title":"J. Am. Pharm. Assoc."},{"key":"10.1016\/j.ejphar.2021.174276_bib17","doi-asserted-by":"crossref","first-page":"3714","DOI":"10.1021\/jm000942e","article-title":"Fast calculation of molecular polar surface area as a sum of fragment-based contributions and its application to the prediction of drug transport properties","volume":"43","author":"Ertl","year":"2000","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejphar.2021.174276_bib18","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/S0031-6997(24)01511-4","article-title":"Linden J. International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors","volume":"53","author":"Fredholm","year":"2001","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.ejphar.2021.174276_bib19","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/s00213-015-4118-4","article-title":"Behavioral and neurochemical effects induced by reserpine in mice","volume":"233","author":"Freitas","year":"2016","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.ejphar.2021.174276_bib20","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0014-2999(02)01552-2","article-title":"2-Chloro-N(6)-cyclopentyladenosine, adenosine A(1) receptor agonist, antagonizes the adenosine A(3) receptor","volume":"443","author":"Gao","year":"2002","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2021.174276_bib21","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0922-4106(92)90170-Z","article-title":"The molecular pharmacology of L-depreny","volume":"226","author":"Gerlach","year":"1992","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2021.174276_bib22","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1002\/ana.25157","article-title":"Parkinson disease and the risk of epileptic seizures","volume":"83","author":"Gruntz","year":"2018","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.ejphar.2021.174276_bib23","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1152\/japplphysiol.00435.2005","article-title":"Acute dopamine\/norepinephrine reuptake inhibition increases brain and core temperature in rats","volume":"99","author":"Hasegawa","year":"2005","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.ejphar.2021.174276_bib24","doi-asserted-by":"crossref","first-page":"ITC33","DOI":"10.7326\/AITC201809040","article-title":"Parkinson disease","volume":"169","author":"Homayoun","year":"2018","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.ejphar.2021.174276_bib25","doi-asserted-by":"crossref","first-page":"221","DOI":"10.3390\/md17040221","article-title":"Marine-derived natural compounds for the treatment of Parkinson's disease","volume":"17","author":"Huang","year":"2019","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.ejphar.2021.174276_bib26","doi-asserted-by":"crossref","first-page":"5269","DOI":"10.1021\/acs.jmedchem.8b00204","article-title":"Docking screens for dual inhibitors of disparate drug targets for Parkinson's disease","volume":"61","author":"Jaiteh","year":"2018","journal-title":"Med. Chem."},{"key":"10.1016\/j.ejphar.2021.174276_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/PL00005131","article-title":"Comparative pharmacology of human adenosine receptor subtipes \u2013 characterization of stably transfected receptors in CHO cells","volume":"357","author":"Klotz","year":"1998","journal-title":"Naunyn-Schmiedeberg\u2019s Arch. Pharmacol."},{"key":"10.1016\/j.ejphar.2021.174276_bib28","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1002\/cmdc.201900717","article-title":"Novel, dual target-directed annelated xanthine derivatives acting on adenosine receptors and monoamine oxidase B","volume":"15","author":"Kuder","year":"2020","journal-title":"ChemMedChem"},{"key":"10.1016\/j.ejphar.2021.174276_bib29","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1103\/PhysRevB.37.785","article-title":"Development of the Colle-Salvetti correlation-energy formula into a functional of the electron density","volume":"37","author":"Lee","year":"1988","journal-title":"Phys. Rev. B"},{"key":"10.1016\/j.ejphar.2021.174276_bib30","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.2741\/1381","article-title":"Hypothermia in systemic inflammation: role of cytokines","volume":"9","author":"Leon","year":"2004","journal-title":"Front. Biosci."},{"key":"10.1016\/j.ejphar.2021.174276_bib31","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1113\/jphysiol.1979.sp012886","article-title":"Effects of dopaminergic antagonist and agonist on thermoregulation in rabbits","volume":"293","author":"Lin","year":"1979","journal-title":"J. Physiol."},{"key":"10.1016\/j.ejphar.2021.174276_bib32","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1046\/j.1471-4159.1997.69020581.x","article-title":"Mechanism of cellular 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction","volume":"69","author":"Liu","year":"1997","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ejphar.2021.174276_bib33","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0169-409X(00)00129-0","article-title":"Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings","volume":"46","author":"Lipinski","year":"1997","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"4","key":"10.1016\/j.ejphar.2021.174276_bib34","first-page":"1050","article-title":"AlzPlatform: an Alzheimer's disease domain-specific chemogenomics knowledgebase for polypharmacology and target identification research","volume":"54","author":"Liu","year":"2014"},{"key":"10.1016\/j.ejphar.2021.174276_bib35","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.3389\/fnins.2019.01309","article-title":"Anticholinergic drugs in geriatric psychopharmacology","volume":"13","author":"L\u00f3pez-\u00c1lvarez","year":"2019","journal-title":"Front. Neurosci."