{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T05:48:35Z","timestamp":1782020915416,"version":"3.54.5"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005378","name":"Hacettepe \u00dcniversitesi","doi-asserted-by":"publisher","award":["TSA-2017-14475"],"award-info":[{"award-number":["TSA-2017-14475"]}],"id":[{"id":"10.13039\/501100005378","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2023,5]]},"DOI":"10.1016\/j.ejphar.2023.175619","type":"journal-article","created":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T22:34:11Z","timestamp":1677105251000},"page":"175619","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["The effect of mitochondria-targeted slow hydrogen sulfide releasing donor AP39-treatment on airway inflammation"],"prefix":"10.1016","volume":"946","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4491-1394","authenticated-orcid":false,"given":"Yasemin","family":"Karaman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yesim","family":"Kaya-Yasar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cemil Can","family":"Eylem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sevgen Celik","family":"Onder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emirhan","family":"Nemutlu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Turgut Emrah","family":"Bozkurt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inci","family":"Sahin-Erdemli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2023.175619_bib1","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1038\/sj.bjp.0704928","article-title":"An assay to evaluate the long-term effects of inflammatory mediators on murine airway smooth muscle: evidence that TNFalpha up-regulates 5-HT(2A)-mediated contraction","volume":"137","author":"Adner","year":"2002","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2023.175619_bib2","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1097\/SHK.0000000000000478","article-title":"AP39, A mitochondrially targeted hydrogen sulfide donor, exerts protective effects in renal epithelial cells subjected to oxidative stress in vitro and in acute renal injury in vivo","volume":"45","author":"Ahmad","year":"2016","journal-title":"Shock"},{"key":"10.1016\/j.ejphar.2023.175619_bib3","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.resp.2012.03.009","article-title":"The message in the air: hydrogen sulfide metabolism in chronic respiratory diseases","volume":"184","author":"Chen","year":"2012","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.ejphar.2023.175619_bib4","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.cyto.2010.12.006","article-title":"Involvement of endogenous hydrogen sulfide in cigarette smoke-induced changes in airway responsiveness and inflammation of rat lung","volume":"53","author":"Chen","year":"2011","journal-title":"Cytokine"},{"key":"10.1016\/j.ejphar.2023.175619_bib5","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.cyto.2008.11.009","article-title":"Endogenous hydrogen sulfide reduces airway inflammation and remodeling in a rat model of asthma","volume":"45","author":"Chen","year":"2009","journal-title":"Cytokine"},{"key":"10.1016\/j.ejphar.2023.175619_bib6","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1007\/s00018-020-03656-y","article-title":"TLR4 and CD14 trafficking and its influence on LPS-induced pro-inflammatory signaling","volume":"78","author":"Ciesielska","year":"2021","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.ejphar.2023.175619_bib7","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0163-7258(03)00004-4","article-title":"Muscarinic acetylcholine receptors and airway diseases","volume":"98","author":"Coulson","year":"2003","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.ejphar.2023.175619_bib8","doi-asserted-by":"crossref","first-page":"100","DOI":"10.5455\/msm.2012.24.100-105","article-title":"Asthma and chronic obstructive pulmonary disease (COPD) - differences and similarities","volume":"24","author":"Cukic","year":"2012","journal-title":"Mater Sociomed"},{"key":"10.1016\/j.ejphar.2023.175619_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2021.338325","article-title":"Gas chromatography-mass spectrometry based (18)O stable isotope labeling of Krebs cycle intermediates","volume":"1154","author":"Eylem","year":"2021","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.ejphar.2023.175619_bib10","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-33101-x","article-title":"Hydrogen sulfide limits neutrophil transmigration, inflammation, and oxidative burst in lipopolysaccharide-induced acute lung