{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:31:26Z","timestamp":1791919886103,"version":"4.3.4"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,24]],"date-time":"2022-03-24T00:00:00Z","timestamp":1648080000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81900336"],"award-info":[{"award-number":["81900336"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970283"],"award-info":[{"award-number":["81970283"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U1605226"],"award-info":[{"award-number":["U1605226"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1016\/j.ejphar.2022.174916","type":"journal-article","created":{"date-parts":[[2022,3,24]],"date-time":"2022-03-24T18:21:44Z","timestamp":1648146104000},"page":"174916","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"special_numbering":"C","title":["Acacetin attenuates diabetes-induced cardiomyopathy by inhibiting oxidative stress and energy metabolism via PPAR-\u03b1\/AMPK pathway"],"prefix":"10.1016","volume":"922","author":[{"given":"Fei","family":"Song","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Jie","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan-Shan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Yin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gui-Rong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3875-2112","authenticated-orcid":false,"given":"Gang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2022.174916_bib1","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.cger.2015.04.011","article-title":"Diabetes, nutrition, and exercise","volume":"31","author":"Abdelhafiz","year":"2015","journal-title":"Clin. Geriatr. Med."},{"key":"10.1016\/j.ejphar.2022.174916_bib2","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1111\/j.1365-2796.2007.01825.x","article-title":"PPARs and their metabolic modulation: new mechanisms for transcriptional regulation?","volume":"262","author":"Ahmed","year":"2007","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.ejphar.2022.174916_bib3","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.3390\/nu9121310","article-title":"Functional foods and lifestyle approaches for diabetes prevention and management","volume":"9","author":"Alkhatib","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.ejphar.2022.174916_bib4","doi-asserted-by":"crossref","first-page":"S103","DOI":"10.2337\/dc19-S010","article-title":"10. Cardiovascular disease and risk management: standards of medical care in diabetes-2019","volume":"42","author":"American Diabetes","year":"2019","journal-title":"Diabetes Care"},{"key":"10.1016\/j.ejphar.2022.174916_bib5","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.bios.2006.01.008","article-title":"Concanavalin A for in vivo glucose sensing: a biotoxicity review","volume":"22","author":"Ballerstadt","year":"2006","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.ejphar.2022.174916_bib6","doi-asserted-by":"crossref","first-page":"4290","DOI":"10.1002\/jcp.30057","article-title":"Antioxidant Sirt1\/Akt axis expression in resveratrol pretreated adipose-derived stem cells increases regenerative capability in a rat model with cardiomyopathy induced by diabetes mellitus","volume":"236","author":"Chen","year":"2021","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.ejphar.2022.174916_bib7","doi-asserted-by":"crossref","first-page":"174858","DOI":"10.1016\/j.ejphar.2022.174858","article-title":"Acacetin ameliorates cardiac hypertrophy by activating Sirt1\/AMPK\/PGC-1 alpha pathway","volume":"920","author":"Cui","year":"2022","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2022.174916_bib8","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.vph.2004.10.004","article-title":"Peroxisome proliferator-activated receptors gamma ligands and ischemia and reperfusion injury","volume":"41","author":"Cuzzocrea","year":"2004","journal-title":"Vasc. Pharmacol."},{"key":"10.1016\/j.ejphar.2022.174916_bib9","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0027-5107(95)00136-0","article-title":"PPAR: a mediator of peroxisome proliferator action","volume":"333","author":"Green","year":"1995","journal-title":"Mutat. Res."