},{"issue":"2","key":"10.1016\/j.ejphar.2021.174276_bib36","doi-asserted-by":"crossref","first-page":"e1616","DOI":"10.1371\/journal.pone.0001616","article-title":"MAO-B elevation in mouse brain astrocytes results in Parkinson's pathology","volume":"3","author":"Mallajosyula","year":"2008","journal-title":"PloS One"},{"key":"10.1016\/j.ejphar.2021.174276_bib37","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/B978-0-12-801022-8.00004-0","article-title":"Mode of action of adenosine A2A receptor antagonists as symptomatic treatment for Parkinson's disease","volume":"119","author":"Mori","year":"2014","journal-title":"Int. Rev. Neurobiol."},{"key":"10.1016\/j.ejphar.2021.174276_bib38","author":"Molinspiration Cheminformatics"},{"key":"10.1016\/j.ejphar.2021.174276_bib39","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.ejmech.2013.02.009","article-title":"Novel (coumarin-3-yl) carbamates as selective MAO-B inhibitors: synthesis, in vitro and in vivo assays, theoretical evaluation of ADME properties and docking study","volume":"63","author":"Matos","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejphar.2021.174276_bib40","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S0022-3565(24)36404-3","article-title":"Interactions between a novel cholinergic ion channel agonist, SIB-1765F and L-DOPA in the reserpine model of Parkinson's disease in rats","volume":"280","author":"Menzaghi","year":"1997","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.ejphar.2021.174276_bib41","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1212\/01.wnl.0000250236.75053.16","article-title":"The Japan Zonisamide on PD study group. Zonisamide improves motor function in Parkinson disease: a randomized, double-blind study","volume":"68","author":"Murata","year":"2007","journal-title":"Neurology"},{"key":"10.1016\/j.ejphar.2021.174276_bib42","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1758-2946-3-33","article-title":"Open Babel: an open chemical toolbox","volume":"3","author":"O'Boyle","year":"2011","journal-title":"J. Cheminf."},{"key":"10.1016\/j.ejphar.2021.174276_bib43","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0944-7113(96)80028-6","article-title":"Effect of dehydrocostus lactone and costunolide from Saussurea root on the central nervous system in mice","volume":"3","author":"Okugawa","year":"1996","journal-title":"Phytomedicine"},{"key":"10.1016\/j.ejphar.2021.174276_bib44","doi-asserted-by":"crossref","first-page":"491","DOI":"10.7705\/biomedica.4299","article-title":"Coumarin analogue 3-methyl-7H-furo[3,2-g] chromen-7-one as a possible antiparkinsonian agent","volume":"39","author":"Olaya","year":"2019","journal-title":"Biom\u00e9dica"},{"key":"10.1016\/j.ejphar.2021.174276_bib46","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aav0316","article-title":"Newly developed reversible MAO-B inhibitor circumvents the shortcomings of irreversible inhibitors in Alzheimer's disease","volume":"5","author":"Park","year":"2019","journal-title":"Sci. Adv."},{"key":"10.1016\/j.ejphar.2021.174276_bib47","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1023\/A:1021962714034","article-title":"Effect of gamma-decanolactone on glutamate binding in the rat cerebral cortex","volume":"22","author":"Pereira","year":"1997","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.ejphar.2021.174276_bib49","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.ejphar.2016.03.029","article-title":"Gamma-decanolactone inhibits iNOS and TNF-alpha production by lipopolysaccharide-activated microglia in N9 cells","volume":"780","author":"Pfl\u00fcger","year":"2016","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2021.174276_bib50","doi-asserted-by":"crossref","first-page":"162","DOI":"10.2174\/1874467210666171002114954","article-title":"Gamma-decanolactone improves biochemical parameters associated with pilocarpine-induced seizures in male mice","volume":"11","author":"Pfl\u00fcger","year":"2018","journal-title":"Curr. Mol. Pharmacol."},{"key":"10.1016\/j.ejphar.2021.174276_bib51","doi-asserted-by":"crossref","first-page":"222","DOI":"10.2174\/1871524918666180611103802","article-title":"Neuropharmacological profile of gamma-decanolactone on chemically-induced seizure in mice","volume":"18","author":"Pfl\u00fcger","year":"2018","journal-title":"Cent. Nerv. Syst. Agents Med. Chem."},{"key":"10.1016\/j.ejphar.2021.174276_bib52","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1097\/FBP.0000000000000554","article-title":"Gamma-decanolactone attenuates acute and chronic seizures in mice: a possible role of adenosine A1 receptors","volume":"31","author":"Pfl\u00fcger","year":"2020","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.ejphar.2021.174276_bib53","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1002\/jcc.1058","article-title":"6-31G* basis set for third-row atoms","volume":"22","author":"Rassolov","year":"2001","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.ejphar.2021.174276_bib54","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1007\/s00702-018-1876-2","article-title":"Monoamine oxidase-B inhibitors in the treatment of Parkinson's disease: clinical\u2013pharmacological aspects","volume":"125","author":"Riederer","year":"2018","journal-title":"J. Neural. Transm."