{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T02:22:01Z","timestamp":1789006921987,"version":"build-2803163510"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.ejphar.2022.175098","type":"journal-article","created":{"date-parts":[[2022,6,11]],"date-time":"2022-06-11T04:58:11Z","timestamp":1654923491000},"page":"175098","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Liraglutide chronic treatment prevents development of tolerance to antiseizure effects of diazepam in genetically epilepsy prone rats"],"prefix":"10.1016","volume":"928","author":[{"given":"Caterina","family":"De Sarro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Tallarico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Pisano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Gallelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Citraro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovambattista","family":"De Sarro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Leo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2022.175098_bib1","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/795259","article-title":"Oxidative stress and epilepsy: literature review","author":"Aguiar","year":"2012","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.ejphar.2022.175098_bib2","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1007\/s002100000237","article-title":"The AMPA\/kainate receptor antagonist, LY 300164, increases the anticonvulsant effects of diazepam","volume":"3616 361","author":"Borowicz","year":"2000","journal-title":"Naunyn-Schmiedeberg\u2019s Arch. Pharmacol."},{"key":"10.1016\/j.ejphar.2022.175098_bib3","first-page":"103","article-title":"Effects of LY 300164, a selective non-competitive antagonist of AMPA\/KA receptors, on the protective activity of diazepam and diphenylhydantoin in the kindling model of epilepsy in rats","volume":"51","author":"Borowicz","year":"1999","journal-title":"Pol. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2022.175098_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbadis.2021.166124","article-title":"Insulin injections inhibits PTZ-induced mitochondrial dysfunction, oxidative stress and neurological deficits via the SIRT1\/PGC-1\u03b1\/SIRT3 pathway","volume":"1867","author":"Cheng","year":"2021","journal-title":"Biochim. Biophys. Acta, Mol. Basis Dis."},{"key":"10.1016\/j.ejphar.2022.175098_bib5","first-page":"3","article-title":"Mitochondrial dysfunction and oxidative stress in seizure-induced neuronal cell death","volume":"19","author":"Chuang","year":"2010","journal-title":"Acta Neurol. Taiwan"},{"key":"10.1016\/j.ejphar.2022.175098_bib6","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.eplepsyres.2018.07.018","article-title":"Perampanel chronic treatment does not induce tolerance and decreases tolerance to clobazam in genetically epilepsy prone rats","volume":"146","author":"Citraro","year":"2018","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.ejphar.2022.175098_bib7","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.brainresbull.2019.08.001","article-title":"Evaluation of the effects of liraglutide on the development of epilepsy and behavioural alterations in two animal models of epileptogenesis","volume":"153","author":"Citraro","year":"2019","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.ejphar.2022.175098_bib8","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1007\/s13311-014-0318-6","article-title":"Comparative analysis of the treatment of chronic antipsychotic drugs on epileptic susceptibility in genetically epilepsy-prone rats","volume":"12","author":"Citraro","year":"2015","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.ejphar.2022.175098_bib9","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/j.molmet.2015.07.008","article-title":"Distribution and characterisation of Glucagon-like peptide-1 receptor expressing cells in the mouse brain","volume":"4","author":"Cork","year":"2015","journal-title":"Mol. Metabol."},{"key":"10.1016\/j.ejphar.2022.175098_bib10","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0920-1211(89)90063-6","article-title":"Neurobiology of seizure predisposition in the genetically epilepsy-prone rat","volume":"3","author":"Dailey","year":"1989","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.ejphar.2022.175098_bib11","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0091-3057(96)00062-7","article-title":"Tolerance to anticonvulsant effects of some benzodiazepines in genetically epilepsy prone rats","volume":"55","author":"De Sarro","year":"1996","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.ejphar.2022.175098_bib12","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0014-2999(99)00006-0","article-title":"Effects of some AMPA receptor antagonists on the development of tolerance in epilepsy-prone rats and in pentylenetetrazole kindled rats","volume":"368","author":"De Sarro","year":"1999","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2022.175098_bib13","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0920-1211(00)00113-3","article-title":"Influence of D-cycloserine on the anticonvulsant activity of some antiepileptic drugs against audiogenic seizures in DBA\/2 mice","volume":"40","author":"De Sarro","year":"2000","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.ejphar.2022.175098_bib14","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.phrs.2011.11.005","article-title":"Fosinopril and zofenopril, two angiotensin-converting enzyme (ACE) inhibitors, potentiate the anticonvulsant activity of antiepileptic drugs against audiogenic seizures in DBA\/2 mice","volume":"65","author":"De Sarro","year":"2012","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.ejphar.2022.175098_bib15","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.yebeh.2015.06.030","article-title":"Genetically epilepsy-prone rats (GEPRs) and DBA\/2 mice: two animal models of audiogenic reflex epilepsy for the evaluation of new generation AEDs","volume":"71","author":"De Sarro","year":"2017","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.ejphar.2022.175098_bib16","first-page":"249","article-title":"Tolerance to anticonvulsant effects of clobazam, diazepam, and clonazepam in genetically epilepsy prone rats","volume":"47","author":"De Sarro","year":"1992","journal-title":"Adv. Biochem. Psychopharmacol."