{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:12:50Z","timestamp":1791936770805,"version":"4.3.4"},"reference-count":140,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.ejphar.2023.175733","type":"journal-article","created":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T11:34:41Z","timestamp":1682508881000},"page":"175733","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Glutamate dehydrogenase: Potential therapeutic targets for neurodegenerative disease"],"prefix":"10.1016","volume":"950","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3522-2231","authenticated-orcid":false,"given":"Chuqiao","family":"Pan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shijie","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeping","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0561-7520","authenticated-orcid":false,"given":"Ning","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2023.175733_bib1","article-title":"Spectrum of neuro-developmental disorders in children with congenital hyperinsulinism due to activating mutations in GLUD1","volume":"12","author":"Aftab","year":"2022","journal-title":"Endocrine connections"},{"key":"10.1016\/j.ejphar.2023.175733_bib2","doi-asserted-by":"crossref","first-page":"577","DOI":"10.3390\/brainsci12050577","article-title":"Is L-glutamate toxic to neurons and thereby contributes to neuronal loss and neurodegeneration? A systematic review","volume":"12","author":"Al-Nasser","year":"2022","journal-title":"Brain Sci."},{"key":"10.1016\/j.ejphar.2023.175733_bib3","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1186\/s13041-020-00658-6","article-title":"Glutamate-glutamine homeostasis is perturbed in neurons and astrocytes derived from patient iPSC models of frontotemporal dementia","volume":"13","author":"Aldana","year":"2020","journal-title":"Mol. Brain"},{"key":"10.1016\/j.ejphar.2023.175733_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2021.108719","article-title":"Glutamate metabolism and recycling at the excitatory synapse in health and neurodegeneration","volume":"196","author":"Andersen","year":"2021","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ejphar.2023.175733_bib5","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1038\/s41419-021-04237-y","article-title":"Hippocampal disruptions of synaptic and astrocyte metabolism are primary events of early amyloid pathology in the 5xFAD mouse model of Alzheimer's disease","volume":"12","author":"Andersen","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ejphar.2023.175733_bib6","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2148-3-14","article-title":"Evolution of glutamate dehydrogenase genes: evidence for lateral gene transfer within and between prokaryotes and eukaryotes","volume":"3","author":"Andersson","year":"2003","journal-title":"BMC Evol. Biol."},{"key":"10.1016\/j.ejphar.2023.175733_bib7","doi-asserted-by":"crossref","first-page":"E280","DOI":"10.1152\/ajpendo.00380.2003","article-title":"Overexpression of constitutively activated glutamate dehydrogenase induces insulin secretion through enhanced glutamate oxidation","volume":"286","author":"Anno","year":"2004","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.ejphar.2023.175733_bib8","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1002\/jnr.23517","article-title":"Ischemic tolerance in an in vivo model of glutamate preconditioning","volume":"93","author":"Badawi","year":"2015","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.ejphar.2023.175733_bib9","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.seizure.2008.01.005","article-title":"Myoclonic absence epilepsy with photosensitivity and a gain of function mutation in glutamate dehydrogenase","volume":"17","author":"Bahi-Buisson","year":"2008","journal-title":"Seizure"},{"key":"10.1016\/j.ejphar.2023.175733_bib10","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1111\/j.1469-8749.2008.03114.x","article-title":"Neurological aspects of hyperinsulinism-hyperammonaemia syndrome","volume":"50","author":"Bahi-Buisson","year":"2008","journal-title":"Dev. Med. Child Neurol."},{"key":"10.1016\/j.ejphar.2023.175733_bib11","doi-asserted-by":"crossref","first-page":"5579","DOI":"10.1016\/S0021-9258(19)83816-4","article-title":"Regulation of bovine glutamate dehydrogenase. The effects of pH and ADP","volume":"257","author":"Bailey","year":"1982","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2023.175733_bib12","doi-asserted-by":"crossref","first-page":"13929","DOI":"10.1523\/JNEUROSCI.4413-09.2009","article-title":"Transgenic expression of Glud1 (glutamate dehydrogenase 1) in neurons: in vivo model of enhanced glutamate release, altered synaptic plasticity, and selective neuronal vulnerability","volume":"29","author":"Bao","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2023.175733_bib13","doi-asserted-by":"crossref","first-page":"e981","DOI":"10.1212\/NXI.0000000000000981","article-title":"Epigallocatechin gallate in relapsing-remitting multiple sclerosis: a randomized, placebo-controlled trial","volume":"8","author":"Bellmann-Strobl","year":"2021","journal-title":"Neurol. neuroimmunology & neuroinflammation"},{"key":"10.1016\/j.ejphar.2023.175733_bib14","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1007\/s12031-015-0695-2","article-title":"Multifactorial gene therapy enhancing the glutamate uptake system and reducing oxidative stress delays symptom onset and prolongs survival in the SOD1-G93A ALS mouse model","volume":"58","author":"Benkler","year":"2016","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.ejphar.2023.175733_bib15","doi-asserted-by":"crossref","first-page":"2652","DOI":"10.2174\/0929867328666210825105342","article-title":"Glutamate dehydrogenase as a promising target for hyperinsulinism hyperammonemia syndrome therapy","volume":"29","author":"Bian","year":"2022","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.ejphar.2023.175733_bib16","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.2174\/1381612826666200113162641","article-title":"Excitotoxicity as a target against neurodegenerative processes","volume":"26","author":"Binvignat","year":"2020","journal-title":"Curr. Pharmaceut. Des."