{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T22:27:34Z","timestamp":1785450454963,"version":"3.56.0"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100022271","name":"Faculty of Veterinary Medicine, Kasetsart University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100022271","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.ejphar.2021.174279","type":"journal-article","created":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T04:15:49Z","timestamp":1624940149000},"page":"174279","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"special_numbering":"C","title":["Targeting HMGB1\/TLR4\/NF-\u03baB signaling pathway by protocatechuic acid protects against l-arginine induced acute pancreatitis and multiple organs injury in rats"],"prefix":"10.1016","volume":"906","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2283-5327","authenticated-orcid":false,"given":"Marwa E.","family":"Abdelmageed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manar A.","family":"Nader","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7082-481X","authenticated-orcid":false,"given":"Marwa S.","family":"Zaghloul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2021.174279_bib1","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.22502","article-title":"Protocatechuic acid ameliorates testosterone\u2010induced benign prostatic hyperplasia through the regulation of inflammation and oxidative stress in castrated rats","author":"Akanni","year":"2020","journal-title":"J. Biochem. Mol. Toxicol."},{"issue":"1","key":"10.1016\/j.ejphar.2021.174279_bib2","doi-asserted-by":"crossref","first-page":"102","DOI":"10.4067\/S0717-95022021000100102","article-title":"Suppression of L-arginine-induced acute necrotizing pancreatitis in rats by metformin associated with the inhibition of myeloperoxidase and activation of interleukin-10","volume":"39","author":"Al-Hashem","year":"2021","journal-title":"Int. J. Morphol."},{"key":"10.1016\/j.ejphar.2021.174279_bib3","doi-asserted-by":"crossref","first-page":"137969","DOI":"10.1016\/j.scitotenv.2020.137969","article-title":"Protocatechuic acid mitigates cadmium-induced neurotoxicity in rats: role of oxidative stress, inflammation and apoptosis","author":"Al Olayan","year":"2020","journal-title":"Sci. Total Environ."},{"issue":"15","key":"10.1016\/j.ejphar.2021.174279_bib4","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.3748\/wjg.v11.i15.2340","article-title":"Oxidative stress and nitric oxide in rats with alcohol-induced acute pancreatitis","volume":"11","author":"Andican","year":"2005","journal-title":"World J. Gastroenterol.: WJG"},{"issue":"8","key":"10.1016\/j.ejphar.2021.174279_bib5","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1007\/s00210-016-1250-6","article-title":"Effect of tiron on remote organ injury in rats with severe acute pancreatitis induced by L-arginine","volume":"389","author":"Ateyya","year":"2016","journal-title":"Naunyn-Schmiedeberg's Arch. Pharmacol."},{"issue":"2","key":"10.1016\/j.ejphar.2021.174279_bib6","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1097\/MPA.0b013e31818a392f","article-title":"Severe acute pancreatitis: overall and early versus late mortality in intensive care units","volume":"38","author":"Bumbasirevic","year":"2009","journal-title":"Pancreas"},{"issue":"11","key":"10.1016\/j.ejphar.2021.174279_bib7","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1021\/np100281g","article-title":"Inhibition of melanogenesis and oxidation by protocatechuic acid from Origanum vulgare (oregano)","volume":"73","author":"Chou","year":"2010","journal-title":"J. Nat. Prod."},{"issue":"5","key":"10.1016\/j.ejphar.2021.174279_bib8","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0064375","article-title":"Toll-like receptor 4 mediates acute lung injury induced by high mobility group box-1","volume":"8","author":"Deng","year":"2013","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.ejphar.2021.174279_bib9","first-page":"645","article-title":"Toll-like receptor 4-mediated apoptosis of pancreatic cells in cerulein-induced acute pancreatitis in mice","volume":"9","author":"Ding","year":"2010","journal-title":"Hepatobiliary Pancreat. Dis. Int."