{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T12:27:24Z","timestamp":1793881644187,"version":"4.7.0"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.ejphar.2022.174809","type":"journal-article","created":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T10:55:12Z","timestamp":1644490512000},"page":"174809","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Novel preparation of bilirubin-encapsulated pluronic F-127 nanoparticles as a potential biomaterial for wound healing"],"prefix":"10.1016","volume":"919","author":[{"given":"Dhaval J.","family":"Kamothi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9600-4417","authenticated-orcid":false,"given":"Vinay","family":"Kant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babu L.","family":"Jangir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8872-1838","authenticated-orcid":false,"given":"Vinay G.","family":"Joshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Munish","family":"Ahuja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinod","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ejphar.2022.174809_bib1","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1111\/j.1524-475X.2006.00188.x","article-title":"Histologic characterization of vaginal vs. abdominal surgical wound healing in a rabbit model","volume":"15","author":"Abramov","year":"2007","journal-title":"Wound Repair Regen."},{"issue":"3","key":"10.1016\/j.ejphar.2022.174809_bib2","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1111\/iwj.12319","article-title":"Pro\u2010healing effects of bilirubin in open excision wound model in rats","volume":"13","author":"Ahanger","year":"2016","journal-title":"Int. Wound J."},{"issue":"37","key":"10.1016\/j.ejphar.2022.174809_bib3","doi-asserted-by":"crossref","first-page":"33535","DOI":"10.1021\/acsami.9b07626","article-title":"Alfalfa nanofibers for dermal wound healing","volume":"11","author":"Ahn","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.ejphar.2022.174809_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev-bioeng-071811-150124","article-title":"The effect of nanoparticle size, shape, and surface chemistry on biological systems","volume":"14","author":"Albanese","year":"2012","journal-title":"Annu. Rev. Biomed. Eng."},{"key":"10.1016\/j.ejphar.2022.174809_bib5","doi-asserted-by":"crossref","first-page":"102020","DOI":"10.1016\/j.jddst.2020.102020","article-title":"Wound-healing potential of curcumin loaded lignin nanoparticles","volume":"60","author":"Alqahtani","year":"2020","journal-title":"J. Drug Deliv. Sci. Technol."},{"issue":"1","key":"10.1016\/j.ejphar.2022.174809_bib6","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/j.1524-475X.2011.00748.x","article-title":"Tumor necrosis factor-alpha (TNF-\u03b1) is a therapeutic target for impaired cutaneous wound healing","volume":"20","author":"Ashcroft","year":"2012","journal-title":"Wound Repair Regen."},{"key":"10.1016\/j.ejphar.2022.174809_bib7","first-page":"18","article-title":"Debridement: wound bed preparation","volume":"25","author":"Benbow","year":"2011","journal-title":"J. Community Nurs."},{"issue":"1","key":"10.1016\/j.ejphar.2022.174809_bib8","doi-asserted-by":"crossref","first-page":"21836","DOI":"10.1038\/s41598-021-01262-x","article-title":"Enhanced wound healing properties of guar gum\/curcumin-stabilized silver nanoparticle hydrogels","volume":"11","author":"Bhubhanil","year":"2021","journal-title":"Sci. Rep."},{"issue":"12","key":"10.1016\/j.ejphar.2022.174809_bib9","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1038\/nrm3904","article-title":"Remodelling the extracellular matrix in development and disease","volume":"15","author":"Bonnans","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"2","key":"10.1016\/j.ejphar.2022.174809_bib10","first-page":"253","article-title":"Extracellular regulation of TGF-beta activity in wound repair: growth factor latency as a sensor mechanism for injury","volume":"92","author":"Brunner","year":"2004","journal-title":"Thromb. Haemostasis"},{"key":"10.1016\/j.ejphar.2022.174809_bib11","doi-asserted-by":"crossref","first-page":"173172","DOI":"10.1016\/j.ejphar.2020.173172","article-title":"Quercetin loaded chitosan tripolyphosphate nanoparticles accelerated cutaneous wound healing in Wistar rats","volume":"880","author":"Choudhary","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2022.174809_bib12","first-page":"6271547","article-title":"Cytotoxic and genotoxic effects of fluconazole on African green monkey kidney (Vero)","volume":"2018","author":"Correa","year":"2018","journal-title":"Cell Line. Biomed. Res. Int."