},{"key":"10.1016\/j.ejphar.2023.175733_bib17","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1016\/S0140-6736(21)00218-X","article-title":"Parkinson's disease","volume":"397","author":"Bloem","year":"2021","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.ejphar.2023.175733_bib18","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.neurobiolaging.2021.05.011","article-title":"Brain energy metabolism and neurodegeneration: hints from CSF lactate levels in dementias","volume":"105","author":"Bonomi","year":"2021","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.ejphar.2023.175733_bib19","doi-asserted-by":"crossref","first-page":"31380","DOI":"10.1074\/jbc.M110.146084","article-title":"Estrogen modification of human glutamate dehydrogenases is linked to enzyme activation state","volume":"285","author":"Borompokas","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2023.175733_bib20","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1002\/jnr.24810","article-title":"Entering a new era of quantifying glutamate clearance in health and disease","volume":"99","author":"Brymer","year":"2021","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.ejphar.2023.175733_bib21","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.15252\/embj.201695810","article-title":"Brain metabolism in health, aging, and neurodegeneration","volume":"36","author":"Camandola","year":"2017","journal-title":"EMBO J."},{"key":"10.1016\/j.ejphar.2023.175733_bib22","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1111\/j.1471-4159.2008.05226.x","article-title":"Inhibition of ATF-3 expression by B-Raf mediates the neuroprotective action of GW5074","volume":"105","author":"Chen","year":"2008","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ejphar.2023.175733_bib23","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/0006-291X(66)90609-7","article-title":"Cooperative interaction between the GTP binding sites of glutamate dehydrogenase","volume":"22","author":"Colman","year":"1966","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejphar.2023.175733_bib24","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2022.894601","article-title":"GW5074 increases microglial phagocytic activities: potential therapeutic direction for alzheimer's disease","volume":"16","author":"Connor","year":"2022","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.ejphar.2023.175733_bib25","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.neuint.2010.11.011","article-title":"13N as a tracer for studying glutamate metabolism","volume":"59","author":"Cooper","year":"2011","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.ejphar.2023.175733_bib26","doi-asserted-by":"crossref","DOI":"10.3390\/biom6020016","article-title":"Central role of glutamate metabolism in the maintenance of nitrogen homeostasis in normal and hyperammonemic brain","volume":"6","author":"Cooper","year":"2016","journal-title":"Biomolecules"},{"key":"10.1016\/j.ejphar.2023.175733_bib27","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s10549-018-5060-z","article-title":"Glutamate dehydrogenase (GLUD1) expression in breast cancer","volume":"174","author":"Craze","year":"2019","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.ejphar.2023.175733_bib28","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/s41573-020-0072-x","article-title":"Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing","volume":"19","author":"Cunnane","year":"2020","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.ejphar.2023.175733_bib29","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1152\/physrev.00062.2017","article-title":"Brain glucose metabolism: integration of energetics with function","volume":"99","author":"Dienel","year":"2019","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ejphar.2023.175733_bib30","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.bbi.2020.11.038","article-title":"Glutaminase in microglia: a novel regulator of neuroinflammation","volume":"92","author":"Ding","year":"2021","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.ejphar.2023.175733_bib31","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.bcp.2018.07.023","article-title":"Chlorogenic acids inhibit glutamate dehydrogenase and decrease intracellular ATP levels in cultures of chick embryo retina cells","volume":"155","author":"Domith","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejphar.2023.175733_bib32","doi-asserted-by":"crossref","DOI":"10.1242\/dmm.047134","article-title":"Ammonia inhibits energy metabolism in astrocytes in a rapid and glutamate dehydrogenase 2-dependent manner","volume":"13","author":"Drews","year":"2020","journal-title":"Dis Model Mech"},{"key":"10.1016\/j.ejphar.2023.175733_bib33","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.molcel.2012.05.043","article-title":"Glutaminolysis activates Rag-mTORC1 signaling","volume":"47","author":"Duran","year":"2012","journal-title":"Mol Cell"},{"key":"10.1016\/j.ejphar.2023.175733_bib34","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/1098-1136(200010)32:1<15::AID-GLIA20>3.0.CO;2-#","article-title":"Specific alteration in the expression of glial fibrillary acidic protein, glutamate dehydrogenase, and glutamine synthetase in rats with genetic absence epilepsy","volume":"32","author":"Dutuit","year":"2000","journal-title":"Glia"},{"key":"10.1016\/j.ejphar.2023.175733_bib35","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1042\/bj1050691","article-title":"The equilibrium constants of the glutamate dehydrogenase systems","volume":"105","author":"Engel","year":"1967","journal-title":"Biochem. J."