},{"issue":"7","key":"10.1016\/j.ejphar.2021.174279_bib10","first-page":"7654","article-title":"Corticosteroid therapy for severe acute pancreatitis: a meta-analysis of randomized, controlled trials","volume":"8","author":"Dong","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"issue":"6","key":"10.1016\/j.ejphar.2021.174279_bib11","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1007\/s10620-018-5036-1","article-title":"Anti-inflammatory and antioxidant effects of captopril compared to methylprednisolone in L-arginine-induced acute pancreatitis","volume":"63","author":"El-Ashmawy","year":"2018","journal-title":"Dig. Dis. Sci."},{"issue":"1","key":"10.1016\/j.ejphar.2021.174279_bib12","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0003-9861(59)90090-6","article-title":"Tissue sulfhydryl groups","volume":"82","author":"Ellman","year":"1959","journal-title":"Arch. Biochem. Biophys."},{"issue":"3","key":"10.1016\/j.ejphar.2021.174279_bib13","first-page":"164","article-title":"Thioacetamide-induced acute hepatic encephalopathy in rat: behavioral, biochemical and histological changes","volume":"14","author":"Farjam","year":"2012","journal-title":"Iran. Red Crescent Med. J."},{"issue":"8","key":"10.1016\/j.ejphar.2021.174279_bib14","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1177\/27.8.90074","article-title":"The use of avidin-biotin interaction in immunoenzymatic techniques","volume":"27","author":"Guesdon","year":"1979","journal-title":"J. Histochem. Cytochem."},{"issue":"14","key":"10.1016\/j.ejphar.2021.174279_bib15","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.3748\/wjg.v10.i14.2003","article-title":"L-arginine-induced experimental pancreatitis","volume":"10","author":"Hegyi","year":"2004","journal-title":"World J. Gastroenterol.: WJG"},{"issue":"7","key":"10.1016\/j.ejphar.2021.174279_bib16","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.pan.2018.08.001","article-title":"Quercetin protects against intestinal barrier disruption and inflammation in acute necrotizing pancreatitis through TLR4\/MyD88\/p38 MAPK and ERS inhibition","volume":"18","author":"Junyuan","year":"2018","journal-title":"Pancreatology"},{"key":"10.1016\/j.ejphar.2021.174279_bib17","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/952943","article-title":"A review on protocatechuic acid and its pharmacological potential","author":"Kakkar","year":"2014","journal-title":"ISRN Pharmacol."},{"key":"10.1016\/j.ejphar.2021.174279_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mam.2014.05.001","article-title":"HMGB1 in health and disease","volume":"40","author":"Kang","year":"2014","journal-title":"Mol. Aspect. Med."},{"issue":"12","key":"10.1016\/j.ejphar.2021.174279_bib19","doi-asserted-by":"crossref","first-page":"2951","DOI":"10.1080\/13880209.2016.1195848","article-title":"Calendula officinalis ameliorates l-arginine-induced acute necrotizing pancreatitis in rats","volume":"54","author":"Kaur","year":"2016","journal-title":"Pharm. Biol."},{"issue":"5","key":"10.1016\/j.ejphar.2021.174279_bib20","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.phrs.2004.11.007","article-title":"Inhibition of poly (ADP-ribose) polymerase attenuates lung tissue damage after hind limb ischemia-reperfusion in rats","volume":"51","author":"Koksel","year":"2005","journal-title":"Pharmacol. Res."},{"issue":"2","key":"10.1016\/j.ejphar.2021.174279_bib21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0117588","article-title":"New insights into the methodology of L-arginine-induced acute pancreatitis","volume":"10","author":"Kui","year":"2015","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.ejphar.2021.174279_bib22","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3892\/ijmm.2015.2410","article-title":"TLR4-mediated NF-\u03baB signaling pathway mediates HMGB1-induced pancreatic injury in mice with severe acute pancreatitis","volume":"37","author":"Li","year":"2016","journal-title":"Int. J. Mol. Med."