{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:32:31Z","timestamp":1788222751714,"version":"build-2803163510"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004484","name":"Tehran University of Medical Sciences and Health Services","doi-asserted-by":"publisher","award":["28563"],"award-info":[{"award-number":["28563"]}],"id":[{"id":"10.13039\/501100004484","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008091","name":"Golestan University of Medical Sciences","doi-asserted-by":"publisher","award":["971158"],"award-info":[{"award-number":["971158"]}],"id":[{"id":"10.13039\/501100008091","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.ejphar.2021.174281","type":"journal-article","created":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T11:12:58Z","timestamp":1625137978000},"page":"174281","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Dual effects of atorvastatin on angiogenesis pathways in the differentiation of mesenchymal stem cells"],"prefix":"10.1016","volume":"907","author":[{"given":"Solmaz","family":"Khalighfard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vahid","family":"Khori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali Mohammad","family":"Alizadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gelareh","family":"Vahabzadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahboubeh","family":"Tajaldini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sima","family":"Sedighi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zohreh","family":"Nozarian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid","family":"Khodayari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeed","family":"Khodayari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Ganji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziba","family":"Veisi Malekshahi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tahereh","family":"Mirmajidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2021.174281_bib1","article-title":"Chemoprotection of MNNG-initiated gastric cancer in rats using Iranian propolis","volume":"18","author":"Alizadeh","year":"2015","journal-title":"Arch. Iran. Med."},{"key":"10.1016\/j.ejphar.2021.174281_bib2","doi-asserted-by":"crossref","first-page":"S29","DOI":"10.33549\/physiolres.932644","article-title":"Polysaccharides as cell carriers for tissue engineering: the use of cellulose in vascular wall reconstruction","volume":"63","author":"Bacakova","year":"2014","journal-title":"Physiol. Res."},{"key":"10.1016\/j.ejphar.2021.174281_bib3","first-page":"2553","article-title":"The anti-angiogenic effect of atorvastatin in glioblastoma spheroids tumor cultured in fibrin gel: in 3D in vitro model","volume":"19","author":"Bayat","year":"2018","journal-title":"Asian Pac. J. Cancer Prev. APJCP: Asian Pac. J. Cancer Prev. APJCP"},{"key":"10.1016\/j.ejphar.2021.174281_bib4","doi-asserted-by":"crossref","first-page":"3186","DOI":"10.1096\/fj.09-145102","article-title":"RhoA\/ROCK signaling is essential for multiple aspects of VEGF-mediated angiogenesis","volume":"24","author":"Bryan","year":"2010","journal-title":"Faseb. J."},{"key":"10.1016\/j.ejphar.2021.174281_bib5","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/j.cellsig.2012.02.005","article-title":"Angiotensin II modulates VEGF-driven angiogenesis by opposing effects of type 1 and type 2 receptor stimulation in the microvascular endothelium","volume":"24","author":"Carbajo-Lozoya","year":"2012","journal-title":"Cell. Signal."},{"key":"10.1016\/j.ejphar.2021.174281_bib6","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/sj.jcbfm.9600034","article-title":"Atorvastatin induction of VEGF and BDNF promotes brain plasticity after stroke in mice","volume":"25","author":"Chen","year":"2005","journal-title":"J. Cerebr. Blood Flow Metabol."},{"key":"10.1016\/j.ejphar.2021.174281_bib7","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1002\/term.1936","article-title":"Gelatin\u2010based hydrogel for vascular endothelial growth factor release in peripheral nerve tissue engineering","volume":"11","author":"Gnavi","year":"2017","journal-title":"Journal of tissue engineering and regenerative medicine"},{"key":"10.1016\/j.ejphar.2021.174281_bib8","series-title":"Tissue Engineering Scaffolds: History, Types and Construction Methods","author":"Hashemi","year":"2011"},{"key":"10.1016\/j.ejphar.2021.174281_bib9","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.ijpharm.2013.11.041","article-title":"Gene therapy and DNA delivery systems","volume":"459","author":"Ibraheem","year":"2014","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejphar.2021.174281_bib10","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1111\/j.1365-2796.2009.02151.x","article-title":"Effects of atorvastatin on circulating CD34+\/CD133+\/CD45\u2212 progenitor cells and indices of angiogenesis (vascular endothelial growth factor and the angiopoietins 1 and 2) in atherosclerotic vascular disease and diabetes mellitus","volume":"267","author":"Jaumdally","year":"2010","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.ejphar.2021.174281_bib11","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.peptides.2018.07.007","article-title":"Oxytocin effects on the inhibition of the NF-\u03baB\/miR195 pathway in mice breast cancer","volume":"107","author":"Khori","year":"2018","journal-title":"Peptides"},{"key":"10.1016\/j.ejphar.2021.174281_bib12","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/nrm3758","article-title":"Molecular mechanisms of epithelial\u2013mesenchymal transition","volume":"15","author":"Lamouille","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ejphar.2021.174281_bib13","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1007\/s00228-002-0556-0","article-title":"Beyond lipid-lowering: effects of statins on endothelial nitric oxide","volume":"58","author":"Laufs","year":"2003","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"10.1016\/j.ejphar.2021.174281_bib14","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s10439-013-0859-6","article-title":"Biomaterials for tissue engineering","volume":"42","author":"Lee","year":"2014","journal-title":"Ann. Biomed. Eng."