},{"key":"10.1016\/j.ejphar.2023.175733_bib36","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1042\/bj1150621","article-title":"Kinetic studies of glutamate dehydrogenase with glutamate and norvaline as substrates. Coenzyme activation and negative homotropic interactions in allosteric enzymes","volume":"115","author":"Engel","year":"1969","journal-title":"Biochem. J."},{"key":"10.1016\/j.ejphar.2023.175733_bib37","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1111\/j.1471-4159.1990.tb01967.x","article-title":"Activation of glutamate dehydrogenase by leucine and its nonmetabolizable analogue in rat brain synaptosomes","volume":"54","author":"Ereci\u0144ska","year":"1990","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ejphar.2023.175733_bib38","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/S0026-895X(25)15214-0","article-title":"Effects of chlorpromazine on glutamate dehydrogenase","volume":"6","author":"Fahien","year":"1970","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.ejphar.2023.175733_bib39","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1111\/jnc.14464","article-title":"Glutamate metabolism in cerebral mitochondria after ischemia and post-ischemic recovery during aging: relationships with brain energy metabolism","volume":"146","author":"Ferrari","year":"2018","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ejphar.2023.175733_bib40","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.23125","article-title":"Antidiabetic and neuroprotective effects of a novel repaglinide analog","author":"Foroumadi","year":"2022","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.ejphar.2023.175733_bib41","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/0006-3002(58)90364-0","article-title":"The dissociation of glutamic dehydrogenase by reduced diphosphopyridine nucleotide (DPNH)","volume":"27","author":"Frieden","year":"1958","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ejphar.2023.175733_bib42","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1016\/S0021-9258(18)97420-X","article-title":"Glutamate dehydrogenase. VI. Survey of purine nucleotide and other effects on the enzyme from various sources","volume":"240","author":"Frieden","year":"1965","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2023.175733_bib43","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1242\/dmm.030205","article-title":"Neurodegenerative disease: models, mechanisms, and a new hope","volume":"10","author":"Gitler","year":"2017","journal-title":"Dis Model Mech"},{"key":"10.1016\/j.ejphar.2023.175733_bib44","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s00702-020-02158-2","article-title":"Genes to treat excitotoxicity ameliorate the symptoms of the disease in mice models of multiple system atrophy","volume":"127","author":"Glat","year":"2020","journal-title":"J. Neural. Transm."},{"key":"10.1016\/j.ejphar.2023.175733_bib45","article-title":"Glutamate dehydrogenase activator BCH stimulating reductive amination prevents high fat\/high fructose diet-induced steatohepatitis and hyperglycemia in C57BL\/6J mice","volume":"5","author":"Han","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejphar.2023.175733_bib46","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19041177","article-title":"Structure-function relationship of transporters in the glutamate-glutamine cycle of the central nervous system","volume":"19","author":"Hayashi","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2023.175733_bib47","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1111\/jnc.15207","article-title":"Brain endothelial cells metabolize glutamate via glutamate dehydrogenase to replenish TCA-intermediates and produce ATP under hypoglycemic conditions","volume":"157","author":"Hinca","year":"2021","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ejphar.2023.175733_bib48","doi-asserted-by":"crossref","first-page":"4195","DOI":"10.1021\/acs.biochem.9b00722","article-title":"Dissecting the antenna in human glutamate dehydrogenase: understanding its role in subunit communication and allosteric regulation","volume":"58","author":"Hoffpauir","year":"2019","journal-title":"Biochemistry"},{"key":"10.1016\/j.ejphar.2023.175733_bib49","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1177\/0271678X17714680","article-title":"Glutamate dehydrogenase is essential to sustain neuronal oxidative energy metabolism during stimulation","volume":"38","author":"Hohnholt","year":"2018","journal-title":"J. Cerebr. Blood Flow Metabol."},{"key":"10.1016\/j.ejphar.2023.175733_bib50","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.neuint.2017.10.014","article-title":"Distribution of the branched-chain alpha-ketoacid dehydrogenase complex E1alpha subunit and glutamate dehydrogenase in the human brain and their role in neuro-metabolism","volume":"112","author":"Hull","year":"2018","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.ejphar.2023.175733_bib51","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1136\/jnnp-2019-322338","article-title":"Parkinson's disease: etiopathogenesis and treatment","volume":"91","author":"Jankovic","year":"2020","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.ejphar.2023.175733_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114827","article-title":"Chandamarutha Chenduram, an Indian traditional Siddha preparation attenuated the neuronal degeneration in ischemic mice through ameliorating cytokines and oxy-radicals mediated EAAT-2 dysfunction","volume":"284","author":"Justin","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.ejphar.2023.175733_bib53","doi-asserted-by":"crossref","first-page":"2813","DOI":"10.1042\/BCJ20160535","article-title":"Import of a major mitochondrial enzyme depends on synergy between two distinct helices of its presequence","volume":"473","author":"Kalef-Ezra","year":"2016","journal-title":"Biochem. J."