{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T14:43:28Z","timestamp":1793457808009,"version":"4.5.0"},"reference-count":141,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81991525"],"award-info":[{"award-number":["81991525"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.ejphar.2022.175178","type":"journal-article","created":{"date-parts":[[2022,8,7]],"date-time":"2022-08-07T18:23:07Z","timestamp":1659896587000},"page":"175178","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Glutaminyl cyclases, the potential targets of cancer and neurodegenerative diseases"],"prefix":"10.1016","volume":"931","author":[{"given":"Yidan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weixun","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ximing","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4716-2002","authenticated-orcid":false,"given":"Chenyang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2022.175178_bib1","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/BF00235695","article-title":"Pyroglutamic acid. Non-metabolic formation, function in proteins and peptides, and characteristics of the enzymes effecting its removal","volume":"38","author":"Abraham","year":"1981","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.ejphar.2022.175178_bib2","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1158\/1078-0432.CCR-20-3706","article-title":"Phase I study of the CD47 blocker TTI-621 in patients with relapsed or refractory hematologic malignancies","volume":"27","author":"Ansell","year":"2021","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.ejphar.2022.175178_bib3","doi-asserted-by":"crossref","first-page":"573","DOI":"10.7164\/antibiotics.44.573","article-title":"Leuhistin, a new inhibitor of aminopeptidase M, produced by Bacillus laterosporus BMI156-14F1","volume":"44","author":"Aoyagi","year":"1991","journal-title":"J. Antibiot."},{"key":"10.1016\/j.ejphar.2022.175178_bib4","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1002\/prot.340200106","article-title":"Pyrrolidone carboxyl peptidase (Pcp): an enzyme that removes pyroglutamic acid (pGlu) from pGlu-peptides and pGlu-proteins","volume":"20","author":"Awad\u00e9","year":"1994","journal-title":"Proteins"},{"key":"10.1016\/j.ejphar.2022.175178_bib5","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1038\/s41590-022-01153-x","article-title":"Loss of the intracellular enzyme QPCTL limits chemokine function and reshapes myeloid infiltration to augment tumor immunity","volume":"23","author":"Barreira da Silva","year":"2022","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.ejphar.2022.175178_bib6","doi-asserted-by":"crossref","first-page":"11246","DOI":"10.1021\/bi011177o","article-title":"Evidence for essential histidines in human pituitary glutaminyl cyclase","volume":"40","author":"Bateman","year":"2001","journal-title":"Biochemistry"},{"key":"10.1016\/j.ejphar.2022.175178_bib7","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1515\/hsz-2015-0192","article-title":"IsoQC (QPCTL) knock-out mice suggest differential substrate conversion by glutaminyl cyclase isoenzymes","volume":"397","author":"Becker","year":"2016","journal-title":"Biol. Chem."},{"key":"10.1016\/j.ejphar.2022.175178_bib8","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1074\/mcp.R800013-MCP200","article-title":"A genecentric Human Protein Atlas for expression profiles based on antibodies","volume":"7","author":"Berglund","year":"2008","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.ejphar.2022.175178_bib9","doi-asserted-by":"crossref","first-page":"33304","DOI":"10.1074\/jbc.M112.395608","article-title":"The metalloprotease meprin \u03b2 generates amino terminal-truncated amyloid \u03b2 peptide species","volume":"287","author":"Bien","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2022.175178_bib10","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1084\/jem.194.4.541","article-title":"CD47 (integrin-associated protein) engagement of dendritic cell and macrophage counterreceptors is required to prevent the clearance of donor lymphohematopoietic cells","volume":"194","author":"Blazar","year":"2001","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.ejphar.2022.175178_bib11","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2022.2049486","article-title":"QPCTL regulates macrophage and monocyte abundance and inflammatory signatures in the tumor microenvironment","volume":"11","author":"Bresser","year":"2022","journal-title":"OncoImmunology"},{"key":"10.1016\/j.ejphar.2022.175178_bib12","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1021\/jm050756e","article-title":"The first potent inhibitors for human glutaminyl cyclase: synthesis and structure-activity relationship","volume":"49","author":"Buchholz","year":"2006","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejphar.2022.175178_bib13","doi-asserted-by":"crossref","first-page":"31018","DOI":"10.1074\/jbc.M404035200","article-title":"The catalytic role of glutamate 151 in the leucine aminopeptidase from Aeromonas proteolytica","volume":"279","author":"Bzymek","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2022.175178_bib14","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.nbd.2009.10.006","article-title":"Inflammation, microglia, and Alzheimer's disease","volume":"37","author":"Cameron","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.ejphar.2022.175178_bib15","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1161\/01.RES.0000146672.10582.17","article-title":"Chemokines in the pathogenesis of vascular disease","volume":"95","author":"Charo","year":"2004","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2022.175178_bib16","doi-asserted-by":"crossref","first-page":"3179","DOI":"10.4155\/fmc-2019-0163","article-title":"An overview of glutaminyl cyclase inhibitors for Alzheimer's disease","volume":"11","author":"Coimbra","year":"2019","journal-title":"Future Med. Chem."