{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T03:52:47Z","timestamp":1793332367297,"version":"4.5.0"},"reference-count":187,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100020582","name":"National Institute of Pharmaceutical Education and Research, Raebareli","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020582","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.ejphar.2022.175171","type":"journal-article","created":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T20:37:47Z","timestamp":1659386267000},"page":"175171","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"special_numbering":"C","title":["Remodeling of microbiota gut-brain axis using psychobiotics in depression"],"prefix":"10.1016","volume":"931","author":[{"given":"Mani Surya Kumar","family":"Palepu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoj P.","family":"Dandekar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.ejphar.2022.175171_bib1","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1111\/nmo.12295","article-title":"Probiotic gut effect prevents the chronic psychological stress\u2010induced brain activity abnormality in mice","volume":"26","author":"Ait\u2010Belgnaoui","year":"2014","journal-title":"Neuro Gastroenterol. Motil."},{"issue":"11","key":"10.1016\/j.ejphar.2022.175171_bib180","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1016\/j.psyneuen.2012.03.024","article-title":"Prevention of gut leakiness by a probiotic treatment leads to attenuated HPA response to an acute psychological stress in rats","volume":"37","author":"Ait-Belgnaoui","year":"2012","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.ejphar.2022.175171_bib184","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.jad.2016.05.038","article-title":"Possible association of Bifidobacterium and Lactobacillus in the gut microbiota of patients with major depressive disorder","volume":"202","author":"Aizawa","year":"2016","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.ejphar.2022.175171_bib2","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.bbi.2013.10.017","article-title":"NLRP3 inflammasome is activated in mononuclear blood cells from patients with major depressive disorder","volume":"36","author":"Alcocer-G\u00f3mez","year":"2014","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.ejphar.2022.175171_bib3","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.psyneuen.2015.11.021","article-title":"GLP-1 is both anxiogenic and antidepressant; divergent effects of acute and chronic GLP-1 on emotionality","volume":"65","author":"Anderberg","year":"2016","journal-title":"Psychoneuroendocrinology"},{"issue":"1","key":"10.1016\/j.ejphar.2022.175171_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep43522","article-title":"A proliferative probiotic Bifidobacterium strain in the gut ameliorates progression of metabolic disorders via microbiota modulation and acetate elevation","volume":"7","author":"Aoki","year":"2017","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.ejphar.2022.175171_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41398-020-01130-8","article-title":"CD36 deficiency affects depressive-like behaviors possibly by modifying gut microbiota and the inflammasome pathway in mice","volume":"11","author":"Bai","year":"2021","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.ejphar.2022.175171_bib6","series-title":"StatPearls [Internet]","article-title":"Biochemistry, serotonin","author":"Bakshi","year":"2021"},{"issue":"43","key":"10.1016\/j.ejphar.2022.175171_bib7","doi-asserted-by":"crossref","first-page":"11700","DOI":"10.1523\/JNEUROSCI.1636-07.2007","article-title":"Cannabinoids elicit antidepressant-like behavior and activate serotonergic neurons through the medial prefrontal cortex","volume":"27","author":"Bambico","year":"2007","journal-title":"J. Neurosci."},{"issue":"3","key":"10.1016\/j.ejphar.2022.175171_bib8","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1139\/jpn.0421","article-title":"Implication of the hypothalamic\u2013pituitary\u2013adrenal axis in the physiopathology of depression","volume":"29","author":"Barden","year":"2004","journal-title":"J. Psychiatr. Neurosci."},{"issue":"2","key":"10.1016\/j.ejphar.2022.175171_bib9","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1111\/j.1365-2672.2012.05344.x","article-title":"\u03b3\u2010Aminobutyric acid production by culturable bacteria from the human intestine","volume":"113","author":"Barrett","year":"2012","journal-title":"J. Appl. Microbiol."},{"issue":"19","key":"10.1016\/j.ejphar.2022.175171_bib190","doi-asserted-by":"crossref","first-page":"3516","DOI":"10.1021\/acschemneuro.1c00457","article-title":"Linking the triad of telomere length, inflammation, and gut dysbiosis in the manifestation of depression","volume":"12","author":"Bazaz","year":"2021","journal-title":"ACS Chem. Neurosci."},{"issue":"1","key":"10.1016\/j.ejphar.2022.175171_bib10","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1056\/NEJMra073096","article-title":"Major depressive disorder","volume":"358","author":"Belmaker","year":"2008","journal-title":"N. Engl. J. Med."},{"issue":"6","key":"10.1016\/j.ejphar.2022.175171_bib11","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1053\/j.gastro.2010.06.063","article-title":"Chronic gastrointestinal inflammation induces anxiety-like behavior and alters central nervous system biochemistry in mice","volume":"139","author":"Bercik","year":"2010","journal-title":"Gastroenterology"},{"issue":"4","key":"10.1016\/j.ejphar.2022.175171_bib12","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1177\/0706743719900464","article-title":"Gut Microbiome Patterns Associated with Treatment Response in Patients with Major Depressive Disorder: changements du microbiote intestinal associ\u00e9s \u00e0 la r\u00e9ponse au traitement chez des patients souffrant de trouble d\u00e9pressif majeur","volume":"65","author":"Bharwani","year":"2020","journal-title":"Can. J. Psychiatr."},{"issue":"11","key":"10.1016\/j.ejphar.2022.175171_bib13","doi-asserted-by":"crossref","first-page":"6704","DOI":"10.1038\/s41380-021-01093-2","article-title":"Pharmacological and behavioral divergence of ketamine enantiomers: implications for abuse liability","volume":"26","author":"Bonaventura","year":"2021","journal-title":"Mol. Psychiatr."},{"key":"10.1016\/j.ejphar.2022.175171_bib14","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.neulet.2016.02.009","article-title":"Butyrate, neuroepigenetics and the gut microbiome: can a high fiber diet improve brain health?","volume":"625","author":"Bourassa","year":"2016","journal-title":"Neurosci. Lett."},{"issue":"38","key":"10.1016\/j.ejphar.2022.175171_bib15","doi-asserted-by":"crossref","first-page":"16050","DOI":"10.1073\/pnas.1102999108","article-title":"Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve","volume":"108","author":"Bravo","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"3","key":"10.1016\/j.ejphar.2022.175171_bib16","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.biopsych.2017.08.014","article-title":"Harnessing gut microbes for mental health: getting from here to there","volume":"83","author":"Bruce-Keller","year":"2018","journal-title":"Biol. Psychiatr."},{"issue":"1","key":"10.1016\/j.ejphar.2022.175171_bib17","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3945\/ajcn.115.126706","article-title":"Increased colonic propionate reduces anticipatory reward responses in the human striatum to high-energy foods","volume":"104","author":"Byrne","year":"2016","journal-title":"Am. J. Clin. Nutr."},{"issue":"9","key":"10.1016\/j.ejphar.2022.175171_bib18","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.molmet.2016.05.011","article-title":"How gut microbes talk to organs: the role of endocrine and nervous routes","volume":"5","author":"Cani","year":"2016","journal-title":"Mol. Metabol."