},{"key":"10.1016\/j.ejphar.2023.175733_bib54","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1530\/EJE-09-0615","article-title":"Hyperinsulinism-hyperammonaemia syndrome: novel mutations in the GLUD1 gene and genotype-phenotype correlations","volume":"161","author":"Kapoor","year":"2009","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.ejphar.2023.175733_bib55","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.neuint.2011.03.024","article-title":"From pancreatic islets to central nervous system, the importance of glutamate dehydrogenase for the control of energy homeostasis","volume":"59","author":"Karaca","year":"2011","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.ejphar.2023.175733_bib56","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.celrep.2015.09.003","article-title":"GDH-dependent glutamate oxidation in the brain dictates peripheral energy substrate distribution","volume":"13","author":"Karaca","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.ejphar.2023.175733_bib57","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.2337\/db17-1561","article-title":"Liver glutamate dehydrogenase controls whole-body energy partitioning through amino acid-derived gluconeogenesis and ammonia homeostasis","volume":"67","author":"Karaca","year":"2018","journal-title":"Diabetes"},{"key":"10.1016\/j.ejphar.2023.175733_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2019.05.021","article-title":"Structural and molecular aspects of betaine-GABA transporter 1 (BGT1) and its relation to brain function","volume":"161","author":"Kickinger","year":"2019","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ejphar.2023.175733_bib59","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s11064-018-2467-1","article-title":"Glutamate dehydrogenase as a neuroprotective target against neurodegeneration","volume":"44","author":"Kim","year":"2019","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.ejphar.2023.175733_bib60","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.neuroscience.2016.11.007","article-title":"Glutamate dehydrogenase as a neuroprotective target against brain ischemia and reperfusion","volume":"340","author":"Kim","year":"2017","journal-title":"Neuroscience"},{"key":"10.1016\/j.ejphar.2023.175733_bib61","doi-asserted-by":"crossref","first-page":"S143","DOI":"10.1016\/S0893-133X(99)00102-5","article-title":"Therapeutic implications of the hyperglutamatergic effects of NMDA antagonists","volume":"21","author":"Krystal","year":"1999","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.ejphar.2023.175733_bib62","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1002\/hipo.20015","article-title":"Developmental expression of glutamate transporters and glutamate dehydrogenase in astrocytes of the postnatal rat hippocampus","volume":"14","author":"Kugler","year":"2004","journal-title":"Hippocampus"},{"key":"10.1016\/j.ejphar.2023.175733_bib63","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.pneurobio.2013.11.006","article-title":"Excitotoxicity and stroke: identifying novel targets for neuroprotection","volume":"115","author":"Lai","year":"2014","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.ejphar.2023.175733_bib64","doi-asserted-by":"crossref","DOI":"10.1111\/gbb.12636","article-title":"Glutamate dehydrogenase deficiency disrupts glutamate homeostasis in hippocampus and prefrontal cortex and impairs recognition memory","volume":"19","author":"Lander","year":"2020","journal-title":"Gene Brain Behav."},{"key":"10.1016\/j.ejphar.2023.175733_bib65","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1093\/schbul\/sby011","article-title":"Glutamate dehydrogenase-deficient mice display schizophrenia-like behavioral abnormalities and CA1-specific hippocampal dysfunction","volume":"45","author":"Lander","year":"2019","journal-title":"Schizophr. Bull."},{"key":"10.1016\/j.ejphar.2023.175733_bib66","doi-asserted-by":"crossref","first-page":"34164","DOI":"10.1074\/jbc.M111.268599","article-title":"Green tea polyphenols control dysregulated glutamate dehydrogenase in transgenic mice by hijacking the ADP activation site","volume":"286","author":"Li","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2023.175733_bib67","doi-asserted-by":"crossref","first-page":"15064","DOI":"10.1074\/jbc.M600994200","article-title":"Effects of a GTP-insensitive mutation of glutamate dehydrogenase on insulin secretion in transgenic mice","volume":"281","author":"Li","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2023.175733_bib68","doi-asserted-by":"crossref","first-page":"2853","DOI":"10.1074\/jbc.M210577200","article-title":"Regulation of leucine-stimulated insulin secretion and glutamine metabolism in isolated rat islets","volume":"278","author":"Li","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2023.175733_bib69","doi-asserted-by":"crossref","first-page":"15089","DOI":"10.1021\/bi7018783","article-title":"High throughput screening reveals several new classes of glutamate dehydrogenase inhibitors","volume":"46","author":"Li","year":"2007","journal-title":"Biochemistry"},{"key":"10.1016\/j.ejphar.2023.175733_bib70","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.abb.2011.10.015","article-title":"The structure and allosteric regulation of mammalian glutamate dehydrogenase","volume":"519","author":"Li","year":"2012","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.ejphar.2023.175733_bib71","doi-asserted-by":"crossref","first-page":"22988","DOI":"10.1074\/jbc.M109.020222","article-title":"Novel inhibitors complexed with glutamate dehydrogenase: allosteric regulation by control of protein dynamics","volume":"284","author":"Li","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2023.175733_bib72","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1038\/s41598-018-37509-3","article-title":"The ability to utilise ammonia as nitrogen source is cell type specific and intricately linked to GDH, AMPK and mTORC1","volume":"9","author":"Lie","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejphar.2023.175733_bib73","doi-asserted-by":"crossref","DOI":"10.1007\/s00210-022-02252-0","article-title":"GDH promotes isoprenaline-induced cardiac hypertrophy by activating mTOR signaling via elevation of \u03b1-ketoglutarate level","author":"Lin","year":"2022","journal-title":"N. Schmied. Arch. Pharmacol."