{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T06:22:39Z","timestamp":1777616559215,"version":"3.51.4"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100006109","name":"Vedeck\u00e1 Grantov\u00e1 Agent\u00fara M\u0160VVa\u0160 SR a SAV","doi-asserted-by":"publisher","award":["2\/0040\/22"],"award-info":[{"award-number":["2\/0040\/22"]}],"id":[{"id":"10.13039\/501100006109","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005357","name":"Slovak Research and Development Agency","doi-asserted-by":"publisher","award":["APVV-20-0176"],"award-info":[{"award-number":["APVV-20-0176"]}],"id":[{"id":"10.13039\/501100005357","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1016\/j.ejphar.2022.174875","type":"journal-article","created":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T02:45:48Z","timestamp":1647571548000},"page":"174875","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Slow sulfide donor GYY4137 potentiates effect of paclitaxel on colorectal carcinoma cells"],"prefix":"10.1016","volume":"922","author":[{"given":"Marek","family":"Kajsik","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbora","family":"Chovancova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronika","family":"Liskova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petr","family":"Babula","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5377-9159","authenticated-orcid":false,"given":"Olga","family":"Krizanova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2022.174875_bib1","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1523\/JNEUROSCI.16-03-01066.1996","article-title":"The possible role of hydrogen sulfide as an endogenous neuromodulator","volume":"16","author":"Abe","year":"1996","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2022.174875_bib2","doi-asserted-by":"crossref","first-page":"789","DOI":"10.3390\/biom9120789","article-title":"Paclitaxel's mechanistic and clinical effects on breast cancer","volume":"9","author":"Abu Samaan","year":"2019","journal-title":"Biomolecules"},{"key":"10.1016\/j.ejphar.2022.174875_bib3","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/bs.podrm.2018.11.001","article-title":"Paclitaxel","volume":"44","author":"Alqahtania","year":"2019","journal-title":"Profiles Drug Subst. Excipients Relat. Methodol."},{"key":"10.1016\/j.ejphar.2022.174875_bib4","article-title":"Involvement of calcium signaling in different types of cell death in cancer","volume":"10","author":"Babula","year":"2022","journal-title":"Neoplasma"},{"key":"10.1016\/j.ejphar.2022.174875_bib5","first-page":"R409","article-title":"Metabolic regulation via intracellular pH","volume":"246","author":"Busa","year":"1984","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.ejphar.2022.174875_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/ars.2017.7058","article-title":"A review of hydrogen sulfide synthesis, metabolism, and measurement: is modulation of hydrogen sulfide a novel therapeutic for cancer?","volume":"31","author":"Cao","year":"2019","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.ejphar.2022.174875_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2019.113695","article-title":"Calcium signaling affects migration and proliferation differently in individual cancer cells due to nifedipine treatment","volume":"171","author":"Chovancova","year":"2020","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejphar.2022.174875_bib8","doi-asserted-by":"crossref","first-page":"627","DOI":"10.4149\/neo_2013_081","article-title":"Proteasome inhibition leads to altered signaling in the proteome of cisplatin-resistant human ovarian carcinoma cell line","volume":"60","author":"Duraj","year":"2013","journal-title":"Neoplasma"},{"key":"10.1016\/j.ejphar.2022.174875_bib9","first-page":"1835","article-title":"Intracellular ATP levels determine cell death fate by apoptosis or necrosis","volume":"57","author":"Eguchi","year":"1997","journal-title":"Cancer Res"},{"key":"10.1016\/j.ejphar.2022.174875_bib10","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.ejphar.2022.174875_bib11","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.55102","article-title":"The S-phase-induced lncRNA SUNO1 promotes cell proliferation by controlling YAP1\/Hippo signaling pathway","volume":"9","author":"Hao","year":"2020","journal-title":"Elife"},{"key":"10.1016\/j.ejphar.2022.174875_bib12","doi-asserted-by":"crossref","first-page":"61403","DOI":"10.18632\/oncotarget.8968","article-title":"Sulforaphane-induced apoptosis involves the type 1 IP3 receptor","volume":"7","author":"Hudecova","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.ejphar.2022.174875_bib13","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1111\/jvim.12596","article-title":"A review of paclitaxel and novel formulations including those suitable for use in Dogs","volume":"29","author":"Khanna","year":"2015","journal-title":"J. Vet. Intern. Med."