},{"issue":"1","key":"10.1016\/j.ejphar.2022.174809_bib13","first-page":"21","article-title":"Alpha-smooth muscle actin is transiently expressed by myofibroblasts during experimental wound healing","volume":"63","author":"Darby","year":"1990","journal-title":"Lab. Invest.: a journal of technical methods and pathology"},{"key":"10.1016\/j.ejphar.2022.174809_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/PL00007448","article-title":"Animal models for wound repair","volume":"290","author":"Davidson","year":"1998","journal-title":"Arch. Dermatol. Res."},{"issue":"1","key":"10.1016\/j.ejphar.2022.174809_bib15","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1083\/jcb.122.1.103","article-title":"Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts","volume":"122","author":"Desmouli\u00e8re","year":"1993","journal-title":"J. Cell Biol."},{"issue":"265","key":"10.1016\/j.ejphar.2022.174809_bib16","doi-asserted-by":"crossref","first-page":"265sr6","DOI":"10.1126\/scitranslmed.3009337","article-title":"Wound repair and regeneration: mechanisms, signaling, and translation","volume":"6","author":"Eming","year":"2014","journal-title":"Sci. Transl. Med."},{"issue":"2","key":"10.1016\/j.ejphar.2022.174809_bib17","first-page":"160","article-title":"Effect of transforming growth factor beta 1 on wound healing in induced diabetic rats","volume":"7","author":"Gazaerly","year":"2013","journal-title":"Int. J. Health Sci."},{"key":"10.1016\/j.ejphar.2022.174809_bib18","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s00268-003-7397-6","article-title":"Aging and wound healing","volume":"28","author":"Gosain","year":"2004","journal-title":"World J. Surg."},{"key":"10.1016\/j.ejphar.2022.174809_bib19","first-page":"1235","article-title":"PDGF and FGF stimulate healing in the genetically diabetic mouse","volume":"136","author":"Greenhalgh","year":"1990","journal-title":"Am. J. Pathol."},{"issue":"12","key":"10.1016\/j.ejphar.2022.174809_bib20","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2020-045253","article-title":"Cohort study evaluating the burden of wounds to the UK's National Health Service in 2017\/2018: update from 2012\/2013","volume":"10","author":"Guest","year":"2020","journal-title":"BMJ Open"},{"issue":"3","key":"10.1016\/j.ejphar.2022.174809_bib21","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1177\/0022034509359125","article-title":"Factors affecting wound healing","volume":"89","author":"Guo","year":"2010","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.ejphar.2022.174809_bib22","first-page":"7","article-title":"The effect of Camellia sinensis on wound healing potential in an animal model","author":"Hajiaghaalipour","year":"2013","journal-title":"Evid-Based Compl. Alt. Med."},{"issue":"1","key":"10.1016\/j.ejphar.2022.174809_bib23","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1242\/jcs.114.1.131","article-title":"TNF-alpha stimulates activation of pro-MMP2 in human skin through NF-(kappa) B mediated induction of MT1-MMP","volume":"114","author":"Han","year":"2001","journal-title":"J. Cell Sci."},{"issue":"5","key":"10.1016\/j.ejphar.2022.174809_bib24","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1007\/s004280100464","article-title":"Vascular endothelial growth factor expression, angiogenesis, and necrosis in renal cell carcinomas","volume":"439","author":"Hemmerlein","year":"2001","journal-title":"Virchows Arch. : An Int. J. Pathol."},{"issue":"1","key":"10.1016\/j.ejphar.2022.174809_bib25","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.acthis.2013.04.010","article-title":"Topical pluronic F-127 gel application enhances cutaneous wound healing in rats","volume":"116","author":"Kant","year":"2014","journal-title":"Acta Histochem."