},{"key":"10.1016\/j.ejphar.2023.175733_bib74","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.neuron.2020.08.012","article-title":"Astrocyte crosstalk in CNS inflammation","volume":"108","author":"Linnerbauer","year":"2020","journal-title":"Neuron"},{"key":"10.1016\/j.ejphar.2023.175733_bib75","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1192\/bjp.2019.127","article-title":"Polygenic effects of schizophrenia on hippocampal grey matter volume and hippocampus-medial prefrontal cortex functional connectivity","volume":"216","author":"Liu","year":"2020","journal-title":"Br. J. Psychiatry : J. Ment. Sci."},{"key":"10.1016\/j.ejphar.2023.175733_bib76","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114561","article-title":"Role of Glutamine-Glutamate\/GABA cycle and potential target GLUD2 in alleviation of rheumatoid arthritis by Tripterygium hypoglaucum (levl.) Hutch based on metabolomics and molecular pharmacology","volume":"281","author":"Long","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.ejphar.2023.175733_bib77","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1111\/j.1528-1167.2006.00543.x","article-title":"Differential glutamate dehydrogenase (GDH) activity profile in patients with temporal lobe epilepsy","volume":"47","author":"Malthankar-Phatak","year":"2006","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejphar.2023.175733_bib78","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1139\/O09-008","article-title":"Human GLUD1 and GLUD2 glutamate dehydrogenase localize to mitochondria and endoplasmic reticulum","volume":"87","author":"Mastorodemos","year":"2009","journal-title":"Biochem. Cell. Biol."},{"key":"10.1016\/j.ejphar.2023.175733_bib79","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1007\/s11064-018-2575-y","article-title":"Localization of human glutamate dehydrogenases provides insights into their metabolic role and their involvement in disease processes","volume":"44","author":"Mathioudakis","year":"2019","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.ejphar.2023.175733_bib80","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1242\/jcs.060749","article-title":"Weak mitochondrial targeting sequence determines tissue-specific subcellular localization of glutamine synthetase in liver and brain cells","volume":"123","author":"Matthews","year":"2010","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.ejphar.2023.175733_bib81","doi-asserted-by":"crossref","first-page":"3494","DOI":"10.1073\/pnas.85.10.3494","article-title":"Isolation and characterization of cDNA clones encoding human liver glutamate dehydrogenase: evidence for a small gene family","volume":"85","author":"Mavrothalassitis","year":"1988","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejphar.2023.175733_bib82","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0197-0186(00)00042-5","article-title":"Dierential distribution of the enzymes glutamate dehydrogenase and aspartate aminotransferase in cortical synaptic mitochondria contributes to metabolic compartmentation in cortical synaptic terminals","volume":"37","author":"McKenna","year":"2000","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.ejphar.2023.175733_bib83","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1007\/s12031-018-1143-x","article-title":"Combined gene therapy to reduce the neuronal damage in the mouse model of focal ischemic injury","volume":"66","author":"Molcho","year":"2018","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.ejphar.2023.175733_bib84","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.nbd.2013.12.017","article-title":"Hyperleucinemia causes hippocampal retromer deficiency linking diabetes to Alzheimer's disease","volume":"65","author":"Morabito","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.ejphar.2023.175733_bib85","doi-asserted-by":"crossref","first-page":"429","DOI":"10.3389\/fonc.2020.00429","article-title":"Physiological role of glutamate dehydrogenase in cancer cells","volume":"10","author":"Moreno-Sanchez","year":"2020","journal-title":"Front. Oncol."},{"key":"10.1016\/j.ejphar.2023.175733_bib86","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.bbr.2016.06.002","article-title":"Hippocampal proteomics defines pathways associated with memory decline and resilience in normal aging and Alzheimer's disease mouse models","volume":"322","author":"Neuner","year":"2017","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ejphar.2023.175733_bib87","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1002\/glia.23105","article-title":"Expression of the human isoform of glutamate dehydrogenase, hGDH2, augments TCA cycle capacity and oxidative metabolism of glutamate during glucose deprivation in astrocytes","volume":"65","author":"Nissen","year":"2017","journal-title":"Glia"},{"key":"10.1016\/j.ejphar.2023.175733_bib88","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s00726-021-02943-7","article-title":"High performance liquid chromatography determination of L-glutamate, L-glutamine and glycine content in brain, cerebrospinal fluid and blood serum of patients affected by Alzheimer's disease","volume":"53","author":"Nuzzo","year":"2021","journal-title":"Amino acids"},{"key":"10.1016\/j.ejphar.2023.175733_bib89","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1021\/pr800667a","article-title":"Proteomics-determined differences in the concanavalin-A-fractionated proteome of hippocampus and inferior parietal lobule in subjects with Alzheimer's disease and mild cognitive impairment: implications for progression of AD","volume":"8","author":"Owen","year":"2009","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.ejphar.2023.175733_bib90","doi-asserted-by":"crossref","first-page":"605","DOI":"10.3389\/fneur.2019.00605","article-title":"Comprehensive profile of acute mitochondrial dysfunction in a preclinical model of severe penetrating TBI","volume":"10","author":"Pandya","year":"2019","journal-title":"Front. Neurol."