},{"issue":"2","key":"10.1016\/j.ejphar.2022.175171_bib19","first-page":"203","article-title":"The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems","volume":"28","author":"Carabotti","year":"2015","journal-title":"Ann. Gastroenterol.: Quart. Publ. Hellenic Soc. Gastroenterol."},{"key":"10.1016\/j.ejphar.2022.175171_bib20","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.ygcen.2013.02.022","article-title":"Effects of probiotic administration on zebrafish development and reproduction","volume":"188","author":"Carnevali","year":"2013","journal-title":"Gen. Comp. Endocrinol."},{"issue":"8","key":"10.1016\/j.ejphar.2022.175171_bib21","doi-asserted-by":"crossref","first-page":"2676","DOI":"10.3390\/ijms21082676","article-title":"d-Glutamate and gut microbiota in Alzheimer's disease","volume":"21","author":"Chang","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.ejphar.2022.175171_bib22","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1177\/0269881120972331","article-title":"Plasma d-glutamate levels for detecting mild cognitive impairment and Alzheimer's disease: machine learning approaches","volume":"35","author":"Chang","year":"2021","journal-title":"J. Psychopharmacol."},{"issue":"8","key":"10.1016\/j.ejphar.2022.175171_bib23","doi-asserted-by":"crossref","first-page":"3382","DOI":"10.1021\/acs.jproteome.5b00434","article-title":"Divergent urinary metabolic phenotypes between major depressive disorder and bipolar disorder identified by a combined GC\u2013MS and NMR spectroscopic metabonomic approach","volume":"14","author":"Chen","year":"2015","journal-title":"J. Proteome Res."},{"issue":"1","key":"10.1016\/j.ejphar.2022.175171_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-020-19931-2","article-title":"Effect of gut microbiota on depressive-like behaviors in mice is mediated by the endocannabinoid system","volume":"11","author":"Chevalier","year":"2020","journal-title":"Nat. Commun."},{"issue":"6","key":"10.1016\/j.ejphar.2022.175171_bib25","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/mp.2012.77","article-title":"The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner","volume":"18","author":"Clarke","year":"2013","journal-title":"Mol. Psychiatr."},{"issue":"7","key":"10.1016\/j.ejphar.2022.175171_bib26","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/S0024-3205(97)00990-9","article-title":"Depression, stress and immunological activation: the role of cytokines in depressive disorders","volume":"62","author":"Connor","year":"1998","journal-title":"Life Sci."},{"issue":"6","key":"10.1016\/j.ejphar.2022.175171_bib27","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1093\/ibd\/izz017","article-title":"Palmitoylethanolamide and cannabidiol prevent inflammation-induced hyperpermeability of the human gut in vitro and in vivo\u2014a randomized, placebo-controlled, double-blind controlled trial","volume":"25","author":"Couch","year":"2019","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.ejphar.2022.175171_bib176","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.psyneuen.2014.01.014","article-title":"Absence of the gut microbiota enhances anxiety-like behavior and neuroendocrine response to acute stress in rats","volume":"42","author":"Crumeyrolle-Arias","year":"2014","journal-title":"Psychoneuroendocrinology"},{"issue":"1","key":"10.1016\/j.ejphar.2022.175171_bib28","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.tips.2004.11.004","article-title":"Don't worry \u2018B\u2019happy!: a role for GABAB receptors in anxiety and depression","volume":"26","author":"Cryan","year":"2005","journal-title":"Trends Pharmacol. Sci."},{"issue":"5","key":"10.1016\/j.ejphar.2022.175171_bib29","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1038\/mp.2018.2","article-title":"Deep brain stimulation for treatment-resistant depression: an integrative review of preclinical and clinical findings and translational implications","volume":"23","author":"Dandekar","year":"2018","journal-title":"Mol. Psychiatr."},{"issue":"3","key":"10.1016\/j.ejphar.2022.175171_bib30","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1590\/1516-4446-2021-1874","article-title":"A narrative review on invasive brain stimulation for treatment-resistant depression","volume":"44","author":"Dandekar","year":"2021","journal-title":"Braz. J. Psychiatr."},{"issue":"13","key":"10.1016\/j.ejphar.2022.175171_bib31","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1021\/acschemneuro.2c00143","article-title":"Multi-strain probiotic formulation reverses maternal separation and chronic unpredictable mild stress-generated anxiety-and depression-like phenotypes by modulating gut microbiome\u2013brain activity in rats","volume":"13","author":"Dandekar","year":"2022","journal-title":"ACS Chem. Neurosci."},{"issue":"2","key":"10.1016\/j.ejphar.2022.175171_bib32","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.jaci.2018.12.755","article-title":"Cytokine, sickness behavior, and depression","volume":"29","author":"Dantzer","year":"2009","journal-title":"Immunol. Allergy Clin."},{"issue":"4","key":"10.1016\/j.ejphar.2022.175171_bib33","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1038\/s41591-022-01744-z","article-title":"Increased global integration in the brain after psilocybin therapy for depression","volume":"28","author":"Daws","year":"2022","journal-title":"Nat. Med."},{"issue":"4","key":"10.1016\/j.ejphar.2022.175171_bib34","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1006\/frne.1993.1009","article-title":"Central nervous system effects of the neurohypophyseal hormones and related peptides","volume":"14","author":"de Wied","year":"1993","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.ejphar.2022.175171_bib35","first-page":"1","author":"Depression","year":"2017"},{"key":"10.1016\/j.ejphar.2022.175171_bib36","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.bbi.2015.04.004","article-title":"Gut microbiota depletion from early adolescence in mice: implications for brain and behaviour","volume":"48","author":"Desbonnet","year":"2015","journal-title":"Brain Behav. Immun."},{"issue":"2","key":"10.1016\/j.ejphar.2022.175171_bib37","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.jpsychires.2008.03.009","article-title":"The probiotic Bifidobacteria infantis: an assessment of potential antidepressant properties in the rat","volume":"43","author":"Desbonnet","year":"2008","journal-title":"J. Psychiatr. Res."},{"issue":"4","key":"10.1016\/j.ejphar.2022.175171_bib38","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1016\/j.neuroscience.2010.08.005","article-title":"Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression","volume":"170","author":"Desbonnet","year":"2010","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/j.ejphar.2022.175171_bib39","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1111\/jam.13765","article-title":"Lactobacillus plantarum MTCC 9510 supplementation protects from chronic unpredictable and sleep deprivation\u2010induced behaviour, biochemical and selected gut microbial aberrations in mice","volume":"125","author":"Dhaliwal","year":"2018","journal-title":"J. Appl. Microbiol."},{"issue":"9","key":"10.1016\/j.ejphar.2022.175171_bib40","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1111\/nmo.12198","article-title":"Melancholic microbes: a link between gut microbiota and depression?","volume":"25","author":"Dinan","year":"2013","journal-title":"Neuro Gastroenterol. Motil."},{"key":"10.1016\/j.ejphar.2022.175171_bib41","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.neuint.2018.03.008","article-title":"Deletion of serine racemase confers D-serine\u2013dependent resilience to chronic social defeat stress","volume":"116","author":"Dong","year":"2018","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.ejphar.2022.175171_bib42","doi-asserted-by":"crossref","first-page":"36","DOI":"10.3389\/fnins.2013.00036","article-title":"Serotonin and the regulation of mammalian energy balance","volume":"7","author":"Donovan","year":"2013","journal-title":"Front. Neurosci."