{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T22:22:07Z","timestamp":1789424527541,"version":"build-2803163510"},"reference-count":180,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81,503,272"],"award-info":[{"award-number":["81,503,272"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81,630,101"],"award-info":[{"award-number":["81,630,101"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016350","name":"Sichuan Provincial Administration of Traditional Chinese Medicine","doi-asserted-by":"publisher","award":["2020JC0031"],"award-info":[{"award-number":["2020JC0031"]}],"id":[{"id":"10.13039\/501100016350","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.ejphar.2023.175695","type":"journal-article","created":{"date-parts":[[2023,3,26]],"date-time":"2023-03-26T09:43:56Z","timestamp":1679823836000},"page":"175695","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Therapeutic potential of puerarin against cerebral diseases: From bench to bedside"],"prefix":"10.1016","volume":"953","author":[{"given":"Tian","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiye","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Ao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxiu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2023.175695_bib1","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1002\/ptr.5595","article-title":"Neurotherapeutic effects of Pueraria mirifica extract in early- and late-stage cognitive impaired rats","volume":"30","author":"Anukulthanakorn","year":"2016","journal-title":"Phytother Res."},{"key":"10.1016\/j.ejphar.2023.175695_bib2","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s40360-018-0216-3","article-title":"Absolute oral bioavailability and disposition kinetics of puerarin in female rats","volume":"19","author":"Anukunwithaya","year":"2018","journal-title":"BMC Pharmacol Toxicol"},{"key":"10.1016\/j.ejphar.2023.175695_bib3","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.bbadis.2011.10.017","article-title":"Antioxidant therapies in traumatic brain and spinal cord injury","volume":"1822","author":"Bains","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ejphar.2023.175695_bib4","doi-asserted-by":"crossref","first-page":"875","DOI":"10.3233\/JPD-202004","article-title":"GDNF and Parkinson's disease: where next? A summary from a recent workshop","volume":"10","author":"Barker","year":"2020","journal-title":"J. Parkinsons Dis."},{"key":"10.1016\/j.ejphar.2023.175695_bib5","doi-asserted-by":"crossref","first-page":"245","DOI":"10.3233\/JAD-2009-1041","article-title":"Oxidative stress in vascular dementia and Alzheimer's disease: a common pathology","volume":"17","author":"Bennett","year":"2009","journal-title":"J Alzheimers Dis"},{"issue":"Suppl. 1","key":"10.1016\/j.ejphar.2023.175695_bib6","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1016\/j.expneurol.2004.08.021","article-title":"Ubiquitin-proteasome system and Parkinson's diseases","volume":"191","author":"Betarbet","year":"2005","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.ejphar.2023.175695_bib7","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.jep.2017.07.030","article-title":"Radix Puerariae modulates glutamatergic synaptic architecture and potentiates functional synaptic plasticity in primary hippocampal neurons","volume":"209","author":"Bhuiyan","year":"2017","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.ejphar.2023.175695_bib8","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1001\/jamaneurol.2013.5847","article-title":"Amyloid-\u03b2 and tau: the trigger and bullet in Alzheimer disease pathogenesis","volume":"71","author":"Bloom","year":"2014","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.ejphar.2023.175695_bib9","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0021-9673(99)00715-3","article-title":"Separation and purification of isoflavones from Pueraria lobata by high-speed counter-current chromatography","volume":"855","author":"Cao","year":"1999","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.ejphar.2023.175695_bib10","doi-asserted-by":"crossref","first-page":"3702","DOI":"10.2174\/0929867325666180226094351","article-title":"Role of autophagy in Parkinson's disease","volume":"26","author":"Cerri","year":"2019","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.ejphar.2023.175695_bib11","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1007\/s11064-010-0178-3","article-title":"The role of excitatory amino acid transporters in cerebral ischemia","volume":"35","author":"Chao","year":"2010","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.ejphar.2023.175695_bib12","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.reprotox.2009.07.004","article-title":"Impact effects of puerarin on mouse embryonic development","volume":"28","author":"Chen","year":"2009","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.ejphar.2023.175695_bib13","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.3736\/jcim20111109","article-title":"[Flavonoids of puerarin versus tanshinone II A for ischemic stroke: a randomized controlled trial]","volume":"9","author":"Chen","year":"2011","journal-title":"Zhong Xi Yi Jie He Xue Bao"},{"key":"10.1016\/j.ejphar.2023.175695_bib14","doi-asserted-by":"crossref","first-page":"45276","DOI":"10.1021\/acsami.9b16047","article-title":"Nanoparticles mediating the sustained puerarin release facilitate improved brain delivery to treat Parkinson's disease","volume":"11","author":"Chen","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.ejphar.2023.175695_bib15","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.bcp.2019.06.025","article-title":"FGF-2 signaling activation in the hippocampus contributes to the behavioral and cellular responses to puerarin","volume":"168","author":"Cheng","year":"2019","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejphar.2023.175695_bib16","first-page":"1222","article-title":"[Protective effects of puerarin against 1-methyl-4-phenylpyridinium-induced mitochondrial apoptotic death in differentiated SH-SY5Y cells]","volume":"36","author":"Cheng","year":"2011","journal-title":"Zhongguo Zhongyao Zazhi"},{"key":"10.1016\/j.ejphar.2023.175695_bib17","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s12031-016-0856-y","article-title":"GPR30 activation contributes to the puerarin-mediated neuroprotection in MPP(+)-Induced SH-SY5Y cell death","volume":"61","author":"Cheng","year":"2017","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.ejphar.2023.175695_bib18","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.neures.2008.10.009","article-title":"Involvement of ubiquitin proteasome system in protective mechanisms of Puerarin to MPP(+)-elicited apoptosis","volume":"63","author":"Cheng","year":"2009","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.ejphar.2023.175695_bib19","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.jpba.2006.07.013","article-title":"Major isoflavonoid contents of the phytoestrogen rich-herb Pueraria mirifica in comparison with Pueraria lobata","volume":"43","author":"Cherdshewasart","year":"2007","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.ejphar.2023.175695_bib20","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s00217-009-1156-3","article-title":"Toxicological evaluation of the isoflavone puerarin and its glycosides","volume":"230","author":"Chung","year":"2009","journal-title":"Eur. Food Res. Technol."