},{"key":"10.1016\/j.ejphar.2023.175733_bib91","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1002\/ana.410150206","article-title":"Neurological disorders associated with deficiency of glutamate dehydrogenase","volume":"15","author":"Plaitakis","year":"1984","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.ejphar.2023.175733_bib92","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3390\/biology6010011","article-title":"The glutamate dehydrogenase pathway and its roles in cell and tissue biology in health and disease","volume":"6","author":"Plaitakis","year":"2017","journal-title":"Biology"},{"key":"10.1016\/j.ejphar.2023.175733_bib93","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1007\/s11064-018-2546-3","article-title":"Transgenic mice carrying GLUD2 as a tool for studying the expressional and the functional adaptation of this positive selected gene in human brain evolution","volume":"44","author":"Plaitakis","year":"2019","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.ejphar.2023.175733_bib94","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/ejhg.2009.179","article-title":"Gain-of-function variant in GLUD2 glutamate dehydrogenase modifies Parkinson's disease onset","volume":"18","author":"Plaitakis","year":"2010","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.ejphar.2023.175733_bib95","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.neuint.2011.03.015","article-title":"The human GLUD2 glutamate dehydrogenase and its regulation in health and disease","volume":"59","author":"Plaitakis","year":"2011","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.ejphar.2023.175733_bib96","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S0197-0186(03)00028-7","article-title":"Study of structure\u2013function relationships in human glutamate dehydrogenases reveals novel molecular mechanisms for the regulation of the nerve tissue-specific (GLUD2) isoenzyme","volume":"43","author":"Plaitakis","year":"2003","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.ejphar.2023.175733_bib97","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1002\/jnr.23176","article-title":"Deregulation of glutamate dehydrogenase in human neurologic disorders","volume":"91","author":"Plaitakis","year":"2013","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.ejphar.2023.175733_bib98","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.biocel.2017.01.012","article-title":"Epigallocatechin-3-gallate (EGCG) activates AMPK through the inhibition of glutamate dehydrogenase in muscle and pancreatic \u00df-cells: a potential beneficial effect in the pre-diabetic state?","volume":"88","author":"Pournourmohammadi","year":"2017","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.ejphar.2023.175733_bib99","doi-asserted-by":"crossref","first-page":"44","DOI":"10.17116\/jnevro20161163144-48","article-title":"Glutamate dehydrogenase activity in platelets of patients with endogenous psychosis","volume":"116","author":"Prokhorova capital Te","year":"2016","journal-title":"Zh. Nevrol. Psikhiatr. Im. S S Korsakova"},{"key":"10.1016\/j.ejphar.2023.175733_bib100","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.jpeds.2004.10.040","article-title":"Central nervous system hyperexcitability associated with glutamate dehydrogenase gain of function mutations","volume":"146","author":"Raizen","year":"2005","journal-title":"J. Pediatr."},{"key":"10.1016\/j.ejphar.2023.175733_bib101","doi-asserted-by":"crossref","DOI":"10.3390\/ph15040485","article-title":"The potential use of ebselen in treatment-resistant depression","volume":"15","author":"Ramli","year":"2022","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.ejphar.2023.175733_bib102","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1515\/acph-2015-0033","article-title":"Modulation of brain glutamate dehydrogenase as a tool for controlling seizures","volume":"65","author":"Rasgado","year":"2015","journal-title":"Acta Pharm."},{"key":"10.1016\/j.ejphar.2023.175733_bib103","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1186\/s13023-022-02398-3","article-title":"Characterizing the neurological phenotype of the hyperinsulinism hyperammonemia syndrome","volume":"17","author":"Rosenfeld","year":"2022","journal-title":"Orphanet J. Rare Dis."},{"key":"10.1016\/j.ejphar.2023.175733_bib104","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/35002090","article-title":"Glutamate release in severe brain ischaemia is mainly by reversed uptake","volume":"403","author":"Rossi","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2023.175733_bib105","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-1-4939-0835-6_1","article-title":"Pseudogene redux with new biological significance","volume":"1167","author":"Salmena","year":"2014","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.ejphar.2023.175733_bib106","first-page":"54","article-title":"Platelet glutamate dehydrogenase activity and efficacy of antipsychotic therapy in patients with schizophrenia","volume":"39","author":"Savushkina","year":"2020","journal-title":"J. Med. Biochem."