},{"key":"10.1016\/j.ejphar.2022.174875_bib14","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1002\/jcb.240540411","article-title":"Cell cycle control and cancer chemotherapy","volume":"54","author":"Kohn","year":"1994","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.ejphar.2022.174875_bib15","article-title":"Colorectal cancer","volume":"1","author":"Kuipers","year":"2015","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.ejphar.2022.174875_bib16","article-title":"The slow-releasing hydrogen sulfide donor, GYY4137, exhibits novel anti-cancer effects in vitro and in vivo","volume":"6","author":"Lee","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2022.174875_bib17","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1006\/excr.1999.4514","article-title":"Inhibition of mitochondrial ATP generation by nitric oxide switches apoptosis to necrosis","volume":"249","author":"Leist","year":"1999","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.ejphar.2022.174875_bib18","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1111\/apha.12105","article-title":"Sulphide signalling potentiates apoptosis through the up-regulation of IP3 receptor types 1 and 2","volume":"208","author":"Lencesova","year":"2013","journal-title":"Acta Physiol."},{"key":"10.1016\/j.ejphar.2022.174875_bib19","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1016\/j.lfs.2004.09.021","article-title":"Cell cycle specific induction of apoptosis and necrosis by paclitaxel in the leukemic U937 cells","volume":"76","author":"Liao","year":"2005","journal-title":"Life Sci"},{"key":"10.1016\/j.ejphar.2022.174875_bib20","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1002\/jcb.21730","article-title":"Involvement of endoplasmic reticulum in paclitaxel-induced apoptosis","volume":"104","author":"Liao","year":"2008","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.ejphar.2022.174875_bib21","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.3390\/cancers11081139","article-title":"Type 1 sodium calcium exchanger forms a complex with carbonic anhydrase IX and via reverse mode activity contributes to pH control in hypoxic tumors","volume":"11","author":"Liskova","year":"2019","journal-title":"Cancers"},{"key":"10.1016\/j.ejphar.2022.174875_bib22","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.neures.2009.09.1713","article-title":"Hydrogen sulfide regulates intracellular pH in rat primary cultured glia cells","volume":"66","author":"Lu","year":"2010","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.ejphar.2022.174875_bib23","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.3892\/ijo.2014.2305","article-title":"GYY4137, a hydrogen sulfide (H\u2082S) donor, shows potent anti-hepatocellular carcinoma activity through blocking the STAT3 pathway","volume":"44","author":"Lu","year":"2014","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.ejphar.2022.174875_bib24","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1007\/s00424-013-1366-1","article-title":"Sodium\/calcium exchanger is upregulated by sulfide signaling, forms complex with the \u03b21 and \u03b23 but not \u03b22 adrenergic receptors, and induces apoptosis","volume":"466","author":"Markova","year":"2014","journal-title":"Pfl\u00fcgers Archiv"},{"key":"10.1016\/j.ejphar.2022.174875_bib25","doi-asserted-by":"crossref","first-page":"197","DOI":"10.3390\/ijms18010197","article-title":"Colorectal carcinoma: a general overview and future perspectives in colorectal cancer","volume":"18","author":"Marmol","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2022.174875_bib26","doi-asserted-by":"crossref","first-page":"6012","DOI":"10.1038\/onc.2008.197","article-title":"A mitochondrial block and expression of XIAP lead to resistance to TRAIL-induced apoptosis during progression to metastasis of a colon carcinoma","volume":"27","author":"Ndozangue-Touriguine","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.ejphar.2022.174875_bib27","doi-asserted-by":"crossref","first-page":"51","DOI":"10.3892\/ijo.2015.2987","article-title":"Sulforaphane reduces molecular response to hypoxia in ovarian tumor cells independently of their resistance to chemotherapy","volume":"47","author":"Pastorek","year":"2015","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.ejphar.2022.174875_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110210","article-title":"H2S donor GYY4137 ameliorates paclitaxel-induced neuropathic pain in mice","volume":"127","author":"Qabazard","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ejphar.2022.174875_bib29","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.jss.2007.04.021","article-title":"Characterization of HCT116 human colon cancer