{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:34:58Z","timestamp":1790948098468,"version":"4.1.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.ejphar.2022.174953","type":"journal-article","created":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T23:05:04Z","timestamp":1650927904000},"page":"174953","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Resveratrol ameliorates high-phosphate-induced VSMCs to osteoblast-like cells transdifferentiation and arterial medial calcification in CKD through regulating Wnt\/\u03b2-catenin signaling"],"prefix":"10.1016","volume":"925","author":[{"given":"Xiaowen","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumei","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinbo","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danqin","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junwei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunsun","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5685-7802","authenticated-orcid":false,"given":"Weichun","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2022.174953_bib1","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.atherosclerosis.2015.11.005","article-title":"A novel organ culture model of aorta for vascular calcification","volume":"244","author":"Akiyoshi","year":"2016","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.ejphar.2022.174953_bib2","doi-asserted-by":"crossref","first-page":"4135","DOI":"10.1002\/jcp.29327","article-title":"Resveratrol targeting the Wnt signaling pathway: a focus on therapeutic activities","volume":"235","author":"Ashrafizadeh","year":"2020","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.ejphar.2022.174953_bib3","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.cell.2006.02.049","article-title":"Wntless, a conserved membrane protein dedicated to the secretion of Wnt proteins from signaling cells","volume":"125","author":"Banziger","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.ejphar.2022.174953_bib4","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1038\/s41598-018-37027-2","article-title":"Suppression of SIRT1 in diabetic conditions induces osteogenic differentiation of human vascular smooth muscle cells via RUNX2 signalling","volume":"9","author":"Bartoli-Leonard","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejphar.2022.174953_bib5","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1161\/CIRCRESAHA.110.234278","article-title":"The regulation of valvular and vascular sclerosis by osteogenic morphogens","volume":"109","author":"Bostrom","year":"2011","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2022.174953_bib6","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.yexcr.2016.06.007","article-title":"WNT\/beta-catenin signaling promotes VSMCs to osteogenic transdifferentiation and calcification through directly modulating Runx2 gene expression","volume":"345","author":"Cai","year":"2016","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.ejphar.2022.174953_bib7","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.molcel.2012.11.022","article-title":"Glucose-induced beta-catenin acetylation enhances Wnt signaling in cancer","volume":"49","author":"Chocarro-Calvo","year":"2013","journal-title":"Mol. Cell"},{"key":"10.1016\/j.ejphar.2022.174953_bib8","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1016\/j.cell.2012.05.012","article-title":"Wnt\/beta-catenin signaling and disease","volume":"149","author":"Clevers","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.ejphar.2022.174953_bib9","doi-asserted-by":"crossref","first-page":"451","DOI":"10.3109\/10641963.2016.1163366","article-title":"Effects of extracellular acid stimulation on rat vascular smooth muscle cell in Gas6\/Axl or PI3K\/Akt signaling pathway","volume":"38","author":"Cui","year":"2016","journal-title":"Clin. Exp. Hypertens."},{"key":"10.1016\/j.ejphar.2022.174953_bib10","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1007\/s11515-012-1200-8","article-title":"Wntless in Wnt secretion: molecular, cellular and genetic aspects","volume":"7","author":"Das","year":"2012","journal-title":"Front. Biol."},{"key":"10.1016\/j.ejphar.2022.174953_bib11","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19061812","article-title":"Anti-inflammatory effects of resveratrol: mechanistic insights","volume":"19","author":"de Sa Coutinho","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2022.174953_bib12","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1161\/ATVBAHA.113.302070","article-title":"Inflammatory, metabolic, and genetic mechanisms of vascular calcification","volume":"34","author":"Demer","year":"2014","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.ejphar.2022.174953_bib13","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1007\/s00223-016-0117-7","article-title":"Secreted frizzled-related protein 5 attenuates high phosphate-induced calcification in vascular smooth muscle cells by inhibiting the Wnt\/ss-catenin pathway","volume":"99","author":"Deng","year":"2016","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.ejphar.2022.174953_bib14","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s00109-019-01870-1","article-title":"Deletion of FHL2 in fibroblasts attenuates fibroblasts activation and kidney fibrosis via restraining TGF-beta1-induced Wnt\/beta-catenin signaling","volume":"98","author":"Duan","year":"2020","journal-title":"J. Mol. Med. (Berl.)"