{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T22:16:10Z","timestamp":1787436970139,"version":"build-2736575974"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30901291"],"award-info":[{"award-number":["30901291"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81573043"],"award-info":[{"award-number":["81573043"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82003346"],"award-info":[{"award-number":["82003346"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.ejphar.2022.175276","type":"journal-article","created":{"date-parts":[[2022,9,18]],"date-time":"2022-09-18T09:54:06Z","timestamp":1663494846000},"page":"175276","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Inhibition of JAK1\/STAT3 pathway by 2-methoxyestradiol ameliorates psoriatic features in vitro and in an imiquimod-induced psoriasis-like mouse model"],"prefix":"10.1016","volume":"933","author":[{"given":"Jiaxuan","family":"Tang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaofan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghao","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lubing","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2022.175276_bib1","article-title":"NFATc1 supports imiquimod-induced skin inflammation by suppressing IL-10 synthesis in B cells","volume":"7","author":"Alrefai","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejphar.2022.175276_bib2","doi-asserted-by":"crossref","first-page":"273","DOI":"10.4155\/fmc-2019-0258","article-title":"Advance of 2-methoxyestradiol as a promising anticancer agent for cancer therapy","volume":"12","author":"Ba","year":"2020","journal-title":"Future Med. Chem."},{"key":"10.1016\/j.ejphar.2022.175276_bib3","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1046\/j.1365-2133.1999.03205.x","article-title":"Levels of endothelial cell stimulating angiogenesis factor and vascular endothelial growth factor are elevated in psoriasis","volume":"141","author":"Bhushan","year":"1999","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.ejphar.2022.175276_bib4","article-title":"DGT, a novel heterocyclic diterpenoid, effectively suppresses psoriasis via inhibition of STAT3 phosphorylation","author":"Bian","year":"2020","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2022.175276_bib5","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/978-1-4939-9473-1_7","article-title":"Isolation and culture of human dermal microvascular endothelial cells","author":"Bourland","year":"2019","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.ejphar.2022.175276_bib6","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19010171","article-title":"Psoriasis: a STAT3-centric view","volume":"19","author":"Calautti","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2022.175276_bib7","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1007\/s00403-020-02056-3","article-title":"Small molecules under development for psoriasis: on the road to the individualized therapies","volume":"312","author":"Claudia","year":"2020","journal-title":"Arch. Dermatol. Res."},{"key":"10.1016\/j.ejphar.2022.175276_bib8","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.jaad.2016.12.005","article-title":"JAK inhibitors in dermatology: the promise of a new drug class","volume":"76","author":"Damsky","year":"2017","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.ejphar.2022.175276_bib10","doi-asserted-by":"crossref","DOI":"10.1136\/annrheumdis-2020-eular.3161","article-title":"AB0089 the analysis for the inhibition of angiogenesis by JAK inhibitor","volume":"79","author":"Fujita","year":"2020","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.ejphar.2022.175276_bib11","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/S0140-6736(21)00184-7","article-title":"Therapeutics targeting the IL-23 and IL-17 pathway in psoriasis","volume":"397","author":"Ghoreschi","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.ejphar.2022.175276_bib12","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/S0140-6736(20)32549-6","article-title":"Psoriasis","volume":"397","author":"Griffiths","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.ejphar.2022.175276_bib13","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.ejpb.2017.04.003","article-title":"High oral bioavailability of 2-methoxyestradiol in PEG-PLGA micelles-microspheres for cancer therapy","volume":"117","author":"Guo","year":"2017","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ejphar.2022.175276_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173106","article-title":"2-Methoxyestradiol inhibits high fat diet-induced obesity in rats through modulation of adipose tissue macrophage infiltration and immunophenotype","volume":"878","author":"Hamza","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2022.175276_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/pharmaceutics12090789","article-title":"Advanced characterization of imiquimod\u2010induced psoriasis\u2010like mouse model","volume":"12","author":"Jabeen","year":"2020","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ejphar.2022.175276_bib16","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.ejphar.2013.10.064","article-title":"2-Methoxyestradiol binding of GPR30 down-regulates angiotensin AT 1 receptor","volume":"723","author":"Koganti","year":"2014","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2022.175276_bib17","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.ejphar.2018.01.048","article-title":"Topical Sunitinib ointment alleviates Psoriasis-like inflammation by inhibiting the proliferation and apoptosis of keratinocytes","volume":"824","author":"Kuang","year":"2018","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2022.175276_bib18","series-title":"Recent Advances in Chemistry and Pharmacology of 2-methoxyestradiol: an Anticancer Investigational Drug, Steroids","author":"Kumar","year":"2016"},{"key":"10.1016\/j.ejphar.2022.175276_bib19","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1093\/rheumatology\/kez159","article-title":"Autophagy mediates 2-methoxyestradiol-inhibited scleroderma collagen synthesis and endothelial-to-mesenchymal transition induced by hypoxia","volume":"58","author":"Liu","year":"2019","journal-title":"Rheumatology"},{"key":"10.1016\/j.ejphar.2022.175276_bib20","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1111\/exd.14151","article-title":"Vascular endothelial growth factor-A as a promising therapeutic target for the management of psoriasis","volume":"29","author":"Luengas-Martinez","year":"2020","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.ejphar.2022.175276_bib21","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1517\/13543784.2016.1153064","article-title":"Novel