},{"issue":"5","key":"10.1016\/j.ejphar.2022.175171_bib43","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.biopsych.2009.09.033","article-title":"A meta-analysis of cytokines in major depression","volume":"67","author":"Dowlati","year":"2010","journal-title":"Biol. Psychiatr."},{"issue":"12","key":"10.1016\/j.ejphar.2022.175171_bib44","doi-asserted-by":"crossref","first-page":"5782","DOI":"10.1210\/en.2012-1595","article-title":"A major lineage of enteroendocrine cells coexpress CCK, secretin, GIP, GLP-1, PYY, and neurotensin but not somatostatin","volume":"153","author":"Egerod","year":"2012","journal-title":"Endocrinology"},{"key":"10.1016\/j.ejphar.2022.175171_bib45","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.bbi.2019.06.015","article-title":"Markers of central inflammation in major depressive disorder: a systematic review and meta-analysis of studies examining cerebrospinal fluid, positron emission tomography and post-mortem brain tissue","volume":"81","author":"Enache","year":"2019","journal-title":"Brain Behav. Immun."},{"issue":"7","key":"10.1016\/j.ejphar.2022.175171_bib46","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1038\/nn.4030","article-title":"Host microbiota constantly control maturation and function of microglia in the CNS","volume":"18","author":"Erny","year":"2015","journal-title":"Nat. Neurosci."},{"issue":"9","key":"10.1016\/j.ejphar.2022.175171_bib47","doi-asserted-by":"crossref","first-page":"311","DOI":"10.3390\/biomedicines8090311","article-title":"Exploring the role of gut microbiota in major depressive disorder and in treatment resistance to antidepressants","volume":"8","author":"Fontana","year":"2020","journal-title":"Biomedicines"},{"key":"10.1016\/j.ejphar.2022.175171_bib48","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.ynstr.2017.03.001","article-title":"Stress & the gut-brain axis: regulation by the microbiome","volume":"7","author":"Foster","year":"2017","journal-title":"Neurobiol. Stress"},{"issue":"2","key":"10.1016\/j.ejphar.2022.175171_bib49","first-page":"315","article-title":"Gut microbiota and immunity in common variable immunodeficiency: crosstalk with pro-inflammatory cytokines","volume":"33","author":"Franza","year":"2019","journal-title":"J. Biol. Regul. Homeost. Agents"},{"issue":"9","key":"10.1016\/j.ejphar.2022.175171_bib50","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S0166-2236(03)00227-3","article-title":"Interneuron diversity series: rhythm and mood in perisomatic inhibition","volume":"26","author":"Freund","year":"2003","journal-title":"Trends Neurosci."},{"issue":"1","key":"10.1016\/j.ejphar.2022.175171_bib51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep37261","article-title":"Supplementation with D-serine prevents the onset of cognitive deficits in adult offspring after maternal immune activation","volume":"6","author":"Fujita","year":"2016","journal-title":"Sci. Rep."},{"issue":"11","key":"10.1016\/j.ejphar.2022.175171_bib52","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1136\/gut.2006.117176","article-title":"Probiotic treatment of rat pups normalises corticosterone release and ameliorates colonic dysfunction induced by maternal separation","volume":"56","author":"Gareau","year":"2007","journal-title":"Gut"},{"key":"10.1016\/j.ejphar.2022.175171_bib53","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.jad.2018.02.057","article-title":"Palmitoylethanolamide as adjunctive therapy in major depressive disorder: a double-blind, randomized and placebo-controlled trial","volume":"232","author":"Ghazizadeh-Hashemi","year":"2018","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.ejphar.2022.175171_bib54","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jpsychires.2019.05.001","article-title":"Maternal deprivation increases microglial activation and neuroinflammatory markers in the prefrontal cortex and hippocampus of infant rats","volume":"115","author":"Giridharan","year":"2019","journal-title":"J. Psychiatr. Res."},{"issue":"4","key":"10.1016\/j.ejphar.2022.175171_bib55","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1023\/B:DDAS.0000026302.92898.ae","article-title":"In vivo effects of bifidobacteria and lactoferrin on gut endotoxin concentration and mucosal immunity in Balb\/c mice","volume":"49","author":"Griffiths","year":"2004","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.ejphar.2022.175171_bib56","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.bbi.2017.09.001","article-title":"Antibiotic-induced microbiota perturbation causes gut endocannabinoidome changes, hippocampal neuroglial reorganization and depression in mice","volume":"67","author":"Guida","year":"2018","journal-title":"Brain Behav. Immun."},{"issue":"3","key":"10.1016\/j.ejphar.2022.175171_bib57","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1042\/bj3600617","article-title":"Kynurenine aminotransferase and glutamine transaminase K of Escherichia coli: identity with aspartate aminotransferase","volume":"360","author":"Han","year":"2001","journal-title":"Biochem. J."},{"key":"10.1016\/j.ejphar.2022.175171_bib58","series-title":"Lactobacillus Mucosae and Bifidobacterium Longum Synergistically Alleviate Immobilization Stress-Induced Anxiety\/depression in Mice by Suppressing Gut Dysbiosis","author":"Han","year":"2019"},{"key":"10.1016\/j.ejphar.2022.175171_bib59","series-title":"Lactobacillus Reuteri NK33 and Bifidobacterium Adolescentis NK98 Alleviate Escherichia Coli-Induced Depression and Gut Dysbiosis in Mice","author":"Han","year":"2020"},{"key":"10.1016\/j.ejphar.2022.175171_bib60","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.psyneuen.2019.02.025","article-title":"Faecalibacterium prausnitzii (ATCC 27766) has preventive and therapeutic effects on chronic unpredictable mild stress-induced depression-like and anxiety-like behavior in rats","volume":"104","author":"Hao","year":"2019","journal-title":"Psychoneuroendocrinology"},{"issue":"10","key":"10.1016\/j.ejphar.2022.175171_bib61","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1111\/pcn.12902","article-title":"Rapid\u2010acting antidepressant ketamine, its metabolites and other candidates: a historical overview and future perspective","volume":"73","author":"Hashimoto","year":"2019","journal-title":"Psychiatr. Clin. Neurosci."},{"key":"10.1016\/j.ejphar.2022.175171_bib62","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2020.113935","article-title":"Molecular mechanisms of the rapid-acting and long-lasting antidepressant actions of (R)-ketamine","volume":"177","author":"Hashimoto","year":"2020","journal-title":"Biochem. Pharmacol."},{"issue":"7","key":"10.1016\/j.ejphar.2022.175171_bib63","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0180745","article-title":"Regulation of gut luminal serotonin by commensal microbiota in mice","volume":"12","author":"Hata","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2022.175171_bib64","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.3389\/fpsyg.2017.01561","article-title":"The relationships among tryptophan, kynurenine, indoleamine 2, 3-dioxygenase, depression, and neuropsychological performance","volume":"8","author":"Hestad","year":"2017","journal-title":"Front. Psychol."},{"issue":"3","key":"10.1016\/j.ejphar.2022.175171_bib65","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1159\/000443358","article-title":"Gastrointestinal microbiota and colon cancer","volume":"34","author":"Hold","year":"2016","journal-title":"Dig. Dis."},{"key":"10.1016\/j.ejphar.2022.175171_bib66","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.pbb.2018.12.001","article-title":"Role of Actinobacteria and Coriobacteriia in the antidepressant effects of ketamine in an inflammation model of depression","volume":"176","author":"Huang","year":"2019","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.ejphar.2022.175171_bib187","doi-asserted-by":"crossref","first-page":"3329","DOI":"10.2147\/NDT.S188340","article-title":"Possible association of Firmicutes in the gut microbiota of patients with major depressive disorder","volume":"14","author":"Huang","year":"2018","journal-title":"Neuropsychiatric Dis. Treat."