},{"issue":"1\u20132","key":"10.1016\/j.ejphar.2021.174279_bib23","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.jim.2004.04.019","article-title":"Recombinant HMGB1 with cytokine-stimulating activity","volume":"289","author":"Li","year":"2004","journal-title":"J. Immunol. Methods"},{"issue":"4","key":"10.1016\/j.ejphar.2021.174279_bib24","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1097\/01.mpa.0000160959.21580.41","article-title":"Toll-like receptor 4 detected in exocrine pancreas and the change of expression in cerulein-induced pancreatitis","volume":"30","author":"Li","year":"2005","journal-title":"Pancreas"},{"issue":"1","key":"10.1016\/j.ejphar.2021.174279_bib25","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/j.1600-065X.2007.00579.x","article-title":"The grateful dead: damage\u2010associated molecular pattern molecules and reduction\/oxidation regulate immunity","volume":"220","author":"Lotze","year":"2007","journal-title":"Immunol. Rev."},{"issue":"10","key":"10.1016\/j.ejphar.2021.174279_bib26","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/j.imbio.2013.04.013","article-title":"Downregulation of HMGB1 protects against the development of acute lung injury after severe acute pancreatitis","volume":"218","author":"Luan","year":"2013","journal-title":"Immunobiology"},{"issue":"10","key":"10.1016\/j.ejphar.2021.174279_bib27","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0046291","article-title":"Role of TLR4\/NF-\u03baB in damage to intestinal mucosa barrier function and bacterial translocation in rats exposed to hypoxia","volume":"7","author":"Luo","year":"2012","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.ejphar.2021.174279_bib28","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/s005340200049","article-title":"Cytokine storm in acute pancreatitis","volume":"9","author":"Makhija","year":"2002","journal-title":"J. Hepatobiliary Pancreat. Surg."},{"issue":"3","key":"10.1016\/j.ejphar.2021.174279_bib29","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/j.1432-1033.1974.tb03714.x","article-title":"Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase","volume":"47","author":"Marklund","year":"1974","journal-title":"Eur. J. Biochem."},{"issue":"18","key":"10.1016\/j.ejphar.2021.174279_bib30","doi-asserted-by":"crossref","first-page":"2901","DOI":"10.2174\/092986712800672102","article-title":"Protocatechuic acid and human disease prevention: biological activities and molecular mechanisms","volume":"19","author":"Masella","year":"2012","journal-title":"Curr. Med. Chem."},{"issue":"8","key":"10.1016\/j.ejphar.2021.174279_bib31","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1172\/JCI0215623","article-title":"Neutrophil-independent mechanisms of caspase-1\u2013and IL-18\u2013mediated ischemic acute tubular necrosis in mice","volume":"110","author":"Melnikov","year":"2002","journal-title":"J. Clin. Invest."},{"issue":"8","key":"10.1016\/j.ejphar.2021.174279_bib32","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/j.intimp.2010.05.009","article-title":"Anti-inflammatory effects of black rice, cyanidin-3-O-\u03b2-D-glycoside, and its metabolites, cyanidin and protocatechuic acid","volume":"10","author":"Min","year":"2010","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.ejphar.2021.174279_bib33","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/5818479","article-title":"Antioxidant and anti-inflammatory effects of coenzyme Q10 on L-arginine-induced acute pancreatitis in rat","author":"Mirmalek","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"3","key":"10.1016\/j.ejphar.2021.174279_bib34","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s00210-016-1327-2","article-title":"Nilotinib, a tyrosine kinase inhibitor exhibits protection against acute pancreatitis-induced lung and liver damage in rats","volume":"390","author":"Nader","year":"2017","journal-title":"Naunyn-Schmiedeberg's Arch. Pharmacol."