},{"key":"10.1016\/j.ejphar.2023.175695_bib21","doi-asserted-by":"crossref","DOI":"10.3390\/antiox9030260","article-title":"Antioxidant therapies in traumatic brain injury","volume":"9","author":"Di Pietro","year":"2020","journal-title":"Antioxidants"},{"key":"10.1016\/j.ejphar.2023.175695_bib22","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/j.neuron.2014.05.044","article-title":"The cost of brain diseases: a burden or a challenge?","volume":"82","author":"DiLuca","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.ejphar.2023.175695_bib23","doi-asserted-by":"crossref","DOI":"10.3389\/fpubh.2022.952161","article-title":"Global, regional, and national burden and attributable risk factors of neurological disorders: the Global Burden of Disease study 1990-2019","volume":"10","author":"Ding","year":"2022","journal-title":"Front. Public Health"},{"key":"10.1016\/j.ejphar.2023.175695_bib24","first-page":"2515","article-title":"[Effects of puerarin on expression of nuclear factor kappaB after cerebral ischemia\/reperfusion in rats]","volume":"32","author":"Ding","year":"2007","journal-title":"Zhongguo Zhongyao Zazhi"},{"key":"10.1016\/j.ejphar.2023.175695_bib25","doi-asserted-by":"crossref","first-page":"A32","DOI":"10.1038\/399a032","article-title":"Prospects for new restorative and neuroprotective treatments in Parkinson's disease","volume":"399","author":"Dunnett","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2023.175695_bib26","first-page":"106","article-title":"The acute management of intracerebral hemorrhage","volume":"17","author":"Flower","year":"2011","journal-title":"Curr. Opin. Crit. Care"},{"key":"10.1016\/j.ejphar.2023.175695_bib27","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1007\/s11655-014-1347-9","article-title":"Scutellaria baicalensis in stroke management: nature's blessing in traditional Eastern medicine","volume":"20","author":"Gaire","year":"2014","journal-title":"Chin. J. Integr. Med."},{"key":"10.1016\/j.ejphar.2023.175695_bib28","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1211\/jpp.62.03.0011","article-title":"Pharmacokinetic interaction between puerarin and edaravone, and effect of borneol on the brain distribution kinetics of puerarin in rats","volume":"62","author":"Gao","year":"2010","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.ejphar.2023.175695_bib29","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.apsb.2019.01.006","article-title":"Menthol-modified casein nanoparticles loading 10-hydroxycamptothecin for glioma targeting therapy","volume":"9","author":"Gao","year":"2019","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.ejphar.2023.175695_bib30","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1179\/174313209X444017","article-title":"Puerarin protects against ischemic brain injury in a rat model of transient focal ischemia","volume":"31","author":"Gao","year":"2009","journal-title":"Neurol. Res."},{"key":"10.1016\/j.ejphar.2023.175695_bib31","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.767333","article-title":"Puerarin alleviates depression-like behavior induced by high-fat diet combined with chronic unpredictable mild stress via repairing TLR4-induced inflammatory damages and phospholipid metabolism disorders","volume":"12","author":"Gao","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejphar.2023.175695_bib32","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.reprotox.2015.03.010","article-title":"Impact of kudzu and puerarin on sperm function","volume":"53","author":"Gray","year":"2015","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.ejphar.2023.175695_bib33","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.jchromb.2014.12.014","article-title":"Large scale purification of puerarin from Puerariae Lobatae Radix through resins adsorption and acid hydrolysis","volume":"980","author":"Guo","year":"2015","journal-title":"J. Chromatogr., B: Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.ejphar.2023.175695_bib34","first-page":"1069","article-title":"[Effects of puerarin on the neurocyte apoptosis and p-Akt (Ser473) expressions in rats with cerebral ischemia\/reperfusion injury]","volume":"32","author":"Han","year":"2012","journal-title":"Zhongguo Zhong Xi Yi Jie He Za Zhi"},{"key":"10.1016\/j.ejphar.2023.175695_bib35","doi-asserted-by":"crossref","first-page":"2306","DOI":"10.1016\/j.apsb.2020.11.023","article-title":"Evolution of blood-brain barrier in brain diseases and related systemic nanoscale brain-targeting drug delivery strategies","volume":"11","author":"Han","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.ejphar.2023.175695_bib36","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1038\/s41591-021-01382-x","article-title":"Biomarkers for neurodegenerative diseases","volume":"27","author":"Hansson","year":"2021","journal-title":"Nat. Med."},{"key":"10.1016\/j.ejphar.2023.175695_bib37","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.jep.2015.07.013","article-title":"The neuritogenic and synaptogenic effects of the ethanolic extract of radix Puerariae in cultured rat hippocampal neurons","volume":"173","author":"Haque Bhuiyan","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.ejphar.2023.175695_bib38","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.chroma.2003.09.045","article-title":"Separation and purification of puerarin using beta-cyclodextrin-coupled agarose gel media","volume":"1022","author":"He","year":"2004","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.ejphar.2023.175695_bib39","doi-asserted-by":"crossref","first-page":"605","DOI":"10.3233\/JAD-150566","article-title":"Puerarin ameliorates D-galactose induced enhanced hippocampal neurogenesis and tau hyperphosphorylation in rat brain","volume":"51","author":"Hong","year":"2016","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.ejphar.2023.175695_bib40","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.neulet.2017.02.009","article-title":"Puerarin provides a neuroprotection against transient cerebral ischemia by attenuating autophagy at the ischemic penumbra in neurons but not in astrocytes","volume":"643","author":"Hongyun","year":"2017","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ejphar.2023.175695_bib41","first-page":"2827","article-title":"[Effects of puerarin with aspirin on the markers of damaged vascular endothelial cells in patients with acute cerebral infarction]","volume":"33","author":"Hu","year":"2008","journal-title":"Zhongguo Zhongyao Zazhi"},{"key":"10.1016\/j.ejphar.2023.175695_bib42","article-title":"Activity dependent mammalian target of rapamycin pathway and brain derived neurotrophic factor release is required for the rapid antidepressant effects of puerarin","volume":"1\u201316","author":"Huang","year":"2018","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.ejphar.2023.175695_bib43","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.neuron.2013.10.008","article-title":"The pathobiology of vascular