{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T06:24:38Z","timestamp":1789453478043,"version":"build-2803163510"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100008091","name":"Golestan University of Medical Sciences and Health Services","doi-asserted-by":"publisher","award":["111299"],"award-info":[{"award-number":["111299"]}],"id":[{"id":"10.13039\/501100008091","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.ejphar.2022.174981","type":"journal-article","created":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T11:11:34Z","timestamp":1650971494000},"page":"174981","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Reduction of iron toxicity in the heart of iron-overloaded mice with natural compounds"],"prefix":"10.1016","volume":"924","author":[{"given":"Mehrdad","family":"Alikhani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahdi","family":"Aalikhani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masoumeh","family":"Khalili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2022.174981_bib1","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1097\/MPH.0b013e3180437e02","article-title":"Thalassemia in Iran: epidemiology, prevention, and management","volume":"29","author":"Abolghasemi","year":"2007","journal-title":"J. Pediatr. Hematol. Oncol."},{"key":"10.1016\/j.ejphar.2022.174981_bib2","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1056\/NEJM199912233412607","article-title":"Disorders of iron metabolism","volume":"341","author":"Andrews","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejphar.2022.174981_bib3","first-page":"159","article-title":"Comparison of iron chelation effects of deferoxamine, deferasirox, and combination of deferoxamine and deferiprone on liver and cardiac T2* MRI in thalassemia maior","volume":"8","author":"Ansari","year":"2017","journal-title":"Caspian J. Internal Med."},{"key":"10.1016\/j.ejphar.2022.174981_bib4","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0134156","article-title":"Curcumin attenuates iron accumulation and oxidative stress in the liver and spleen of chronic iron-overloaded rats","volume":"10","author":"Badria","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2022.174981_bib5","first-page":"1187","article-title":"Survival and complications in patients with thalassemia major treated with transfusion and deferoxamine","volume":"89","author":"Borgna-Pignatti","year":"2004","journal-title":"Haematologica"},{"key":"10.1016\/j.ejphar.2022.174981_bib6","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.fct.2016.11.001","article-title":"An overview of herb and dietary supplement efficacy, safety and government regulations in the United States with suggested improvements. Part 1 of 5 series","volume":"107","author":"Brown","year":"2017","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.ejphar.2022.174981_bib7","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1177\/0960327108092294","article-title":"Iron-generated hydroxyl radicals kill retinal cells in vivo: effect of ferulic acid","volume":"27","author":"Chao","year":"2008","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.ejphar.2022.174981_bib8","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/740573","article-title":"Prooxidant mechanisms in iron overload cardiomyopathy","volume":"2013","author":"Cheng","year":"2013","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.ejphar.2022.174981_bib9","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.foodchem.2019.01.142","article-title":"Effects of a moderate iron overload and its interaction with yacon flour, and\/or phytate, in the diet on liver antioxidant enzymes and hepatocyte apoptosis in rats","volume":"285","author":"Cocato","year":"2019","journal-title":"Food Chem."},{"key":"10.1016\/j.ejphar.2022.174981_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep18132","article-title":"Iron-overload injury and cardiomyopathy in acquired and genetic models is attenuated by resveratrol therapy","volume":"5","author":"Das","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejphar.2022.174981_bib11","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.jneumeth.2004.06.010","article-title":"Monitoring thiobarbituric acid-reactive substances (TBARs) as an assay for oxidative damage in neuronal cultures and central nervous system","volume":"141","author":"Dawn-Linsley","year":"2005","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.ejphar.2022.174981_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.21608\/djvs.2020.39292.1023","article-title":"Effect of iron oxide nanoparticles and quercetin on rat body weight and brain iron content","volume":"5","author":"Dora","year":"2021","journal-title":"Damanhour J. Veterin. Sci."