},{"key":"10.1016\/j.ejphar.2022.174916_bib10","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3390\/pharmaceutics13020175","article-title":"Investigation of the factors responsible for the poor oral bioavailability of acacetin in rats: physicochemical and biopharmaceutical aspects","volume":"13","author":"Han","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ejphar.2022.174916_bib11","doi-asserted-by":"crossref","first-page":"607796","DOI":"10.3389\/fphar.2020.607796","article-title":"Acacetin protects against high glucose-induced endothelial cells injury by preserving mitochondrial function via activating sirt1\/sirt3\/AMPK signals","volume":"11","author":"Han","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejphar.2022.174916_bib12","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.yjmcc.2011.01.007","article-title":"Metabolism, hypoxia and the diabetic heart","volume":"50","author":"Heather","year":"2011","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.ejphar.2022.174916_bib13","doi-asserted-by":"crossref","first-page":"16381","DOI":"10.18632\/aging.203163","article-title":"Cardiac senescence is alleviated by the natural flavone acacetin via enhancing mitophagy","volume":"13","author":"Hong","year":"2021","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.ejphar.2022.174916_bib14","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1161\/CIRCRESAHA.117.311586","article-title":"Diabetic cardiomyopathy: an update of mechanisms contributing to this clinical entity","volume":"122","author":"Jia","year":"2018","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2022.174916_bib15","doi-asserted-by":"crossref","first-page":"317","DOI":"10.3892\/ijmm.2013.1571","article-title":"Acacetin (5,7-dihydroxy-4'-methoxyflavone) exhibits in vitro and in vivo anticancer activity through the suppression of NF-kappaB\/Akt signaling in prostate cancer cells","volume":"33","author":"Kim","year":"2014","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.ejphar.2022.174916_bib16","first-page":"549101","article-title":"AMPK-dependent metabolic regulation by PPAR agonists","author":"Lee","year":"2010","journal-title":"PPAR Res"},{"key":"10.1016\/j.ejphar.2022.174916_bib17","doi-asserted-by":"crossref","first-page":"4688","DOI":"10.1111\/jcmm.13706","article-title":"Bradykinin-mediated Ca(2+) signalling regulates cell growth and mobility in human cardiac c-Kit(+) progenitor cells","volume":"22","author":"Li","year":"2018","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.ejphar.2022.174916_bib18","doi-asserted-by":"crossref","first-page":"2449","DOI":"10.1161\/CIRCULATIONAHA.108.769554","article-title":"Acacetin, a natural flavone, selectively inhibits human atrial repolarization potassium currents and prevents atrial fibrillation in dogs","volume":"117","author":"Li","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2022.174916_bib19","doi-asserted-by":"crossref","first-page":"25743","DOI":"10.1038\/srep25743","article-title":"Synthesis of a highly water-soluble acacetin prodrug for treating experimental atrial fibrillation in beagle dogs","volume":"6","author":"Liu","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejphar.2022.174916_bib20","doi-asserted-by":"crossref","first-page":"36435","DOI":"10.1038\/srep36435","article-title":"Water-soluble acacetin prodrug confers significant cardioprotection against ischemia\/reperfusion injury","volume":"6","author":"Liu","year":"2016","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.ejphar.2022.174916_bib21","doi-asserted-by":"crossref","first-page":"S833","DOI":"10.1016\/j.dsx.2017.07.003","article-title":"Evaluation of current trends and recent development in insulin therapy for management of diabetes mellitus","volume":"11","author":"Nawaz","year":"2017","journal-title":"Diabetes Metab Syndr"},{"key":"10.1016\/j.ejphar.2022.174916_bib22","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1007\/s11033-020-06087-x","article-title":"The natural flavones, acacetin and apigenin, induce Cdk-Cyclin mediated G2\/M phase arrest and trigger ROS-mediated apoptosis in glioblastoma cells","volume":"48","author":"Shendge","year":"2021","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.ejphar.2022.174916_bib23","doi-asserted-by":"crossref","first-page":"2612","DOI":"10.3390\/ijms21072612","article-title":"Trace elements, PPARs, and metabolic syndrome","volume":"21","author":"Shi","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2022.174916_bib24","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1186\/s12906-016-1460-y","article-title":"Citrus junos Tanaka peel ameliorates hepatic lipid accumulation in HepG2 cells and in mice fed a high-cholesterol diet","volume":"16","author":"Shin","year":"2016","journal-title":"BMC Compl. Alternative Med."