dementia","volume":"80","author":"Iadecola","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.ejphar.2023.175695_bib44","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1080\/13543784.2019.1683160","article-title":"Investigational BACE inhibitors for the treatment of Alzheimer's disease","volume":"28","author":"Imbimbo","year":"2019","journal-title":"Expet Opin. Invest. Drugs"},{"key":"10.1016\/j.ejphar.2023.175695_bib45","doi-asserted-by":"crossref","first-page":"735","DOI":"10.3389\/fnins.2019.00735","article-title":"Targeting the synapse in Alzheimer's disease","volume":"13","author":"Jackson","year":"2019","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.ejphar.2023.175695_bib46","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.jchromb.2012.12.011","article-title":"Simultaneous determination of gastrodin and puerarin in rat plasma by HPLC and the application to their interaction on pharmacokinetics","volume":"915\u2013916","author":"Jiang","year":"2013","journal-title":"J. Chromatogr., B: Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.ejphar.2023.175695_bib47","doi-asserted-by":"crossref","DOI":"10.4238\/gmr.15047501","article-title":"Puerarin prevents inflammation and apoptosis in the neurocytes of a murine Parkinson's disease model","volume":"15","author":"Jiang","year":"2016","journal-title":"Genet. Mol. Res."},{"key":"10.1016\/j.ejphar.2023.175695_bib48","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.jep.2004.08.029","article-title":"A comparative study on aqueous root extracts of Pueraria thomsonii and Pueraria lobata by antioxidant assay and HPLC fingerprint analysis","volume":"96","author":"Jiang","year":"2005","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.ejphar.2023.175695_bib50","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/978-981-32-9705-0_9","article-title":"The role of early life stress in HPA Axis and anxiety","volume":"1191","author":"Juruena","year":"2020","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.ejphar.2023.175695_bib51","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.bbadis.2016.01.015","article-title":"Stroke injury, cognitive impairment and vascular dementia","volume":"1862","author":"Kalaria","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ejphar.2023.175695_bib52","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/S1474-4422(12)70104-7","article-title":"Intracerebral haemorrhage: mechanisms of injury and therapeutic targets","volume":"11","author":"Keep","year":"2012","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.ejphar.2023.175695_bib53","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/mp.2016.120","article-title":"HPA axis in major depression: cortisol, clinical symptomatology and genetic variation predict cognition","volume":"22","author":"Keller","year":"2017","journal-title":"Mol. Psychiatr."},{"key":"10.1016\/j.ejphar.2023.175695_bib54","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.neuron.2014.03.003","article-title":"Stepwise recruitment of transcellular and paracellular pathways underlies blood-brain barrier breakdown in stroke","volume":"82","author":"Knowland","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.ejphar.2023.175695_bib55","doi-asserted-by":"crossref","DOI":"10.3390\/molecules22060939","article-title":"Pharmacokinetics and tissue distribution kinetics of puerarin in rats using indirect competitive ELISA","volume":"22","author":"Kong","year":"2017","journal-title":"Molecules"},{"key":"10.1016\/j.ejphar.2023.175695_bib56","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.jpba.2018.10.038","article-title":"Distribution kinetics of puerarin in rat hippocampus after acute local cerebral ischemia","volume":"164","author":"Kong","year":"2019","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.ejphar.2023.175695_bib57","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21207609","article-title":"Pathophysiology and treatment of stroke: present status and future perspectives","volume":"21","author":"Kuriakose","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2023.175695_bib58","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/ene.13439","article-title":"Alzheimer's disease","volume":"25","author":"Lane","year":"2018","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.ejphar.2023.175695_bib59","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0278-5846(03)00019-8","article-title":"Apoptosis and Parkinson's disease","volume":"27","author":"Lev","year":"2003","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.ejphar.2023.175695_bib60","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.ijpharm.2014.03.014","article-title":"Biopharmaceutics classification of puerarin and comparison of perfusion approaches in rats","volume":"466","author":"Li","year":"2014","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejphar.2023.175695_bib61","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.ejphar.2010.09.045","article-title":"Puerarin attenuates amyloid-beta-induced cognitive impairment through suppression of apoptosis in rat hippocampus in vivo","volume":"649","author":"Li","year":"2010","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2023.175695_bib62","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.brainres.2016.11.023","article-title":"Puerarin suppression of Abeta1-42-induced primary cortical neuron death is largely dependent on ERbeta","volume":"1657","author":"Li","year":"2017","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2023.175695_bib63","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.talanta.2012.11.037","article-title":"Determination of glibenclamide and puerarin in rat plasma by UPLC-MS\/MS: application to their pharmacokinetic interaction study","volume":"104","author":"Li","year":"2013","journal-title":"Talanta"},{"key":"10.1016\/j.ejphar.2023.175695_bib64","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1007\/s13318-016-0388-4","article-title":"In vivo pharmacokinetics of puerarin via different drug administration routes based on middle cerebral artery occlusion model","volume":"42","author":"Li","year":"2017","journal-title":"Eur. J. Drug Metab. Pharmacokinet."},{"key":"10.1016\/j.ejphar.2023.175695_bib65","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.neuropharm.2017.11.011","article-title":"Oxidative stress and DNA damage after cerebral ischemia: potential therapeutic targets to repair the genome and improve stroke recovery","volume":"134","author":"Li","year":"2018","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ejphar.2023.175695_bib66","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1515\/biol-2020-0053","article-title":"Coexisting flavonoids and administration route effect on pharmacokinetics of Puerarin in MCAO rats","volume":"15","author":"Li","year":"2020","journal-title":"Open Life Sci."