},{"key":"10.1016\/j.ejphar.2022.174981_bib13","doi-asserted-by":"crossref","first-page":"415","DOI":"10.2174\/1568026615666150206152233","article-title":"Antioxidant effects of coumarins include direct radical scavenging, metal chelation and inhibition of ROS-producing enzymes","volume":"15","author":"Filipsky","year":"2015","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.ejphar.2022.174981_bib14","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.jep.2012.10.060","article-title":"Mechanism of protective effects of Danshen against iron overload-induced injury in mice","volume":"145","author":"Gao","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.ejphar.2022.174981_bib15","article-title":"Antioxidant activity of caffeic acid against iron-induced free radical generation\u2014a chemical approach","volume":"10","author":"Genaro-Mattos","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2022.174981_bib16","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0009-8981(91)90067-M","article-title":"A simple method for determination of serum catalase activity and revision of reference range","volume":"196","author":"Goth","year":"1991","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.ejphar.2022.174981_bib17","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1517\/13543776.2011.569493","article-title":"Advances in iron chelation: an update","volume":"21","author":"Heli","year":"2011","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.ejphar.2022.174981_bib18","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.3389\/fphar.2021.651156","article-title":"Naringin chelates excessive iron and prevents the formation of amyloid-beta plaques in the Hippocampus of iron-overloaded mice","volume":"12","author":"Jahanshahi","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejphar.2022.174981_bib19","volume":"vol. 19e","author":"Kasper","year":"2015"},{"key":"10.1016\/j.ejphar.2022.174981_bib20","doi-asserted-by":"crossref","DOI":"10.1615\/IntJMedMushrooms.v17.i9.50","article-title":"In vivo iron-chelating activity and phenolic profiles of the angel's wings mushroom, pleurotus porrigens (higher basidiomycetes)","volume":"17","author":"Khalili","year":"2015","journal-title":"Int. J. Med. Mushrooms"},{"key":"10.1016\/j.ejphar.2022.174981_bib21","doi-asserted-by":"crossref","first-page":"4804","DOI":"10.1039\/C4RA11561A","article-title":"Iron chelation and liver disease healing activity of edible mushroom (Cantharellus cibarius), in vitro and in vivo assays","volume":"5","author":"Khalili","year":"2015","journal-title":"RSC Adv."},{"key":"10.1016\/j.ejphar.2022.174981_bib22","doi-asserted-by":"crossref","first-page":"7873","DOI":"10.1021\/jf301237y","article-title":"Lipophilic caffeic acid derivatives protect cells against H2O2-Induced DNA damage by chelating intracellular labile iron","volume":"60","author":"Kitsati","year":"2012","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.ejphar.2022.174981_bib23","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1161\/CIRCULATIONAHA.111.050773","article-title":"Iron overload cardiomyopathy in clinical practice","volume":"124","author":"Kremastinos","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2022.174981_bib24","doi-asserted-by":"crossref","first-page":"60","DOI":"10.2298\/VSP1401060K","article-title":"Evaluating the bioactive effects of flavonoid hesperidin: a new literature data survey","volume":"71","author":"Kunti\u0107","year":"2014","journal-title":"Vojnosanit. Pregl."},{"key":"10.1016\/j.ejphar.2022.174981_bib25","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1042\/bj2370175","article-title":"A spectrophotometric assay for superoxide dismutase activities in crude tissue fractions","volume":"237","author":"Kuthan","year":"1986","journal-title":"Biochem. J."},{"key":"10.1016\/j.ejphar.2022.174981_bib26","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3390\/foods10010029","article-title":"Natural compounds for the prevention and treatment of cardiovascular and neurodegenerative diseases","volume":"10","author":"Leuci","year":"2021","journal-title":"Foods"},{"key":"10.1016\/j.ejphar.2022.174981_bib27","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1016\/j.biochi.2010.03.025","article-title":"In vitro interactions of coumarins with iron","volume":"92","author":"Mlad\u011bnka","year":"2010","journal-title":"Biochimie"},{"key":"10.1016\/j.ejphar.2022.174981_bib28","first-page":"110","article-title":"Co-administration of silymarin and deferoxamine against kidney, liver and heart iron deposition in male iron overload rat model","volume":"5","author":"Navidi-Shishaone","year":"2014","journal-title":"Int. J. Prev. Med."},{"key":"10.1016\/j.ejphar.2022.174981_bib29","doi-asserted-by":"crossref","first-page":"5984","DOI":"10.1039\/c1dt00005e","article-title":"Kojic acid derivatives as powerful chelators for iron(III) and aluminium(III)","volume":"40","author":"Nurchi","year":"2011","journal-title":"Dalton Trans."