},{"key":"10.1016\/j.ejphar.2022.175098_bib17","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.biopha.2018.10.066","article-title":"Prevention of pentylenetetrazole-induced kindling and behavioral comorbidities in mice by levetiracetam combined with the GLP-1 agonist liraglutide: involvement of brain antioxidant and BDNF upregulating properties","volume":"109","author":"de Souza","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ejphar.2022.175098_bib18","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1111\/epi.14069","article-title":"Determination of minimal steady-state plasma level of diazepam causing seizure threshold elevation in rats","volume":"59","author":"Dhir","year":"2018","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejphar.2022.175098_bib19","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1038\/nm919","article-title":"Glucagon-like peptide-1 receptor is involved in learning and neuroprotection","volume":"9","author":"During","year":"2003","journal-title":"Nat. Med."},{"key":"10.1016\/j.ejphar.2022.175098_bib20","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.phrs.2015.11.007","article-title":"Challenges in the clinical development of new antiepileptic drugs","volume":"103","author":"Franco","year":"2016","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.ejphar.2022.175098_bib21","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/j.neuropharm.2004.08.021","article-title":"Anticonvulsant effects of carbenoxolone in genetically epilepsy prone rats (GEPRs)","volume":"47","author":"Gareri","year":"2004","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ejphar.2022.175098_bib22","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2015.00046","article-title":"Central serotonin-2A (5-HT2A) receptor dysfunction in depression and epilepsy: the missing link?","volume":"6","author":"Guiard","year":"2015","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejphar.2022.175098_bib23","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.npep.2010.02.002","article-title":"Effects of centrally-injected glucagon-like peptide-1 on pilocarpine-induced seizures, anxiety and locomotor and exploratory activity in rat","volume":"44","author":"Gulec","year":"2010","journal-title":"Neuropeptides"},{"key":"10.1016\/j.ejphar.2022.175098_bib24","first-page":"752","article-title":"Anticonvulsant effect of liraglutide, GLP-1 agonist by averting a change in GABA and brain glutathione level on picrotoxin-induced seizures","volume":"16","author":"Gupta","year":"2017","journal-title":"EXCLI J"},{"key":"10.1016\/j.ejphar.2022.175098_bib25","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1097\/WNR.0b013e32832fbf14","article-title":"Receptors for the incretin glucagon-like peptide-1 are expressed on neurons in the central nervous system","volume":"20","author":"Hamilton","year":"2009","journal-title":"Neuroreport"},{"key":"10.1016\/j.ejphar.2022.175098_bib26","doi-asserted-by":"crossref","DOI":"10.3390\/brainsci9050108","article-title":"Effects of glp-1 receptor activation on a pentylenetetrazole\u2014kindling rat model","volume":"9","author":"Hussein","year":"2019","journal-title":"Brain Sci."},{"key":"10.1016\/j.ejphar.2022.175098_bib27","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1111\/j.1528-1157.1982.tb05421.x","article-title":"Abnormalities in monoamine levels in the central nervous system of the genetically epilepsy\u2010prone rat","volume":"23","author":"Jobe","year":"1982","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejphar.2022.175098_bib28","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s13311-014-0266-1","article-title":"The potential of antiseizure drugs and agents that act on novel molecular targets as antiepileptogenic treatments","volume":"11","author":"Kaminski","year":"2014","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.ejphar.2022.175098_bib29","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1111\/epi.16450","article-title":"Repurposed molecules for antiepileptogenesis: missing an opportunity to prevent epilepsy?","volume":"61","author":"Klein","year":"2020","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejphar.2022.175098_bib30","doi-asserted-by":"crossref","first-page":"79","DOI":"10.2337\/db14-0668","article-title":"GLP-1 and exendin-4 transiently enhance gabaa receptor-mediated synaptic and tonic currents in rat hippocampal ca3 pyramidal neurons","volume":"64","author":"Korol","year":"2015","journal-title":"Diabetes"},{"key":"10.1016\/j.ejphar.2022.175098_bib31","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.neuropharm.2017.11.015","article-title":"Glucagon-like Peptide-1 (GLP-1) and neurotransmitters signaling in epilepsy: an insight review","volume":"136","author":"Koshal","year":"2018","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ejphar.2022.175098_bib32","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s11010-016-2678-1","article-title":"Neurochemical modulation involved in the beneficial effect of liraglutide, GLP-1 agonist on PTZ kindling epilepsy-induced comorbidities in mice","volume":"415","author":"Koshal","year":"2016","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.ejphar.2022.175098_bib33","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1007\/s11064-016-1890-4","article-title":"Effect of liraglutide on corneal kindling epilepsy induced depression and cognitive impairment in mice","volume":"41","author":"Koshal","year":"2016","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.ejphar.2022.175098_bib34","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1007\/s13311-017-0550-y","article-title":"Fingolimod exerts only temporary antiepileptogenic effects but longer-lasting positive effects on behavior in the WAG\/Rij rat absence epilepsy model","volume":"14","author":"Leo","year":"2017","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.ejphar.2022.175098_bib35","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1073\/pnas.0806720106","article-title":"GLP-1 receptor stimulation preserves primary cortical and dopaminergic neurons in cellular and rodent models of stroke and Parkinsonism","volume":"106","author":"Li","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ejphar.2022.175098_bib53","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0022-3565(25)03549-9","article-title":"A