{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T01:52:27Z","timestamp":1792633947008,"version":"4.5.0"},"reference-count":136,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005421","name":"Guilan University of Medical Sciences","doi-asserted-by":"publisher","award":["1715"],"award-info":[{"award-number":["1715"]}],"id":[{"id":"10.13039\/501100005421","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010318","name":"University of Manitoba","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010318","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.ejphar.2021.174310","type":"journal-article","created":{"date-parts":[[2021,7,12]],"date-time":"2021-07-12T11:01:46Z","timestamp":1626087706000},"page":"174310","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":143,"special_numbering":"C","title":["NMDA and AMPA receptors dysregulation in Alzheimer's disease"],"prefix":"10.1016","volume":"908","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4870-8182","authenticated-orcid":false,"given":"Parvin","family":"Babaei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2021.174310_bib1","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1038\/sj.emboj.7600126","article-title":"Tyrosine phosphorylation of GluR2 is required for insulin\u2010stimulated AMPA receptor endocytosis and LTD","volume":"23","author":"Ahmadian","year":"2004","journal-title":"EMBO J."},{"key":"10.1016\/j.ejphar.2021.174310_bib2","doi-asserted-by":"crossref","first-page":"10869","DOI":"10.1523\/JNEUROSCI.5531-08.2009","article-title":"NMDA receptor GluN2B (GluR\u03b52\/NR2B) subunit is crucial for channel function, postsynaptic macromolecular organization, and actin cytoskeleton at hippocampal CA3 synapses","volume":"29","author":"Akashi","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2021.174310_bib3","doi-asserted-by":"crossref","first-page":"8334","DOI":"10.1523\/JNEUROSCI.2155-07.2007","article-title":"NMDA di-heteromeric receptor populations and associated proteins in rat hippocampus","volume":"27","author":"Al-Hallaq","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2021.174310_bib4","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2019.00430","article-title":"Amyloid beta and MicroRNAs in Alzheimer's disease","volume":"13","author":"Amakiri","year":"2019","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.ejphar.2021.174310_bib5","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1124\/mol.112.078998","article-title":"Ifenprodil effects on GluN2B-containing glutamate receptors","volume":"82","author":"Amico-Ruvio","year":"2012","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.ejphar.2021.174310_bib6","first-page":"206","article-title":"PKM\u03b6 contributes in consolidation, retrieval and maintenance of amygdala dependent fear memory in rats","volume":"21","author":"Amirshabani","year":"2017","journal-title":"Physiol. Pharmacol."},{"key":"10.1016\/j.ejphar.2021.174310_bib7","first-page":"1","article-title":"Co-treatment of AMPA endocytosis inhibitor and GluN2B antagonist facilitate consolidation and retrieval of memory impaired by \u03b2 amyloid peptide","author":"Ashourpour","year":"2020","journal-title":"Int. J. Neurosci."},{"key":"10.1016\/j.ejphar.2021.174310_bib8","first-page":"1","article-title":"Chronic administration of Tat-GluR23Y ameliorates cognitive dysfunction targeting CREB signaling in rats with amyloid beta neurotoxicity","author":"Ashourpour","year":"2021","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.ejphar.2021.174310_bib9","doi-asserted-by":"crossref","first-page":"962","DOI":"10.15252\/embr.201643519","article-title":"Posttranslational modification impact on the mechanism by which amyloid-\u03b2 induces synaptic dysfunction","volume":"18","author":"M","year":"2017","journal-title":"EMBO Rep."},{"key":"10.1016\/j.ejphar.2021.174310_bib10","doi-asserted-by":"crossref","first-page":"626","DOI":"10.3389\/fnins.2017.00626","article-title":"Cognitive decline in neuronal aging and Alzheimer's disease: role of NMDA receptors and associated proteins","volume":"11","author":"Avila","year":"2017","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.ejphar.2021.174310_bib11","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1084\/jem.20161673","article-title":"Therapeutic targeting of the pathological triad of extrasynaptic NMDA receptor signaling in neurodegenerations","volume":"214","author":"Bading","year":"2017","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.ejphar.2021.174310_bib12","doi-asserted-by":"crossref","DOI":"10.1111\/acel.12791","article-title":"Impaired AMPA signaling and cytoskeletal alterations induce early synaptic dysfunction in a mouse model of Alzheimer's disease","volume":"17","author":"Baglietto-Vargas","year":"2018","journal-title":"Aging Cell"},{"key":"10.1016\/j.ejphar.2021.174310_bib13","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.neuroscience.2008.10.007","article-title":"The GLUR2 subunit of AMPA receptors: synaptic role","volume":"158","author":"Bassani","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.ejphar.2021.174310_bib14","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1093\/hmg\/ddr470","article-title":"Inherited and de novo SHANK2 variants associated with autism spectrum disorder impair neuronal morphogenesis and physiology","volume":"21","author":"Berkel","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ejphar.2021.174310_bib15","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.31599","article-title":"Cerebellar