},{"key":"10.1016\/j.ejphar.2022.174809_bib26","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.cyto.2014.12.015","article-title":"Topical application of substance P promotes wound healing in streptozotocin-induced diabetic rats","volume":"73","author":"Kant","year":"2015","journal-title":"Cytokine"},{"key":"10.1016\/j.ejphar.2022.174809_bib27","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.jss.2017.01.011","article-title":"Combined effect of substance P and curcumin on cutaneous wound healing in diabetic rats","volume":"212","author":"Kant","year":"2017","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.ejphar.2022.174809_bib28","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.biomaterials.2017.04.029","article-title":"PEGylated bilirubin nanoparticle as an anti-oxidative and anti-inflammatory demulcent in pancreatic islet xenotransplantation","volume":"133","author":"Kim","year":"2017","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.ejphar.2022.174809_bib29","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.clindermatol.2006.09.007","article-title":"Pathophysiology of acute wound healing","volume":"25","author":"Li","year":"2007","journal-title":"Clin. Dermatol."},{"key":"10.1016\/j.ejphar.2022.174809_bib30","series-title":"Manual of Histologic Staining Methods of Armed Forces Institute of Pathology","first-page":"94","author":"Luna","year":"1968"},{"key":"10.1016\/j.ejphar.2022.174809_bib31","series-title":"Cutaneous Wound Healing","first-page":"109","article-title":"Experimental models of wound healing","author":"Mogford","year":"2001"},{"issue":"6","key":"10.1016\/j.ejphar.2022.174809_bib32","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1164\/rccm.200404-465SO","article-title":"Hemeoxygenase-1: from bench to bedside","volume":"172","author":"Morse","year":"2005","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"1","key":"10.1016\/j.ejphar.2022.174809_bib33","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1471-2091-3-17","article-title":"Low solubility of unconjugated bilirubin in dimethylsulfoxide\u2013water systems: implications for pKa determinations","volume":"3","author":"Mukerjee","year":"2002","journal-title":"BMC Biochem."},{"issue":"5","key":"10.1016\/j.ejphar.2022.174809_bib34","doi-asserted-by":"crossref","first-page":"3926","DOI":"10.1021\/nn3057005","article-title":"Gold nanoparticles as a vaccine platform: influence of size and shape on immunological responses in vitro and in vivo","volume":"7","author":"Niikura","year":"2013","journal-title":"ACS Nano"},{"issue":"1","key":"10.1016\/j.ejphar.2022.174809_bib35","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.ijpharm.2005.10.010","article-title":"Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles","volume":"307","author":"Owens","year":"2006","journal-title":"Int. J. Pharm."},{"issue":"31","key":"10.1016\/j.ejphar.2022.174809_bib36","doi-asserted-by":"crossref","first-page":"4600","DOI":"10.1016\/j.biomaterials.2007.07.029","article-title":"Protein adsorption and cellular uptake of cerium oxide nanoparticles as a function of zeta potential","volume":"28","author":"Patil","year":"2007","journal-title":"Biomaterials"},{"issue":"14","key":"10.1016\/j.ejphar.2022.174809_bib37","doi-asserted-by":"crossref","first-page":"5759","DOI":"10.1158\/0008-5472.CAN-10-0507","article-title":"Increased expression of alpha6 integrin in endothelial cells unveils a proangiogenic role for basement membrane","volume":"70","author":"Primo","year":"2010","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.ejphar.2022.174809_bib38","first-page":"7","article-title":"Antibacterial and hemolytic activity of green silver nanoparticles from Catharanthus roseus","volume":"9","author":"Raja","year":"2016","journal-title":"Int. J. Pharm. Sci. Nanotechnol."},{"key":"10.1016\/j.ejphar.2022.174809_bib39","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.intimp.2015.11.037","article-title":"Bilirubin modulated cytokines, growth factors and angiogenesis to improve cutaneous wound healing process in diabetic rats","volume":"30","author":"Ram","year":"2016","journal-title":"Int. Immunopharm."},{"issue":"2","key":"10.1016\/j.ejphar.2022.174809_bib40","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.ejpb.2004.03.019","article-title":"In situ-forming hydrogels--review of temperature-sensitive systems","volume":"58","author":"Ruel-Gari\u00e9py","year":"2004","journal-title":"Eur. J. Pharm. Biopharm. : official journal of Arbeitsgemeinschaft fur PharmazeutischeVerfahrenstechnike.V."