},{"key":"10.1016\/j.ejphar.2022.175178_bib17","doi-asserted-by":"crossref","first-page":"2795","DOI":"10.1038\/s41467-020-16466-4","article-title":"Activation of JUN in fibroblasts promotes pro-fibrotic programme and modulates protective immunity","volume":"11","author":"Cui","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejphar.2022.175178_bib18","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1002\/emmm.201100158","article-title":"The isoenzyme of glutaminyl cyclase is an important regulator of monocyte infiltration under inflammatory conditions","volume":"3","author":"Cynis","year":"2011","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.ejphar.2022.175178_bib19","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/iep.12020","article-title":"Inhibition of Glutaminyl Cyclases alleviates CCL2-mediated inflammation of non-alcoholic fatty liver disease in mice","volume":"94","author":"Cynis","year":"2013","journal-title":"Int. J. Exp. Pathol."},{"key":"10.1016\/j.ejphar.2022.175178_bib20","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1016\/j.jmb.2008.03.078","article-title":"Isolation of an isoenzyme of human glutaminyl cyclase: retention in the Golgi complex suggests involvement in the protein maturation machinery","volume":"379","author":"Cynis","year":"2008","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.ejphar.2022.175178_bib21","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1042\/bj2900921","article-title":"Identification of the thyrotropin-releasing-hormone-degrading ectoenzyme as a metallopeptidase","volume":"290","author":"Czekay","year":"1993","journal-title":"Biochem. J."},{"key":"10.1016\/j.ejphar.2022.175178_bib22","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1002\/bip.21271","article-title":"N-terminal truncated pyroglutamyl \u03b2 amyloid peptide A\u03b2py3-42 shows a faster aggregation kinetics than the full-length A\u03b21-42","volume":"91","author":"D'Arrigo","year":"2009","journal-title":"Biopolymers"},{"key":"10.1016\/j.ejphar.2022.175178_bib23","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1006\/prep.2000.1273","article-title":"Carica papaya glutamine cyclotransferase belongs to a novel plant enzyme subfamily: cloning and characterization of the recombinant enzyme","volume":"20","author":"Dahl","year":"2000","journal-title":"Protein Expr. Purif."},{"key":"10.1016\/j.ejphar.2022.175178_bib24","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1089\/jir.2008.0027","article-title":"Monocyte chemoattractant protein-1 (MCP-1): an overview","volume":"29","author":"Deshmane","year":"2009","journal-title":"J. Interferon Cytokine Res."},{"key":"10.1016\/j.ejphar.2022.175178_bib25","doi-asserted-by":"crossref","first-page":"4851","DOI":"10.1039\/C4SC01531B","article-title":"Synthetic flavonoids, aminoisoflavones: interaction and reactivity with metal-free and metal-associated amyloid-\u03b2 species","volume":"5","author":"DeToma","year":"2014","journal-title":"Chem. Sci."},{"key":"10.1016\/j.ejphar.2022.175178_bib26","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.ijbiomac.2020.12.118","article-title":"Piperidine-4-carboxamide as a new scaffold for designing secretory glutaminyl cyclase inhibitors","volume":"170","author":"Dileep","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ejphar.2022.175178_bib27","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.tips.2008.08.004","article-title":"Mechanisms of microglia accumulation in Alzheimer's disease: therapeutic implications","volume":"29","author":"El Khoury","year":"2008","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.ejphar.2022.175178_bib28","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1158\/2159-8290.CD-19-0094","article-title":"Cross-species single-cell analysis of pancreatic ductal adenocarcinoma reveals antigen-presenting cancer-associated fibroblasts","volume":"9","author":"Elyada","year":"2019","journal-title":"Cancer Discov."},{"key":"10.1016\/j.ejphar.2022.175178_bib29","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1523\/JNEUROSCI.3863-05.2006","article-title":"CCL2\/monocyte chemoattractant protein-1 mediates enhanced transmigration of human immunodeficiency virus (HIV)-infected leukocytes across the blood-brain barrier: a potential mechanism of HIV-CNS invasion and NeuroAIDS","volume":"26","author":"Eugenin","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2022.175178_bib30","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1359\/JBMR.040324","article-title":"Association of multiple nucleotide variations in the pituitary glutaminyl cyclase gene (QPCT) with low radial BMD in adult women","volume":"19","author":"Ezura","year":"2004","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.ejphar.2022.175178_bib31","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.febslet.2004.07.001","article-title":"Identification of the catalytic residues in the double-zinc aminopeptidase from Streptomyces griseus","volume":"571","author":"Fundoiano-Hershcovitz","year":"2004","journal-title":"FEBS Lett."