learning using perturbations","volume":"7","author":"Bouvier","year":"2018","journal-title":"Elife"},{"key":"10.1016\/j.ejphar.2021.174310_bib16","doi-asserted-by":"crossref","first-page":"3660","DOI":"10.1523\/JNEUROSCI.5309-08.2009","article-title":"The cause of the imbalance in the neuronal network leading to seizure activity can be predicted by the electrographic pattern of the seizure onset","volume":"29","author":"Bragin","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2021.174310_bib17","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1101\/lm.037044.114","article-title":"Serine 133 phosphorylation is not required for hippocampal CREB-mediated transcription and behavior","volume":"22","author":"Briand","year":"2015","journal-title":"Learn. Mem."},{"key":"10.1016\/j.ejphar.2021.174310_bib18","doi-asserted-by":"crossref","first-page":"641","DOI":"10.2165\/00023210-200317090-00004","article-title":"The glutamatergic system and Alzheimer's disease","volume":"17","author":"Butterfield","year":"2003","journal-title":"CNS Drugs"},{"key":"10.1016\/j.ejphar.2021.174310_bib19","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1083\/jcb.86.3.831","article-title":"Isolation and characterization of postsynaptic densities from various brain regions","volume":"86","author":"Carlin","year":"1980","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ejphar.2021.174310_bib20","doi-asserted-by":"crossref","first-page":"12359","DOI":"10.1074\/jbc.M200528200","article-title":"Phosphorylation of stargazin by protein kinase A regulates its interaction with PSD-95","volume":"277","author":"Choi","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2021.174310_bib21","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.neuron.2006.08.033","article-title":"Arc\/Arg3.1 interacts with the endocytic machinery to regulate AMPA receptor trafficking","volume":"52","author":"Chowdhury","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.ejphar.2021.174310_bib22","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s10059-013-0113-y","article-title":"NMDA receptor as a newly identified member of the metabotropic glutamate receptor family: clinical implications for neurodegenerative diseases","volume":"36","author":"Chung","year":"2013","journal-title":"Mol. Cell"},{"key":"10.1016\/j.ejphar.2021.174310_bib23","first-page":"609","article-title":"Presynaptic NMDA receptors: newly appreciated roles in cortical synaptic function and plasticity","volume":"14","author":"Corlew","year":"2008","journal-title":"Neuroscience"},{"key":"10.1016\/j.ejphar.2021.174310_bib24","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1007\/s12035-013-8534-3","article-title":"Glutamatergic postsynaptic density protein dysfunctions in synaptic plasticity and dendritic spines morphology: relevance to schizophrenia and other behavioral disorders pathophysiology, and implications for novel therapeutic approaches","volume":"49","author":"De Bartolomeis","year":"2014","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.ejphar.2021.174310_bib25","doi-asserted-by":"crossref","first-page":"e34","DOI":"10.1371\/journal.pbio.0060034","article-title":"Caldendrin-Jacob: a protein liaison that couples NMDA receptor signalling to the nucleus","volume":"6","author":"Dieterich","year":"2008","journal-title":"PLoS Biol."},{"key":"10.1016\/j.ejphar.2021.174310_bib26","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1172\/JCI77888","article-title":"Long-term potentiation decay and memory loss are mediated by AMPAR endocytosis","volume":"125","author":"Dong","year":"2015","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ejphar.2021.174310_bib27","doi-asserted-by":"crossref","first-page":"10800","DOI":"10.1523\/JNEUROSCI.1825-17.2017","article-title":"Unconventional NMDA receptor signaling","volume":"37","author":"Dore","year":"2017","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2021.174310_bib28","doi-asserted-by":"crossref","first-page":"10800","DOI":"10.1523\/JNEUROSCI.1825-17.2017","article-title":"Unconventional NMDA receptor signaling","volume":"37","author":"Dore","year":"2017","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2021.174310_bib29","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/0165-0173(94)00014-G","article-title":"The N-methyl-d-aspartate antagonists phencyclidine, ketamine and dizocilpine as both behavioral and anatomical models of the dementias","volume":"20","author":"Ellison","year":"1995","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.ejphar.2021.174310_bib30","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/nn997","article-title":"PKA phosphorylation of AMPA receptor subunits controls synaptic trafficking underlying plasticity","volume":"6","author":"Esteban","year":"2003","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.ejphar.2021.174310_bib31","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.neurobiolaging.2014.09.006","article-title":"A\u03b2 and NMDAR activation cause mitochondrial dysfunction involving ER calcium release","volume":"36","author":"Ferreira","year":"2015","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.ejphar.2021.174310_bib32","doi-asserted-by":"crossref","DOI":"10.1177\/1759091419855541","article-title":"Amyloid beta-related alterations to glutamate signaling dynamics during Alzheimer's disease