},{"key":"10.1016\/j.ejphar.2022.174953_bib15","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1056\/NEJMoa041031","article-title":"Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization","volume":"351","author":"Go","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejphar.2022.174953_bib16","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.3390\/cimb43020075","article-title":"Resveratrol ameliorates aortic calcification in ovariectomized rats via SIRT1 signaling","volume":"43","author":"Hammad","year":"2021","journal-title":"Curr. Issues Mol. Biol."},{"key":"10.1016\/j.ejphar.2022.174953_bib17","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.molmed.2012.06.008","article-title":"WNT secretion and signalling in human disease","volume":"18","author":"Herr","year":"2012","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.ejphar.2022.174953_bib18","doi-asserted-by":"crossref","first-page":"16502","DOI":"10.1074\/jbc.M512494200","article-title":"Bone morphogenetic protein-2 stimulates Runx2 acetylation","volume":"281","author":"Jeon","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2022.174953_bib19","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1016\/j.yexcr.2013.06.007","article-title":"Sp1 mediates microRNA-29c-regulated type I collagen production in renal tubular epithelial cells","volume":"319","author":"Jiang","year":"2013","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.ejphar.2022.174953_bib20","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1517\/13543784.2013.778971","article-title":"Therapeutic potential of serum and glucocorticoid inducible kinase inhibition","volume":"22","author":"Lang","year":"2013","journal-title":"Expet Opin. Invest. Drugs"},{"key":"10.1016\/j.ejphar.2022.174953_bib21","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.bbrc.2020.07.136","article-title":"Metformin, resveratrol, and exendin-4 inhibit high phosphate-induced vascular calcification via AMPK-RANKL signaling","volume":"530","author":"Lee","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejphar.2022.174953_bib22","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.tcm.2014.10.021","article-title":"Vascular calcification: mechanisms of vascular smooth muscle cell calcification","volume":"25","author":"Leopold","year":"2015","journal-title":"Trends Cardiovasc. Med."},{"key":"10.1016\/j.ejphar.2022.174953_bib23","doi-asserted-by":"crossref","first-page":"3404","DOI":"10.1128\/MCB.24.8.3404-3414.2004","article-title":"Acetylation of beta-catenin by p300 regulates beta-catenin-Tcf4 interaction","volume":"24","author":"Levy","year":"2004","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.ejphar.2022.174953_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.108990","article-title":"Small molecules from natural products targeting the Wnt\/beta-catenin pathway as a therapeutic strategy","volume":"117","author":"Liu","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ejphar.2022.174953_bib25","doi-asserted-by":"crossref","first-page":"20224","DOI":"10.1073\/pnas.1314239110","article-title":"Targeting wnt-driven cancer through the inhibition of porcupine by LGK974","volume":"110","author":"Liu","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejphar.2022.174953_bib26","article-title":"Sirtuin-1 and its relevance in vascular calcification","volume":"21","author":"Lu","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2022.174953_bib27","doi-asserted-by":"crossref","first-page":"F1136","DOI":"10.1152\/ajprenal.00684.2011","article-title":"In vascular smooth muscle cells paricalcitol prevents phosphate-induced Wnt\/beta-catenin activation","volume":"303","author":"Martinez-Moreno","year":"2012","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.ejphar.2022.174953_bib28","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/6686597","article-title":"Prevention of vascular calcification by magnesium and selected polyphenols","author":"Mehansho","year":"2021","journal-title":"Adv. Prev. Med."},{"key":"10.1016\/j.ejphar.2022.174953_bib29","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0089525","article-title":"Magnesium inhibits Wnt\/beta-catenin activity and reverses the osteogenic transformation of vascular smooth muscle cells","volume":"9","author":"Montes de Oca","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2022.174953_bib30","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.jacbts.2020.02.002","article-title":"Targeting vascular calcification in chronic kidney disease","volume":"5","author":"Nelson","year":"2020","journal-title":"JACC Basic Transl. Sci."