},{"issue":"1","key":"10.1016\/j.ejphar.2022.175171_bib67","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.ejphar.2010.10.008","article-title":"The glucagon-like peptide 1 receptor agonist exendin-4 improves reference memory performance and decreases immobility in the forced swim test","volume":"650","author":"Isacson","year":"2011","journal-title":"Eur. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.ejphar.2022.175171_bib179","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.pharmthera.2009.12.005","article-title":"Cannabinoids and the gut: new developments and emerging concepts","volume":"126","author":"Izzo","year":"2010","journal-title":"Pharmacol. Ther."},{"issue":"4","key":"10.1016\/j.ejphar.2022.175171_bib68","doi-asserted-by":"crossref","first-page":"819","DOI":"10.3390\/nu11040819","article-title":"The preventive and curative effects of Lactobacillus reuteri NK33 and Bifidobacterium adolescentis NK98 on immobilization stress-induced anxiety\/depression and colitis in mice","volume":"11","author":"Jang","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.ejphar.2022.175171_bib183","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.bbi.2015.03.016","article-title":"Altered fecal microbiota composition in patients with major depressive disorder","volume":"48","author":"Jiang","year":"2015","journal-title":"Brain Behav. Immun."},{"issue":"8","key":"10.1016\/j.ejphar.2022.175171_bib69","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.1677","article-title":"Altered gut bacterial\u2013fungal interkingdom networks in patients with current depressive episode","volume":"10","author":"Jiang","year":"2020","journal-title":"Brain Behav."},{"issue":"10","key":"10.1016\/j.ejphar.2022.175171_bib70","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1111\/apt.12950","article-title":"Intestinal barrier dysfunction and central nervous system disorders\u2013a controversial association","volume":"40","author":"Julio\u2010Pieper","year":"2014","journal-title":"Aliment. Pharmacol. Ther."},{"issue":"13","key":"10.1016\/j.ejphar.2022.175171_bib71","doi-asserted-by":"crossref","first-page":"2511","DOI":"10.1007\/s00018-016-2175-4","article-title":"Modulatory effects of \u03b17 nAChRs on the immune system and its relevance for CNS disorders","volume":"73","author":"Kalkman","year":"2016","journal-title":"Cell. Mol. Life Sci."},{"issue":"6","key":"10.1016\/j.ejphar.2022.175171_bib72","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1097\/JCP.0000000000000581","article-title":"Targeting the endocannabinoid system in psychiatric illness","volume":"36","author":"Katzman","year":"2016","journal-title":"J. Clin. Psychopharmacol."},{"issue":"2","key":"10.1016\/j.ejphar.2022.175171_bib73","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.clnu.2018.04.010","article-title":"Effect of probiotic and prebiotic vs placebo on psychological outcomes in patients with major depressive disorder: a randomized clinical trial","volume":"38","author":"Kazemi","year":"2019","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.ejphar.2022.175171_bib74","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.bbi.2016.11.018","article-title":"Lost in translation? The potential psychobiotic Lactobacillus rhamnosus (JB-1) fails to modulate stress or cognitive performance in healthy male subjects","volume":"61","author":"Kelly","year":"2017","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.ejphar.2022.175171_bib75","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.jpsychires.2016.07.019","article-title":"Transferring the blues: depression-associated gut microbiota induces neurobehavioural changes in the rat","volume":"82","author":"Kelly","year":"2016","journal-title":"J. Psychiatr. Res."},{"issue":"3","key":"10.1016\/j.ejphar.2022.175171_bib76","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.gtc.2019.04.006","article-title":"Mood and microbes: gut to brain communication in depression","volume":"48","author":"Kelly","year":"2019","journal-title":"Gastroenterol. Clin."},{"issue":"2","key":"10.1016\/j.ejphar.2022.175171_bib77","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s13668-019-0276-z","article-title":"Impact of brain insulin signaling on dopamine function, food intake, reward, and emotional behavior","volume":"8","author":"Kleinridders","year":"2019","journal-title":"Curr. Nutr. Rep."},{"issue":"5","key":"10.1016\/j.ejphar.2022.175171_bib78","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.neuron.2019.02.005","article-title":"Ketamine: a paradigm shift for depression research and treatment","volume":"101","author":"Krystal","year":"2019","journal-title":"Neuron"},{"issue":"2","key":"10.1016\/j.ejphar.2022.175171_bib79","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1007\/s00726-007-0631-z","article-title":"Micromolar concentration of kynurenic acid in rat small intestine","volume":"35","author":"Kuc","year":"2008","journal-title":"Amino Acids"},{"issue":"8","key":"10.1016\/j.ejphar.2022.175171_bib80","doi-asserted-by":"crossref","first-page":"3672","DOI":"10.1038\/s41380-020-00869-2","article-title":"Sick for science: experimental endotoxemia as a translational tool to develop and test new therapies for inflammation-associated depression","volume":"26","author":"Lasselin","year":"2021","journal-title":"Mol. Psychiatr."},{"issue":"3","key":"10.1016\/j.ejphar.2022.175171_bib81","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1007\/s00406-020-01110-5","article-title":"Intravenous arketamine for treatment-resistant depression: open-label pilot study","volume":"271","author":"Leal","year":"2021","journal-title":"Eur. Arch. Psychiatr. Clin. Neurosci."},{"issue":"5","key":"10.1016\/j.ejphar.2022.175171_bib82","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0097342","article-title":"Identification of the porcine G protein-coupled receptor 41 and 43 genes and their expression pattern in different tissues and development stages","volume":"9","author":"Li","year":"2014","journal-title":"PLoS One"},{"issue":"10","key":"10.1016\/j.ejphar.2022.175171_bib83","article-title":"Effects of regulating gut microbiota on the serotonin metabolism in the chronic unpredictable mild stress rat model","volume":"31","author":"Li","year":"2019","journal-title":"Neuro Gastroenterol. Motil."},{"key":"10.1016\/j.ejphar.2022.175171_bib84","doi-asserted-by":"crossref","first-page":"454","DOI":"10.3389\/fpsyt.2018.00454","article-title":"Short term intrarectal administration of sodium propionate induces antidepressant-like effects in rats exposed to chronic unpredictable mild stress","volume":"9","author":"Li","year":"2018","journal-title":"Front. Psychiatr."},{"key":"10.1016\/j.ejphar.2022.175171_bib85","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.neuroscience.2015.09.033","article-title":"Administration of Lactobacillus helveticus NS8 improves behavioral, cognitive, and biochemical aberrations caused by chronic restraint stress","volume":"310","author":"Liang","year":"2015","journal-title":"Neuroscience"},{"issue":"4","key":"10.1016\/j.ejphar.2022.175171_bib86","doi-asserted-by":"crossref","first-page":"425","DOI":"10.3920\/BM2018.0077","article-title":"Lactobacillus paracasei PS23 reduced early-life stress abnormalities in maternal separation mouse model","volume":"10","author":"Liao","year":"2019","journal-title":"Benef. Microbes"},{"issue":"7","key":"10.1016\/j.ejphar.2022.175171_bib87","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1093\/ijnp\/pyac006","article-title":"Effects of sodium benzoate, a D-amino acid oxidase inhibitor, on perceived stress and cognitive function among patients with late-life depression: a randomized, double-blind, sertraline-and placebo-controlled trial","volume":"25","author":"Lin","year":"2022","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.ejphar.2022.175171_bib186","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.jad.2016.09.051","article-title":"Prevotella and Klebsiella proportions in fecal microbial communities are potential characteristic parameters for patients with major depressive disorder","volume":"207","author":"Lin","year":"2017","journal-title":"J. Affect. Disord."