progression","volume":"11","author":"Findley","year":"2019","journal-title":"ASN Neuro"},{"key":"10.1016\/j.ejphar.2021.174310_bib33","doi-asserted-by":"crossref","first-page":"13814","DOI":"10.1523\/JNEUROSCI.1943-10.2010","article-title":"Mechanisms involved in systemic nicotine-induced glutamatergic synaptic plasticity on dopamine neurons in the ventral tegmental area","volume":"30","author":"Gao","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2021.174310_bib34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2012.07.032","article-title":"Inflammatory activation enhances NMDA-triggered Ca2 signalling and IL-1\u03b2 secretion in primary cultures of rat astrocytes","volume":"1473","author":"G\u00e9rard","year":"2012","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2021.174310_bib35","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.ceca.2012.02.008","article-title":"Mitochondrial Ca2+ and apoptosis","volume":"52","author":"Giorgi","year":"2012","journal-title":"Cell Calcium"},{"key":"10.1016\/j.ejphar.2021.174310_bib36","doi-asserted-by":"crossref","first-page":"8186","DOI":"10.1074\/jbc.M116.774554","article-title":"GluA1 subunit ubiquitination mediates amyloid-\u03b2-induced loss of surface \u03b1-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors","volume":"292","author":"Guntupalli","year":"2017","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2021.174310_bib37","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1038\/nrn2911","article-title":"Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders","volume":"11","author":"Hardingham","year":"2010","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.ejphar.2021.174310_bib38","doi-asserted-by":"crossref","first-page":"11","DOI":"10.31887\/DCNS.2013.15.1\/jhenley","article-title":"AMPA receptor trafficking and the mechanisms underlying synaptic plasticity and cognitive aging","volume":"15","author":"Henley","year":"2013","journal-title":"Dialogues Clin. Neurosci."},{"key":"10.1016\/j.ejphar.2021.174310_bib39","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nrn.2016.37","article-title":"Synaptic AMPA receptor composition in development, plasticity and disease","volume":"17","author":"Henley","year":"2016","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.ejphar.2021.174310_bib40","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.tips.2016.05.012","article-title":"Physiological roles of non-neuronal NMDA receptors","volume":"37","author":"Hogan-Cann","year":"2016","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.ejphar.2021.174310_bib41","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.neuron.2006.10.035","article-title":"AMPAR removal underlies A\u03b2-induced synaptic depression and dendritic spine loss","volume":"52","author":"Hsieh","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.ejphar.2021.174310_bib42","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2017.140","article-title":"Overexpression of EphB2 in hippocampus rescues impaired NMDA receptors trafficking and cognitive dysfunction in Alzheimer model","volume":"8","author":"Hu","year":"2017","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ejphar.2021.174310_bib43","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1038\/nrn.2017.24","article-title":"NMDA receptors: linking physiological output to biophysical operation","volume":"18","author":"Iacobucci","year":"2017","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.ejphar.2021.174310_bib44","first-page":"1","article-title":"The CaMKII\/NMDA receptor complex controls hippocampal synaptic transmission by kinase-dependent and independent mechanisms","volume":"9","author":"Incontro","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejphar.2021.174310_bib45","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.cell.2010.06.036","article-title":"Dendritic function of tau mediates amyloid-\u03b2 toxicity in Alzheimer's disease mouse models","volume":"142","author":"Ittner","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.ejphar.2021.174310_bib46","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1038\/nn.2362","article-title":"SAP97 and CASK mediate sorting of NMDA receptors through a previously unknown secretory pathway","volume":"12","author":"Jeyifous","year":"2009","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.ejphar.2021.174310_bib47","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/j.cell.2013.02.002","article-title":"Encoding and transducing the synaptic or extrasynaptic origin of NMDA receptor signals to the nucleus","volume":"152","author":"Karpova","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.ejphar.2021.174310_bib48","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1016\/j.bpj.2014.07.074","article-title":"Beta-amyloid oligomers activate apoptotic BAK pore for cytochrome c release","volume":"107","author":"Kim","year":"2014","journal-title":"Biophys. J."