},{"key":"10.1016\/j.ejphar.2023.175695_bib67","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2013.05.046","article-title":"Puerarin attenuates neuronal degeneration in the substantia nigra of 6-OHDA-lesioned rats through regulating BDNF expression and activating the Nrf2\/ARE signaling pathway","volume":"1523","author":"Li","year":"2013","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2023.175695_bib68","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.brainres.2013.04.013","article-title":"Puerarin attenuates neuronal degeneration and blocks oxidative stress to elicit a neuroprotective effect on substantia nigra injury in 6-OHDA-lesioned rats","volume":"1517","author":"Li","year":"2013","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2023.175695_bib69","first-page":"148","article-title":"Experimental study on the protective effect of puerarin to Parkinson disease","volume":"23","author":"Li","year":"2003","journal-title":"J Huazhong Univ Sci Technolog Med Sci"},{"key":"10.1016\/j.ejphar.2023.175695_bib70","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2020.111644","article-title":"Puerarin suppresses MPP(+)\/MPTP-induced oxidative stress through an Nrf2-dependent mechanism","volume":"144","author":"Li","year":"2020","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.ejphar.2023.175695_bib71","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1080\/03639040600559123","article-title":"Pharmacokinetic, tissue distribution, and excretion of puerarin and puerarin-phospholipid complex in rats","volume":"32","author":"Li","year":"2006","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.ejphar.2023.175695_bib72","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1055\/s-0031-1299763","article-title":"Protective effect of Puerarin on beta-amyloid-induced neurotoxicity in rat hippocampal neurons","volume":"62","author":"Lin","year":"2012","journal-title":"Arzneimittelforschung"},{"key":"10.1016\/j.ejphar.2023.175695_bib73","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1039\/D0FO02388D","article-title":"In silico-determined compound from the root of Pueraria lobate alleviates synaptic plasticity injury induced by Alzheimer's disease via the p38MAPK-CREB signaling pathway","volume":"12","author":"Liu","year":"2021","journal-title":"Food Funct."},{"key":"10.1016\/j.ejphar.2023.175695_bib74","first-page":"852","article-title":"[Occurrence and prevention of adverse reaction induced by puerarin injection]","volume":"25","author":"Liu","year":"2005","journal-title":"Zhongguo Zhong Xi Yi Jie He Za Zhi"},{"key":"10.1016\/j.ejphar.2023.175695_bib75","first-page":"3203","article-title":"Puerarin partly counteracts the inflammatory response after cerebral ischemia\/reperfusion via activating the cholinergic anti-inflammatory pathway","volume":"8","author":"Liu","year":"2013","journal-title":"Neural Regen Res"},{"key":"10.1016\/j.ejphar.2023.175695_bib76","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1002\/j.2040-4603.2019.tb00076.x","article-title":"Studying human neurological disorders using induced pluripotent stem cells: from 2D monolayer to 3D organoid and blood brain barrier models","volume":"9","author":"Logan","year":"2019","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.ejphar.2023.175695_bib77","first-page":"423","article-title":"Clinical efficacy and CT perfusion of puerarin combined with naloxone in the treatment of traumatic cerebral infarction","volume":"33","author":"Lubo","year":"2020","journal-title":"Pak. J. Pharm. Sci."},{"key":"10.1016\/j.ejphar.2023.175695_bib78","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.ijpharm.2011.02.064","article-title":"Pharmacokinetics, tissue distribution and relative bioavailability of puerarin solid lipid nanoparticles following oral administration","volume":"410","author":"Luo","year":"2011","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejphar.2023.175695_bib79","first-page":"1059","article-title":"[Purification technology of puerarin by agar gel microspheres]","volume":"41","author":"Lv","year":"2016","journal-title":"Zhongguo Zhongyao Zazhi"},{"key":"10.1016\/j.ejphar.2023.175695_bib80","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2020.120002","article-title":"Comparative study of oral and intranasal puerarin for prevention of brain injury induced by acute high-altitude hypoxia","volume":"591","author":"Ma","year":"2020","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejphar.2023.175695_bib81","article-title":"Current concepts of neurodegenerative mechanisms in Alzheimer's disease","author":"Magalingam","year":"2018","journal-title":"Biomed Res Int 2018"},{"key":"10.1016\/j.ejphar.2023.175695_bib82","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/nature19318","article-title":"Serotonin engages an anxiety and fear-promoting circuit in the extended amygdala","volume":"537","author":"Marcinkiewcz","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2023.175695_bib83","doi-asserted-by":"crossref","first-page":"2296","DOI":"10.1021\/acs.molpharmaceut.8b01058","article-title":"Potent acetylcholinesterase selective and reversible homodimeric agent based on tacrine for theranostics","volume":"16","author":"Meena","year":"2019","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.ejphar.2023.175695_bib84","first-page":"3285","article-title":"[Puerarin alleviates cognitive impairment and tau hyperphosphorylation in APP\/PS1 transgenic mice]","volume":"41","author":"Mei","year":"2016","journal-title":"Zhongguo Zhongyao Zazhi"},{"key":"10.1016\/j.ejphar.2023.175695_bib85","first-page":"4888","article-title":"[Determination of 9 isoflavonoids in Puerariae Lobatae Radix with quantitative analysis of multi-components by single marker]","volume":"44","author":"Mu","year":"2019","journal-title":"Zhongguo Zhongyao Zazhi"},{"key":"10.1016\/j.ejphar.2023.175695_bib86","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1055\/a-1271-7092","article-title":"Comparative pharmacokinetics of puerarin alone and in Pueraria mirifica extract in female cynomolgus monkeys","volume":"87","author":"Namken","year":"2021","journal-title":"Planta Med."},{"key":"10.1016\/j.ejphar.2023.175695_bib87","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-75253-9","article-title":"Investigating the optimum size of nanoparticles for their delivery into the brain assisted by focused ultrasound-induced blood-brain barrier opening","volume":"10","author":"Ohta","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejphar.2023.175695_bib88","doi-asserted-by":"crossref","DOI":"10.3390\/cells9071687","article-title":"Inflammation in Parkinson's disease: mechanisms and therapeutic implications","volume":"9","author":"Pajares","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.ejphar.2023.175695_bib89","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1248\/yakushi.128.1689","article-title":"Protecting mechanism of puerarin on the brain neurocyte of rat in acute local ischemia brain injury and local cerebral ischemia-reperfusion injury","volume":"128","author":"Pan","year":"2008","journal-title":"Yakugaku Zasshi"},{"key":"10.1016\/j.ejphar.2023.175695_bib90","first-page":"538","article-title":"[Effect of puerarin on the expression of Hsp70 in the rats with cerebral injury induced by acute local ischemia]","volume":"30","author":"Pan","year":"2005","journal-title":"Zhongguo Zhongyao Zazhi"},{"key":"10.1016\/j.ejphar.2023.175695_bib91","first-page":"482","article-title":"[Isolation and purification of puerarin from puerarin extractive by chelate complex