},{"issue":"5","key":"10.1016\/j.ejphar.2022.174809_bib41","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.cytogfr.2010.09.002","article-title":"Biology of interleukin-10","volume":"21","author":"Sabat","year":"2010","journal-title":"Cytokine Growth Factor Rev."},{"issue":"2","key":"10.1016\/j.ejphar.2022.174809_bib42","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1089\/wound.2019.0946","article-title":"Human wounds and its burden: an updated compendium of estimates","volume":"8","author":"Sen","year":"2019","journal-title":"Adv. Wound Care"},{"key":"10.1016\/j.ejphar.2022.174809_bib43","first-page":"229","volume":"vol. 360","author":"Settipalli","year":"2015"},{"issue":"2","key":"10.1016\/j.ejphar.2022.174809_bib44","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.jdermsci.2010.05.002","article-title":"Regulation of epidermal keratinocytes by growth factors","volume":"59","author":"Shirakata","year":"2010","journal-title":"J. Dermatol. Sci."},{"issue":"1","key":"10.1016\/j.ejphar.2022.174809_bib45","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1177\/1534734604273660","article-title":"Wound healing research: a perspective from India","volume":"4","author":"Shukla","year":"2005","journal-title":"Int. J. Low. Extrem. Wounds"},{"issue":"1\u20132","key":"10.1016\/j.ejphar.2022.174809_bib46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0168-3659(00)00339-4","article-title":"Biodegradable polymeric nanoparticles as drug delivery devices","volume":"70","author":"Soppimath","year":"2001","journal-title":"J. Contr. Release"},{"issue":"4792","key":"10.1016\/j.ejphar.2022.174809_bib47","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1126\/science.3029864","article-title":"Bilirubin is an antioxidant of possible physiological importance","volume":"235","author":"Stocker","year":"1987","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2022.174809_bib48","first-page":"30","article-title":"A novel non-angiogenic mechanism of VEGF: stimulation of keratinocyte and fibroblast migration","volume":"15","author":"Stojadinovic","year":"2007","journal-title":"Wound Repair Regen."},{"issue":"5","key":"10.1016\/j.ejphar.2022.174809_bib49","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/nrm809","article-title":"Myofibroblasts and mechano-regulation of connective tissue remodelling","volume":"3","author":"Tomasek","year":"2002","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"1","key":"10.1016\/j.ejphar.2022.174809_bib50","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1006\/excr.2000.4869","article-title":"Transforming growth factor-beta1 promotes the morphological and functional differentiation of the myofibroblast","volume":"257","author":"Vaughan","year":"2000","journal-title":"Exp. Cell Res."},{"issue":"3","key":"10.1016\/j.ejphar.2022.174809_bib51","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1124\/pr.55.3.5","article-title":"Different faces of the heme-heme oxygenase system in inflammation","volume":"55","author":"Wagener","year":"2003","journal-title":"Pharmacol. Rev."},{"issue":"3","key":"10.1016\/j.ejphar.2022.174809_bib52","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/S0008-6363(00)00268-6","article-title":"Signaling transduction mechanisms mediating biological actions of the vascular endothelial growth factor family","volume":"49","author":"Zachary","year":"2001","journal-title":"Cardiovasc. Res."},{"issue":"12","key":"10.1016\/j.ejphar.2022.174809_bib53","first-page":"275","article-title":"Fibromodulin enhances angiogenesis during cutaneous wound healing","volume":"2","author":"Zheng","year":"2014","journal-title":"Plast. Reconstr. Surg."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001429992200070X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001429992200070X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T22:59:31Z","timestamp":1757977171000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S001429992200070X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":53,"alternative-id":["S001429992200070X"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2022.174809","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel preparation of bilirubin-encapsulated pluronic F-127 nanoparticles as a potential biomaterial for wound healing","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2022.174809","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"174809"}}