},{"key":"10.1016\/j.ejphar.2021.174310_bib49","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s12035-008-8018-z","article-title":"Dendritic spine loss and synaptic alterations in Alzheimer's disease","volume":"37","author":"Knobloch","year":"2008","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.ejphar.2021.174310_bib50","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s00441-006-0273-6","article-title":"NMDA receptor function: subunit composition versus spatial distribution","volume":"326","author":"K\u00f6hr","year":"2006","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.ejphar.2021.174310_bib51","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/nrn2207","article-title":"Long-term synaptic plasticity in hippocampal interneurons","volume":"8","author":"Kullmann","year":"2007","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.ejphar.2021.174310_bib52","doi-asserted-by":"crossref","first-page":"7762","DOI":"10.1523\/JNEUROSCI.2482-12.2013","article-title":"Presynaptic NMDA receptor mechanisms for enhancing spontaneous neurotransmitter release","volume":"33","author":"Kunz","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2021.174310_bib53","doi-asserted-by":"crossref","first-page":"10191","DOI":"10.1523\/JNEUROSCI.3432-04.2004","article-title":"Synaptic targeting by Alzheimer\u2019s-related amyloid \u03b2 oligomers","volume":"24","author":"Lacor","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2021.174310_bib54","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.brainres.2014.10.034","article-title":"Theta-burst LTP","volume":"1621","author":"Larson","year":"2015","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2021.174310_bib55","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1038\/35016089","article-title":"Regulation of distinct AMPA receptor phosphorylation sites during bidirectional synaptic plasticity","volume":"405","author":"Lee","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2021.174310_bib56","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1523\/JNEUROSCI.4288-04.2005","article-title":"Activity-dependent neuroprotection and cAMP response element-binding protein (CREB): kinase coupling, stimulus intensity, and temporal regulation of CREB phosphorylation at serine 133","volume":"25","author":"Lee","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2021.174310_bib57","doi-asserted-by":"crossref","first-page":"4258","DOI":"10.1096\/fj.08-107268","article-title":"Neuronal viability is controlled by a functional relation between synaptic and extrasynaptic NMDA receptors","volume":"22","author":"Leveille","year":"2008","journal-title":"Faseb. J."},{"key":"10.1016\/j.ejphar.2021.174310_bib58","doi-asserted-by":"crossref","first-page":"469","DOI":"10.3389\/fnins.2015.00469","article-title":"Chronic glutamate toxicity in neurodegenerative diseases\u2014what is the evidence?","volume":"9","author":"Lewerenz","year":"2015","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.ejphar.2021.174310_bib59","article-title":"GluN2B-NMDA receptors in Alzheimers disease: What do they got to do with AD?","author":"Li","year":"2015","journal-title":"J. Neurol. Disord."},{"key":"10.1016\/j.ejphar.2021.174310_bib60","doi-asserted-by":"crossref","first-page":"4437","DOI":"10.1091\/mbc.e05-01-0010","article-title":"Calcium-activated RAF\/MEK\/ERK signaling pathway mediates p53-dependent apoptosis and is abrogated by \u03b1B-crystallin through inhibition of RAS activation","volume":"16","author":"Li","year":"2005","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.ejphar.2021.174310_bib61","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.cell.2010.03.053","article-title":"Caspase-3 activation via mitochondria is required for long-term depression and AMPA receptor internalization","volume":"141","author":"Li","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.ejphar.2021.174310_bib62","doi-asserted-by":"crossref","first-page":"6627","DOI":"10.1523\/JNEUROSCI.0203-11.2011","article-title":"Soluble A\u03b2 oligomers inhibit long-term potentiation through a mechanism involving excessive activation of extrasynaptic NR2B-containing NMDA receptors","volume":"31","author":"Li","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2021.174310_bib63","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/112_2014_19","article-title":"Glial calcium signalling in Alzheimer's disease","volume":"167","author":"Lim","year":"2014","journal-title":"Rev. Physiol. Biochem. Pharmacol."},{"key":"10.1016\/j.ejphar.2021.174310_bib64","doi-asserted-by":"crossref","first-page":"2846","DOI":"10.1523\/JNEUROSCI.0116-07.2007","article-title":"NMDA receptor subunits have differential roles in mediating excitotoxic neuronal death both in vitro and in vivo","volume":"27","author":"Liu","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2021.174310_bib65","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3389\/fnins.2019.00043","article-title":"The role of NMDA receptors in Alzheimer's disease","volume":"13","author":"Liu","year":"2019","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.ejphar.2021.174310_bib66","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.neuron.2009.02.027","article-title":"Subunit composition of synaptic AMPA receptors revealed by a single-cell genetic approach","volume":"62","author":"Lu","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.ejphar.2021.174310_bib67","doi-asserted-by":"crossref","first-page":"5589","DOI":"10.1523\/JNEUROSCI.6566-10.2011","article-title":"Amyloid \u03b2-induced impairments in hippocampal synaptic plasticity are rescued by decreasing mitochondrial superoxide","volume":"31","author":"Ma","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2021.174310_bib68","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.neuron.2013.03.009","article-title":"Nanoscale scaffolding domains within the postsynaptic density concentrate synaptic ampa