chromatography]","volume":"24","author":"Pan","year":"2006","journal-title":"Se Pu"},{"key":"10.1016\/j.ejphar.2023.175695_bib92","doi-asserted-by":"crossref","first-page":"514","DOI":"10.2174\/1570159X1304150831120428","article-title":"Research on the pathological mechanism and drug treatment mechanism of depression","volume":"13","author":"Peng","year":"2015","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.ejphar.2023.175695_bib93","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s11011-017-0127-9","article-title":"The anxiolytic-like effects of puerarin are associated with the changes of monoaminergic neurotransmitters and biosynthesis of allopregnanolone in the brain","volume":"33","author":"Qiu","year":"2018","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.ejphar.2023.175695_bib94","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1007\/s12031-020-01754-x","article-title":"Unfolding the role of BDNF as a biomarker for treatment of depression","volume":"71","author":"Rana","year":"2021","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.ejphar.2023.175695_bib95","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1530\/REP-11-0423","article-title":"Puerarin, a selective oestrogen receptor modulator, disrupts pregnancy in rats at pre-implantation stage","volume":"144","author":"Saha","year":"2012","journal-title":"Reproduction"},{"key":"10.1016\/j.ejphar.2023.175695_bib96","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.nbd.2008.08.005","article-title":"Blood-brain barrier tight junction permeability and ischemic stroke","volume":"32","author":"Sandoval","year":"2008","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.ejphar.2023.175695_bib97","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0006-8993(96)00846-3","article-title":"HSP70 is essential to the neuroprotective effect of heat-shock","volume":"740","author":"Sato","year":"1996","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2023.175695_bib98","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1002\/mds.23732","article-title":"Etiology and pathogenesis of Parkinson's disease","volume":"26","author":"Schapira","year":"2011","journal-title":"Mov. Disord."},{"key":"10.1016\/j.ejphar.2023.175695_bib99","doi-asserted-by":"crossref","first-page":"e50","DOI":"10.2196\/mental.5842","article-title":"Social networking sites, depression, and anxiety: a systematic review","volume":"3","author":"Seabrook","year":"2016","journal-title":"JMIR Ment Health"},{"key":"10.1016\/j.ejphar.2023.175695_bib100","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1016\/j.biopha.2018.07.058","article-title":"Puerarin promoted proliferation and differentiation of dopamine-producing cells in Parkinson's animal models","volume":"106","author":"Shiying","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ejphar.2023.175695_bib101","doi-asserted-by":"crossref","DOI":"10.1016\/j.cpr.2020.101943","article-title":"The gut microbiota in anxiety and depression - a systematic review","volume":"83","author":"Simpson","year":"2021","journal-title":"Clin. Psychol. Rev."},{"key":"10.1016\/j.ejphar.2023.175695_bib102","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1007\/s12291-019-00838-9","article-title":"Modes of calcium regulation in ischemic neuron","volume":"34","author":"Singh","year":"2019","journal-title":"Indian J. Clin. Biochem."},{"key":"10.1016\/j.ejphar.2023.175695_bib103","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.jad.2021.04.037","article-title":"Puerarin ameliorates depression-like behaviors of with chronic unpredictable mild stress mice by remodeling their gut microbiota","volume":"290","author":"Song","year":"2021","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.ejphar.2023.175695_bib104","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.jad.2022.05.044","article-title":"Exploring the potential antidepressant mechanisms of puerarin: anti-inflammatory response via the gut-brain axis","volume":"310","author":"Song","year":"2022","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.ejphar.2023.175695_bib105","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.108978","article-title":"The anxiolytic-like effects of puerarin on an animal model of PTSD","volume":"115","author":"Su","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ejphar.2023.175695_bib106","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105419","article-title":"Phytochemicals as regulators of microglia\/macrophages activation in cerebral ischemia","volume":"165","author":"Subedi","year":"2021","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.ejphar.2023.175695_bib107","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.jphs.2020.11.007","article-title":"Microglial metabolic disturbances and neuroinflammation in cerebral infarction","volume":"145","author":"Takeda","year":"2021","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.ejphar.2023.175695_bib108","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.neulet.2014.04.019","article-title":"Brn4 and TH synergistically promote the differentiation of neural stem cells into dopaminergic neurons","volume":"571","author":"Tan","year":"2014","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ejphar.2023.175695_bib109","first-page":"2720","article-title":"[Borneol promotes oral absorption and penetration into brain of puerarin and catalpol]","volume":"41","author":"Tang","year":"2016","journal-title":"Zhongguo Zhongyao Zazhi"},{"key":"10.1016\/j.ejphar.2023.175695_bib110","doi-asserted-by":"crossref","DOI":"10.3390\/molecules24244569","article-title":"Effects of puerarin on the ovariectomy-induced depressive-like behavior in ICR mice and its possible mechanism of action","volume":"24","author":"Tantipongpiradet","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.ejphar.2023.175695_bib111","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s00210-012-0804-5","article-title":"HP-\u03b2-CD-PLGA nanoparticles improve the penetration and bioavailability of puerarin and enhance the therapeutic effects on brain ischemia-reperfusion injury in rats","volume":"386","author":"Tao","year":"2013","journal-title":"Naunyn-Schmiedeberg\u2019s Arch. Pharmacol."},{"key":"10.1016\/j.ejphar.2023.175695_bib112","doi-asserted-by":"crossref","first-page":"106283","DOI":"10.18632\/oncotarget.22290","article-title":"Puerarin attenuates locomotor and cognitive deficits as well as hippocampal neuronal injury through the PI3K\/Akt1\/GSK-3\u03b2 signaling pathway in an in vivo model of cerebral ischemia","volume":"8","author":"Tao","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.ejphar.2023.175695_bib113","doi-asserted-by":"crossref","first-page":"809","DOI":"10.2174\/1381612822666161208120422","article-title":"Role of neurotrophic factors in Parkinson's disease","volume":"23","author":"Tome","year":"2017","journal-title":"Curr. Pharmaceut. Des."