injury","volume":"8","author":"Faller","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejphar.2023.175619_bib11","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1111\/j.1365-2222.2008.02971.x","article-title":"Pathogenesis of asthma","volume":"38","author":"Holgate","year":"2008","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.ejphar.2023.175619_bib12","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1165\/rcmb.2013-0519OC","article-title":"Mitochondrial-targeted antioxidant therapy decreases transforming growth factor-beta-mediated collagen production in a murine asthma model","volume":"52","author":"Jaffer","year":"2015","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.ejphar.2023.175619_bib13","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1111\/bcpt.13551","article-title":"Hydrogen sulfide donors prevent lipopolysaccharide-induced airway hyperreactivity in an in vitro model of chronic inflammation in mice","volume":"128","author":"Karaman","year":"2021","journal-title":"Basic Clin. Pharmacol."},{"key":"10.1016\/j.ejphar.2023.175619_bib14","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.pupt.2017.06.006","article-title":"Effects of intranasal treatment with slow (GYY4137) and rapid (NaHS) donors of hydrogen sulfide in lipopolysaccharide-induced airway inflammation in mice","volume":"45","author":"Kaya-Yasar","year":"2017","journal-title":"Pulm. Pharmacol. Ther."},{"key":"10.1016\/j.ejphar.2023.175619_bib15","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1254\/jphs.SC0070199","article-title":"Hydrogen sulfide causes relaxation in mouse bronchial smooth muscle","volume":"104","author":"Kubo","year":"2007","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.ejphar.2023.175619_bib16","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1055\/s-0032-1325617","article-title":"Airway hyperresponsiveness: new insights into the pathogenesis","volume":"33","author":"Lommatzsch","year":"2012","journal-title":"Semin. Respir. Crit. Care Med."},{"key":"10.1016\/j.ejphar.2023.175619_bib18","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1038\/ni.3704","article-title":"Mitochondria are the powerhouses of immunity","volume":"18","author":"Mills","year":"2017","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.ejphar.2023.175619_bib19","doi-asserted-by":"crossref","first-page":"13098","DOI":"10.1096\/fj.201901304R","article-title":"Hydrogen sulfide signaling in mitochondria and disease","volume":"33","author":"Murphy","year":"2019","journal-title":"Faseb. J."},{"key":"10.1016\/j.ejphar.2023.175619_bib20","doi-asserted-by":"crossref","first-page":"529","DOI":"10.3325\/cmj.2012.53.529","article-title":"18O-assisted dynamic metabolomics for individualized diagnostics and treatment of human diseases","volume":"53","author":"Nemutlu","year":"2012","journal-title":"Croat. Med. J."},{"key":"10.1016\/j.ejphar.2023.175619_bib21","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.abb.2019.01.002","article-title":"Mitochondrial regulation of airway smooth muscle functions in health and pulmonary diseases","volume":"663","author":"Pan","year":"2019","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.ejphar.2023.175619_bib22","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1002\/JLB.3MIR1118-415R","article-title":"Regulation of leukocyte function by citric acid cycle intermediates","volume":"106","author":"Patil","year":"2019","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.ejphar.2023.175619_bib23","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1165\/rcmb.2010-0304OC","article-title":"Hydrogen sulfide inhibits proliferation and release of IL-8 from human airway smooth muscle cells","volume":"45","author":"Perry","year":"2011","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.ejphar.2023.175619_bib24","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.bcp.2017.11.014","article-title":"A review of hydrogen sulfide (H2S) donors: chemistry and potential therapeutic applications","volume":"149","author":"Powell","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejphar.2023.175619_bib25","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.chest.2017.03.020","article-title":"Mitochondrial dysfunction in airway disease","volume":"152","author":"Prakash","year":"2017","journal-title":"Chest"},{"key":"10.1016\/j.ejphar.2023.175619_bib26","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s004080000032","article-title":"Use of bronchoalveolar lavage in humans--past necessity and future imperative","volume":"178","author":"Reynolds","year":"2000","journal-title":"Lung"},{"key":"10.1016\/j.ejphar.2023.175619_bib27","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.phrs.2015.07.032","article-title":"Hydrogen