receptors","volume":"78","author":"MacGillavry","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.ejphar.2021.174310_bib69","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/6701324","article-title":"Intracellular calcium dysregulation: implications for Alzheimer's disease","author":"Magi","year":"2016","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.ejphar.2021.174310_bib70","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/j.neuron.2011.08.017","article-title":"Regulation of AMPA receptor function by the human memory-associated gene KIBRA","volume":"71","author":"Makuch","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.ejphar.2021.174310_bib71","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1126\/science.2549638","article-title":"Inhibition of postsynaptic PKC or CaMKII blocks induction but not expression of LTP","volume":"245","author":"Malinow","year":"1989","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2021.174310_bib72","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/S0896-6273(00)81067-3","article-title":"Regulation of AMPA receptor-mediated synaptic transmission by clathrin-dependent receptor internalization","volume":"25","author":"Man","year":"2000","journal-title":"Neuron"},{"key":"10.1016\/j.ejphar.2021.174310_bib73","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/nature02617","article-title":"Structural basis of long-term potentiation in single dendritic spines","volume":"429","author":"Matsuzaki","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2021.174310_bib74","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0134385","article-title":"Amyloid-\u03b2(25-35) modulates the expression of GirK and KCNQ channel genes in the Hippocampus","volume":"10","author":"Mayordomo-Cava","year":"2015","journal-title":"PloS One"},{"key":"10.1016\/j.ejphar.2021.174310_bib75","doi-asserted-by":"crossref","first-page":"12537","DOI":"10.1523\/JNEUROSCI.2332-16.2016","article-title":"NR2A-containing NMDARs in the prefrontal cortex are required for working memory and associated with age-related cognitive decline","volume":"36","author":"McQuail","year":"2016","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2021.174310_bib76","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1152\/jn.00458.2019","article-title":"Rapid exchange of synaptic and extrasynaptic NMDA receptors in hippocampal CA1 neurons","volume":"123","author":"McQuate","year":"2020","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.ejphar.2021.174310_bib77","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1038\/nn.2531","article-title":"PKM\u03b6 maintains memories by regulating GluR2-dependent AMPA receptor trafficking","volume":"13","author":"Migues","year":"2010","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.ejphar.2021.174310_bib78","volume":"vol. 59","author":"Morimoto","year":"2018"},{"key":"10.1016\/j.ejphar.2021.174310_bib79","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1038\/nn1506","article-title":"Distinct triggering and expression mechanisms underlie LTD of AMPA and NMDA synaptic responses","volume":"8","author":"Morishita","year":"2005","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.ejphar.2021.174310_bib80","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/S0166-2236(00)02031-2","article-title":"Alzheimer's disease \u2013 do tauists and baptists finally shake hands?","volume":"25","author":"Mudher","year":"2002","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.ejphar.2021.174310_bib81","doi-asserted-by":"crossref","first-page":"4027","DOI":"10.1073\/pnas.1219454110","article-title":"Metabotropic NMDA receptor function is required for NMDA receptor-dependent long-term depression","volume":"110","author":"Nabavi","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ejphar.2021.174310_bib82","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-019-10830-9","article-title":"Astrocytic p38\u03b1 MAPK drives NMDA receptor-dependent long-term depression and modulates long-term memory","volume":"10","author":"Navarrete","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejphar.2021.174310_bib83","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2021.113307","article-title":"Synergistic enhancing-memory effect of D-serine and RU360, a mitochondrial calcium uniporter blocker in rat model of Alzheimer's disease","volume":"409","author":"Nikseresht","year":"2021","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ejphar.2021.174310_bib84","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1111\/bph.12240","article-title":"Calcium channel blockers and dementia","volume":"169","author":"Nimmrich","year":"2013","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2021.174310_bib85","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1074\/jbc.M509677200","article-title":"Extrasynaptic membrane trafficking regulated by GluR1 serine 845 phosphorylation primes AMPA receptors for long-term potentiation","volume":"281","author":"Oh","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2021.174310_bib86","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.neuron.2010.06.007","article-title":"CaMKII triggers the diffusional trapping of surface AMPARs through phosphorylation of stargazin","volume":"67","author":"Opazo","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.ejphar.2021.174310_bib87","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/s41537-017-0037-1","article-title":"The role of glutamate transporters in