},{"key":"10.1016\/j.ejphar.2021.174279_bib35","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.intimp.2017.12.024","article-title":"Protocatechuic acid inhibits Toll-like receptor-4-dependent activation of NF-\u03baB by suppressing activation of the Akt, mTOR, JNK and p38-MAPK","volume":"55","author":"Nam","year":"2018","journal-title":"Int. Immunopharm."},{"issue":"8","key":"10.1016\/j.ejphar.2021.174279_bib36","doi-asserted-by":"crossref","first-page":"420","DOI":"10.5694\/mja14.01333","article-title":"Acute pancreatitis: update on management","volume":"202","author":"Nesvaderani","year":"2015","journal-title":"Med. J. Aust."},{"issue":"2","key":"10.1016\/j.ejphar.2021.174279_bib37","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.ejphar.2021.174279_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.redox.2015.01.014","article-title":"Redox signaling in acute pancreatitis","volume":"5","author":"P\u00e9rez","year":"2015","journal-title":"Redox Biol."},{"issue":"3","key":"10.1016\/j.ejphar.2021.174279_bib39","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1053\/j.gastro.2010.06.010","article-title":"Clinical advances in liver, pancreas, and biliary tract","volume":"139","author":"Petrov","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ejphar.2021.174279_bib40","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1146\/annurev.clinpsy.032408.153553","article-title":"Item response theory and clinical measurement","volume":"5","author":"Reise","year":"2009","journal-title":"Annu. Rev. Clin. Psychol."},{"issue":"1","key":"10.1016\/j.ejphar.2021.174279_bib41","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1097\/00000658-199201000-00007","article-title":"A better model of acute pancreatitis for evaluating therapy","volume":"215","author":"Schmidt","year":"1992","journal-title":"Ann. Surg."},{"issue":"1","key":"10.1016\/j.ejphar.2021.174279_bib42","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1530\/JOE-14-0273","article-title":"Protocatechuic acid exerts a cardioprotective effect in type 1 diabetic rats","volume":"223","author":"Semaming","year":"2014","journal-title":"J. Endocrinol."},{"issue":"5","key":"10.1016\/j.ejphar.2021.174279_bib43","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.3748\/wjg.v21.i5.1424","article-title":"High-mobility group box 1 protein and its role in severe acute pancreatitis","volume":"21","author":"Shen","year":"2015","journal-title":"World J. Gastroenterol.: WJG"},{"issue":"3","key":"10.1016\/j.ejphar.2021.174279_bib44","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.neulet.2006.02.057","article-title":"Alpinia protocatechuic acid protects against oxidative damage in vitro and reduces oxidative stress in vivo","volume":"403","author":"Shi","year":"2006","journal-title":"Neurosci. Lett."},{"issue":"6","key":"10.1016\/j.ejphar.2021.174279_bib45","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/S0278-6915(02)00329-0","article-title":"Hydrogen peroxide scavenging, antioxidant and anti-radical activity of some phenolic acids","volume":"41","author":"Sroka","year":"2003","journal-title":"Food Chem. Toxicol."},{"issue":"4","key":"10.1016\/j.ejphar.2021.174279_bib46","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1007\/s00134-012-2775-x","article-title":"The impact of early goal-directed fluid management on survival in an experimental model of severe acute pancreatitis","volume":"39","author":"Trepte","year":"2013","journal-title":"Intensive Care Med."},{"issue":"2","key":"10.1016\/j.ejphar.2021.174279_bib47","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0925-4439(02)00160-6","article-title":"Time-course of oxygen free radical production in acinar cells during acute pancreatitis induced by pancreatic duct obstruction","volume":"1588","author":"Urunuela","year":"2002","journal-title":"Biochim. Biophys. Acta (BBA) - Mol. Basis Dis."},{"issue":"5","key":"10.1016\/j.ejphar.2021.174279_bib48","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.jnutbio.2010.03.008","article-title":"Protocatechuic acid induces antioxidant\/detoxifying enzyme expression through JNK-mediated Nrf2 activation in murine macrophages","volume":"22","author":"Var\u00ec","year":"2011","journal-title":"J. Nutr. Biochem."