},{"key":"10.1016\/j.ejphar.2022.175178_bib32","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1479-5876-4-27","article-title":"Microarray evidence of glutaminyl cyclase gene expression in melanoma: implications for tumor antigen specific immunotherapy","volume":"4","author":"Gillis","year":"2006","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.ejphar.2022.175178_bib33","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.cca.2007.12.010","article-title":"Glutaminyl cyclase activity is a characteristic feature of human cerebrospinal fluid","volume":"389","author":"Gontsarova","year":"2008","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.ejphar.2022.175178_bib34","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","article-title":"A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes","volume":"72","author":"Group","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.ejphar.2022.175178_bib35","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1126\/science.1072994","article-title":"The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics","volume":"297","author":"Hardy","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2022.175178_bib36","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1038\/nature10317","article-title":"Molecular chaperones in protein folding and proteostasis","volume":"475","author":"Hartl","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2022.175178_bib37","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s00401-021-02349-5","article-title":"A glutaminyl cyclase-catalyzed \u03b1-synuclein modification identified in human synucleinopathies","volume":"142","author":"Hartlage-R\u00fcbsamen","year":"2021","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.ejphar.2022.175178_bib38","doi-asserted-by":"crossref","first-page":"924","DOI":"10.3390\/molecules23040924","article-title":"Immunohistochemical evidence from APP-transgenic mice for glutaminyl cyclase as drug target to diminish pE-Abeta formation","volume":"23","author":"Hartlage-R\u00fcbsamen","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.ejphar.2022.175178_bib39","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1007\/s00401-011-0806-2","article-title":"Glutaminyl cyclase contributes to the formation of focal and diffuse pyroglutamate (pGlu)-A\u03b2 deposits in hippocampus via distinct cellular mechanisms","volume":"121","author":"Hartlage-R\u00fcbsamen","year":"2011","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.ejphar.2022.175178_bib40","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1007\/s00401-015-1395-2","article-title":"Isoglutaminyl cyclase contributes to CCL2-driven neuroinflammation in Alzheimer's disease","volume":"129","author":"Hartlage-R\u00fcbsamen","year":"2015","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.ejphar.2022.175178_bib41","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.molcel.2008.05.026","article-title":"Paired receptor specificity explained by structures of signal regulatory proteins alone and complexed with CD47","volume":"31","author":"Hatherley","year":"2008","journal-title":"Mol. Cell"},{"key":"10.1016\/j.ejphar.2022.175178_bib42","doi-asserted-by":"crossref","first-page":"10871","DOI":"10.1021\/bi990563r","article-title":"The A \u03b2 3-pyroglutamyl and 11-pyroglutamyl peptides found in senile plaque have greater \u03b2-sheet forming and aggregation propensities in vitro than full-length A\u03b2","volume":"38","author":"He","year":"1999","journal-title":"Biochemistry"},{"key":"10.1016\/j.ejphar.2022.175178_bib43","doi-asserted-by":"crossref","first-page":"203","DOI":"10.3390\/md14110203","article-title":"Natural products from microalgae with potential against Alzheimer's disease: sulfolipids are potent glutaminyl cyclase inhibitors","volume":"14","author":"Hielscher-Michael","year":"2016","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.ejphar.2022.175178_bib44","doi-asserted-by":"crossref","first-page":"8011","DOI":"10.1021\/acs.jmedchem.9b00751","article-title":"Discovery of conformationally restricted human glutaminyl cyclase inhibitors as potent anti-Alzheimer's agents by structure-based design","volume":"62","author":"Hoang","year":"2019","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejphar.2022.175178_bib45","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1124\/jpet.117.240614","article-title":"Glutaminyl cyclase inhibitor PQ912 improves cognition in mouse models of Alzheimer's disease-studies on relation to effective target occupancy","volume":"362","author":"Hoffmann","year":"2017","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.ejphar.2022.175178_bib46","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/j.1365-2990.2012.01307.x","article-title":"Review: systemic inflammation and Alzheimer's disease","volume":"39","author":"Holmes","year":"2013","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.ejphar.2022.175178_bib47","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1107\/S1399004713033488","article-title":"Structural and functional analyses of a glutaminyl cyclase from Ixodes scapularis reveal metal-independent catalysis and inhibitor binding","volume":"70","author":"Huang","year":"2014","journal-title":"Acta Crystallogr. D"},{"key":"10.1016\/j.ejphar.2022.175178_bib48","doi-asserted-by":"crossref","first-page":"12439","DOI":"10.1074\/jbc.M110.208595","article-title":"Structures of human Golgi-resident glutaminyl cyclase and its complexes with inhibitors reveal a large loop movement upon inhibitor binding","volume":"286","author":"Huang","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2022.175178_bib49","doi-asserted-by":"crossref","first-page":"13117","DOI":"10.1073\/pnas.0504184102","article-title":"Crystal structures of human glutaminyl cyclase, an enzyme responsible for protein N-terminal pyroglutamate formation","volume":"102","author":"Huang","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ejphar.2022.175178_bib50","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.pep.2005.02.020","article-title":"Cloning, expression, characterization, and crystallization of a glutaminyl cyclase from human bone marrow: a single zinc metalloenzyme","volume":"43","author":"Huang","year":"2005","journal-title":"Protein Expr. Purif."},{"key":"10.1016\/j.ejphar.2022.175178_bib51","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1042\/BJ20071073","article-title":"A conserved hydrogen-bond network in the catalytic centre of animal glutaminyl cyclases is critical for catalysis","volume":"411","author":"Huang","year":"2008","journal-title":"Biochem. J."