},{"key":"10.1016\/j.ejphar.2023.175695_bib114","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.3233\/JAD-161088","article-title":"Oxidative stress, synaptic dysfunction, and Alzheimer's disease","volume":"57","author":"T\u00f6nnies","year":"2017","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.ejphar.2023.175695_bib115","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13031","article-title":"Oxidative stress in the aging substantia nigra and the etiology of Parkinson's disease","volume":"18","author":"Trist","year":"2019","journal-title":"Aging Cell"},{"key":"10.1016\/j.ejphar.2023.175695_bib116","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/ejn.14720","article-title":"Neuroinflammation and depression: a review","volume":"53","author":"Troubat","year":"2021","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.ejphar.2023.175695_bib117","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173412","article-title":"Neuroprotective role of polyphenols against oxidative stress-mediated neurodegeneration","volume":"886","author":"Uddin","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2023.175695_bib118","doi-asserted-by":"crossref","DOI":"10.3390\/molecules23102485","article-title":"Neuroprotective role of phytochemicals","volume":"23","author":"Velmurugan","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.ejphar.2023.175695_bib119","doi-asserted-by":"crossref","first-page":"e139","DOI":"10.1161\/CIR.0000000000000757","article-title":"Heart disease and stroke statistics-2020 update: a report from the American heart association","volume":"141","author":"Virani","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2023.175695_bib120","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1097\/MNM.0b013e3283108995","article-title":"Protective effect of chuanxiongzine-puerarin in a rat model of transient middle cerebral artery occlusion-induced focal cerebral ischemia","volume":"29","author":"Wan","year":"2008","journal-title":"Nucl. Med. Commun."},{"key":"10.1016\/j.ejphar.2023.175695_bib121","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.jgr.2021.03.001","article-title":"Panax ginseng and its ginsenosides: potential candidates for the prevention and treatment of chemotherapy-induced side effects","volume":"45","author":"Wan","year":"2021","journal-title":"J Ginseng Res"},{"key":"10.1016\/j.ejphar.2023.175695_bib122","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.106002","article-title":"Nuciferine, an active ingredient derived from lotus leaf, lights up the way for the potential treatment of obesity and obesity-related diseases","volume":"175","author":"Wan","year":"2022","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.ejphar.2023.175695_bib123","article-title":"TRPV1-Mediated microglial autophagy attenuates Alzheimer's disease-associated pathology and cognitive decline","volume":"12","author":"Wang","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejphar.2023.175695_bib124","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1007\/s11064-014-1420-1","article-title":"Puerarin protects against beta-amyloid-induced microglia apoptosis via a PI3K-dependent signaling pathway","volume":"39","author":"Wang","year":"2014","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.ejphar.2023.175695_bib125","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.jep.2015.11.005","article-title":"Evaluation of kudzu root extract-induced hepatotoxicity","volume":"176","author":"Wang","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.ejphar.2023.175695_bib126","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.neulet.2010.10.002","article-title":"Implication of the c-Jun-NH2-terminal kinase pathway in the neuroprotective effect of puerarin against 1-methyl-4-phenylpyridinium (MPP+)-induced apoptosis in PC-12 cells","volume":"487","author":"Wang","year":"2011","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ejphar.2023.175695_bib127","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1007\/s11655-018-2822-0","article-title":"Puerarin up-regulates methyl-CpG binding protein 2 phosphorylation in Hippocampus of vascular dementia rats","volume":"24","author":"Wang","year":"2018","journal-title":"Chin. J. Integr. Med."},{"key":"10.1016\/j.ejphar.2023.175695_bib128","doi-asserted-by":"crossref","first-page":"989","DOI":"10.4103\/1673-5374.233441","article-title":"Puerarin protects rat brain against ischemia\/reperfusion injury by suppressing autophagy via the AMPK-mTOR-ULK1 signaling pathway","volume":"13","author":"Wang","year":"2018","journal-title":"Neural Regen Res"},{"key":"10.1016\/j.ejphar.2023.175695_bib129","first-page":"164","article-title":"[Effects of puerarin on the vascular active factor related to cerebral vasospasm after aneurysm subarachnoid hemorrhage]","volume":"32","author":"Wang","year":"2012","journal-title":"Zhongguo Zhong Xi Yi Jie He Za Zhi"},{"key":"10.1016\/j.ejphar.2023.175695_bib130","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.jss.2013.08.027","article-title":"Puerarin ameliorates oxidative stress in a rodent model of traumatic brain injury","volume":"186","author":"Wang","year":"2014","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.ejphar.2023.175695_bib131","first-page":"949","article-title":"[Progress in regulation effect of aromatic refreshing traditional Chinese medicine on BBB permeability and its mechanism]","volume":"39","author":"Wang","year":"2014","journal-title":"Zhongguo Zhongyao Zazhi"},{"key":"10.1016\/j.ejphar.2023.175695_bib132","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jchromb.2012.11.009","article-title":"Magnetic solid-phase extraction and determination of puerarin in rat plasma using C(18)-functionalized magnetic silica nanoparticles by high performance liquid chromatography","volume":"912","author":"Wang","year":"2013","journal-title":"J. Chromatogr., B: Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.ejphar.2023.175695_bib133","first-page":"106","article-title":"[Effect of chaperone-mediated autophagy in MPP(+) -induced SH-SY5Y cells and interventional effect of puerarin]","volume":"39","author":"Wang","year":"2014","journal-title":"Zhongguo Zhongyao Zazhi"},{"key":"10.1016\/j.ejphar.2023.175695_bib134","first-page":"9601","article-title":"Inflammation, apoptosis and autophagy as critical players in vascular dementia","volume":"24","author":"Wang","year":"2020","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.ejphar.2023.175695_bib135","first-page":"424","article-title":"[Effect of puerarin and ligustrazine on cultured hippocampal neurons injury induced by Abeta25-35]","volume":"33","author":"Wang","year":"2008","journal-title":"Zhongguo Zhongyao Zazhi"},{"key":"10.1016\/j.ejphar.2023.175695_bib136","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1007\/s11064-012-0791-4","article-title":"Necrostatin-1 suppresses autophagy and apoptosis in mice traumatic brain injury model","volume":"37","author":"Wang","year":"2012","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.ejphar.2023.175695_bib137","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1038\/356314a0","article-title":"Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis","volume":"356","author":"Watanabe-Fukunaga","year":"1992","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2023.175695_bib138","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1146\/annurev.pa.21.040181.001121","article-title":"Excitatory amino acid transmitters","volume":"21","author":"Watkins","year":"1981","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.ejphar.2023.175695_bib139","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1039\/C7MD00457E","article-title":"Design, synthesis and biological evaluation of tacrine-1,2,3-triazole derivatives as potent cholinesterase inhibitors","volume":"9","author":"Wu","year":"2018","journal-title":"Medchemcomm"},{"key":"10.1016\/j.ejphar.2023.175695_bib140","first-page":"421","article-title":"Puerarin decreases hypoxia inducible factor-1 alpha in the hippocampus of vascular dementia rats","volume":"7","author":"Wu","year":"2012","journal-title":"Neural Regen Res"},{"key":"10.1016\/j.ejphar.2023.175695_bib141","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1007\/s11655-009-0054-4","article-title":"Protective effects and mechanism of puerarin on learning-memory disorder after global cerebral ischemia-reperfusion injury in rats","volume":"15","author":"Wu","year":"2009","journal-title":"Chin. J. Integr. Med."