},{"key":"10.1016\/j.ejphar.2022.174916_bib25","doi-asserted-by":"crossref","first-page":"152808","DOI":"10.1016\/j.phymed.2018.12.031","article-title":"AMPK in microvascular complications of diabetes and the beneficial effects of AMPK activators from plants","volume":"73","author":"Shrikanth","year":"2020","journal-title":"Phytomedicine"},{"key":"10.1016\/j.ejphar.2022.174916_bib26","doi-asserted-by":"crossref","first-page":"111708","DOI":"10.1016\/j.fct.2020.111708","article-title":"Acacetin, a flavone with diverse therapeutic potential in cancer, inflammation, infections and other metabolic disorders","volume":"145","author":"Singh","year":"2020","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.ejphar.2022.174916_bib27","doi-asserted-by":"crossref","first-page":"112091","DOI":"10.1016\/j.fct.2021.112091","article-title":"Acacetin and pinostrobin as a promising inhibitor of cancer-associated protein kinases","author":"Singh","year":"2021","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.ejphar.2022.174916_bib28","doi-asserted-by":"crossref","first-page":"446","DOI":"10.3390\/nu14030446","article-title":"Combined phyllostachys pubescens and scutellaria baicalensis prevent high-fat diet-induced obesity via upregulating thermogenesis and energy expenditure by UCP1 in male C57BL\/6J mice","volume":"14","author":"Sung","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.ejphar.2022.174916_bib29","first-page":"BR243","article-title":"Ligands of the peroxisome proliferator-activated receptor-PPAR-a reduce myocardial infarct size","volume":"8","author":"Wayman","year":"2002","journal-title":"Med. Sci. Mon. Int. Med. J. Exp. Clin. Res."},{"key":"10.1016\/j.ejphar.2022.174916_bib30","doi-asserted-by":"crossref","first-page":"6899","DOI":"10.1007\/s11033-020-05746-3","article-title":"Acacetin improves endothelial dysfunction and aortic fibrosis in insulin-resistant SHR rats by estrogen receptors","volume":"47","author":"Wei","year":"2020","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.ejphar.2022.174916_bib31","doi-asserted-by":"crossref","first-page":"12141","DOI":"10.1111\/jcmm.15859","article-title":"Doxorubicin cardiomyopathy is ameliorated by acacetin via Sirt1-mediated activation of AMPK\/Nrf2 signal molecules","volume":"24","author":"Wu","year":"2020","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.ejphar.2022.174916_bib32","doi-asserted-by":"crossref","first-page":"497","DOI":"10.3389\/fphar.2018.00497","article-title":"The natural flavone acacetin confers cardiomyocyte protection against hypoxia\/reoxygenation injury via AMPK-mediated activation of Nrf2 signaling pathway","volume":"9","author":"Wu","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejphar.2022.174916_bib33","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1111\/jcmm.16106","article-title":"Acacetin exerts antioxidant potential against atherosclerosis through Nrf2 pathway in apoE(-\/-) Mice","volume":"25","author":"Wu","year":"2021","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.ejphar.2022.174916_bib34","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.cmet.2009.03.012","article-title":"AMPK: an emerging drug target for diabetes and the metabolic syndrome","volume":"9","author":"Zhang","year":"2009","journal-title":"Cell Metabol."},{"key":"10.1016\/j.ejphar.2022.174916_bib35","doi-asserted-by":"crossref","first-page":"4921","DOI":"10.1021\/acs.jafc.7b00854","article-title":"Sulfonation Disposition of acacetin: in vitro and in vivo","volume":"65","author":"Zhang","year":"2017","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.ejphar.2022.174916_bib36","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1007\/s13300-020-00802-4","article-title":"Systemic delivery of siRNA specific for silencing TLR4 gene expression reduces diabetic cardiomyopathy in a mouse model of streptozotocin-induced type 1 diabetes","volume":"11","author":"Zhang","year":"2020","journal-title":"Diabetes Ther"},{"key":"10.1016\/j.ejphar.2022.174916_bib37","doi-asserted-by":"crossref","first-page":"579","DOI":"10.3390\/antiox8120579","article-title":"Effect of rosmarinic acid and sinapic acid on oxidative stress parameters in the cardiac tissue and serum of type 2 diabetic female rats","volume":"8","author":"Zych","year":"2019","journal-title":"Antioxidants"}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299922001777?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299922001777?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T04:18:36Z","timestamp":1762143516000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299922001777"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":37,"alternative-id":["S0014299922001777"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2022.174916","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Acacetin attenuates diabetes-induced cardiomyopathy by inhibiting oxidative stress and energy metabolism via PPAR-\u03b1\/AMPK pathway","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2022.174916","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"174916"}}