{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T05:22:10Z","timestamp":1792646530271,"version":"4.5.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1016\/j.ejphar.2022.174830","type":"journal-article","created":{"date-parts":[[2022,2,16]],"date-time":"2022-02-16T02:54:55Z","timestamp":1644980095000},"page":"174830","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"special_numbering":"C","title":["GSK-3\u03b2-mediated activation of NLRP3 inflammasome leads to pyroptosis and apoptosis of rat cardiomyocytes and fibroblasts"],"prefix":"10.1016","volume":"920","author":[{"given":"Shu-Hui","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu-Gen","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Ling","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumra","family":"Komal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui-Cong","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Xi","family":"Zang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Rong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng-Na","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2022.174830_bib1","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1111\/cas.14271","article-title":"Glycogen synthase kinase 3\u03b2 as a potential therapeutic target in synovial sarcoma and fibrosarcoma","volume":"2","author":"Abe","year":"2020","journal-title":"Cancer Sci."},{"key":"10.1016\/j.ejphar.2022.174830_bib2","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/s41419-020-02985-x","article-title":"NLRP3 inflammasome in endothelial dysfunction","volume":"9","author":"Bai","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ejphar.2022.174830_bib3","doi-asserted-by":"crossref","first-page":"7971","DOI":"10.1073\/pnas.0932746100","article-title":"A low molecular weight mimic of the Toll\/IL-1 receptor\/resistance domain inhibits IL-1 receptor-mediated responses","volume":"13","author":"Bartfai","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejphar.2022.174830_bib4","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/s41401-019-0307-8","article-title":"Kanglexin, a novel anthraquinone compound, protects against myocardial ischemic injury in mice by suppressing NLRP3 and pyroptosis","volume":"3","author":"Bian","year":"2020","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.ejphar.2022.174830_bib5","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1161\/CIRCULATIONAHA.116.024369","article-title":"NLRP3 inflammasome mediates aldosterone-induced vascular damage","volume":"23","author":"Bruder-Nascimento","year":"2016","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2022.174830_bib6","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1093\/cvr\/cvu264","article-title":"Functional crosstalk between cardiac fibroblasts and adult cardiomyocytes by soluble mediators","volume":"3","author":"Cartledge","year":"2015","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ejphar.2022.174830_bib7","doi-asserted-by":"crossref","first-page":"3461","DOI":"10.1111\/bph.12856","article-title":"Experimental design and analysis and their reporting: new guidance for publication in BJP","volume":"14","author":"Curtis","year":"2015","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2022.174830_bib8","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1002\/cbin.11137","article-title":"Cell death: a review of the major forms of apoptosis, necrosis and autophagy","volume":"6","author":"D'Arcy","year":"2019","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.ejphar.2022.174830_bib9","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1152\/physrev.00022.2018","article-title":"Fundamental mechanisms of regulated cell death and implications for heart disease","volume":"4","author":"Del Re","year":"2019","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ejphar.2022.174830_bib10","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.brainresbull.2020.03.011","article-title":"Hypothermia protects neurons against ischemia\/reperfusion-induced pyroptosis via m6A-mediated activation of PTEN and the PI3K\/Akt\/GSK-3\u03b2 signaling pathway","volume":"1","author":"Diao","year":"2020","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.ejphar.2022.174830_bib11","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nature18590","article-title":"Pore-forming activity and structural autoinhibition of the gasdermin family","volume":"7610","author":"Ding","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2022.174830_bib12","doi-asserted-by":"crossref","first-page":"7100","DOI":"10.7150\/thno.45939","article-title":"NLRP3 inflammasome via IL-1beta regulates PCSK9 secretion","volume":"16","author":"Ding","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.ejphar.2022.174830_bib13","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1038\/nature08938","article-title":"NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals","volume":"7293","author":"Duewell","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2022.174830_bib14","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/nrcardio.2014.28","article-title":"The inflammatory response in myocardial injury, repair, and remodelling","volume":"5","author":"Frangogiannis","year":"2014","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.ejphar.2022.174830_bib15","first-page":"1841","article-title":"Pathophysiology of myocardial infarction","volume":"4","author":"Frangogiannis","year":"2015","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.ejphar.2022.174830_bib16","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1161\/CIRCRESAHA.119.311148","article-title":"The