},{"key":"10.1016\/j.ejphar.2022.174953_bib31","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.cell.2017.05.016","article-title":"Wnt\/beta-Catenin signaling, disease, and emerging therapeutic modalities","volume":"169","author":"Nusse","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.ejphar.2022.174953_bib32","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1161\/ATVBAHA.113.302642","article-title":"Has our understanding of calcification in human coronary atherosclerosis progressed?","volume":"34","author":"Otsuka","year":"2014","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.ejphar.2022.174953_bib33","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0196232","article-title":"FTI-277 inhibits smooth muscle cell calcification by up-regulating PI3K\/Akt signaling and inhibiting apoptosis","volume":"13","author":"Ponnusamy","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2022.174953_bib34","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines6030091","article-title":"Resveratrol: a double-edged sword in health benefits","volume":"6","author":"Salehi","year":"2018","journal-title":"Biomedicines"},{"key":"10.1016\/j.ejphar.2022.174953_bib35","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1038\/s41581-020-00343-w","article-title":"WNT-beta-catenin signalling - a versatile player in kidney injury and repair","volume":"17","author":"Schunk","year":"2021","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.ejphar.2022.174953_bib36","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1161\/ATVBAHA.110.216739","article-title":"Sirtuin 1 retards hyperphosphatemia-induced calcification of vascular smooth muscle cells","volume":"31","author":"Takemura","year":"2011","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.ejphar.2022.174953_bib37","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1089\/jmf.2012.0219","article-title":"Resveratrol supplementation reduces aortic atherosclerosis and calcification and attenuates loss of aerobic capacity in a mouse model of uremia","volume":"17","author":"Tomayko","year":"2014","journal-title":"J. Med. Food"},{"key":"10.1016\/j.ejphar.2022.174953_bib38","doi-asserted-by":"crossref","first-page":"2714","DOI":"10.1038\/emboj.2012.150","article-title":"The many faces and functions of beta-catenin","volume":"31","author":"Valenta","year":"2012","journal-title":"EMBO J."},{"key":"10.1016\/j.ejphar.2022.174953_bib39","first-page":"2077","article-title":"Signaling pathways involved in vascular smooth muscle cell calcification during hyperphosphatemia","volume":"76","author":"Voelkl","year":"2019","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.ejphar.2022.174953_bib40","doi-asserted-by":"crossref","first-page":"3024","DOI":"10.1172\/JCI96477","article-title":"SGK1 induces vascular smooth muscle cell calcification through NF-kappaB signaling","volume":"128","author":"Voelkl","year":"2018","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ejphar.2022.174953_bib41","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s00223-014-9929-5","article-title":"Phosphate binders prevent phosphate-induced cellular senescence of vascular smooth muscle cells and vascular calcification in a modified, adenine-based uremic rat model","volume":"96","author":"Yamada","year":"2015","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.ejphar.2022.174953_bib42","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1159\/000370250","article-title":"High phosphorus level leads to aortic calcification via beta-catenin in chronic kidney disease","volume":"41","author":"Yao","year":"2015","journal-title":"Am. J. Nephrol."},{"key":"10.1016\/j.ejphar.2022.174953_bib43","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1242\/dev.013540","article-title":"Initiation of Wnt signaling: control of Wnt coreceptor Lrp6 phosphorylation\/activation via frizzled, dishevelled and axin functions","volume":"135","author":"Zeng","year":"2008","journal-title":"Development"},{"key":"10.1016\/j.ejphar.2022.174953_bib44","doi-asserted-by":"crossref","first-page":"3378","DOI":"10.1016\/j.transproceed.2016.10.023","article-title":"Resveratrol ameliorated vascular calcification by regulating Sirt-1 and Nrf2","volume":"48","author":"Zhang","year":"2016","journal-title":"Transplant. Proc."},{"key":"10.1016\/j.ejphar.2022.174953_bib45","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.1681\/ASN.2016080902","article-title":"Tubule-derived Wnts are required for fibroblast activation and kidney fibrosis","volume":"28","author":"Zhou","year":"2017","journal-title":"J. Am. Soc. Nephrol."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001429992200214X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001429992200214X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T23:01:04Z","timestamp":1757977264000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S001429992200214X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":45,"alternative-id":["S001429992200214X"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2022.174953","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Resveratrol ameliorates high-phosphate-induced VSMCs to osteoblast-like cells transdifferentiation and arterial medial calcification in CKD through regulating Wnt\/\u03b2-catenin signaling","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2022.174953","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"174953"}}