sulfide inhalation ameliorates allergen induced airway hypereactivity by modulating mast cell activation","volume":"100","author":"Roviezzo","year":"2015","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.ejphar.2023.175619_bib28","doi-asserted-by":"crossref","first-page":"262","DOI":"10.4049\/jimmunol.175.1.262","article-title":"Dual effects of p38 MAPK on TNF-dependent bronchoconstriction and TNF-independent neutrophil recruitment in lipopolysaccharide-induced acute respiratory distress syndrome","volume":"175","author":"Schnyder-Candrian","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.ejphar.2023.175619_bib29","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1046\/j.1440-1681.2002.03756.x","article-title":"Effects of cytokines on contractile and dilator responses of airway smooth muscle","volume":"29","author":"Shore","year":"2002","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.ejphar.2023.175619_bib30","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.niox.2014.04.008","article-title":"AP39, a novel mitochondria-targeted hydrogen sulfide donor, stimulates cellular bioenergetics, exerts cytoprotective effects and protects against the loss of mitochondrial DNA integrity in oxidatively stressed endothelial cells in vitro","volume":"41","author":"Szczesny","year":"2014","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.ejphar.2023.175619_bib31","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/nature11986","article-title":"Succinate is an inflammatory signal that induces IL-1beta through HIF-1alpha","volume":"496","author":"Tannahill","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2023.175619_bib32","doi-asserted-by":"crossref","first-page":"335","DOI":"10.3892\/mmr.2012.904","article-title":"Correlation between serum H2S and pulmonary function in children with bronchial asthma","volume":"6","author":"Tian","year":"2012","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.ejphar.2023.175619_bib33","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.it.2017.03.001","article-title":"Macrophage immunometabolism: where are we (going)?","volume":"38","author":"Van den Bossche","year":"2017","journal-title":"Trends Immunol."},{"key":"10.1016\/j.ejphar.2023.175619_bib34","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19103227","article-title":"Gas signaling molecules and mitochondrial potassium channels","volume":"19","author":"Walewska","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2023.175619_bib35","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1113\/expphysiol.2011.057448","article-title":"Hydrogen sulfide and asthma","volume":"96","author":"Wang","year":"2011","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.ejphar.2023.175619_bib36","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1016\/j.ajpath.2012.12.008","article-title":"The inhibitory role of hydrogen sulfide in airway hyperresponsiveness and inflammation in a mouse model of asthma","volume":"182","author":"Zhang","year":"2013","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.ejphar.2023.175619_bib37","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1165\/rcmb.2013-0415OC","article-title":"Inhibitory effect of hydrogen sulfide on ozone-induced airway inflammation, oxidative stress, and bronchial hyperresponsiveness","volume":"52","author":"Zhang","year":"2015","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.ejphar.2023.175619_fur1","doi-asserted-by":"crossref","unstructured":"Mills, E.L., Kelly, B., Logan, A., Costa, A.S.H., Varma, M., Bryant, C.E., Tourlomousis, P., Dabritz, J.H.M., Gottlieb, E., Latorre, I., Corr, S.C., McManus, G., Ryan, D., Jacobs, H.T., Szibor, M., Xavier, R.J., Braun, T., Frezza, C., Murphy, M.P., O\u2019Neill, L.A., 2016. Succinate dehydrogenase supports metabolic repurposing of mitochondria to drive inflammatory macrophages. Cell 167, 457\u2013470 e413.","DOI":"10.1016\/j.cell.2016.08.064"}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299923001309?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299923001309?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T23:18:09Z","timestamp":1757978289000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299923001309"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":37,"alternative-id":["S0014299923001309"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2023.175619","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The effect of mitochondria-targeted slow hydrogen sulfide releasing donor AP39-treatment on airway inflammation","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2023.175619","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"175619"}}