cells in an orthotopic model","volume":"147","author":"Rajput","year":"2008","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.ejphar.2022.174875_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2019.e02244","article-title":"Hydrogen sulfide donor GYY4137 suppresses proliferation of human colorectal cancer Caco-2 cells by inducing both cell cycle arrest and cell death","volume":"5","author":"Sakuma","year":"2019","journal-title":"Heliyon"},{"key":"10.1016\/j.ejphar.2022.174875_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.niox.2019.02.011","article-title":"Sodium\/calcium exchanger is involved in apoptosis induced by H2S in tumor cells through decreased levels of intracellular pH","volume":"87","author":"Szadvari","year":"2019","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.ejphar.2022.174875_bib32","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.bcp.2017.03.025","article-title":"H2S-induced S-sulfhydration of lactate dehydrogenase A (LDHA) stimulates cellular bioenergetics in HCT116 colon cancer cells","volume":"136","author":"Untereiner","year":"2017","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejphar.2022.174875_bib33","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1113\/JP278810","article-title":"Revisiting the Warburg effect: historical dogma versus current understanding","volume":"599","author":"Vaupel","year":"2021","journal-title":"J. Physiol."},{"key":"10.1016\/j.ejphar.2022.174875_bib34","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1096\/fj.02-0211hyp","article-title":"Two's company, three's a crowd: can H2S be the third endogenous gaseous transmitter?","volume":"16","author":"Wang","year":"2002","journal-title":"Faseb. J."},{"key":"10.1016\/j.ejphar.2022.174875_bib35","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1007\/s00018-005-5425-4","article-title":"Colorectal carcinoma: from tumorigenesis to treatment","volume":"63","author":"Wang","year":"2006","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.ejphar.2022.174875_bib36","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.1091\/mbc.e14-04-0916","article-title":"How Taxol\/paclitaxel kills cancer cells","volume":"25","author":"Weaver","year":"2014","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.ejphar.2022.174875_bib37","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1007\/s12253-020-00805-3","article-title":"Comparison of different colorectal cancer with liver metastases models using six colorectal cancer cell lines","volume":"26","author":"Xu","year":"2020","journal-title":"Pathol. Oncol. Res."},{"key":"10.1016\/j.ejphar.2022.174875_bib38","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.3390\/ijms18081733","article-title":"Taxol\u00ae: the first microtubule stabilizing agent","volume":"18","author":"Yang","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2022.174875_bib39","first-page":"890","article-title":"Research progress on the source, production, and anti-cancer mechanisms of paclitaxel","volume":"18","author":"Yang","year":"2020","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.ejphar.2022.174875_bib40","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1006\/bbrc.1999.1375","article-title":"The mode of action of taxol: apoptosis at low concentration and necrosis at high concentration","volume":"263","author":"Yeung","year":"1999","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejphar.2022.174875_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2020.112438","article-title":"Src-mediated Tyr353 phosphorylation of IP3R1 promotes its stability and causes apoptosis in palmitic acid-treated hepatocytes","volume":"399","author":"Yu","year":"2021","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.ejphar.2022.174875_bib42","doi-asserted-by":"crossref","first-page":"8543","DOI":"10.2147\/IJN.S219820","article-title":"Co-administration of iRGD enhances tumor-targeted delivery and anti-tumor effects of paclitaxel-loaded PLGA nanoparticles for colorectal cancer treatment","volume":"14","author":"Zhong","year":"2019","journal-title":"Int. J. Nanomed."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299922001364?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299922001364?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T21:34:10Z","timestamp":1777412050000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299922001364"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":42,"alternative-id":["S0014299922001364"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2022.174875","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Slow sulfide donor GYY4137 potentiates effect of paclitaxel on colorectal carcinoma cells","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2022.174875","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"174875"}}