},{"issue":"4","key":"10.1016\/j.ejphar.2022.175171_bib88","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0035240","article-title":"Butyrate and propionate protect against diet-induced obesity and regulate gut hormones via free fatty acid receptor 3-independent mechanisms","volume":"7","author":"Lin","year":"2012","journal-title":"PLoS One"},{"issue":"13","key":"10.1016\/j.ejphar.2022.175171_bib89","doi-asserted-by":"crossref","first-page":"4608","DOI":"10.3390\/ijms21134608","article-title":"Lactobacillus plantarum DR7 modulated bowel movement and gut microbiota associated with dopamine and serotonin pathways in stressed adults","volume":"21","author":"Liu","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2022.175171_bib90","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.bbr.2015.10.046","article-title":"Alteration of behavior and monoamine levels attributable to Lactobacillus plantarum PS128 in germ-free mice","volume":"298","author":"Liu","year":"2016","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ejphar.2022.175171_bib91","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2015.11.018","article-title":"Psychotropic effects of Lactobacillus plantarum PS128 in early life-stressed and na\u00efve adult mice","volume":"1631","author":"Liu","year":"2016","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2022.175171_bib92","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.neures.2021.04.001","article-title":"Vagotomy and insights into the microbiota-gut-brain axis","volume":"168","author":"Liu","year":"2021","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.ejphar.2022.175171_bib93","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2021.108682","article-title":"Loss of vagal integrity disrupts immune components of the microbiota-gut-brain axis and inhibits the effect of Lactobacillus rhamnosus on behavior and the corticosterone stress response","volume":"195","author":"Liu","year":"2021","journal-title":"Neuropharmacology"},{"issue":"3","key":"10.1016\/j.ejphar.2022.175171_bib94","doi-asserted-by":"crossref","first-page":"169","DOI":"10.4161\/chan.28956","article-title":"Free fatty acid receptor 3 is a key target of short chain fatty acid: what is the impact on the sympathetic nervous system?","volume":"8","author":"L\u00f3pez Soto","year":"2014","journal-title":"Channels"},{"issue":"3","key":"10.1016\/j.ejphar.2022.175171_bib95","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s11427-014-4615-4","article-title":"Ingestion of Lactobacillus strain reduces anxiety and improves cognitive function in the hyperammonemia rat","volume":"57","author":"Luo","year":"2014","journal-title":"Sci. China Life Sci."},{"key":"10.1016\/j.ejphar.2022.175171_bib96","doi-asserted-by":"crossref","first-page":"64","DOI":"10.3389\/fpsyg.2019.00064","article-title":"Vagus nerve stimulation for depression: a systematic review","volume":"10","author":"Lv","year":"2019","journal-title":"Front. Psychol."},{"key":"10.1016\/j.ejphar.2022.175171_bib182","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jad.2019.12.020","article-title":"The gut microbiota is associated with psychiatric symptom severity and treatment outcome among individuals with serious mental illness","volume":"264","author":"Madan","year":"2020","journal-title":"J. Affect. Disord."},{"issue":"7","key":"10.1016\/j.ejphar.2022.175171_bib97","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1080\/09168451.2019.1591263","article-title":"Heat-killed Lactobacillus helveticus strain MCC1848 confers resilience to anxiety or depression-like symptoms caused by subchronic social defeat stress in mice","volume":"83","author":"Maehata","year":"2019","journal-title":"Biosci., Biotechnol., Biochem."},{"issue":"3","key":"10.1016\/j.ejphar.2022.175171_bib98","first-page":"287","article-title":"The cytokine hypothesis of depression: inflammation, oxidative & nitrosative stress (IO&NS) and leaky gut as new targets for adjunctive treatments in depression","volume":"29","author":"Maes","year":"2008","journal-title":"Neuroendocrinol. Lett."},{"key":"10.1016\/j.ejphar.2022.175171_bib99","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.jad.2016.09.056","article-title":"Liraglutide promotes improvements in objective measures of cognitive dysfunction in individuals with mood disorders: a pilot, open-label study","volume":"207","author":"Mansur","year":"2017","journal-title":"J. Affect. Disord."},{"issue":"1","key":"10.1016\/j.ejphar.2022.175171_bib100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep43859","article-title":"Microbiota alteration is associated with the development of stress-induced despair behavior","volume":"7","author":"Marin","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejphar.2022.175171_bib101","doi-asserted-by":"crossref","first-page":"2838","DOI":"10.3389\/fimmu.2018.02838","article-title":"Butyrate produced by commensal bacteria down-regulates indolamine 2, 3-dioxygenase 1 (Ido-1) expression via a dual mechanism in human intestinal epithelial cells","volume":"9","author":"Martin-Gallausiaux","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejphar.2022.175171_bib185","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.jad.2020.01.137","article-title":"Reduced anti-inflammatory gut microbiota are associated with depression and anhedonia","volume":"266","author":"Mason","year":"2020","journal-title":"J. Affect. Disord."},{"issue":"1","key":"10.1016\/j.ejphar.2022.175171_bib102","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-018-36244-z","article-title":"Free D-amino acids produced by commensal bacteria in the colonic lumen","volume":"8","author":"Matsumoto","year":"2018","journal-title":"Sci. Rep."},{"issue":"8","key":"10.1016\/j.ejphar.2022.175171_bib103","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/nrgastro.2013.105","article-title":"Serotonin signalling in the gut\u2014functions, dysfunctions and therapeutic targets","volume":"10","author":"Mawe","year":"2013","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.ejphar.2022.175171_bib104","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.neubiorev.2014.02.006","article-title":"A critical role for prefrontocortical endocannabinoid signaling in the regulation of stress and emotional behavior","volume":"42","author":"McLaughlin","year":"2014","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.ejphar.2022.175171_bib105","doi-asserted-by":"crossref","first-page":"294","DOI":"10.3389\/fnins.2018.00294","article-title":"Mouse strain affects behavioral and neuroendocrine stress responses following administration of probiotic Lactobacillus rhamnosus JB-1 or traditional antidepressant fluoxetine","volume":"12","author":"McVey Neufeld","year":"2018","journal-title":"Front. Neurosci."},{"issue":"5","key":"10.1016\/j.ejphar.2022.175171_bib106","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1017\/S0007114510004319","article-title":"Assessment of psychotropic-like properties of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in rats and human subjects","volume":"105","author":"Messaoudi","year":"2011","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.ejphar.2022.175171_bib107","first-page":"1","article-title":"Endocannabinoid system mediates the association between gut-microbial diversity and anhedonia\/amotivation in a general population cohort","author":"Minichino","year":"2021","journal-title":"Mol. Psychiatr."},{"issue":"9","key":"10.1016\/j.ejphar.2022.175171_bib108","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1002\/jcp.25518","article-title":"Neurotransmitters: the critical modulators regulating gut\u2013brain axis","volume":"232","author":"Mittal","year":"2017","journal-title":"J. Cell. Physiol."