},{"key":"10.1016\/j.ejphar.2022.174981_bib30","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1038\/nm920","article-title":"L-type Ca 2+ channels provide a major pathway for iron entry into cardiomyocytes in iron-overload cardiomyopathy","volume":"9","author":"Oudit","year":"2003","journal-title":"Nat. Med."},{"key":"10.1016\/j.ejphar.2022.174981_bib31","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.toxrep.2014.11.003","article-title":"Protective effects of hesperidin on oxidative stress, dyslipidaemia and histological changes in iron-induced hepatic and renal toxicity in rats","volume":"2","author":"Pari","year":"2015","journal-title":"Toxicol Rep"},{"key":"10.1016\/j.ejphar.2022.174981_bib32","doi-asserted-by":"crossref","first-page":"9978","DOI":"10.1021\/jf060974w","article-title":"Phenolic compounds of barley grain and their implication in food product discoloration","volume":"54","author":"Quinde-Axtell","year":"2006","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.ejphar.2022.174981_bib33","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.jbbm.2003.11.003","article-title":"Microanalysis of non-heme iron in animal tissues","volume":"58","author":"Rebouche","year":"2004","journal-title":"J. Biochem. Biophys. Methods"},{"key":"10.1016\/j.ejphar.2022.174981_bib34","doi-asserted-by":"crossref","first-page":"109690","DOI":"10.1016\/j.biopha.2019.109690","article-title":"Puerarin protects against iron overload-induced retinal injury through regulation of iron-handling proteins","volume":"122","author":"Song","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ejphar.2022.174981_bib35","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.cca.2019.11.029","article-title":"Iron overload: effects on cellular biochemistry","volume":"504","author":"Sousa","year":"2020","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.ejphar.2022.174981_bib36","series-title":"Biology Today and Tomorrow with Physiology","author":"Starr","year":"2020"},{"key":"10.1016\/j.ejphar.2022.174981_bib37","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1161\/01.RES.84.11.1302","article-title":"Modulation of iron uptake in heart by L-type Ca2+ channel modifiers: possible implications in iron overload","volume":"84","author":"Tsushima","year":"1999","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2022.174981_bib38","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1159\/000491755","article-title":"Antioxidant properties of ferulic acid and its possible application","volume":"31","author":"Zdu\u0144ska","year":"2018","journal-title":"Skin Pharmacol. Physiol."},{"key":"10.1016\/j.ejphar.2022.174981_bib39","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.ejmech.2019.07.031","article-title":"Design, synthesis and biological evaluation of hydroxypyridinone-coumarin hybrids as multimodal monoamine oxidase B inhibitors and iron chelates against Alzheimer's disease","volume":"180","author":"Zhang","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejphar.2022.174981_bib40","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1016\/j.bbadis.2018.08.030","article-title":"Role of iron metabolism in heart failure: from iron deficiency to iron overload","volume":"1865","author":"Zhang","year":"2019","journal-title":"Biochim. Biophys. Acta (BBA) - Mol. Basis Dis."},{"key":"10.1016\/j.ejphar.2022.174981_bib41","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1055\/s-0032-1328588","article-title":"Salvia miltiorrhiza (Danshen) injection ameliorates iron overload-induced cardiac damage in mice","volume":"79","author":"Zhang","year":"2013","journal-title":"Planta Med."},{"key":"10.1016\/j.ejphar.2022.174981_bib42","article-title":"Continuing treatment with Salvia miltiorrhiza injection attenuates myocardial fibrosis in chronic iron-overloaded mice","volume":"10","author":"Zhang","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2022.174981_bib43","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.foodchem.2008.02.039","article-title":"Chemistry, natural sources, dietary intake and pharmacokinetic properties of ferulic acid: a review","volume":"109","author":"Zhao","year":"2008","journal-title":"Food Chem."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299922002424?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299922002424?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T23:02:41Z","timestamp":1757977361000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299922002424"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":43,"alternative-id":["S0014299922002424"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2022.174981","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reduction of iron toxicity in the heart of iron-overloaded mice with natural compounds","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2022.174981","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"174981"}}