},{"key":"10.1016\/j.ejphar.2022.175178_bib52","first-page":"1823","article-title":"Full-length amyloid-\u03b2(1-42(43)) and amino-terminally modified and truncated amyloid-\u03b242(43) deposit in diffuse plaques","volume":"149","author":"Iwatsubo","year":"1996","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.ejphar.2022.175178_bib53","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.cell.2009.05.046","article-title":"CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis","volume":"138","author":"Jaiswal","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.ejphar.2022.175178_bib54","doi-asserted-by":"crossref","first-page":"38825","DOI":"10.1074\/jbc.R111.288308","article-title":"Pyroglutamate amyloid-\u03b2 (A\u03b2): a hatchet man in Alzheimer disease","volume":"286","author":"Jawhar","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2022.175178_bib55","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/nchembio.1790","article-title":"siRNA screen identifies QPCT as a druggable target for Huntington's disease","volume":"11","author":"Jimenez-Sanchez","year":"2015","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.ejphar.2022.175178_bib56","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1182\/blood.V100.5.1852.h81702001852_1852_1859","article-title":"SHP-1 regulates Fcgamma receptor-mediated phagocytosis and the activation of RAC","volume":"100","author":"Kant","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.ejphar.2022.175178_bib57","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20170712","article-title":"N-terminal pyroglutamate formation in CX3CL1 is essential for its full biologic activity","volume":"37","author":"Kehlen","year":"2017","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.ejphar.2022.175178_bib58","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1530\/ERC-12-0053","article-title":"Role of glutaminyl cyclases in thyroid carcinomas","volume":"20","author":"Kehlen","year":"2013","journal-title":"Endocr. Relat. Cancer"},{"key":"10.1016\/j.ejphar.2022.175178_bib59","doi-asserted-by":"crossref","first-page":"16746","DOI":"10.1074\/jbc.M910386199","article-title":"Kinetic investigation of the specificity of porcine brain thyrotropin-releasing hormone-degrading ectoenzyme for thyrotropin-releasing hormone-like peptides","volume":"275","author":"Kelly","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2022.175178_bib60","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1002\/ajmg.b.32397","article-title":"Common variants in QPCT gene confer risk of schizophrenia in the Han Chinese population","volume":"171b","author":"Khan","year":"2016","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"key":"10.1016\/j.ejphar.2022.175178_bib61","doi-asserted-by":"crossref","first-page":"e156","DOI":"10.1182\/blood-2011-04-348946","article-title":"In vivo structure\/function and expression analysis of the CX3C chemokine fractalkine","volume":"118","author":"Kim","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.ejphar.2022.175178_bib62","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0006197","article-title":"CCL2 accelerates microglia-mediated A\u03b2 oligomer formation and progression of neurocognitive dysfunction","volume":"4","author":"Kiyota","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2022.175178_bib63","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1006\/bbrc.1997.7083","article-title":"Isolation, chemical characterization, and quantitation of A\u03b2 3-pyroglutamyl peptide from neuritic plaques and vascular amyloid deposits","volume":"237","author":"Kuo","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejphar.2022.175178_bib64","doi-asserted-by":"crossref","first-page":"2585","DOI":"10.1021\/acs.biochem.0c00337","article-title":"Hydrazides are potent transition-state analogues for glutaminyl cyclase implicated in the pathogenesis of Alzheimer's disease","volume":"59","author":"Kupski","year":"2020","journal-title":"Biochemistry"},{"key":"10.1016\/j.ejphar.2022.175178_bib65","doi-asserted-by":"crossref","first-page":"22294","DOI":"10.1074\/jbc.M311224200","article-title":"Identification of the glycosaminoglycan binding site of the CC chemokine, MCP-1: implications for structure and function in vivo","volume":"279","author":"Lau","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2022.175178_bib66","doi-asserted-by":"crossref","first-page":"6664","DOI":"10.1021\/acs.jmedchem.7b00648","article-title":"Synthesis and evaluation of diphenyl conjugated imidazole derivatives as potential glutaminyl cyclase inhibitors for treatment of Alzheimer's disease","volume":"60","author":"Li","year":"2017","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejphar.2022.175178_bib67","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.1016\/j.bmc.2016.03.064","article-title":"Inhibitory effect of flavonoids on human glutaminyl cyclase","volume":"24","author":"Li","year":"2016","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejphar.2022.175178_bib68","doi-asserted-by":"crossref","DOI":"10.1016\/j.tranon.2021.101129","article-title":"Luteolin promotes macrophage-mediated phagocytosis by inhibiting CD47 pyroglutamation","volume":"14","author":"Li","year":"2021","journal-title":"Transl. Oncol."},{"key":"10.1016\/j.ejphar.2022.175178_bib69","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1021\/cr950042j","article-title":"Recent advances in Zinc enzymology","volume":"96","author":"Lipscomb","year":"1996","journal-title":"Chem. Rev."