},{"key":"10.1016\/j.ejphar.2023.175695_bib142","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1080\/10717544.2018.1516005","article-title":"Borneol and \u0391-asarone as adjuvant agents for improving blood-brain barrier permeability of puerarin and tetramethylpyrazine by activating adenosine receptors","volume":"25","author":"Wu","year":"2018","journal-title":"Drug Deliv."},{"key":"10.1016\/j.ejphar.2023.175695_bib143","first-page":"224","article-title":"Protective effects of puerarin against abeta 1-42-induced learning and memory impairments in mice","volume":"83","author":"Wu","year":"2017","journal-title":"Planta Med."},{"key":"10.1016\/j.ejphar.2023.175695_bib144","first-page":"3956","article-title":"[Evaluation on safety of puerarin injection in clinical use]","volume":"43","author":"Xie","year":"2018","journal-title":"Zhongguo Zhongyao Zazhi"},{"key":"10.1016\/j.ejphar.2023.175695_bib145","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.brainresbull.2011.03.024","article-title":"Neuroprotective effects of puerarin against beta-amyloid-induced neurotoxicity in PC12 cells via a PI3K-dependent signaling pathway","volume":"85","author":"Xing","year":"2011","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.ejphar.2023.175695_bib146","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1021\/acs.molpharmaceut.8b01012","article-title":"Oral delivery of puerarin nanocrystals to improve brain accumulation and anti-parkinsonian efficacy","volume":"16","author":"Xiong","year":"2019","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.ejphar.2023.175695_bib147","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.neuroscience.2011.12.050","article-title":"Decrease of synaptic plasticity associated with alteration of information flow in a rat model of vascular dementia","volume":"206","author":"Xu","year":"2012","journal-title":"Neuroscience"},{"key":"10.1016\/j.ejphar.2023.175695_bib148","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1055\/s-2005-871261","article-title":"The Neuroprotection of puerarin against cerebral ischemia is associated with the prevention of apoptosis in rats","volume":"71","author":"Xu","year":"2005","journal-title":"Planta Med."},{"key":"10.1016\/j.ejphar.2023.175695_bib149","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1002\/bmc.549","article-title":"Determination of puerarin in rat cortex by high-performance liquid chromatography after intravenous administration of Puerariae flavonoids","volume":"20","author":"Yan","year":"2006","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.ejphar.2023.175695_bib150","doi-asserted-by":"crossref","first-page":"9081","DOI":"10.3892\/mmr.2017.7702","article-title":"Puerarin inhibits betaamyloid peptide 142induced tau hyperphosphorylation via the Wnt\/betacatenin signaling pathway","volume":"16","author":"Yao","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.ejphar.2023.175695_bib151","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1080\/10717544.2016.1259372","article-title":"Enhancing both oral bioavailability and brain penetration of puerarin using borneol in combination with preparation technologies","volume":"24","author":"Yi","year":"2017","journal-title":"Drug Deliv."},{"key":"10.1016\/j.ejphar.2023.175695_bib152","doi-asserted-by":"crossref","first-page":"7809","DOI":"10.1111\/jcmm.16679","article-title":"Puerarin attenuates intracerebral hemorrhage-induced early brain injury possibly by PI3K\/Akt signal activation-mediated suppression of NF-\u03baB pathway","volume":"25","author":"Zeng","year":"2021","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.ejphar.2023.175695_bib153","first-page":"315","article-title":"[Effects of puerarin on hippocampal synaptic long term potentiation in vascular dementia rats]","volume":"25","author":"Zhang","year":"2009","journal-title":"Zhongguo Ying Yong Sheng Li Xue Za Zhi"},{"key":"10.1016\/j.ejphar.2023.175695_bib154","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.exger.2010.09.013","article-title":"Puerarin protects Alzheimer's disease neuronal cybrids from oxidant-stress induced apoptosis by inhibiting pro-death signaling pathways","volume":"46","author":"Zhang","year":"2011","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.ejphar.2023.175695_bib155","first-page":"543","article-title":"[Effect of puerarin on PC12 cells apoptosis induced by Abeta25-35 in vitro]","volume":"31","author":"Zhang","year":"2008","journal-title":"Zhong Yao Cai"},{"key":"10.1016\/j.ejphar.2023.175695_bib156","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1016\/j.cellbi.2008.07.006","article-title":"Puerarin protects PC12 cells against beta-amyloid-induced cell injury","volume":"32","author":"Zhang","year":"2008","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.ejphar.2023.175695_bib157","first-page":"763","article-title":"[The protective effect of puerarin on Abeta(25-35)-induced PC12 cell injury]","volume":"33","author":"Zhang","year":"2010","journal-title":"Zhong Yao Cai"},{"key":"10.1016\/j.ejphar.2023.175695_bib158","first-page":"4695","article-title":"Puerarin attenuates cognitive dysfunction and oxidative stress in vascular dementia rats induced by chronic ischemia","volume":"8","author":"Zhang","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.ejphar.2023.175695_bib159","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1080\/10717544.2019.1660732","article-title":"Pharmacokinetics and drug delivery systems for puerarin, a bioactive flavone from traditional Chinese medicine","volume":"26","author":"Zhang","year":"2019","journal-title":"Drug Deliv."},{"key":"10.1016\/j.ejphar.2023.175695_bib160","first-page":"3650","article-title":"[Mechanism of puerarin reversing SH-SY5Y cell injury induced by A\u03b2_(1-42) based on proteomics]","volume":"46","author":"Zhang","year":"2021","journal-title":"Zhongguo Zhongyao Zazhi"},{"key":"10.1016\/j.ejphar.2023.175695_bib161","article-title":"BAD-mediated neuronal apoptosis and neuroinflammation contribute to Alzheimer's disease pathology","volume":"24","author":"Zhang","year":"2021","journal-title":"iScience"},{"key":"10.1016\/j.ejphar.2023.175695_bib162","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1080\/10717544.2017.1346002","article-title":"Borneol, a novel agent that improves central nervous system drug delivery by enhancing blood-brain barrier permeability","volume":"24","author":"Zhang","year":"2017","journal-title":"Drug Deliv."