},{"issue":"5","key":"10.1016\/j.ejphar.2022.175171_bib109","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1097\/WNF.0000000000000299","article-title":"Clostridium butyricum MIYAIRI 588 as adjunctive therapy for treatment-resistant major depressive disorder: a prospective open-label trial","volume":"41","author":"Miyaoka","year":"2018","journal-title":"Clin. Neuropharmacol."},{"key":"10.1016\/j.ejphar.2022.175171_bib110","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.bbr.2017.07.026","article-title":"Microbial regulation of hippocampal miRNA expression: implications for transcription of kynurenine pathway enzymes","volume":"334","author":"Moloney","year":"2017","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ejphar.2022.175171_bib111","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.bbi.2017.05.011","article-title":"Bifidobacterium CECT 7765 modulates early stress-induced immune, neuroendocrine and behavioral alterations in mice","volume":"65","author":"Moya-Perez","year":"2017","journal-title":"Brain Behav. Immun."},{"issue":"20","key":"10.1016\/j.ejphar.2022.175171_bib112","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.97957","article-title":"Gut microbiota\u2013derived D-serine protects against acute kidney injury","volume":"3","author":"Nakade","year":"2018","journal-title":"JCI Insight"},{"issue":"8","key":"10.1016\/j.ejphar.2022.175171_bib113","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1038\/nrd1157","article-title":"Understanding\u2019global\u2019systems biology: metabonomics and the continuum of metabolism","volume":"2","author":"Nicholson","year":"2003","journal-title":"Nat. Rev. Drug Discov."},{"issue":"10","key":"10.1016\/j.ejphar.2022.175171_bib114","doi-asserted-by":"crossref","first-page":"3552","DOI":"10.1210\/en.2013-1142","article-title":"GPR41\/FFAR3 and GPR43\/FFAR2 as cosensors for short-chain fatty acids in enteroendocrine cells vs FFAR3 in enteric neurons and FFAR2 in enteric leukocytes","volume":"154","author":"N\u00f8hr","year":"2013","journal-title":"Endocrinology"},{"issue":"4","key":"10.1016\/j.ejphar.2022.175171_bib115","doi-asserted-by":"crossref","first-page":"R1131","DOI":"10.1152\/ajpregu.90434.2008","article-title":"Protective effects of Lactobacillus rhamnosus [corrected] and Bifidobacterium infantis in murine models for colitis do not involve the vagus nerve","volume":"295","author":"O'Mahony","year":"2008","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"issue":"2","key":"10.1016\/j.ejphar.2022.175171_bib116","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/acps.12978","article-title":"Leaky gut biomarkers in depression and suicidal behavior","volume":"139","author":"Ohlsson","year":"2019","journal-title":"Acta Psychiatr. Scand."},{"issue":"2","key":"10.1016\/j.ejphar.2022.175171_bib117","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1113\/jphysiol.2010.196832","article-title":"Electrophysiological evidence for distinct vagal pathways mediating CCK\u2010evoked motor effects in the proximal versus distal stomach","volume":"589","author":"Okano\u2010Matsumoto","year":"2011","journal-title":"J. Physiol."},{"key":"10.1016\/j.ejphar.2022.175171_bib118","doi-asserted-by":"crossref","DOI":"10.1016\/j.ynstr.2018.100141","article-title":"Stress matters: randomized controlled trial on the effect of probiotics on neurocognition","volume":"10","author":"Papalini","year":"2019","journal-title":"Neurobiol. Stress"},{"issue":"5\u20136","key":"10.1016\/j.ejphar.2022.175171_bib119","first-page":"555","article-title":"Contribution of serotonin type 3 receptors in the successful extinction of cued or contextual fear conditioned responses: interactions with GABAergic signaling","volume":"23","author":"Park","year":"2012","journal-title":"Rev. Neurosci."},{"key":"10.1016\/j.ejphar.2022.175171_bib120","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.bbr.2018.02.005","article-title":"Acute and repeated exposure to social stress reduces gut microbiota diversity in Syrian hamsters","volume":"345","author":"Partrick","year":"2018","journal-title":"Behav. Brain Res."},{"issue":"5","key":"10.1016\/j.ejphar.2022.175171_bib177","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1192\/bjp.bp.109.076430","article-title":"Association of high-sensitivity C-reactive protein with de novo major depression","volume":"197","author":"Pasco","year":"2010","journal-title":"Br. J. Psychiatr."},{"issue":"5","key":"10.1016\/j.ejphar.2022.175171_bib121","first-page":"1563","article-title":"Gut microbiota composition associated with alterations in cardiorespiratory fitness and psychosocial outcomes among breast cancer survivors","volume":"25","author":"Paulsen","year":"2017","journal-title":"Support. Care Cancer"},{"issue":"14","key":"10.1016\/j.ejphar.2022.175171_bib122","doi-asserted-by":"crossref","first-page":"2799","DOI":"10.1007\/s00213-014-3452-2","article-title":"Continuous kynurenine administration during the prenatal period, but not during adolescence, causes learning and memory deficits in adult rats","volume":"231","author":"Pocivavsek","year":"2014","journal-title":"Psychopharmacology"},{"issue":"1","key":"10.1016\/j.ejphar.2022.175171_bib123","article-title":"GABA\u2010producing Bifidobacterium dentium modulates visceral sensitivity in the intestine","volume":"29","author":"Pokusaeva","year":"2017","journal-title":"Neuro Gastroenterol. Motil."},{"issue":"6","key":"10.1016\/j.ejphar.2022.175171_bib124","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0129501","article-title":"The olfactory receptor OR51E1 is present along the gastrointestinal tract of pigs, co-localizes with enteroendocrine cells and is modulated by intestinal microbiota","volume":"10","author":"Priori","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2022.175171_bib125","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.bbi.2020.12.032","article-title":"A role of the subdiaphragmatic vagus nerve in depression-like phenotypes in mice after fecal microbiota transplantation from Chrna7 knock-out mice with depression-like phenotypes","volume":"94","author":"Pu","year":"2021","journal-title":"Brain Behav. Immun."},{"issue":"5","key":"10.1016\/j.ejphar.2022.175171_bib126","doi-asserted-by":"crossref","DOI":"10.21037\/atm-20-4411","article-title":"Lactobacillus delbrueckii alleviates depression-like behavior through inhibiting toll-like receptor 4 (TLR4) signaling in mice","volume":"9","author":"Qiu","year":"2021","journal-title":"Ann. Transl. Med."},{"issue":"1","key":"10.1016\/j.ejphar.2022.175171_bib127","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-017-16060-7","article-title":"Comparison of (R)-ketamine and lanicemine on depression-like phenotype and abnormal composition of gut microbiota in a social defeat stress model","volume":"7","author":"Qu","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejphar.2022.175171_bib128","doi-asserted-by":"crossref","DOI":"10.1016\/j.jneuroim.2021.577498","article-title":"Crosstalk between gut microbiome and immunology in the management of ischemic brain injury","author":"Rahman","year":"2021","journal-title":"J. Neuroimmunol."},{"issue":"2","key":"10.1016\/j.ejphar.2022.175171_bib129","first-page":"145","article-title":"Effect of the probiotic Lactobacillus plantarum IS-10506 on BDNF and 5HT stimulation: role of intestinal microbiota on the gut-brain axis","volume":"11","author":"Ranuh","year":"2019","journal-title":"Iran. J. Microbiol."},{"key":"10.1016\/j.ejphar.2022.175171_bib130","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.jpsychires.2021.02.057","article-title":"Fecal microbiota transplantation ameliorates stress-induced depression-like behaviors associated with the inhibition of glial and NLRP3 inflammasome in rat brain","volume":"137","author":"Rao","year":"2021","journal-title":"J. Psychiatr. Res."