},{"issue":"14","key":"10.1016\/j.ejphar.2021.174279_bib49","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.2174\/1389450120666190618125100","article-title":"High mobility group box-1 (HMGB1): a potential target in therapeutics","volume":"20","author":"Vijayakumar","year":"2019","journal-title":"Curr. Drug Targets"},{"issue":"9","key":"10.1016\/j.ejphar.2021.174279_bib50","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1093\/jn\/137.9.2043","article-title":"Protocatechuic acid is the major human metabolite of cyanidin-glucosides","volume":"137","author":"Vitaglione","year":"2007","journal-title":"J. Nutr."},{"issue":"24","key":"10.1016\/j.ejphar.2021.174279_bib51","doi-asserted-by":"crossref","first-page":"12722","DOI":"10.1021\/jf103427j","article-title":"Protocatechuic acid, a metabolite of anthocyanins, inhibits monocyte adhesion and reduces atherosclerosis in apolipoprotein E-deficient mice","volume":"58","author":"Wang","year":"2010","journal-title":"J. Agric. Food Chem."},{"issue":"3","key":"10.1016\/j.ejphar.2021.174279_bib52","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1111\/j.1365-2796.2003.01302.x","article-title":"Extracellular role of HMGB1 in inflammation and sepsis","volume":"255","author":"Wang","year":"2004","journal-title":"J. Intern. Med."},{"issue":"6","key":"10.1016\/j.ejphar.2021.174279_bib53","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1053\/j.gastro.2013.01.068","article-title":"The epidemiology of pancreatitis and pancreatic cancer","volume":"144","author":"Yadav","year":"2013","journal-title":"Gastroenterology"},{"issue":"4","key":"10.1016\/j.ejphar.2021.174279_bib54","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/S1499-3872(13)60067-3","article-title":"Effect of L-cysteine on remote organ injury in rats with severe acute pancreatitis induced by bile-pancreatic duct obstruction","volume":"12","author":"Yang","year":"2013","journal-title":"Hepatobiliary Pancreat. Dis. Int."},{"issue":"7","key":"10.1016\/j.ejphar.2021.174279_bib55","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1038\/labinvest.2013.66","article-title":"TLR4 as receptor for HMGB1-mediated acute lung injury after liver ischemia\/reperfusion injury","volume":"93","author":"Yang","year":"2013","journal-title":"Lab. Invest."},{"issue":"1","key":"10.1016\/j.ejphar.2021.174279_bib56","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.taap.2015.01.001","article-title":"Protocatechuic aldehyde ameliorates experimental pulmonary fibrosis by modulating HMGB1\/RAGE pathway","volume":"283","author":"Zhang","year":"2015","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"4","key":"10.1016\/j.ejphar.2021.174279_bib57","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1002\/cbf.1757","article-title":"Anti\u2010ageing effects of protocatechuic acid from Alpinia on spleen and liver antioxidative system of senescent mice","volume":"29","author":"Zhang","year":"2011","journal-title":"Cell Biochem. Funct."},{"issue":"9","key":"10.1016\/j.ejphar.2021.174279_bib58","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.1007\/s10620-009-1073-0","article-title":"Antioxidant inhibits HMGB1 expression and reduces pancreas injury in rats with severe acute pancreatitis","volume":"55","author":"Zhang","year":"2010","journal-title":"Dig. Dis. Sci."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299921004325?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299921004325?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T22:55:36Z","timestamp":1757976936000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299921004325"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":58,"alternative-id":["S0014299921004325"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2021.174279","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeting HMGB1\/TLR4\/NF-\u03baB signaling pathway by protocatechuic acid protects against l-arginine induced acute pancreatitis and multiple organs injury in rats","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2021.174279","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"174279"}}