extracellular matrix in ischemic and nonischemic heart failure","volume":"1","author":"Frangogiannis","year":"2019","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2022.174830_bib17","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/cdd.2011.96","article-title":"Molecular definitions of cell death subroutines: recommendations of the nomenclature committee on cell death 2012","volume":"1","author":"Galluzzi","year":"2012","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.ejphar.2022.174830_bib18","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.yjmcc.2019.05.007","article-title":"MicroRNA-124 regulates cardiomyocyte apoptosis and myocardial infarction through targeting Dhcr24","volume":"1","author":"Han","year":"2019","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.ejphar.2022.174830_bib19","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1097\/FJC.0000000000000550","article-title":"Low-dose sinapic acid abates the pyroptosis of macrophages by downregulation of lncRNA-MALAT1 in rats with diabetic atherosclerosis","volume":"2","author":"Han","year":"2018","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.ejphar.2022.174830_bib20","doi-asserted-by":"crossref","first-page":"112012","DOI":"10.1016\/j.ecoenv.2021.112012","article-title":"Polystyrene microplastics lead to pyroptosis and apoptosis of ovarian granulosa cells via NLRP3\/Caspase-1 signaling pathway in rats","volume":"1","author":"Hou","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ejphar.2022.174830_bib21","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1002\/ppul.21262","article-title":"Meconium exposure dependent cell death and apoptosis in human alveolar epithelial cells","volume":"8","author":"Jeng","year":"2010","journal-title":"Pediatr. Pulmonol."},{"key":"10.1016\/j.ejphar.2022.174830_bib22","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1161\/CIRCULATIONAHA.110.982777","article-title":"Inflammasome activation of cardiac fibroblasts is essential for myocardial ischemia\/reperfusion injury","volume":"6","author":"Kawaguchi","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2022.174830_bib23","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1111\/j.1476-5381.2010.00872.x","article-title":"Animal research: reporting in vivo experiments: the ARRIVE guidelines","volume":"7","author":"Kilkenny","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2022.174830_bib24","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/sj.cdd.4401325","article-title":"Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibiting the IKK complex","volume":"1","author":"Kobori","year":"2004","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.ejphar.2022.174830_bib25","article-title":"Caspase-1 and caspase-11 mediate pyroptosis, inflammation, and control of brucella joint infection","volume":"9","author":"Lacey","year":"2018","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ejphar.2022.174830_bib26","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/bs.ai.2017.02.002","article-title":"A mechanistic understanding of pyroptosis: the fiery death triggered by invasive infection","author":"Liu","year":"2017","journal-title":"Adv. Immunol."},{"key":"10.1016\/j.ejphar.2022.174830_bib27","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/nature18629","article-title":"Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores","volume":"7610","author":"Liu","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2022.174830_bib28","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/imr.12534","article-title":"Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases","volume":"1","author":"Man","year":"2017","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.ejphar.2022.174830_bib29","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/s41420-021-00404-4","article-title":"IP3R1 regulates Ca(2+) transport and pyroptosis through the NLRP3\/Caspase-1 pathway in myocardial ischemia\/reperfusion injury","volume":"1","author":"Mo","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ejphar.2022.174830_bib30","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.yjmcc.2016.03.005","article-title":"Myocyte-fibroblast communication in cardiac fibrosis and arrhythmias: mechanisms and model systems","volume":"1","author":"Pellman","year":"2016","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.ejphar.2022.174830_bib31","article-title":"Innate immune receptors over expression correlate with chronic chagasic cardiomyopathy and digestive damage in patients","volume":"7","author":"Pereira","year":"2018","journal-title":"PLoS Neglected Trop. Dis."},{"key":"10.1016\/j.ejphar.2022.174830_bib32","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1093\/cvr\/cvt091","article-title":"The NLRP3 inflammasome is up-regulated in cardiac fibroblasts and mediates myocardial ischaemia-reperfusion injury","volume":"1","author":"Sandanger","year":"2013","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ejphar.2022.174830_bib33","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1007\/s10741-020-09961-9","article-title":"Crosstalk between GSK-3\u03b2-actuated molecular cascades and myocardial physiology","volume":"6","author":"Sharma","year":"2021","journal-title":"Heart Fail. Rev."