},{"key":"10.1016\/j.ejphar.2022.175178_bib70","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s00401-006-0077-5","article-title":"Characterization of A\u03b211-40\/42 peptide deposition in Alzheimer's disease and young Down's syndrome brains: implication of N-terminally truncated A\u03b2 species in the pathogenesis of Alzheimer's disease","volume":"112","author":"Liu","year":"2006","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.ejphar.2022.175178_bib71","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1038\/s41591-019-0356-z","article-title":"Glutaminyl cyclase is an enzymatic modifier of the CD47- SIRP\u03b1 axis and a target for cancer immunotherapy","volume":"25","author":"Logtenberg","year":"2019","journal-title":"Nat. Med."},{"key":"10.1016\/j.ejphar.2022.175178_bib72","doi-asserted-by":"crossref","first-page":"4581","DOI":"10.1021\/cr0101757","article-title":"Metalloaminopeptidases: common functional themes in disparate structural surroundings","volume":"102","author":"Lowther","year":"2002","journal-title":"Chem. Rev."},{"key":"10.1016\/j.ejphar.2022.175178_bib73","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1002\/bdra.20507","article-title":"Genetic and biochemical determinants of serum concentrations of monocyte chemoattractant protein-1, a potential neural tube defect risk factor","volume":"82","author":"Lu","year":"2008","journal-title":"Birth Defects Res. A Clin. Mol. Teratol."},{"key":"10.1016\/j.ejphar.2022.175178_bib74","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.trci.2015.08.002","article-title":"A phase 1 study to evaluate the safety and pharmacokinetics of PQ912, a glutaminyl cyclase inhibitor, in healthy subjects","volume":"1","author":"Lues","year":"2015","journal-title":"Alzheimer's Dementia"},{"key":"10.1016\/j.ejphar.2022.175178_bib75","doi-asserted-by":"crossref","first-page":"3693","DOI":"10.1074\/jbc.M110.135244","article-title":"Amyloid-\u03b2 protein oligomer at low nanomolar concentrations activates microglia and induces microglial neurotoxicity","volume":"286","author":"Maezawa","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2022.175178_bib76","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1038\/s41551-019-0454-8","article-title":"High-throughput genome-wide phenotypic screening via immunomagnetic cell sorting","volume":"3","author":"Mair","year":"2019","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.ejphar.2022.175178_bib77","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.cell.2009.05.045","article-title":"CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells","volume":"138","author":"Majeti","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.ejphar.2022.175178_bib78","doi-asserted-by":"crossref","first-page":"156","DOI":"10.2174\/187152710791012071","article-title":"Microglia and inflammation in Alzheimer's disease","volume":"9","author":"Mandrekar-Colucci","year":"2010","journal-title":"CNS Neurol. Disord.: Drug Targets"},{"key":"10.1016\/j.ejphar.2022.175178_bib79","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/imr.12527","article-title":"The CD47-SIRP\u03b1 signaling axis as an innate immune checkpoint in cancer","volume":"276","author":"Matlung","year":"2017","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.ejphar.2022.175178_bib80","doi-asserted-by":"crossref","first-page":"3597","DOI":"10.1158\/1078-0432.CCR-14-2520","article-title":"Molecular Pathways: activating T cells after cancer cell phagocytosis from blockade of CD47 \"don't eat me\" signals","volume":"21","author":"McCracken","year":"2015","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.ejphar.2022.175178_bib81","doi-asserted-by":"crossref","DOI":"10.1016\/j.smim.2020.101417","article-title":"Fibroblast heterogeneity in tumor micro-environment: role in immunosuppression and new therapies","volume":"48","author":"Mhaidly","year":"2020","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.ejphar.2022.175178_bib82","doi-asserted-by":"crossref","first-page":"385","DOI":"10.3233\/JAD-131535","article-title":"Glutaminyl cyclase in human cortex: correlation with (pGlu)-amyloid-\u03b2 load and cognitive decline in Alzheimer's disease","volume":"39","author":"Morawski","year":"2014","journal-title":"J. Alzheim. Dis."},{"key":"10.1016\/j.ejphar.2022.175178_bib83","first-page":"327","article-title":"Anti-amyloid failures stack up as Alzheimer antibody flops","volume":"18","author":"Mullard","year":"2019","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.ejphar.2022.175178_bib84","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1271\/bbb.59.2010","article-title":"Isolation and characterization of a novel 5-oxoprolinase (without ATP-hydrolyzing) from Alcaligenes faecalis N-38A","volume":"59","author":"Murao","year":"1995","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"10.1016\/j.ejphar.2022.175178_bib85","doi-asserted-by":"crossref","first-page":"8378","DOI":"10.1073\/pnas.91.18.8378","article-title":"Relative abundance of Alzheimer A\u03b2 amyloid peptide variants in Alzheimer disease and normal aging","volume":"91","author":"N\u00e4slund","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ejphar.2022.175178_bib86","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/nature11060","article-title":"Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-\u03b2","volume":"485","author":"Nussbaum","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2022.175178_bib87","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1084\/jem.20162024","article-title":"Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer","volume":"214","author":"Ohlund","year":"2017","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.ejphar.2022.175178_bib88","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1080\/1042819042000201989","article-title":"Role of CD47 in erythroid cells and in autoimmunity","volume":"45","author":"Oldenborg","year":"2004","journal-title":"Leuk. Lymphoma"},{"key":"10.1016\/j.ejphar.2022.175178_bib89","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1084\/jem.193.7.855","article-title":"CD47-signal