the pathophysiology of neuropsychiatric disorders","volume":"3","author":"O'Donovan","year":"2017","journal-title":"NPJ Schizophr"},{"key":"10.1016\/j.ejphar.2021.174310_bib88","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1124\/pr.57.2.7","article-title":"The molecular pharmacology and cell biology of \u03b1-amino-3-hydroxy-5- methyl-4-isoxazolepropionic acid receptors","volume":"57","author":"Palmer","year":"2005","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.ejphar.2021.174310_bib89","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1001\/archneurol.2009.15","article-title":"Epilepsy and cognitive impairments in alzheimer disease","volume":"66","author":"Palop","year":"2009","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.ejphar.2021.174310_bib90","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1038\/nature05289","article-title":"A network dysfunction perspective on neurodegenerative diseases","volume":"443","author":"Palop","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2021.174310_bib91","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/nrn3504","article-title":"NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease","volume":"14","author":"Paoletti","year":"2013","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.ejphar.2021.174310_bib92","doi-asserted-by":"crossref","first-page":"4279","DOI":"10.1523\/JNEUROSCI.5019-04.2005","article-title":"Nuclear Ca2+ and the cAMP response element-binding protein family mediate a late phase of activity-dependent neuroprotection","volume":"25","author":"Papadia","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2021.174310_bib93","doi-asserted-by":"crossref","first-page":"20130601","DOI":"10.1098\/rstb.2013.0601","article-title":"Organization, control and function of extrasynaptic NMDA receptors","volume":"369","author":"Papouin","year":"2014","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.ejphar.2021.174310_bib94","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/nature01781","article-title":"Induction of dendritic spines by an extracellular domain of AMPA receptor subunit GluR2","volume":"424","author":"Passafaro","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2021.174310_bib95","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.brainresrev.2011.01.003","article-title":"Impaired regulation of synaptic actin cytoskeleton in Alzheimer's disease","volume":"67","author":"Penzes","year":"2011","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.ejphar.2021.174310_bib96","doi-asserted-by":"crossref","first-page":"5187","DOI":"10.1523\/JNEUROSCI.4255-14.2015","article-title":"Conditional deletion of the glutamate transporter GLT-1 reveals that astrocytic GLT-1 protects against fatal epilepsy while neuronal GLT-1 contributes significantly to glutamate uptake into synaptosomes","volume":"35","author":"Petr","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2021.174310_bib97","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1056\/NEJMra0909142","article-title":"Mechanisms of disease","volume":"362","author":"Querfurth","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejphar.2021.174310_bib98","doi-asserted-by":"crossref","first-page":"E6526","DOI":"10.1073\/pnas.1614249113","article-title":"Amyloid-\u03b2 effects on synapses and memory require AMPA receptor subunit GluA3","volume":"113","author":"Reinders","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejphar.2021.174310_bib99","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1016\/S0896-6273(00)80144-0","article-title":"Characterization of multiple phosphorylation sites on the AMPA receptor GluR1 subunit","volume":"16","author":"Roche","year":"1996","journal-title":"Neuron"},{"key":"10.1016\/j.ejphar.2021.174310_bib100","doi-asserted-by":"crossref","first-page":"131","DOI":"10.14336\/AD.2014.0423","article-title":"The role of the tripartite glutamatergic synapse in the pathophysiology of Alzheimer's disease","volume":"6","author":"Rudy","year":"2015","journal-title":"Aging Dis."},{"key":"10.1016\/j.ejphar.2021.174310_bib101","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep22771","article-title":"Forgetting of long-term memory requires activation of NMDA receptors, L-type voltage-dependent Ca 2+ channels, and calcineurin","volume":"6","author":"Sachser","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejphar.2021.174310_bib102","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/nrn1368","article-title":"SRC kinases: a hub for NMDA receptor regulation","volume":"5","author":"Salter","year":"2004","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.ejphar.2021.174310_bib103","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1515\/revneuro-2013-0056","article-title":"Why calcium channel blockers could be an elite choice in the treatment of Alzheimer's disease: a comprehensive review of evidences","volume":"25","author":"Saravanaraman","year":"2014","journal-title":"Rev. Neurosci."},{"key":"10.1016\/j.ejphar.2021.174310_bib104","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1073\/pnas.0503839103","article-title":"Nonsteroidal anti-inflammatory drugs repress \u03b2-secretase gene promoter activity by the activation of PPAR\u03b3","volume":"103","author":"Sastre","year":"2006","journal-title":"Proc. Natl. Acad. Sci. Unit. States Am."