},{"key":"10.1016\/j.ejphar.2021.174276_bib55","doi-asserted-by":"crossref","first-page":"103986","DOI":"10.1016\/j.bioorg.2020.103986","article-title":"Discovery and optimization of 3-thiophenylcoumarins as novel agents against Parkinson's disease: synthesis, in vitro and in vivo studies","volume":"101","author":"Rodr\u00edguez-Enr\u00edquez","year":"2020","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejphar.2021.174276_bib56","doi-asserted-by":"crossref","first-page":"W471","DOI":"10.1093\/nar\/gks372","article-title":"COFACTOR: an accurate comparative algorithm for structure-based protein function annotation","volume":"40","author":"Roy","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ejphar.2021.174276_bib57","doi-asserted-by":"crossref","first-page":"47","DOI":"10.3389\/fneur.2020.00047","article-title":"Imaging mild cognitive impairment and dementia in Parkinson's disease","volume":"11","author":"Sasikumar","year":"2020","journal-title":"Front. Neurol."},{"key":"10.1016\/j.ejphar.2021.174276_bib58","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s13195-017-0279-1","article-title":"Monoamine oxidase B is elevated in Alzheimer disease neurons, is associated with gamma-secretase and regulates neuronal amyloid beta-peptide levels","volume":"9","author":"Schedin-Weiss","year":"2017","journal-title":"Alzheimer's Res. Ther."},{"key":"10.1016\/j.ejphar.2021.174276_bib59","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.yebeh.2018.03.023","article-title":"Parkinson's disease, epileptic seizures, and sudden death: three faces of the same coin","volume":"83","author":"Scorza","year":"2018","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.ejphar.2021.174276_bib60","first-page":"1","article-title":"Parkinson's disease and cryptogenic epilepsy","volume":"374563","author":"Son","year":"2016","journal-title":"Case Rep. Neurol. Med."},{"key":"10.1016\/j.ejphar.2021.174276_bib61","doi-asserted-by":"crossref","first-page":"5739","DOI":"10.1073\/pnas.0710626105","article-title":"Structure of human monoamine oxidase a at 2.2-a resolution: the control of opening the entry for substrates\/inhibitors","volume":"105","author":"Son","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ejphar.2021.174276_bib62","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.ejphar.2006.02.004","article-title":"Different effects of 7-nitroindazole in reserpine-induced hypolocomotion in two strains of mice","volume":"535","author":"Tadaiesky","year":"2006","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2021.174276_bib63","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.ejphar.2021.174276_bib64","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1093\/aje\/kwg068","article-title":"Incidence of Parkinson's disease: variation by age, gender, and race\/ethnicity","volume":"157","author":"Van Den Eeden","year":"2003","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.ejphar.2021.174276_bib65","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1021\/jm020017n","article-title":"Molecular properties that influence the oral bioavailability of drugs candidates","volume":"45","author":"Veber","year":"2002","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejphar.2021.174276_bib66","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1006\/ebeh.2000.0044","article-title":"Parkinsonims and epilepsy: case report and reappraisal of an old question","volume":"1","author":"Vercueil","year":"2000","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.ejphar.2021.174276_bib67","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1016\/j.lfs.2006.11.042","article-title":"Gamma-decanolactone effect on behavioral and genotoxic parameters","volume":"80","author":"Viana","year":"2007","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2021.174276_bib68","doi-asserted-by":"crossref","first-page":"W438","DOI":"10.1093\/nar\/gky439","article-title":"COACH-D: improved protein-ligand binding site prediction with refined ligand-binding poses through molecular docking","volume":"46","author":"Wu","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ejphar.2021.174276_bib69","doi-asserted-by":"crossref","first-page":"2588","DOI":"10.1093\/bioinformatics\/btt447","article-title":"Protein-ligand binding site recognition using complementary binding-specific substructure comparison and sequence profile alignment","volume":"29","author":"Yang","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ejphar.2021.174276_bib70","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.bbrc.2006.03.190","article-title":"Inhibitory effects of cis- and trans-resveratrol on noradrenaline and 5-hydroxytryptamine uptake and on monoamine oxidase activity","volume":"344","author":"Y\u00e1\u00f1ez","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejphar.2021.174276_bib71","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/mdc3.12063","article-title":"Sleep attacks in patiens with Parkinson's disease on dopaminergic medications: a systematic review","volume":"1","author":"Yeung","year":"2014","journal-title":"Mov. Disord. Clin. Pract."},{"key":"10.1016\/j.ejphar.2021.174276_bib72","doi-asserted-by":"crossref","first-page":"367","DOI":"10.2165\/00002512-199710050-00005","article-title":"Neuropsychiatric adverse effects of antiparkinsonian drugs","volume":"10","author":"Young","year":"1997","journal-title":"Drugs Aging"}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299921004295?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299921004295?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:57:41Z","timestamp":1777402661000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299921004295"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":70,"alternative-id":["S0014299921004295"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2021.174276","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gamma-decanolactone: Preliminary evaluation as potential antiparkinsonian drug","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2021.174276","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"174276"}}