regulatory protein alpha (SIRPalpha) regulates Fcgamma and complement receptor-mediated phagocytosis","volume":"193","author":"Oldenborg","year":"2001","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.ejphar.2022.175178_bib90","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/s41582-018-0116-6","article-title":"A critical appraisal of amyloid-\u03b2-targeting therapies for Alzheimer disease","volume":"15","author":"Panza","year":"2019","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.ejphar.2022.175178_bib91","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/nrneurol.2010.17","article-title":"Microglia in neurodegenerative disease","volume":"6","author":"Perry","year":"2010","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.ejphar.2022.175178_bib92","doi-asserted-by":"crossref","first-page":"23895","DOI":"10.1074\/jbc.270.41.23895","article-title":"Amino-terminal deletions enhance aggregation of \u03b2-amyloid peptides in vitro","volume":"270","author":"Pike","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2022.175178_bib93","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1007\/s00775-018-1605-1","article-title":"The structure of the human glutaminyl cyclase-SEN177 complex indicates routes for developing new potent inhibitors as possible agents for the treatment of neurological disorders","volume":"23","author":"Pozzi","year":"2018","journal-title":"J. Biol. Inorg. Chem."},{"key":"10.1016\/j.ejphar.2022.175178_bib94","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1136\/annrheumdis-2016-210426","article-title":"CCL2\/CCR2, but not CCL5\/CCR5, mediates monocyte recruitment, inflammation and cartilage destruction in osteoarthritis","volume":"76","author":"Raghu","year":"2017","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.ejphar.2022.175178_bib95","doi-asserted-by":"crossref","first-page":"6613","DOI":"10.1021\/jm4001709","article-title":"Structure-activity relationships of benzimidazole-based glutaminyl cyclase inhibitors featuring a heteroaryl scaffold","volume":"56","author":"Ramsbeck","year":"2013","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejphar.2022.175178_bib96","doi-asserted-by":"crossref","first-page":"W320","DOI":"10.1093\/nar\/gku316","article-title":"Deciphering key features in protein structures with the new ENDscript server","volume":"42","author":"Robert","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ejphar.2022.175178_bib97","doi-asserted-by":"crossref","first-page":"6280","DOI":"10.1021\/bi200249h","article-title":"Structures of glycosylated mammalian glutaminyl cyclases reveal conformational variability near the active center","volume":"50","author":"Ruiz-Carrillo","year":"2011","journal-title":"Biochemistry"},{"key":"10.1016\/j.ejphar.2022.175178_bib98","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/35014735","article-title":"Presenilin-1 mutations in Alzheimer's disease","volume":"405","author":"Russo","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2022.175178_bib99","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1046\/j.1471-4159.2002.01107.x","article-title":"Pyroglutamate-modified amyloid \u03b2-peptides-A\u03b2N3(pE)-strongly affect cultured neuron and astrocyte survival","volume":"82","author":"Russo","year":"2002","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ejphar.2022.175178_bib100","doi-asserted-by":"crossref","first-page":"S69","DOI":"10.1016\/S0197-4580(98)00033-5","article-title":"Alzheimer's disease as proteolytic disorders: anabolism and catabolism of \u03b2-amyloid","volume":"19","author":"Saido","year":"1998","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.ejphar.2022.175178_bib101","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1054\/mehy.1999.0866","article-title":"Involvement of polyglutamine endolysis followed by pyroglutamate formation in the pathogenesis of triplet repeat\/polyglutamine-expansion diseases","volume":"54","author":"Saido","year":"2000","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.ejphar.2022.175178_bib102","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/0896-6273(95)90301-1","article-title":"Dominant and differential deposition of distinct \u03b2-amyloid peptide species, A\u03b2 N3(pE), in senile plaques","volume":"14","author":"Saido","year":"1995","journal-title":"Neuron"},{"key":"10.1016\/j.ejphar.2022.175178_bib103","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0304-3940(96)12970-0","article-title":"Amino- and carboxyl-terminal heterogeneity of \u03b2-amyloid peptides deposited in human brain","volume":"215","author":"Saido","year":"1996","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ejphar.2022.175178_bib104","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.pneurobio.2009.01.001","article-title":"Inflammation in Alzheimer's disease: amyloid-\u03b2 oligomers trigger innate immunity defence via pattern recognition receptors","volume":"87","author":"Salminen","year":"2009","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.ejphar.2022.175178_bib105","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/s13195-018-0431-6","article-title":"Safety, tolerability and efficacy of the glutaminyl cyclase inhibitor PQ912 in Alzheimer's disease: results of a randomized, double-blind, placebo-controlled phase 2a study","volume":"10","author":"Scheltens","year":"2018","journal-title":"Alzheimer's Res. Ther."},{"key":"10.1016\/j.ejphar.2022.175178_bib106","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1111\/j.1471-4159.2008.05471.x","article-title":"Inhibition of glutaminyl cyclase prevents pGlu-A\u03b2 formation after intracortical\/hippocampal microinjection in vivo\/in situ","volume":"106","author":"Schilling","year":"2008","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ejphar.2022.175178_bib107","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0014-5793(04)00300-X","article-title":"Glutaminyl cyclases unfold glutamyl cyclase activity under mild acid conditions","volume":"563","author":"Schilling","year":"2004","journal-title":"FEBS Lett."