investigational vascular endothelial growth factor (VEGF) receptor antagonists for psoriasis","volume":"25","author":"Malecic","year":"2016","journal-title":"Expet Opin. Invest. Drugs"},{"key":"10.1016\/j.ejphar.2022.175276_bib22","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1038\/jid.2011.46","article-title":"Suppression of VEGFR2 expression in human endothelial cells by dimethylfumarate treatment: evidence for anti-angiogenic action","volume":"131","author":"Meissner","year":"2011","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.ejphar.2022.175276_bib23","doi-asserted-by":"crossref","first-page":"2668","DOI":"10.1016\/j.jid.2021.04.016","article-title":"A targetable, noncanonical signal transducer and activator of transcription 3 activation induced by the Y-less region of IL-22 receptor orchestrates imiquimod-induced psoriasis-like dermatitis in mice","volume":"141","author":"Michiels","year":"2021","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.ejphar.2022.175276_bib24","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/jid.2010.255","article-title":"Stat3 as a therapeutic target for the treatment of psoriasis: a clinical feasibility study with STA-21, a Stat3 Inhibitor","volume":"131","author":"Miyoshi","year":"2011","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.ejphar.2022.175276_bib39","doi-asserted-by":"crossref","first-page":"6162","DOI":"10.1158\/1078-0432.CCR-07-0807","article-title":"Novel therapy with 2-methoxyestradiol for the treatment of relapsed and plateau phase multiple myeloma","volume":"13","author":"Rajkumar","year":"2007","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.ejphar.2022.175276_bib26","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/nm1162","article-title":"Stat3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model","volume":"11","author":"Sano","year":"2005","journal-title":"Nat. Med."},{"key":"10.1016\/j.ejphar.2022.175276_bib27","first-page":"1","article-title":"Animal models of psoriasis\u2014highlights and drawbacks","author":"Sch\u00f6n","year":"2020","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.ejphar.2022.175276_bib28","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/nrrheum.2015.167","article-title":"Type I\/II cytokines, JAKs, and new strategies for treating autoimmune diseases","volume":"12","author":"Schwartz","year":"2016","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.ejphar.2022.175276_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fimmu.2019.02847","article-title":"Emerging topical and systemic JAK inhibitors in dermatology","volume":"10","author":"Solimani","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejphar.2022.175276_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13073-017-0415-3","article-title":"Imiquimod has strain-dependent effects in mice and does not uniquely model human psoriasis","volume":"9","author":"Swindell","year":"2017","journal-title":"Genome Med."},{"key":"10.1016\/j.ejphar.2022.175276_bib31","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jdermsci.2020.06.003","article-title":"Short-term effectiveness of biologics in patients with moderate-to-severe plaque psoriasis: a systematic review and network meta-analysis","volume":"99","author":"Tada","year":"2020","journal-title":"J. Dermatol. Sci."},{"key":"10.1016\/j.ejphar.2022.175276_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-018-20805-3","article-title":"A new strategy for the passive skin delivery of nanoparticulate, high molecular weight hyaluronic acid prepared by a polyion complex method","volume":"8","author":"Tokudome","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejphar.2022.175276_bib33","doi-asserted-by":"crossref","first-page":"5836","DOI":"10.4049\/jimmunol.0802999","article-title":"Imiquimod-induced psoriasis-like skin inflammation in mice is mediated via the IL-23\/IL-17 Axis","volume":"182","author":"van der Fits","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.ejphar.2022.175276_bib34","article-title":"2-methoxyestradiol alleviates experimental autoimmune uveitis by inhibiting lymphocytes proliferation and T cell differentiation","author":"Xu","year":"2016","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.ejphar.2022.175276_bib35","first-page":"1","article-title":"Heme oxygenase-1 induction attenuates imiquimod-induced psoriasiform inflammation by negative regulation of Stat3 signaling","volume":"6","author":"Zhang","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejphar.2022.175276_bib40","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1007\/s10637-009-9383-9","article-title":"A phase I dose-escalation, safety and pharmacokinetic study of the 2-methoxyestradiol analog ENMD-1198 administered orally to patients with advanced cancer","volume":"29","author":"Zhou","year":"2011","journal-title":"Invest. New Drugs"},{"key":"10.1016\/j.ejphar.2022.175276_bib36","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1093\/rheumatology\/key166","article-title":"2-Methoxyestradiol inhibits hypoxia-induced scleroderma fibroblast collagen synthesis by phosphatidylinositol 3-kinase\/Akt\/mTOR signalling","volume":"57","author":"Zhou","year":"2018","journal-title":"Rheumatology"},{"key":"10.1016\/j.ejphar.2022.175276_bib37","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/ced.13033","article-title":"Association between plasma interleukin-17 levels and risk of psoriasis: a meta-analysis","volume":"42","author":"Zhou","year":"2017","journal-title":"Clin. Exp. Dermatol."},{"key":"10.1016\/j.ejphar.2022.175276_bib38","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jdermsci.2014.10.007","article-title":"2-Methoxyestradiol inhibits bleomycin-induced systemic sclerosis through suppression of fibroblast activation","volume":"77","author":"Zhu","year":"2015","journal-title":"J. Dermatol. Sci."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299922005374?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299922005374?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T23:09:14Z","timestamp":1757977754000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299922005374"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":38,"alternative-id":["S0014299922005374"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2022.175276","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibition of JAK1\/STAT3 pathway by 2-methoxyestradiol ameliorates psoriatic features in vitro and in an imiquimod-induced psoriasis-like mouse model","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2022.175276","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"175276"}}