{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T11:45:58Z","timestamp":1792842358675,"version":"4.5.0"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100017950","name":"Shanghai Municipal Commission of Health and Family Planning","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014175","name":"Shanghai Municipal Health and Family Planning Commission","doi-asserted-by":"publisher","award":["CCCX-2001-01"],"award-info":[{"award-number":["CCCX-2001-01"]}],"id":[{"id":"10.13039\/501100014175","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.ejphar.2021.174687","type":"journal-article","created":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T19:38:41Z","timestamp":1638819521000},"page":"174687","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Trans-cinnamaldehyde suppresses microtubule detyrosination and alleviates cardiac hypertrophy"],"prefix":"10.1016","volume":"914","author":[{"given":"Jing","family":"Tian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Li","family":"Shan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si-Ning","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Hua","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Dong","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8992-0481","authenticated-orcid":false,"given":"Ming","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9425-6127","authenticated-orcid":false,"given":"Chen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2021.174687_bib1","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1126\/science.aao4165","article-title":"Vasohibins\/SVBP are tubulin carboxypeptidases (TCPs) that regulate neuron differentiation","volume":"358","author":"Aillaud","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2021.174687_bib2","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1126\/science.aar3895","article-title":"Closing the tubulin detyrosination cycle","volume":"358","author":"Akhmanova","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2021.174687_bib3","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19020551","article-title":"The neuroprotective effects of cinnamic aldehyde in an MPTP mouse model of Parkinson's disease","volume":"19","author":"Bae","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2021.174687_bib4","article-title":"Cardiac remodeling and disease: current understanding of STIM1\/Orai1-mediated store-operated Ca2+ entry in cardiac function and Pathology","volume":"vol. 993","author":"Bartoli","year":"2017"},{"key":"10.1016\/j.ejphar.2021.174687_bib5","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1093\/cvr\/cvu151","article-title":"Emerging roles of junctophilin-2 in the heart and implications for cardiac diseases","volume":"103","author":"Beavers","year":"2014","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ejphar.2021.174687_bib6","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/s41580-018-0009-y","article-title":"Microtubule dynamics: an interplay of biochemistry and mechanics","volume":"19","author":"Brouhard","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ejphar.2021.174687_bib7","series-title":"Microtubules Increase Diastolic Stiffness in Failing Human Cardiomyocytes and Myocardium","author":"Caporizzo","year":"2020"},{"key":"10.1016\/j.ejphar.2021.174687_bib8","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1177\/1535370219868960","article-title":"Cardiac microtubules in health and heart disease","volume":"244","author":"Caporizzo","year":"2019","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.ejphar.2021.174687_bib9","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1038\/s41591-018-0046-2","article-title":"Suppression of detyrosinated microtubules improves cardiomyocyte function in human heart failure","volume":"24","author":"Chen","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.ejphar.2021.174687_bib10","doi-asserted-by":"crossref","first-page":"625","DOI":"10.3390\/antiox8120625","article-title":"Dietary antioxidant trans-cinnamaldehyde reduced visfatin-induced breast cancer progression: in vivo and in vitro study","volume":"8","author":"Chiang","year":"2019","journal-title":"Antioxidants"},{"key":"10.1016\/j.ejphar.2021.174687_bib11","doi-asserted-by":"crossref","first-page":"H1003","DOI":"10.1152\/ajpheart.00132.2006","article-title":"Cytoskeletal networks and the regulation of cardiac contractility: microtubules, hypertrophy, and cardiac dysfunction","volume":"291","author":"Cooper","year":"2006","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.ejphar.2021.174687_bib12","doi-asserted-by":"crossref","first-page":"104405","DOI":"10.1016\/j.fitote.2019.104405","article-title":"A review of cinnamaldehyde and its derivatives as antibacterial agents","volume":"139","author":"Doyle","year":"2019","journal-title":"Fitoterapia"},{"key":"10.1016\/j.ejphar.2021.174687_bib13","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1042\/BST20150279","article-title":"Supramolecular architecture of endoplasmic reticulum\u2013plasma membrane contact sites","volume":"44","author":"Fern\u00e1ndez-Busnadiego","year":"2016","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.ejphar.2021.174687_bib14","doi-asserted-by":"crossref","first-page":"4695","DOI":"10.1007\/s00018-013-1410-5","article-title":"The transverse-axial tubular system of cardiomyocytes","volume":"70","author":"Ferrantini","year":"2013","journal-title":"Cell. Mol. Life Sci. : CM"},{"key":"10.1016\/j.ejphar.2021.174687_bib15","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1016\/j.bbamcr.2015.11.004","article-title":"BIN1 regulates dynamic t-tubule membrane","volume":"1863","author":"Fu","year":"2016","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"10.1016\/j.ejphar.2021.174687_bib16","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.indcrop.2010.10.018","article-title":"Variations in essential oil yield and composition during Cinnamomum cassia bark growth","volume":"33","author":"Geng","year":"2011","journal-title":"Ind. Crop. Prod."