},{"key":"10.1016\/j.ejphar.2022.175178_bib108","doi-asserted-by":"crossref","first-page":"10849","DOI":"10.1021\/bi0260381","article-title":"Heterologous expression and characterization of human glutaminyl cyclase: evidence for a disulfide bond with importance for catalytic activity","volume":"41","author":"Schilling","year":"2002","journal-title":"Biochemistry"},{"key":"10.1016\/j.ejphar.2022.175178_bib109","doi-asserted-by":"crossref","first-page":"14199","DOI":"10.1074\/jbc.M111.229385","article-title":"Glutaminyl cyclase knock-out mice exhibit slight hypothyroidism but no hypogonadism: implications for enzyme function and drug development","volume":"286","author":"Schilling","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2022.175178_bib110","doi-asserted-by":"crossref","first-page":"12393","DOI":"10.1021\/bi0612667","article-title":"On the seeding and oligomerization of pGlu-amyloid peptides (in vitro)","volume":"45","author":"Schilling","year":"2006","journal-title":"Biochemistry"},{"key":"10.1016\/j.ejphar.2022.175178_bib111","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1515\/BC.2003.175","article-title":"Substrate specificity of glutaminyl cyclases from plants and animals","volume":"384","author":"Schilling","year":"2003","journal-title":"Biol. Chem."},{"key":"10.1016\/j.ejphar.2022.175178_bib112","doi-asserted-by":"crossref","first-page":"49773","DOI":"10.1074\/jbc.M309077200","article-title":"Identification of human glutaminyl cyclase as a metalloenzyme. Potent inhibition by imidazole derivatives and heterocyclic chelators","volume":"278","author":"Schilling","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2022.175178_bib113","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1515\/BC.2008.111","article-title":"Glutaminyl cyclases from animals and plants: a case of functionally convergent protein evolution","volume":"389","author":"Schilling","year":"2008","journal-title":"Biol. Chem."},{"key":"10.1016\/j.ejphar.2022.175178_bib114","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1038\/nm.1872","article-title":"Glutaminyl cyclase inhibition attenuates pyroglutamate A\u03b2 and Alzheimer's disease-like pathology","volume":"14","author":"Schilling","year":"2008","journal-title":"Nat. Med."},{"key":"10.1016\/j.ejphar.2022.175178_bib115","series-title":"The PyMOL Molecular Graphics System","author":"Schrodinger","year":"2015"},{"key":"10.1016\/j.ejphar.2022.175178_bib116","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.bioorg.2015.04.005","article-title":"Phosphate ions and glutaminyl cyclases catalyze the cyclization of glutaminyl residues by facilitating synchronized proton transfers","volume":"60","author":"Seifert","year":"2015","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejphar.2022.175178_bib117","doi-asserted-by":"crossref","first-page":"11831","DOI":"10.1021\/bi9018835","article-title":"Glutaminyl cyclases display significant catalytic proficiency for glutamyl substrates","volume":"48","author":"Seifert","year":"2009","journal-title":"Biochemistry"},{"key":"10.1016\/j.ejphar.2022.175178_bib118","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1111\/j.1750-3639.2008.00188.x","article-title":"Monocyte chemoattractant protein-1 plays a dominant role in the chronic inflammation observed in Alzheimer's disease","volume":"19","author":"Sokolova","year":"2009","journal-title":"Brain Pathol."},{"key":"10.1016\/j.ejphar.2022.175178_bib119","doi-asserted-by":"crossref","first-page":"6522","DOI":"10.1111\/j.1742-4658.2009.07337.x","article-title":"Mammalian glutaminyl cyclases and their isoenzymes have identical enzymatic characteristics","volume":"276","author":"Stephan","year":"2009","journal-title":"FEBS J."},{"key":"10.1016\/j.ejphar.2022.175178_bib120","doi-asserted-by":"crossref","first-page":"W556","DOI":"10.1093\/nar\/gkz430","article-title":"GEPIA2: an enhanced web server for large-scale expression profiling and interactive analysis","volume":"47","author":"Tang","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ejphar.2022.175178_bib121","doi-asserted-by":"crossref","first-page":"4865","DOI":"10.1210\/jc.2007-1253","article-title":"Identification of potential gene markers and insights into the pathophysiology of pheochromocytoma malignancy","volume":"92","author":"Thou\u00ebnnon","year":"2007","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ejphar.2022.175178_bib122","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.131882","article-title":"CD47 blockade augmentation of trastuzumab antitumor efficacy dependent on antibody-dependent cellular phagocytosis","volume":"4","author":"Tsao","year":"2019","journal-title":"JCI Insight"},{"key":"10.1016\/j.ejphar.2022.175178_bib123","doi-asserted-by":"crossref","first-page":"4642","DOI":"10.1093\/hmg\/ddx346","article-title":"Pyroglutamate-amyloid-\u03b2 peptide expression in Drosophila leads to caspase-dependent and endoplasmic reticulum stress-related progressive neurodegeneration","volume":"26","author":"Tsuda","year":"2017","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ejphar.2022.175178_bib124","doi-asserted-by":"crossref","first-page":"263","DOI":"10.3233\/JAD-120517","article-title":"Increased glutaminyl cyclase expression in peripheral blood of Alzheimer's disease patients","volume":"34","author":"Valenti","year":"2013","journal-title":"J. Alzheim. Dis."