simplified method of evaluating dose-effect experiments","volume":"96","author":"Litchfield","year":"1949","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2022.175098_bib36","article-title":"The glucagon-like peptide-1 analogue liraglutide reduces seizures susceptibility, cognition dysfunction and neuronal apoptosis in a mouse model of Dravet syndrome","volume":"11","author":"Liu","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejphar.2022.175098_bib37","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1677\/joe.0.1730465","article-title":"Glucagon-like peptide-1 (GLP-1) and glucose metabolism in human myocytes","volume":"173","author":"Luque","year":"2002","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.ejphar.2022.175098_bib38","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.talanta.2009.06.074","article-title":"Simultaneous analysis of diazepam and its metabolites in rat plasma and brain tissue by HPLC-UV and SPE","volume":"80","author":"Mercolini","year":"2009","journal-title":"Talanta"},{"key":"10.1016\/j.ejphar.2022.175098_bib39","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1002\/phar.1639","article-title":"Liraglutide: a new option for the treatment of obesity","volume":"35","author":"Nuffer","year":"2015","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.ejphar.2022.175098_bib40","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.bbr.2017.01.004","article-title":"Liraglutide prevents cognitive decline in a rat model of streptozotocin-induced diabetes independently from its peripheral metabolic effects","volume":"321","author":"Palleria","year":"2017","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ejphar.2022.175098_bib41","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.yfrne.2016.07.002","article-title":"Potential effects of current drug therapies on cognitive impairment in patients with type 2 diabetes","volume":"42","author":"Palleria","year":"2016","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.ejphar.2022.175098_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2019.146474","article-title":"Low-dose intranasal insulin improves cognitive function and suppresses the development of epilepsy","volume":"1726","author":"Peng","year":"2020","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2022.175098_bib43","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1124\/jpet.102.037481","article-title":"Protection and reversal of excitotoxic neuronal damage by glucagon-like peptide-1 and exendin-4","volume":"302","author":"Perry","year":"2002","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.ejphar.2022.175098_bib44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5152\/NSN.2019.11632","article-title":"Role of the oxidative stress in the pathogenesis of epilepsy","volume":"36","author":"Roganovic","year":"2019","journal-title":"Neurol. Sci. Neurophysiol."},{"key":"10.1016\/j.ejphar.2022.175098_bib45","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1111\/j.1476-5381.2012.01971.x","article-title":"Neuroprotective and neurotrophic actions of glucagon-like peptide-1: an emerging opportunity to treat neurodegenerative and cerebrovascular disorders","volume":"166","author":"Salcedo","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2022.175098_bib46","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1016\/j.neuint.2007.12.003","article-title":"Role of glutathione peroxidase in the ontogeny of hippocampal oxidative stress and kainate seizure sensitivity in the genetically epilepsy-prone rats","volume":"52","author":"Shin","year":"2008","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.ejphar.2022.175098_bib47","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/S1474-4422(14)70076-6","article-title":"The challenge and promise of anti-epileptic therapy development in animal models","volume":"13","author":"Simonato","year":"2014","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.ejphar.2022.175098_bib48","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1016\/j.coph.2013.09.006","article-title":"The gut hormone glucagon-like peptide-1 produced in brain: is this physiologically relevant?","volume":"13","author":"Trapp","year":"2013","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.ejphar.2022.175098_bib49","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.eplepsyres.2018.03.009","article-title":"Post-treatment with the GLP-1 analogue liraglutide alleviate chronic inflammation and mitochondrial stress induced by Status epilepticus","volume":"142","author":"Wang","year":"2018","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.ejphar.2022.175098_bib50","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.bbrc.2019.02.028","article-title":"Inhibitory effects of glucagon-like peptide-1 receptor on epilepsy","volume":"511","author":"Wen","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejphar.2022.175098_bib51","first-page":"1","article-title":"The pleiotropic of GLP-1\/GLP-1R axis in central nervous system diseases","author":"Zhang","year":"2021","journal-title":"Int. J. Neurosci."},{"key":"10.1016\/j.ejphar.2022.175098_bib52","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.bcp.2018.08.004","article-title":"Inhibition of DPP4 enhances inhibitory synaptic transmission through activating the GLP-1\/GLP-1R signaling pathway in a rat model of febrile seizures","volume":"156","author":"Zhang","year":"2018","journal-title":"Biochem. Pharmacol."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299922003594?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299922003594?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T23:03:19Z","timestamp":1757977399000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299922003594"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":53,"alternative-id":["S0014299922003594"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2022.175098","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Liraglutide chronic treatment prevents development of tolerance to antiseizure effects of diazepam in genetically epilepsy prone rats","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2022.175098","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"175098"}}