{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T15:44:50Z","timestamp":1778773490094,"version":"3.51.4"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970242"],"award-info":[{"award-number":["81970242"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1016\/j.ejphar.2022.174913","type":"journal-article","created":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T20:37:34Z","timestamp":1647981454000},"page":"174913","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Baicalin promotes the activation of brown and white adipose tissue through AMPK\/PGC1\u03b1 pathway"],"prefix":"10.1016","volume":"922","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2785-938X","authenticated-orcid":false,"given":"Yanqing","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenzhen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiwei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leiming","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanzhou","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.ejphar.2022.174913_bib1","first-page":"1411","article-title":"Role of PRDM16 in the activation of brown fat programming. Relevance to the development of obesity","volume":"28","author":"Becerril","year":"2013","journal-title":"Histol. Histopathol."},{"issue":"6","key":"10.1016\/j.ejphar.2022.174913_bib2","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/s41580-021-00350-0","article-title":"The cellular and functional complexity of thermogenic fat","volume":"22","author":"Cohen","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"9","key":"10.1016\/j.ejphar.2022.174913_bib3","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1210\/me.2004-0193","article-title":"Learning new tricks from old dogs: beta-adrenergic receptors teach new lessons on firing up adipose tissue metabolism","volume":"18","author":"Collins","year":"2004","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.ejphar.2022.174913_bib4","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.diabres.2018.03.007","article-title":"Beneficial effect of baicalin on insulin sensitivity in adipocytes of diet-induced obese mice","volume":"139","author":"Fang","year":"2018","journal-title":"Diabetes Res. Clin. Pract."},{"issue":"1","key":"10.1016\/j.ejphar.2022.174913_bib5","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s43440-019-00024-x","article-title":"Baicalin and its aglycone: a novel approach for treatment of metabolic disorders","volume":"72","author":"Fang","year":"2020","journal-title":"Pharmacol. Rep."},{"issue":"4","key":"10.1016\/j.ejphar.2022.174913_bib6","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/s41574-019-0165-y","article-title":"Molecular pathways linking adipose innervation to insulin action in obesity and diabetes mellitus","volume":"15","author":"Guilherme","year":"2019","journal-title":"Nat. Rev. Endocrinol."},{"issue":"8","key":"10.1016\/j.ejphar.2022.174913_bib7","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/nrm.2017.72","article-title":"Transcriptional and epigenetic control of brown and beige adipose cell fate and function","volume":"18","author":"Inagaki","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"15","key":"10.1016\/j.ejphar.2022.174913_bib8","doi-asserted-by":"crossref","first-page":"3267","DOI":"10.1113\/JP270805","article-title":"Two key temporally distinguishable molecular and cellular components of white adipose tissue browning during cold acclimation","volume":"593","author":"Jankovic","year":"2015","journal-title":"J. Physiol."},{"issue":"6","key":"10.1016\/j.ejphar.2022.174913_bib9","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.cell.2006.11.013","article-title":"Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha","volume":"127","author":"Lagouge","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.ejphar.2022.174913_bib10","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.ejphar.2014.06.039","article-title":"Baicalin and geniposide attenuate atherosclerosis involving lipids regulation and immunoregulation in ApoE-\/- mice","volume":"740","author":"Liao","year":"2014","journal-title":"Eur. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.ejphar.2022.174913_bib11","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.intimp.2014.02.037","article-title":"Oral administration of baicalin and geniposide induces regression of atherosclerosis via inhibiting dendritic cells in ApoE-knockout mice","volume":"20","author":"Liu","year":"2014","journal-title":"Int. Immunopharm."},{"issue":"11","key":"10.1016\/j.ejphar.2022.174913_bib12","doi-asserted-by":"crossref","first-page":"471","DOI":"10.3390\/metabo10110471","article-title":"Control of adipose cell browning and its therapeutic potential","volume":"10","author":"Lizcano","year":"2020","journal-title":"Metabolites"},{"issue":"4","key":"10.1016\/j.ejphar.2022.174913_bib13","first-page":"368","article-title":"Brown fat fuel use and regulation of energy homeostasis","volume":"17","author":"Loyd","year":"2014","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"issue":"5","key":"10.1016\/j.ejphar.2022.174913_bib14","doi-asserted-by":"crossref","first-page":"E729","DOI":"10.1152\/ajpendo.00020.2019","article-title":"In the absence of UCP1-mediated diet-induced thermogenesis, obesity is augmented even in the obesity-resistant 129S mouse strain","volume":"316","author":"Luijten","year":"2019","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"12","key":"10.1016\/j.ejphar.2022.174913_bib15","doi-asserted-by":"crossref","first-page":"3628","DOI":"10.1111\/febs.15470","article-title":"The