},{"key":"10.1016\/j.ejphar.2021.174687_bib17","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/978-1-61779-523-7_20","article-title":"Isolation of cardiac myocytes and fibroblasts from neonatal rat pups","volume":"843","author":"Golden","year":"2012","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.ejphar.2021.174687_bib18","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/978-3-319-57732-6_24","article-title":"Cardiovascular and hemostatic disorders: SOCE in cardiovascular cells: emerging targets for therapeutic intervention","volume":"993","author":"Groschner","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.ejphar.2021.174687_bib19","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1021\/jf048116s","article-title":"Authentication and quantitative analysis on the chemical profile of cassia bark (cortex cinnamomi) by high-pressure liquid chromatography","volume":"53","author":"He","year":"2005","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.ejphar.2021.174687_bib20","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1152\/physrev.00037.2015","article-title":"Cardiac T-tubule microanatomy and function","volume":"97","author":"Hong","year":"2017","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ejphar.2021.174687_bib21","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1161\/CIRCULATIONAHA.111.031229","article-title":"Critical role for stromal interaction molecule 1 in cardiac hypertrophy","volume":"124","author":"Hulot","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2021.174687_bib22","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/nrm3227","article-title":"Post-translational regulation of the microtubule cytoskeleton: mechanisms and functions","volume":"12","author":"Janke","year":"2011","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ejphar.2021.174687_bib23","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1159\/000488835","article-title":"CaMKII potentiates store-operated Ca2+ entry through enhancing STIM1 aggregation and interaction with Orai1","volume":"46","author":"Li","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.ejphar.2021.174687_bib24","doi-asserted-by":"crossref","first-page":"279","DOI":"10.4062\/biomolther.2016.070","article-title":"Cinnamaldehyde derivatives inhibit coxsackievirus B3-induced viral myocarditis","volume":"25","author":"Li","year":"2017","journal-title":"Biomolecules & Therapeutics"},{"key":"10.1016\/j.ejphar.2021.174687_bib25","first-page":"429320","article-title":"Anti-inflammatory activities of Cinnamomum cassia constituents in vitro and in vivo","volume":"2012","author":"Liao","year":"2012","journal-title":"Evid. base Compl. Alternative Med. : eCAM"},{"key":"10.1016\/j.ejphar.2021.174687_bib26","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/j.cub.2005.05.055","article-title":"STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx","volume":"15","author":"Liou","year":"2005","journal-title":"Curr. Biol. : CB"},{"key":"10.1016\/j.ejphar.2021.174687_bib27","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.yjmcc.2011.11.003","article-title":"STIM1-dependent store-operated Ca2+ entry is required for pathological cardiac hypertrophy","volume":"52","author":"Luo","year":"2012","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.ejphar.2021.174687_bib28","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/s41569-018-0007-y","article-title":"Mechanisms of physiological and pathological cardiac hypertrophy","volume":"15","author":"Nakamura","year":"2018","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.ejphar.2021.174687_bib29","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1126\/science.aao5676","article-title":"Vasohibins encode tubulin detyrosinating activity","volume":"358","author":"Nieuwenhuis","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2021.174687_bib30","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.tcb.2018.08.003","article-title":"The tubulin detyrosination cycle: function and enzymes","volume":"29","author":"Nieuwenhuis","year":"2019","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.ejphar.2021.174687_bib31","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.1113\/JP271142","article-title":"Endoplasmic reticulum-plasma membrane junctions: structure, function and dynamics","volume":"594","author":"Okeke","year":"2016","journal-title":"J. Physiol."