},{"key":"10.1016\/j.ejphar.2022.175178_bib125","doi-asserted-by":"crossref","first-page":"12672","DOI":"10.1021\/bi980497d","article-title":"Functional comparison of two human monocyte chemotactic protein-2 isoforms, role of the amino-terminal pyroglutamic acid and processing by CD26\/dipeptidyl peptidase IV","volume":"37","author":"Van Coillie","year":"1998","journal-title":"Biochemistry"},{"key":"10.1016\/j.ejphar.2022.175178_bib126","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.it.2017.12.005","article-title":"SIRPalpha-CD47 Immune checkpoint blockade in anticancer therapy","volume":"39","author":"Veillette","year":"2018","journal-title":"Trends Immunol."},{"key":"10.1016\/j.ejphar.2022.175178_bib127","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2019.104342","article-title":"Human glutaminyl cyclase: structure, function, inhibitors and involvement in Alzheimer's disease","volume":"147","author":"Vijayan","year":"2019","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.ejphar.2022.175178_bib128","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2019.105770","article-title":"Glutaminyl cyclase inhibitor exhibits anti-inflammatory effects in both AD and LPS-induced inflammatory model mice","volume":"75","author":"Wang","year":"2019","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.ejphar.2022.175178_bib129","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.ejca.2017.02.013","article-title":"Cancer immunotherapy targeting the CD47\/SIRP\u03b1 axis","volume":"76","author":"Weiskopf","year":"2017","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.ejphar.2022.175178_bib130","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1126\/science.1238856","article-title":"Engineered SIRP\u03b1 variants as immunotherapeutic adjuvants to anticancer antibodies","volume":"341","author":"Weiskopf","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2022.175178_bib131","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0030525","article-title":"CCL2 is associated with a faster rate of cognitive decline during early stages of Alzheimer's disease","volume":"7","author":"Westin","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2022.175178_bib132","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/s00401-009-0557-5","article-title":"Intraneuronal pyroglutamate-Abeta 3-42 triggers neurodegeneration and lethal neurological deficits in a transgenic mouse model","volume":"118","author":"Wirths","year":"2009","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.ejphar.2022.175178_bib133","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.4155\/fmc-2017-0190","article-title":"Can small molecule inhibitors of glutaminyl cyclase be used as a therapeutic for Alzheimer's disease?","volume":"9","author":"Wu","year":"2017","journal-title":"Future Med. Chem."},{"key":"10.1016\/j.ejphar.2022.175178_bib134","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/s41422-019-0177-0","article-title":"Identification of glutaminyl cyclase isoenzyme isoQC as a regulator of SIRP\u03b1-CD47 axis","volume":"29","author":"Wu","year":"2019","journal-title":"Cell Res."},{"key":"10.1016\/j.ejphar.2022.175178_bib135","doi-asserted-by":"crossref","first-page":"6549","DOI":"10.1021\/acs.jmedchem.1c00325","article-title":"Glutaminyl cyclase, diseases, and development of glutaminyl cyclase inhibitors","volume":"64","author":"Xu","year":"2021","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejphar.2022.175178_bib136","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1016\/S0002-9440(10)62364-4","article-title":"Overexpression of monocyte chemotactic protein-1\/CCL2 in \u03b2-amyloid precursor protein transgenic mice show accelerated diffuse \u03b2-amyloid deposition","volume":"166","author":"Yamamoto","year":"2005","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.ejphar.2022.175178_bib137","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.drudis.2020.11.003","article-title":"The development of small-molecule inhibitors targeting CD47","volume":"26","author":"Yu","year":"2021","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.ejphar.2022.175178_bib138","doi-asserted-by":"crossref","first-page":"9460","DOI":"10.1002\/jcb.28222","article-title":"Glutaminyl cyclase inhibitor contributes to the regulation of HSP70, HSP90, actin, and ribosome on gene and protein levels in vitro","volume":"120","author":"Yu","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.ejphar.2022.175178_bib139","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3389\/fimmu.2020.00018","article-title":"Advances in anti-tumor treatments targeting the CD47\/SIRP\u03b1 axis","volume":"11","author":"Zhang","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejphar.2022.175178_bib140","doi-asserted-by":"crossref","first-page":"6175","DOI":"10.7150\/thno.35572","article-title":"DNA methylation-regulated QPCT promotes sunitinib resistance by increasing HRAS stability in renal cell carcinoma","volume":"9","author":"Zhao","year":"2019","journal-title":"Theranostics"},{"key":"10.1016\/j.ejphar.2022.175178_bib141","doi-asserted-by":"crossref","first-page":"18342","DOI":"10.1073\/pnas.1106550108","article-title":"CD47-signal regulatory protein-\u03b1 (SIRP\u03b1) interactions form a barrier for antibody-mediated tumor cell destruction","volume":"108","author":"Zhao","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299922004393?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299922004393?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T04:18:43Z","timestamp":1762143523000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299922004393"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":141,"alternative-id":["S0014299922004393"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2022.175178","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Glutaminyl cyclases, the potential targets of cancer and neurodegenerative diseases","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2022.175178","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"175178"}}