},{"key":"10.1016\/j.ejphar.2021.174310_bib105","doi-asserted-by":"crossref","first-page":"13902","DOI":"10.1073\/pnas.172511199","article-title":"Direct interactions between PSD-95 and stargazin control synaptic AMPA receptor number","volume":"99","author":"Schnell","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ejphar.2021.174310_bib106","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/978-3-319-08894-5_2","article-title":"Glutamate metabolism in the brain focusing on astrocytes","volume":"11","author":"Schousboe","year":"2014","journal-title":"Adv. Neurobiol."},{"key":"10.1016\/j.ejphar.2021.174310_bib107","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s00401-011-0843-x","article-title":"Postsynaptic degeneration as revealed by PSD-95 reduction occurs after advanced A\u03b2 and tau pathology in transgenic mouse models of Alzheimer's disease","volume":"122","author":"Shao","year":"2011","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.ejphar.2021.174310_bib108","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1146\/annurev.biochem.76.060805.160029","article-title":"The postsynaptic architecture of excitatory synapses: a more quantitative view","volume":"76","author":"Sheng","year":"2007","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.ejphar.2021.174310_bib109","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.neuron.2006.08.034","article-title":"Arc\/Arg3.1 mediates homeostatic synaptic scaling of AMPA receptors","volume":"52","author":"Shepherd","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.ejphar.2021.174310_bib110","doi-asserted-by":"crossref","first-page":"11959","DOI":"10.1523\/JNEUROSCI.1327-16.2016","article-title":"Blocking the interaction between EphB2 and ADDLs by a small peptide rescues impaired synaptic plasticity and memory deficits in a mouse model of Alzheimer's disease","volume":"36","author":"Shi","year":"2016","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2021.174310_bib111","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s12929-019-0524-y","article-title":"Alzheimer's disease: risk factors and potentially protective measures","volume":"26","author":"Silva","year":"2019","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.ejphar.2021.174310_bib112","doi-asserted-by":"crossref","first-page":"571","DOI":"10.2174\/1871527317666180627122448","article-title":"Therapeutic advancement in Alzheimer disease: new hopes on the horizon?","volume":"17","author":"Singh","year":"2018","journal-title":"CNS Neurol. Disord. Targets (Formerly Curr. Drug Targets-CNS Neurol. Disord."},{"key":"10.1016\/j.ejphar.2021.174310_bib113","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1590\/S0100-879X2003000200004","article-title":"Mitochondria, calcium and pro-apoptotic proteins as mediators in cell death signaling","volume":"36","author":"Smaili","year":"2003","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.ejphar.2021.174310_bib114","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1038\/nn1503","article-title":"Regulation of NMDA receptor trafficking by amyloid-\u03b2","volume":"8","author":"Snyder","year":"2005","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.ejphar.2021.174310_bib115","series-title":"Etude de l\u2019expression de l\u2019hom\u00e9oprot\u00e9ine Engrailed dans l\u2019hippocampe et de ses effets sur la complexit\u00e9 dendritique","author":"Soltani","year":"2014"},{"key":"10.1016\/j.ejphar.2021.174310_bib116","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.pbb.2014.10.001","article-title":"GLT-1 transporter: an effective pharmacological target for various neurological disorders","volume":"127","author":"Soni","year":"2014","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.ejphar.2021.174310_bib117","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/S0896-6273(00)80568-1","article-title":"Novel anchorage of GluR2\/3 to the postsynaptic density by the AMPA receptor-binding protein ABP","volume":"21","author":"Srivastava","year":"1998","journal-title":"Neuron"},{"key":"10.1016\/j.ejphar.2021.174310_bib118","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1038\/sj.npp.1300268","article-title":"AMPA receptor stimulation within the central nucleus of the amygdala elicits a differential activation of central dopaminergic systems","volume":"28","author":"Stalnaker","year":"2003","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.ejphar.2021.174310_bib119","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.neuron.2006.02.025","article-title":"Targeted in vivo mutations of the AMPA receptor subunit GluR2 and its interacting protein PICK1 eliminate cerebellar long-term depression","volume":"49","author":"Steinberg","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.ejphar.2021.174310_bib120","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1146\/annurev.neuro.26.041002.131412","article-title":"The synaptic vesicle cycle","volume":"27","author":"S\u00fcdhof","year":"2004","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.ejphar.2021.174310_bib121","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1038\/jcbfm.2012.195","article-title":"Kinetic analysis of the metabotropic glutamate subtype 5 tracer [18F] FPEB in bolus and bolus-plus-constant-infusion studies in humans","volume":"33","author":"Sullivan","year":"2013","journal-title":"J. Cerebr. Blood Flow Metabol."