},{"key":"10.1016\/j.ejphar.2023.175733_bib107","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/s41419-018-0273-y","article-title":"Canagliflozin mediated dual inhibition of mitochondrial glutamate dehydrogenase and complex I: an off-target adverse effect","volume":"9","author":"Secker","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ejphar.2023.175733_bib108","doi-asserted-by":"crossref","first-page":"173","DOI":"10.3389\/fnagi.2017.00173","article-title":"Divergent metabolic regulation of autophagy and mTORC1\u2014early events in Alzheimer's disease?","volume":"9","author":"Shafei","year":"2017","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.ejphar.2023.175733_bib109","doi-asserted-by":"crossref","first-page":"16971","DOI":"10.1016\/S0021-9258(19)89484-X","article-title":"Novel human glutamate dehydrogenase expressed in neural and testicular tissues and encoded by an X-linked intronless gene","volume":"269","author":"Shashidharan","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2023.175733_bib110","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2021.579806","article-title":"Drug repurposing: in vitro and in vivo antimicrobial and antibiofilm effects of bithionol against Enterococcus faecalis and Enterococcus faecium","volume":"12","author":"She","year":"2021","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.ejphar.2023.175733_bib111","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.neuint.2012.04.014","article-title":"siRNA knock down of glutamate dehydrogenase in astrocytes affects glutamate metabolism leading to extensive accumulation of the neuroactive amino acids glutamate and aspartate","volume":"61","author":"Skytt","year":"2012","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.ejphar.2023.175733_bib112","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s11064-017-2428-0","article-title":"Glutamate dehydrogenase, a complex enzyme at a crucial metabolic branch point","volume":"44","author":"Smith","year":"2019","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.ejphar.2023.175733_bib113","doi-asserted-by":"crossref","first-page":"6568","DOI":"10.1021\/acs.biochem.6b00979","article-title":"Identification of a novel activator of mammalian glutamate dehydrogenase","volume":"55","author":"Smith","year":"2016","journal-title":"Biochemistry"},{"key":"10.1016\/j.ejphar.2023.175733_bib114","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1006\/jmbi.2001.4499","article-title":"Structures of bovine glutamate dehydrogenase complexes elucidate the mechanism of purine regulation","volume":"307","author":"Smith","year":"2001","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.ejphar.2023.175733_bib115","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/S0022-2836(02)00161-4","article-title":"The structure of apo human glutamate dehydrogenase details subunit communication and allostery","volume":"318","author":"Smith","year":"2002","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.ejphar.2023.175733_bib116","doi-asserted-by":"crossref","first-page":"3645","DOI":"10.1172\/JCI71886","article-title":"Extrasynaptic glutamate release through cystine\/glutamate antiporter contributes to ischemic damage","volume":"124","author":"Soria","year":"2014","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ejphar.2023.175733_bib117","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1007\/s11064-013-1235-5","article-title":"Heterogeneous cellular distribution of glutamate dehydrogenase in brain and in non-neural tissues","volume":"39","author":"Spanaki","year":"2014","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.ejphar.2023.175733_bib118","doi-asserted-by":"crossref","first-page":"16748","DOI":"10.1074\/jbc.M109.092999","article-title":"Human GLUD2 glutamate dehydrogenase is expressed in neural and testicular supporting cells","volume":"285","author":"Spanaki","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2023.175733_bib119","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.neuint.2012.05.020","article-title":"The complex regulation of human glud1 and glud2 glutamate dehydrogenases and its implications in nerve tissue biology","volume":"61","author":"Spanaki","year":"2012","journal-title":"Neurochem. Int."},{"issue":"Suppl. 1","key":"10.1016\/j.ejphar.2023.175733_bib120","doi-asserted-by":"crossref","first-page":"S45","DOI":"10.1016\/j.ymgme.2003.10.013","article-title":"Hyperinsulinism\/hyperammonemia syndrome: insights into the regulatory role of glutamate dehydrogenase in ammonia metabolism","volume":"81","author":"Stanley","year":"2004","journal-title":"Mol. Genet. Metabol."},{"key":"10.1016\/j.ejphar.2023.175733_bib121","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1056\/NEJM199805073381904","article-title":"Hyperinsulinism and hyperammonemia in infants with regulatory mutations of the glutamate dehydrogenase gene","volume":"338","author":"Stanley","year":"1998","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejphar.2023.175733_bib122","doi-asserted-by":"crossref","first-page":"3489","DOI":"10.1007\/s00018-015-1937-8","article-title":"Glutamate transporter EAAT2: regulation, function, and potential as a therapeutic target for neurological and psychiatric disease","volume":"72","author":"Takahashi","year":"2015","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.ejphar.2023.175733_bib123","doi-asserted-by":"crossref","first-page":"101","DOI":"10.17116\/jnevro2017117111101-107","article-title":"Comparative study of glutamate dehydrogenase in the brain of patients with schizophrenia and mentally healthy people","volume":"117","author":"Tereshkina","year":"2017","journal-title":"Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova"},{"key":"10.1016\/j.ejphar.2023.175733_bib124","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1002\/ana.410210603","article-title":"Neocortical