},{"issue":"11","key":"10.1016\/j.ejphar.2022.175171_bib131","doi-asserted-by":"crossref","first-page":"3598","DOI":"10.1111\/ejn.15192","article-title":"Fecal microbiota transplantation ameliorates gut microbiota imbalance and intestinal barrier damage in rats with stress\u2010induced depressive\u2010like behavior","volume":"53","author":"Rao","year":"2021","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.ejphar.2022.175171_bib132","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.ynstr.2016.03.001","article-title":"The microbiome: a key regulator of stress and neuroinflammation","volume":"4","author":"Rea","year":"2016","journal-title":"Neurobiol. Stress"},{"key":"10.1016\/j.ejphar.2022.175171_bib133","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.jpsychires.2015.05.007","article-title":"Kynurenine pathway dysfunction in the pathophysiology and treatment of depression: evidences from animal and human studies","volume":"68","author":"R\u00e9us","year":"2015","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.ejphar.2022.175171_bib134","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0065-2164(03)01007-4","article-title":"Acid resistance in Escherichia coli","volume":"52","author":"Richard","year":"2003","journal-title":"Adv. Appl. Microbiol."},{"issue":"10","key":"10.1016\/j.ejphar.2022.175171_bib135","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.nut.2007.07.002","article-title":"Encapsulated Bifidobacteria reduced bacterial translocation in rats following hemorrhagic shock and resuscitation","volume":"23","author":"Ruan","year":"2007","journal-title":"Nutrition"},{"key":"10.1016\/j.ejphar.2022.175171_bib136","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.psyneuen.2018.10.010","article-title":"Probiotic Lactobacillus Plantarum 299v decreases kynurenine concentration and improves cognitive functions in patients with major depression: a double-blind, randomized, placebo controlled study","volume":"100","author":"Rudzki","year":"2019","journal-title":"Psychoneuroendocrinology"},{"issue":"6","key":"10.1016\/j.ejphar.2022.175171_bib137","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1016\/j.cell.2016.11.018","article-title":"Gut microbiota regulate motor deficits and neuroinflammation in a model of Parkinson's disease","volume":"167","author":"Sampson","year":"2016","journal-title":"Cell"},{"issue":"11","key":"10.1016\/j.ejphar.2022.175171_bib138","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.tins.2016.09.002","article-title":"Psychobiotics and the manipulation of bacteria\u2013gut\u2013brain signals","volume":"39","author":"Sarkar","year":"2016","journal-title":"Trends Neurosci."},{"issue":"10","key":"10.1016\/j.ejphar.2022.175171_bib139","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a020545","article-title":"Microglia function in central nervous system development and plasticity","volume":"7","author":"Schafer","year":"2015","journal-title":"Cold Spring Harbor Perspect. Biol."},{"issue":"6","key":"10.1016\/j.ejphar.2022.175171_bib140","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1016\/j.cell.2019.05.004","article-title":"Human gut microbiota from autism spectrum disorder promote behavioral symptoms in mice","volume":"177","author":"Sharon","year":"2019","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.ejphar.2022.175171_bib141","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40779-017-0122-9","article-title":"Interaction between the gut microbiome and mucosal immune system","volume":"4","author":"Shi","year":"2017","journal-title":"Military Medical Research"},{"key":"10.1016\/j.ejphar.2022.175171_bib142","doi-asserted-by":"crossref","DOI":"10.1016\/j.cpr.2020.101943","article-title":"The gut microbiota in anxiety and depression\u2013A systematic review","volume":"83","author":"Simpson","year":"2021","journal-title":"Clin. Psychol. Rev."},{"issue":"11","key":"10.1016\/j.ejphar.2022.175171_bib143","doi-asserted-by":"crossref","first-page":"3682","DOI":"10.1016\/j.celrep.2020.02.099","article-title":"Changes in gut microbiota by chronic stress impair the efficacy of fluoxetine","volume":"30","author":"Siopi","year":"2020","journal-title":"Cell Rep."},{"issue":"22","key":"10.1016\/j.ejphar.2022.175171_bib144","doi-asserted-by":"crossref","first-page":"7283","DOI":"10.1128\/AEM.01064-07","article-title":"Synthesis of \u03b3-aminobutyric acid by lactic acid bacteria isolated from a variety of Italian cheeses","volume":"73","author":"Siragusa","year":"2007","journal-title":"Appl. Environ. Microbiol."},{"issue":"1","key":"10.1016\/j.ejphar.2022.175171_bib145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12967-019-1970-8","article-title":"Metabolomic signatures and microbial community profiling of depressive rat model induced by adrenocorticotrophic hormone","volume":"17","author":"Song","year":"2019","journal-title":"J. Transl. Med."},{"issue":"8","key":"10.1016\/j.ejphar.2022.175171_bib146","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1136\/gutjnl-2017-314759","article-title":"Increased human intestinal barrier permeability plasma biomarkers zonulin and FABP2 correlated with plasma LPS and altered gut microbiome in anxiety or depression","volume":"67","author":"Stevens","year":"2018","journal-title":"Gut"},{"key":"10.1016\/j.ejphar.2022.175171_bib147","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.neuint.2016.06.011","article-title":"The neuropharmacology of butyrate: the bread and butter of the microbiota-gut-brain axis?","volume":"99","author":"Stilling","year":"2016","journal-title":"Neurochem. Int."},{"issue":"5","key":"10.1016\/j.ejphar.2022.175171_bib148","first-page":"1225","article-title":"Effects of different degrees of depression on inflammatory response and immune function in patients with ovarian cancer","volume":"32","author":"Su","year":"2018","journal-title":"J. Biol. Regul. Homeost. Agents"},{"issue":"1","key":"10.1016\/j.ejphar.2022.175171_bib149","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1113\/jphysiol.2004.063388","article-title":"Postnatal microbial colonization programs the hypothalamic\u2013pituitary\u2013adrenal system for stress response in mice","volume":"558","author":"Sudo","year":"2004","journal-title":"J. Physiol."},{"key":"10.1016\/j.ejphar.2022.175171_bib150","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.neulet.2016.03.003","article-title":"Antidepressant-like effects of sodium butyrate and its possible mechanisms of action in mice exposed to chronic unpredictable mild stress","volume":"618","author":"Sun","year":"2016","journal-title":"Neurosci. Lett."},{"issue":"31","key":"10.1016\/j.ejphar.2022.175171_bib151","doi-asserted-by":"crossref","first-page":"8415","DOI":"10.1021\/acs.jafc.8b02462","article-title":"Clostridium butyricum attenuates chronic unpredictable mild stress-induced depressive-like behavior in mice via the gut-brain axis","volume":"66","author":"Sun","year":"2018","journal-title":"J. Agric. Food Chem."},{"issue":"2","key":"10.1016\/j.ejphar.2022.175171_bib152","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1039\/C8FO02096E","article-title":"Supplementation with Lactobacillus kefiranofaciens ZW3 from Tibetan Kefir improves depression-like behavior in stressed mice by modulating the gut microbiota","volume":"10","author":"Sun","year":"2019","journal-title":"Food Funct."},{"issue":"20","key":"10.1016\/j.ejphar.2022.175171_bib153","doi-asserted-by":"crossref","first-page":"2826","DOI":"10.3748\/wjg.v13.i20.2826","article-title":"Anti-inflammatory properties of the short-chain fatty acids acetate and propionate: a study with relevance to inflammatory bowel disease","volume":"13","author":"Tedelind","year":"2007","journal-title":"World J. Gastroenterol.: WJG"},{"key":"10.1016\/j.ejphar.2022.175171_bib154","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jnutbio.2019.01.007","article-title":"Bifidobacterium with the role of 5-hydroxytryptophan synthesis regulation alleviates the symptom of depression and related microbiota dysbiosis","volume":"66","author":"Tian","year":"2019","journal-title":"J. Nutr. Biochem."