},{"key":"10.1016\/j.ejphar.2021.174310_bib122","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1111\/bph.12518","article-title":"GluN2C\/GluN2D subunit-selective NMDA receptor potentiator CIQ reverses MK-801-induced impairment in prepulse inhibition and working memory in Y-maze test in mice","volume":"171","author":"Suryavanshi","year":"2014","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2021.174310_bib123","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1038\/nature03624","article-title":"Stargazin modulates AMPA receptor gating and trafficking by distinct domains","volume":"435","author":"Tomita","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2021.174310_bib124","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1124\/pr.109.002451","article-title":"Glutamate receptor ion channels: structure, regulation, and function","volume":"62","author":"Traynelis","year":"2010","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.ejphar.2021.174310_bib125","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.tins.2005.01.001","article-title":"Surface trafficking of receptors between synaptic and extrasynaptic membranes: and yet they do move!","volume":"28","author":"Triller","year":"2005","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.ejphar.2021.174310_bib126","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/584314","article-title":"Abeta (1-42) enhances neuronal excitability in the CA1 via NR2B subunit-containing NMDA receptors","author":"Varga","year":"2014","journal-title":"Neural Plast."},{"key":"10.1016\/j.ejphar.2021.174310_bib127","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.brainresbull.2012.10.005","article-title":"Role of nonsynaptic GluN2B-containing NMDA receptors in excitotoxicity: evidence that fluoxetine selectively inhibits these receptors and may have neuroprotective effects","volume":"93","author":"Vizi","year":"2013","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.ejphar.2021.174310_bib128","doi-asserted-by":"crossref","first-page":"4332","DOI":"10.1523\/JNEUROSCI.4431-08.2009","article-title":"Synaptic SAP97 isoforms regulate AMPA receptor dynamics and access to presynaptic glutamate","volume":"29","author":"Waites","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2021.174310_bib129","doi-asserted-by":"crossref","first-page":"213","DOI":"10.2174\/0929866043407174","article-title":"Oligomers on the brain: the emerging role of soluble protein aggregates in neurodegeneration","volume":"11","author":"Walsh","year":"2004","journal-title":"Protein Pept. Lett."},{"key":"10.1016\/j.ejphar.2021.174310_bib130","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2012.00034","article-title":"The essential role of AMPA receptor GluA2 subunit RNA editing in the normal and diseased brain","author":"Wright","year":"2012","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.ejphar.2021.174310_bib131","doi-asserted-by":"crossref","first-page":"9330","DOI":"10.1523\/JNEUROSCI.2212-09.2009","article-title":"Extrasynaptic NMDA receptors couple preferentially to excitotoxicity via calpain-mediated cleavage of STEP","volume":"29","author":"Xu","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2021.174310_bib132","doi-asserted-by":"crossref","first-page":"7820","DOI":"10.1523\/JNEUROSCI.0223-08.2008","article-title":"PKM\u03b6 maintains late long-term potentiation by N-ethylmaleimide-sensitive factor\/GluR2-dependent trafficking of postsynaptic AMPA receptors","volume":"28","author":"Yao","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2021.174310_bib133","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1007\/s10072-016-2546-5","article-title":"Dysfunction of NMDA receptors in Alzheimer's disease","volume":"37","author":"Zhang","year":"2016","journal-title":"Neurol. Sci."},{"key":"10.1016\/j.ejphar.2021.174310_bib134","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.3233\/JAD-170879","article-title":"Amyloid-\u03b2 induces AMPA receptor ubiquitination and degradation in primary neurons and human brains of Alzheimer's disease","volume":"62","author":"Zhang","year":"2018","journal-title":"J. Alzheimers. Dis."},{"key":"10.1016\/j.ejphar.2021.174310_bib135","doi-asserted-by":"crossref","first-page":"2853","DOI":"10.1152\/jn.00485.2004","article-title":"Amyloid \u03b2 prevents activation of calcium\/calmodulin-dependent protein kinase II and AMPA receptor phosphorylation during hippocampal long-term potentiation","volume":"92","author":"Zhao","year":"2004","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.ejphar.2021.174310_bib136","doi-asserted-by":"crossref","first-page":"7619","DOI":"10.1074\/jbc.M109.057182","article-title":"Inhibition of calcineurin-mediated endocytosis and \u03b1-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors prevents amyloid \u03b2 oligomer-induced synaptic disruption","volume":"285","author":"Zhao","year":"2010","journal-title":"J. Biol. Chem."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299921004635?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299921004635?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T22:52:00Z","timestamp":1757976720000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299921004635"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":136,"alternative-id":["S0014299921004635"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2021.174310","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"NMDA and AMPA receptors dysregulation in Alzheimer's disease","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2021.174310","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"174310"}}