},{"key":"10.1016\/j.ejphar.2023.175695_bib163","first-page":"1268","article-title":"[Protective effect of puerarin against calcium overload after focal cerebral ischemia injury in rats]","volume":"30","author":"Zhang","year":"2010","journal-title":"Nan Fang Yi Ke Da Xue Xue Bao"},{"key":"10.1016\/j.ejphar.2023.175695_bib164","first-page":"52","article-title":"[Effect of puerarin on the expression of NMDA receptor in the hippocampus CA1 region after focal cerebral ischemia in rats]","volume":"42","author":"Zhang","year":"2011","journal-title":"Sichuan Da Xue Xue Bao Yi Xue Ban"},{"key":"10.1016\/j.ejphar.2023.175695_bib165","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.neuroscience.2014.08.052","article-title":"Puerarin protects dopaminergic neurons in Parkinson's disease models","volume":"280","author":"Zhang","year":"2014","journal-title":"Neuroscience"},{"key":"10.1016\/j.ejphar.2023.175695_bib166","doi-asserted-by":"crossref","first-page":"783","DOI":"10.3109\/00207454.2013.803103","article-title":"Effects of puerarin on cholinergic enzymes in the brain of ovariectomized Guinea pigs","volume":"123","author":"Zhang","year":"2013","journal-title":"Int. J. Neurosci."},{"key":"10.1016\/j.ejphar.2023.175695_bib167","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.biopha.2018.10.161","article-title":"Puerarin attenuates neurological deficits via Bcl-2\/Bax\/cleaved caspase-3 and Sirt3\/SOD2 apoptotic pathways in subarachnoid hemorrhage mice","volume":"109","author":"Zhang","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ejphar.2023.175695_bib168","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1002\/jcph.96","article-title":"Radix Puerariae: an overview of its chemistry, pharmacology, pharmacokinetics, and clinical use","volume":"53","author":"Zhang","year":"2013","journal-title":"J. Clin. Pharmacol."},{"key":"10.1016\/j.ejphar.2023.175695_bib169","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/7716201","article-title":"Botanical drug puerarin ameliorates liposaccharide-induced depressive behaviors in mice via inhibiting Raga\/mTOR\/p70S6K pathways","author":"Zhao","year":"2021","journal-title":"Oxid Med Cell Longev 2021"},{"key":"10.1016\/j.ejphar.2023.175695_bib170","doi-asserted-by":"crossref","first-page":"2801","DOI":"10.1007\/s12035-016-9870-x","article-title":"Plant natural product puerarin ameliorates depressive behaviors and chronic pain in mice with spared nerve injury (SNI)","volume":"54","author":"Zhao","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.ejphar.2023.175695_bib171","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1248\/bpb.b12-00769","article-title":"The permeability of puerarin loaded poly(butylcyanoacrylate) nanoparticles coated with polysorbate 80 on the blood-brain barrier and its protective effect against cerebral ischemia\/reperfusion injury","volume":"36","author":"Zhao","year":"2013","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.ejphar.2023.175695_bib172","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.neuro.2015.10.010","article-title":"Puerarin attenuates learning and memory impairments and inhibits oxidative stress in STZ-induced SAD mice","volume":"51","author":"Zhao","year":"2015","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.ejphar.2023.175695_bib173","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/7635291","article-title":"Botanical drug puerarin promotes neuronal survival and neurite outgrowth against MPTP\/MPP(+)-Induced toxicity via progesterone receptor signaling","author":"Zhao","year":"2020","journal-title":"Oxid Med Cell Longev 2020"},{"key":"10.1016\/j.ejphar.2023.175695_bib174","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.4103\/1673-5374.147934","article-title":"Puerarin protects brain tissue against cerebral ischemia\/reperfusion injury by inhibiting the inflammatory response","volume":"9","author":"Zhou","year":"2014","journal-title":"Neural Regen Res"},{"key":"10.1016\/j.ejphar.2023.175695_bib175","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1017\/S146114571300148X","article-title":"Puerarin alleviates cognitive impairment and oxidative stress in APP\/PS1 transgenic mice","volume":"17","author":"Zhou","year":"2014","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.ejphar.2023.175695_bib176","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1002\/ptr.5083","article-title":"Puerarin: a review of pharmacological effects","volume":"28","author":"Zhou","year":"2014","journal-title":"Phytother Res."},{"key":"10.1016\/j.ejphar.2023.175695_bib177","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1055\/s-0030-1249976","article-title":"Puerarin protects dopaminergic neurons against 6-hydroxydopamine neurotoxicity via inhibiting apoptosis and upregulating glial cell line-derived neurotrophic factor in a rat model of Parkinson's disease","volume":"76","author":"Zhu","year":"2010","journal-title":"Planta Med."},{"key":"10.1016\/j.ejphar.2023.175695_bib178","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.neuint.2012.01.003","article-title":"Involvement of activation of PI3K\/Akt pathway in the protective effects of puerarin against MPP+-induced human neuroblastoma SH-SY5Y cell death","volume":"60","author":"Zhu","year":"2012","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.ejphar.2023.175695_bib179","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1002\/ptr.4975","article-title":"Neuroprotective effects of puerarin on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine induced Parkinson's disease model in mice","volume":"28","author":"Zhu","year":"2014","journal-title":"Phytother Res."},{"key":"10.1016\/j.ejphar.2023.175695_bib180","doi-asserted-by":"crossref","DOI":"10.3389\/fnbeh.2021.717008","article-title":"Puerarin alleviates vascular cognitive impairment in vascular dementia rats","volume":"15","author":"Zhu","year":"2021","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.ejphar.2023.175695_bib181","doi-asserted-by":"crossref","first-page":"55","DOI":"10.3109\/10715762.2012.742518","article-title":"Protective effect of puerarin against beta-amyloid-induced oxidative stress in neuronal cultures from rat hippocampus: involvement of the GSK-3beta\/Nrf2 signaling pathway","volume":"47","author":"Zou","year":"2013","journal-title":"Free Radic. Res."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299923002066?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299923002066?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T04:24:49Z","timestamp":1762143889000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299923002066"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":180,"alternative-id":["S0014299923002066"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2023.175695","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Therapeutic potential of puerarin against cerebral diseases: From bench to bedside","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2023.175695","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"175695"}}