},{"key":"10.1016\/j.ejphar.2022.174830_bib34","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1159\/000456531","article-title":"Metabolites of hypoxic cardiomyocytes induce the migration of cardiac fibroblasts","volume":"1","author":"Shi","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.ejphar.2022.174830_bib35","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.tibs.2016.10.004","article-title":"Pyroptosis: gasdermin-mediated programmed necrotic cell death","volume":"4","author":"Shi","year":"2017","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.ejphar.2022.174830_bib36","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.cyto.2004.12.007","article-title":"Recombinant rat IL-1beta and IL-6 synergistically enhance C3 mRNA levels and complement component C3 secretion by H-35 rat hepatoma cells","volume":"2","author":"Stapp","year":"2005","journal-title":"Cytokine"},{"key":"10.1016\/j.ejphar.2022.174830_bib37","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1248\/bpb.b18-00369","article-title":"Role of NLRP3 inflammasome in cardiac inflammation and remodeling after myocardial infarction","volume":"4","author":"Takahashi","year":"2019","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.ejphar.2022.174830_bib38","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/s12967-017-1191-y","article-title":"Apoptosis in ischemic heart disease","volume":"1","author":"Teringova","year":"2017","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.ejphar.2022.174830_bib39","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1182\/blood-2018-02-791350","article-title":"The rise of apoptosis: targeting apoptosis in hematologic malignancies","volume":"12","author":"Valentin","year":"2018","journal-title":"Blood"},{"key":"10.1016\/j.ejphar.2022.174830_bib40","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/s12872-018-0828-y","article-title":"Renal denervation improves cardiac function by attenuating myocardiocyte apoptosis in dogs after myocardial infarction","volume":"1","author":"Wang","year":"2018","journal-title":"BMC Cardiovasc. Disord."},{"key":"10.1016\/j.ejphar.2022.174830_bib41","first-page":"62","article-title":"Pyroptosis: a pro-inflammatory type of cell death in cardiovascular disease","volume":"1","author":"Wang","year":"2020","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.ejphar.2022.174830_bib42","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.yjmcc.2020.09.009","article-title":"Glycogen synthase kinase-3beta inhibition alleviates activation of the NLRP3 inflammasome in myocardial infarction","volume":"1","author":"Wang","year":"2020","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.ejphar.2022.174830_bib43","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1161\/CIRCRESAHA.116.309538","article-title":"Cardiac fibroblast GRK2 deletion enhances contractility and remodeling following ischemia\/reperfusion injury","volume":"10","author":"Woodall","year":"2016","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2022.174830_bib44","doi-asserted-by":"crossref","first-page":"H265","DOI":"10.1152\/ajpheart.00509.2016","article-title":"L5-LDL from ST-elevation myocardial infarction patients induces IL-1beta production via LOX-1 and NLRP3 inflammasome activation in macrophages","volume":"2","author":"Yang","year":"2017","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.ejphar.2022.174830_bib45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/jb\/mvaa051","article-title":"Efferocytosis during myocardial infarction","volume":"1","author":"Yoshimura","year":"2020","journal-title":"J. Biochem."},{"key":"10.1016\/j.ejphar.2022.174830_bib46","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.7150\/ijbs.33568","article-title":"Role of pyroptosis in cardiovascular diseases and its therapeutic implications","volume":"7","author":"Zeng","year":"2019","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.ejphar.2022.174830_bib47","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1002\/jnr.24385","article-title":"Gasdermin D serves as a key executioner of pyroptosis in experimental cerebral ischemia and reperfusion model both in vivo and in vitro","volume":"6","author":"Zhang","year":"2019","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.ejphar.2022.174830_bib48","doi-asserted-by":"crossref","first-page":"H1385","DOI":"10.1152\/ajpheart.01167.2011","article-title":"Cross talk between cardiac myocytes and fibroblasts: from multiscale investigative approaches to mechanisms and functional consequences","volume":"12","author":"Zhang","year":"2012","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.ejphar.2022.174830_bib49","article-title":"Melatonin prevents endothelial cell pyroptosis via regulation of long noncoding RNA MEG3\/miR-223\/NLRP3 axis","volume":"2","author":"Zhang","year":"2018","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.ejphar.2022.174830_bib50","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1161\/CIRCRESAHA.116.308544","article-title":"Loss of adult cardiac myocyte GSK-3 leads to mitotic catastrophe resulting in fatal dilated cardiomyopathy","volume":"8","author":"Zhou","year":"2016","journal-title":"Circ. Res."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299922000917?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299922000917?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T22:59:57Z","timestamp":1757977197000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299922000917"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":50,"alternative-id":["S0014299922000917"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2022.174830","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"GSK-3\u03b2-mediated activation of NLRP3 inflammasome leads to pyroptosis and apoptosis of rat cardiomyocytes and fibroblasts","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2022.174830","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"174830"}}