},{"issue":"1","key":"10.1016\/j.ejphar.2022.175171_bib155","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.neuint.2006.07.008","article-title":"CCK-8 induces NGF and BDNF synthesis and modulates TrkA and TrkB expression in the rat hippocampus and septum: effects on kindling development","volume":"50","author":"Tirassa","year":"2007","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.ejphar.2022.175171_bib178","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.lfs.2018.04.054","article-title":"Enhanced endocannabinoid tone as a potential target of pharmacotherapy","volume":"204","author":"Toczek","year":"2018","journal-title":"Life Sci."},{"issue":"2","key":"10.1016\/j.ejphar.2022.175171_bib156","doi-asserted-by":"crossref","first-page":"364","DOI":"10.2337\/db11-1019","article-title":"Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein\u2013coupled receptor FFAR2","volume":"61","author":"Tolhurst","year":"2012","journal-title":"Diabetes"},{"issue":"4","key":"10.1016\/j.ejphar.2022.175171_bib157","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/s41564-018-0337-x","article-title":"The neuroactive potential of the human gut microbiota in quality of life and depression","volume":"4","author":"Valles-Colomer","year":"2019","journal-title":"Nat. Microbiol."},{"issue":"20","key":"10.1016\/j.ejphar.2022.175171_bib158","doi-asserted-by":"crossref","first-page":"4923","DOI":"10.1113\/JP276431","article-title":"Short\u2010chain fatty acids: microbial metabolites that alleviate stress\u2010induced brain\u2013gut axis alterations","volume":"596","author":"van de Wouw","year":"2018","journal-title":"J. Physiol."},{"issue":"5","key":"10.1016\/j.ejphar.2022.175171_bib159","doi-asserted-by":"crossref","first-page":"727","DOI":"10.3945\/jn.116.240481","article-title":"Microbiota-gut-brain axis: modulator of host metabolism and appetite","volume":"147","author":"Van de Wouw","year":"2017","journal-title":"J. Nutr."},{"issue":"11","key":"10.1016\/j.ejphar.2022.175171_bib160","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0207038","article-title":"Dopamine production in Enterococcus faecium: a microbial endocrinology-based mechanism for the selection of probiotics based on neurochemical-producing potential","volume":"13","author":"Villageli\u00fa","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2022.175171_bib161","article-title":"Brain dynamics predictive of response to psilocybin for treatment-resistant depression","author":"Vohryzek","year":"2022","journal-title":"bioRxiv"},{"issue":"2","key":"10.1016\/j.ejphar.2022.175171_bib162","doi-asserted-by":"crossref","first-page":"G311","DOI":"10.1152\/ajpgi.2000.279.2.G311","article-title":"Mice lacking the dopamine transporter display altered regulation of distal colonic motility","volume":"279","author":"Walker","year":"2000","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"issue":"1","key":"10.1016\/j.ejphar.2022.175171_bib163","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12974-020-01916-z","article-title":"Ingestion of Lactobacillus intestinalis and Lactobacillus reuteri causes depression-and anhedonia-like phenotypes in antibiotic-treated mice via the vagus nerve","volume":"17","author":"Wang","year":"2020","journal-title":"J. Neuroinflammation"},{"issue":"Suppl. ment_1","key":"10.1016\/j.ejphar.2022.175171_bib164","article-title":"Design of a novel synbiotic formulation to optimize gut-derived phenolic acid mediated gut-brain axis signals for the treatment of stress-induced depression and anxiety (OR23-03-19)","volume":"3","author":"Westfall","year":"2019","journal-title":"Curr. Dev. Nutr."},{"issue":"6","key":"10.1016\/j.ejphar.2022.175171_bib165","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1038\/mp.2016.46","article-title":"Inflammasome signaling affects anxiety-and depressive-like behavior and gut microbiome composition","volume":"21","author":"Wong","year":"2016","journal-title":"Mol. Psychiatr."},{"issue":"7867","key":"10.1016\/j.ejphar.2022.175171_bib166","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/s41586-021-03669-y","article-title":"Microbiota regulate social behaviour via stress response neurons in the brain","volume":"595","author":"Wu","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2022.175171_bib167","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.jpsychires.2019.12.013","article-title":"Oral treatment with Lactobacillus reuteri attenuates depressive-like behaviors and serotonin metabolism alterations induced by chronic social defeat stress","volume":"122","author":"Xie","year":"2020","journal-title":"J. Psychiatr. Res."},{"issue":"12","key":"10.1016\/j.ejphar.2022.175171_bib168","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41398-017-0031-4","article-title":"Possible role of the gut microbiota\u2013brain axis in the antidepressant effects of (R)-ketamine in a social defeat stress model","volume":"7","author":"Yang","year":"2017","journal-title":"Transl. Psychiatry"},{"issue":"49","key":"10.1016\/j.ejphar.2022.175171_bib169","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aba8555","article-title":"Landscapes of bacterial and metabolic signatures and their interaction in major depressive disorders","volume":"6","author":"Yang","year":"2020","journal-title":"Sci. Adv."},{"issue":"2","key":"10.1016\/j.ejphar.2022.175171_bib170","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.cell.2015.02.047","article-title":"Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis","volume":"161","author":"Yano","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.ejphar.2022.175171_bib171","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.anaerobe.2016.10.011","article-title":"GABA production and structure of gadB\/gadC genes in Lactobacillus and Bifidobacterium strains from human microbiota","volume":"42","author":"Yunes","year":"2016","journal-title":"Anaerobe"},{"issue":"1","key":"10.1016\/j.ejphar.2022.175171_bib172","first-page":"1","article-title":"Depression-like phenotype by deletion of \u03b17 nicotinic acetylcholine receptor: role of BDNF-TrkB in nucleus accumbens","volume":"6","author":"Zhang","year":"2016","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.ejphar.2022.175171_bib173","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40168-019-0733-3","article-title":"Gut microbiota from NLRP3-deficient mice ameliorates depressive-like behaviors by regulating astrocyte dysfunction via circHIPK2","volume":"7","author":"Zhang","year":"2019","journal-title":"Microbiome"},{"issue":"6","key":"10.1016\/j.ejphar.2022.175171_bib174","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1038\/mp.2016.44","article-title":"Gut microbiome remodeling induces depressive-like behaviors through a pathway mediated by the host's metabolism","volume":"21","author":"Zheng","year":"2016","journal-title":"Mol. Psychiatr."},{"issue":"8","key":"10.1016\/j.ejphar.2022.175171_bib175","first-page":"435","article-title":"Role of the endocannabinoid system in the formation and development of depression","volume":"72","author":"Zhou","year":"2017","journal-title":"Die Pharmazie Int. Res. J. Pharmaceut. Sci."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299922004320?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299922004320?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T04:19:37Z","timestamp":1762143577000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299922004320"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":187,"alternative-id":["S0014299922004320"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2022.175171","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Remodeling of microbiota gut-brain axis using psychobiotics in depression","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2022.175171","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"175171"}}