},{"key":"10.1016\/j.ejphar.2021.174687_bib32","doi-asserted-by":"crossref","first-page":"C277","DOI":"10.1152\/ajpcell.00094.2016","article-title":"SarcOptiM for ImageJ: high-frequency online sarcomere length computing on stimulated cardiomyocytes","volume":"311","author":"Pasqualin","year":"2016","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.ejphar.2021.174687_bib33","doi-asserted-by":"crossref","DOI":"10.1126\/science.aaf0659","article-title":"Detyrosinated microtubules buckle and bear load in contracting cardiomyocytes","volume":"352","author":"Robison","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2021.174687_bib34","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1083\/jcb.100.1.276","article-title":"Purification of brain tubulin-tyrosine ligase by biochemical and immunological methods","volume":"100","author":"Schroder","year":"1985","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ejphar.2021.174687_bib35","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.bbamem.2013.07.011","article-title":"The physiological role of cardiac cytoskeleton and its alterations in heart failure","volume":"1838","author":"Sequeira","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ejphar.2021.174687_bib36","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.fitote.2016.05.016","article-title":"Cinnamaldehyde and its derivatives, a novel class of antifungal agents","volume":"112","author":"Shreaz","year":"2016","journal-title":"Fitoterapia"},{"key":"10.1016\/j.ejphar.2021.174687_bib37","doi-asserted-by":"crossref","first-page":"3762","DOI":"10.1242\/jcs.015735","article-title":"Role of the microtubule cytoskeleton in the function of the store-operated Ca2+ channel activator STIM1","volume":"120","author":"Smyth","year":"2007","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.ejphar.2021.174687_bib38","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/nrm3414","article-title":"STIM proteins: dynamic calcium signal transducers","volume":"13","author":"Soboloff","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ejphar.2021.174687_bib39","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.jep.2013.08.019","article-title":"Protective effects of cinnamic acid and cinnamic aldehyde on isoproterenol-induced acute myocardial ischemia in rats","volume":"150","author":"Song","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.ejphar.2021.174687_bib40","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1126\/science.8097594","article-title":"Cytoskeletal role in the contractile dysfunction of hypertrophied myocardium","volume":"260","author":"Tsutsui","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2021.174687_bib41","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1016\/j.yjmcc.2010.01.020","article-title":"Orai1 and Stim1 regulate normal and hypertrophic growth in cardiomyocytes","volume":"48","author":"Voelkers","year":"2010","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.ejphar.2021.174687_bib42","doi-asserted-by":"crossref","DOI":"10.1126\/science.aan5835","article-title":"Here, there, and everywhere: the importance of ER membrane contact sites","volume":"361","author":"Wu","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2021.174687_bib43","first-page":"14345","article-title":"Cinnamaldehyde attenuates pressure overload-induced cardiac hypertrophy","volume":"8","author":"Yang","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.ejphar.2021.174687_bib44","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1161\/CIRCULATIONAHA.113.008452","article-title":"Microtubule-mediated defects in junctophilin-2 trafficking contribute to myocyte transverse-tubule remodeling and Ca2+ handling dysfunction in heart failure","volume":"129","author":"Zhang","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2021.174687_bib45","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.yjmcc.2016.10.017","article-title":"Cinnamaldehyde ameliorates LPS-induced cardiac dysfunction via TLR4-NOX4 pathway: the regulation of autophagy and ROS production","volume":"101","author":"Zhao","year":"2016","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.ejphar.2021.174687_bib46","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s11010-017-3209-4","article-title":"SOX2-mediated inhibition of miR-223 contributes to STIM1 activation in phenylephrine-induced hypertrophic cardiomyocytes","volume":"443","author":"Zhao","year":"2017","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.ejphar.2021.174687_bib47","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1093\/cvr\/cvv108","article-title":"Targeted inhibition of ANKRD1 disrupts sarcomeric ERK-GATA4 signal transduction and abrogates phenylephrine-induced cardiomyocyte hypertrophy","volume":"106","author":"Zhong","year":"2015","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ejphar.2021.174687_bib48","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.phrs.2017.05.019","article-title":"Cinnamaldehyde in diabetes: a review of pharmacology, pharmacokinetics and safety","volume":"122","author":"Zhu","year":"2017","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.ejphar.2021.174687_bib49","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1038\/nrcardio.2016.25","article-title":"Epidemiology and aetiology of heart failure","volume":"13","author":"Ziaeian","year":"2016","journal-title":"Nat. Rev. Cardiol."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299921008438?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299921008438?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T22:58:54Z","timestamp":1757977134000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299921008438"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":49,"alternative-id":["S0014299921008438"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2021.174687","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Trans-cinnamaldehyde suppresses microtubule detyrosination and alleviates cardiac hypertrophy","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2021.174687","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"174687"}}