},{"key":"10.1016\/j.ejphar.2021.174281_bib15","doi-asserted-by":"crossref","first-page":"740","DOI":"10.3390\/polym3020740","article-title":"Hydrogels for cardiac tissue engineering","volume":"3","author":"Li","year":"2011","journal-title":"Polymers"},{"key":"10.1016\/j.ejphar.2021.174281_bib16","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1097\/00000478-200109000-00007","article-title":"CD31 expression in intratumoral macrophages: a potential diagnostic pitfall","volume":"25","author":"McKenney","year":"2001","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1016\/j.ejphar.2021.174281_bib17","article-title":"Evaluating the effects of Atorvastatin on cultured human endometrium in a three-dimensional fibrin matrix","volume":"7","author":"Montaseri","year":"2007","journal-title":"J. Reproduction Infertil."},{"key":"10.1016\/j.ejphar.2021.174281_bib18","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.addr.2011.03.004","article-title":"Vascularization is the key challenge in tissue engineering","volume":"63","author":"Novosel","year":"2011","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"85","key":"10.1016\/j.ejphar.2021.174281_bib19","first-page":"50947","article-title":"A three-dimensional tissue culture model to study primary human bone marrow and its malignancies","volume":"8","author":"Parikh","year":"2014","journal-title":"J Vis Exp"},{"key":"10.1016\/j.ejphar.2021.174281_bib20","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1159\/000354445","article-title":"Atorvastatin improves microenvironment to enhance the beneficial effects of BMSCs therapy in a rabbit model of acute myocardial infarction","volume":"32","author":"Qu","year":"2013","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.ejphar.2021.174281_bib21","doi-asserted-by":"crossref","first-page":"3172","DOI":"10.1016\/j.jtcvs.2014.07.104","article-title":"Differential effects of atorvastatin on autophagy in ischemic and nonischemic myocardium in Ossabaw swine with metabolic syndrome","volume":"148","author":"Sabe","year":"2014","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"10.1016\/j.ejphar.2021.174281_bib22","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1080\/10739680600556944","article-title":"Rho and ROCK signaling in VEGF\u2010induced microvascular endothelial hyperpermeability","volume":"13","author":"Sun","year":"2006","journal-title":"Microcirculation"},{"key":"10.1016\/j.ejphar.2021.174281_bib23","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1161\/01.RES.0000014081.30867.F8","article-title":"Double-edged role of statins in angiogenesis signaling","volume":"90","author":"Urbich","year":"2002","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2021.174281_bib24","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.cardiores.2003.09.026","article-title":"Pharmacological therapy can increase capillary density in post-infarction remodeled rat hearts","volume":"61","author":"Van Kerckhoven","year":"2004","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ejphar.2021.174281_bib25","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1097\/01.mca.0000131572.14521.8a","article-title":"Effects of statins on endothelium and their contribution to neovascularization by mobilization of endothelial progenitor cells","volume":"15","author":"Walter","year":"2004","journal-title":"Coron. Artery Dis."},{"key":"10.1016\/j.ejphar.2021.174281_bib26","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.ejvs.2017.10.012","article-title":"Efficient differentiation of bone marrow mesenchymal stem cells into endothelial cells in vitro","volume":"55","author":"Wang","year":"2018","journal-title":"Eur. J. Vasc. Endovasc. Surg."},{"key":"10.1016\/j.ejphar.2021.174281_bib27","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1161\/hc0602.103393","article-title":"Statins have biphasic effects on angiogenesis","volume":"105","author":"Weis","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2021.174281_bib28","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1093\/eurheartj\/ehn167","article-title":"Atorvastatin treatment improves survival and effects of implanted mesenchymal stem cells in post-infarct swine hearts","volume":"29","author":"Yang","year":"2008","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ejphar.2021.174281_bib29","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1089\/scd.2011.0684","article-title":"Autophagy activation: a novel mechanism of atorvastatin to protect mesenchymal stem cells from hypoxia and serum deprivation via AMP-activated protein kinase\/mammalian target of rapamycin pathway","volume":"21","author":"Zhang","year":"2012","journal-title":"Stem Cell. Dev."},{"key":"10.1016\/j.ejphar.2021.174281_bib30","first-page":"1919","article-title":"Effects of various doses of atorvastatin on vascular endothelial cell apoptosis and autophagy in vitro","volume":"19","author":"Zhao","year":"2019","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.ejphar.2021.174281_bib31","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1139\/cjpp-2013-0292","article-title":"Atorvastatin increases endothelial progenitor cells in balloon-injured mouse carotid artery","volume":"92","author":"Zhou","year":"2014","journal-title":"Can. J. Physiol. Pharmacol."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299921004349?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299921004349?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T22:54:09Z","timestamp":1757976849000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299921004349"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":31,"alternative-id":["S0014299921004349"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2021.174281","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dual effects of atorvastatin on angiogenesis pathways in the differentiation of mesenchymal stem cells","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2021.174281","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"174281"}}