cell counts in normal human adult aging","volume":"21","author":"Terry","year":"1987","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.ejphar.2023.175733_bib125","doi-asserted-by":"crossref","first-page":"9607","DOI":"10.3390\/ijms21249607","article-title":"The regulation of astrocytic glutamate transporters in health and neurodegenerative diseases","volume":"21","author":"Todd","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2023.175733_bib126","doi-asserted-by":"crossref","first-page":"4100","DOI":"10.1038\/s41467-021-24353-9","article-title":"Redirected nuclear glutamate dehydrogenase supplies Tet3 with alpha-ketoglutarate in neurons","volume":"12","author":"Traube","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejphar.2023.175733_bib127","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.advenzreg.2009.10.029","article-title":"On the reversibility of glutamate dehydrogenase and the source of hyperammonemia in the hyperinsulinism\/hyperammonemia syndrome","volume":"50","author":"Treberg","year":"2010","journal-title":"Adv. Enzym. Regul."},{"key":"10.1016\/j.ejphar.2023.175733_bib128","doi-asserted-by":"crossref","DOI":"10.5402\/2012\/295853","article-title":"Anticonvulsant drugs, brain glutamate dehydrogenase activity and oxygen consumption","author":"Vega Rasgado","year":"2012","journal-title":"ISRN Pharmacol"},{"key":"10.1016\/j.ejphar.2023.175733_bib129","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1002\/glia.23808","article-title":"AMP-activated protein kinase (AMPK) regulates astrocyte oxidative metabolism by balancing TCA cycle dynamics","volume":"68","author":"Voss","year":"2020","journal-title":"Glia"},{"key":"10.1016\/j.ejphar.2023.175733_bib130","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2021.646291","article-title":"Glutamate dehydrogenase is important for ammonia fixation and amino acid homeostasis in brain during hyperammonemia","volume":"15","author":"Voss","year":"2021","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.ejphar.2023.175733_bib131","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.2217\/bmm-2021-0222","article-title":"Safety and disease monitoring biomarkers in Duchenne muscular dystrophy: results from a Phase II trial","volume":"15","author":"Wagner","year":"2021","journal-title":"Biomarkers Med."},{"key":"10.1016\/j.ejphar.2023.175733_bib132","doi-asserted-by":"crossref","first-page":"4351","DOI":"10.3390\/ijms23084351","article-title":"Glucose metabolism, neural cell senescence and alzheimer's disease","volume":"23","author":"Wang","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2023.175733_bib133","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1186\/1471-2164-11-360","article-title":"Transcriptomic responses in mouse brain exposed to chronic excess of the neurotransmitter glutamate","volume":"11","author":"Wang","year":"2010","journal-title":"BMC Genom."},{"key":"10.1016\/j.ejphar.2023.175733_bib134","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.molcel.2019.07.007","article-title":"\u03b1-Ketoglutarate-Activated NF-\u03baB signaling promotes compensatory glucose uptake and brain tumor development","volume":"76","author":"Wang","year":"2019","journal-title":"Mol Cell"},{"key":"10.1016\/j.ejphar.2023.175733_bib135","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1152\/japplphysiol.01077.2017","article-title":"Glutamate dehydrogenase: role in regulating metabolism and insulin release in pancreatic \u03b2-cells","volume":"125","author":"Wilson","year":"2018","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.ejphar.2023.175733_bib136","doi-asserted-by":"crossref","first-page":"3003","DOI":"10.1021\/acschembio.7b00728","article-title":"Ebselen: mechanisms of glutamate dehydrogenase and glutaminase enzyme inhibition","volume":"12","author":"Yu","year":"2017","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.ejphar.2023.175733_bib137","article-title":"The pharmacological activity of epigallocatechin-3-gallate (EGCG) on Alzheimer's disease animal model: a systematic review. Phytomedicine","volume":"79","author":"Zhang","year":"2020","journal-title":"Int. J. Phytother. Phytopharm."},{"key":"10.1016\/j.ejphar.2023.175733_bib138","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1038\/s41419-020-03043-2","article-title":"Functional validation of a human GLUD2 variant in a murine model of Parkinson's disease","volume":"11","author":"Zhang","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ejphar.2023.175733_bib139","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.tig.2007.03.003","article-title":"The ambiguous boundary between genes and pseudogenes: the dead rise up, or do they?","volume":"23","author":"Zheng","year":"2007","journal-title":"Trends Genet. : TIG (Trends Genet.)"},{"key":"10.1016\/j.ejphar.2023.175733_bib140","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1515\/hsz-2021-0172","article-title":"Rapid metabolic and bioenergetic adaptations of astrocytes under hyperammonemia \u2013 a novel perspective on hepatic encephalopathy","volume":"402","author":"Zimmermann","year":"2021","journal-title":"Biol. Chem."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299923002443?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299923002443?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T04:22:54Z","timestamp":1762143774000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299923002443"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":140,"alternative-id":["S0014299923002443"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2023.175733","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Glutamate dehydrogenase: Potential therapeutic targets for neurodegenerative disease","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2023.175733","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"175733"}}