colorful versatility of adipocytes: white-to-brown transdifferentiation and its therapeutic potential in humans","volume":"288","author":"Maurer","year":"2021","journal-title":"FEBS J"},{"issue":"1","key":"10.1016\/j.ejphar.2022.174913_bib16","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.cell.2009.01.051","article-title":"Twist-1 is a PPARdelta-inducible, negative-feedback regulator of PGC-1alpha in brown fat metabolism","volume":"137","author":"Pan","year":"2009","journal-title":"Cell"},{"issue":"12","key":"10.1016\/j.ejphar.2022.174913_bib17","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.3390\/cells8121552","article-title":"Towards a better understanding of beige adipocyte plasticity","volume":"8","author":"Paulo","year":"2019","journal-title":"Cells"},{"issue":"5","key":"10.1016\/j.ejphar.2022.174913_bib18","doi-asserted-by":"crossref","first-page":"319","DOI":"10.3390\/metabo11050319","article-title":"Browning of white adipose tissue as a therapeutic tool in the fight against atherosclerosis","volume":"11","author":"Roth","year":"2021","journal-title":"Metabolites"},{"issue":"7","key":"10.1016\/j.ejphar.2022.174913_bib19","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/j.bbamcr.2010.09.019","article-title":"Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network","volume":"1813","author":"Scarpulla","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"issue":"12","key":"10.1016\/j.ejphar.2022.174913_bib20","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1038\/s41574-021-00562-6","article-title":"The evolving view of thermogenic adipocytes - ontogeny, niche and function","volume":"17","author":"Shamsi","year":"2021","journal-title":"Nat. Rev. Endocrinol."},{"issue":"11","key":"10.1016\/j.ejphar.2022.174913_bib21","first-page":"1422","article-title":"Herbal combination of phyllostachys pubescens and Scutellaria baicalensis inhibits adipogenesis and promotes browning via AMPK activation in 3T3-L1 adipocytes","volume":"9","author":"Sung","year":"2020","journal-title":"Plants (Basel)"},{"issue":"3","key":"10.1016\/j.ejphar.2022.174913_bib22","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.3390\/ijms23031517","article-title":"Transcription factor movement and exercise-induced mitochondrial biogenesis in human skeletal muscle: current knowledge and future perspectives","volume":"23","author":"Taylor","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.ejphar.2022.174913_bib23","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1194\/jlr.M018846","article-title":"The adipose organ of obesity-prone C57BL\/6J mice is composed of mixed white and brown adipocytes","volume":"53","author":"Vitali","year":"2012","journal-title":"J. Lipid Res."},{"issue":"2","key":"10.1016\/j.ejphar.2022.174913_bib24","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.bbadis.2016.11.024","article-title":"Differential regulation of baicalin and scutellarin on AMPK and Akt in promoting adipose cell glucose disposal","volume":"1863","author":"Yang","year":"2017","journal-title":"Biochim. Biophys. Acta (BBA) - Mol. Basis Dis."},{"issue":"1","key":"10.1016\/j.ejphar.2022.174913_bib25","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/0014-5793(84)80822-4","article-title":"Brown adipose tissue in the parametrial fat pad of the mouse","volume":"167","author":"Young","year":"1984","journal-title":"FEBS Lett"},{"key":"10.1016\/j.ejphar.2022.174913_bib26","doi-asserted-by":"crossref","first-page":"153869","DOI":"10.1016\/j.phymed.2021.153869","article-title":"Baicalin protects against insulin resistance and metabolic dysfunction through activation of GALR2\/GLUT4 signaling","volume":"95","author":"Yu","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.ejphar.2022.174913_bib27","doi-asserted-by":"crossref","first-page":"5493","DOI":"10.1038\/ncomms6493","article-title":"Berberine activates thermogenesis in white and brown adipose tissue","volume":"5","author":"Zhang","year":"2014","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.ejphar.2022.174913_bib28","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1159\/000459708","article-title":"Baicalin attenuates cardiac dysfunction and myocardial remodeling in a chronic pressure-overload mice model","volume":"41","author":"Zhang","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"issue":"4","key":"10.1016\/j.ejphar.2022.174913_bib29","doi-asserted-by":"crossref","first-page":"751","DOI":"10.3390\/cells11040751","article-title":"Functional and genetic characterization of porcine beige adipocytes","volume":"11","author":"Zhang","year":"2022","journal-title":"Cells"}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299922001741?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299922001741?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T23:00:52Z","timestamp":1757977252000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299922001741"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":29,"alternative-id":["S0014299922001741"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2022.174913","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Baicalin promotes the activation of brown and white adipose tissue through AMPK\/PGC1\u03b1 pathway","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2022.174913","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"174913"}}