{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T22:41:23Z","timestamp":1793659283626,"version":"4.5.1"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of\u00a0Hunan Province","doi-asserted-by":"publisher","award":["2023JJ30092"],"award-info":[{"award-number":["2023JJ30092"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.ejphar.2023.175801","type":"journal-article","created":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T23:12:34Z","timestamp":1684365154000},"page":"175801","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":74,"special_numbering":"C","title":["A comparative study of the neuroprotective effects of dl-3-n-butylphthalide and edaravone dexborneol on cerebral ischemic stroke rats"],"prefix":"10.1016","volume":"951","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4513-5606","authenticated-orcid":false,"given":"Hui","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laifa","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bi","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongping","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanhai","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueqin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binsheng","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhui","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2023.175801_bib1","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/5012341","article-title":"A review of recent advances in neuroprotective potential of 3-n-butylphthalide and its derivatives","author":"Abdoulaye","year":"2016","journal-title":"BioMed Res. Int."},{"issue":"13","key":"10.1016\/j.ejphar.2023.175801_bib2","doi-asserted-by":"crossref","DOI":"10.1128\/MCB.00099-20","article-title":"The molecular mechanisms regulating the KEAP1-NRF2 pathway","volume":"40","author":"Baird","year":"2020","journal-title":"Mol. Cell Biol."},{"issue":"11","key":"10.1016\/j.ejphar.2023.175801_bib3","doi-asserted-by":"crossref","first-page":"3302","DOI":"10.1161\/STROKEAHA.115.010508","article-title":"Collateral circulation in ischemic stroke: assessment tools and therapeutic strategies","volume":"46","author":"Bang","year":"2015","journal-title":"Stroke"},{"issue":"1","key":"10.1016\/j.ejphar.2023.175801_bib4","doi-asserted-by":"crossref","first-page":"867","DOI":"10.3892\/mmr.2015.4606","article-title":"Effects of miR-590 on oxLDL-induced endothelial cell apoptosis: roles of p53 and NF-\u03baB","volume":"13","author":"Bao","year":"2016","journal-title":"Mol. Med. Rep."},{"issue":"6","key":"10.1016\/j.ejphar.2023.175801_bib5","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1016\/j.jstrokecerebrovasdis.2018.01.010","article-title":"Meta-analysis on the association between brain-derived neurotrophic factor polymorphism rs6265 and ischemic stroke, poststroke depression","volume":"27","author":"Bao","year":"2018","journal-title":"J. Stroke Cerebrovasc. Dis."},{"issue":"8","key":"10.1016\/j.ejphar.2023.175801_bib6","doi-asserted-by":"crossref","first-page":"7090","DOI":"10.1007\/s12035-018-1136-3","article-title":"Docosanoids promote neurogenesis and angiogenesis, blood-brain barrier integrity, penumbra protection, and neurobehavioral recovery after experimental ischemic stroke","volume":"55","author":"Belayev","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.ejphar.2023.175801_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2019.113059","article-title":"Activation of endothelial ras-related C3 botulinum toxin substrate 1 (Rac1) improves post-stroke recovery and angiogenesis via activating Pak1 in mice","volume":"322","author":"Bu","year":"2019","journal-title":"Exp. Neurol."},{"issue":"4","key":"10.1016\/j.ejphar.2023.175801_bib8","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1172\/JCI124283","article-title":"Calcium-dependent blood-brain barrier breakdown by NOX5 limits postreperfusion benefit in stroke","volume":"129","author":"Casas","year":"2019","journal-title":"J. Clin. Invest."},{"issue":"19","key":"10.1016\/j.ejphar.2023.175801_bib9","first-page":"6448","article-title":"Research on changes in cognitive function, \u03b2-amyloid peptide and neurotrophic factor in stroke patients","volume":"22","author":"Chen","year":"2018","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"issue":"7","key":"10.1016\/j.ejphar.2023.175801_bib10","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1211\/jpp.62.07.0013","article-title":"The orally combined neuroprotective effects of sodium ferulate and borneol against transient global ischaemia in C57 BL\/6J mice","volume":"62","author":"Chen","year":"2010","journal-title":"J. Pharm. Pharmacol."},{"issue":"2","key":"10.1016\/j.ejphar.2023.175801_bib11","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1590\/1980-57642021dn15-020010","article-title":"Clinical correlates of social cognition after an ischemic stroke: preliminary findings","volume":"15","author":"de Souza","year":"2021","journal-title":"Dement. Neuropsychol."},{"key":"10.1016\/j.ejphar.2023.175801_bib12","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.bbrc.2021.04.006","article-title":"Dl-3-n-butylphthalide pretreatment attenuates renal ischemia\/reperfusion injury","volume":"557","author":"Dong","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"9","key":"10.1016\/j.ejphar.2023.175801_bib13","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.2174\/1570159X16666180222155833","article-title":"The role of inflammatory response in stroke associated programmed cell death","volume":"16","author":"Duris","year":"2018","journal-title":"Curr. Neuropharmacol."},{"issue":"4","key":"10.1016\/j.ejphar.2023.175801_bib14","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1515\/revneuro-2017-0065","article-title":"Mechanisms of action of intravenous immunoglobulin in septic encephalopathy","volume":"29","author":"Esen","year":"2018","journal-title":"Rev. Neurosci."},{"issue":"10","key":"10.1016\/j.ejphar.2023.175801_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.jstrokecerebrovasdis.2019.07.015","article-title":"Cognitive rehabilitation improves ischemic stroke-induced cognitive impairment: role of growth factors","volume":"28","author":"Farokhi-Sisakht","year":"2019","journal-title":"J. Stroke Cerebrovasc. Dis."},{"issue":"12","key":"10.1016\/j.ejphar.2023.175801_bib16","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1016\/j.amjmed.2021.07.027","article-title":"Ischemic stroke","volume":"134","author":"Feske","year":"2021","journal-title":"Am. J. Med."},{"key":"10.1016\/j.ejphar.2023.175801_bib17","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.pneurobio.2016.06.006","article-title":"Mitochondrial function in hypoxic ischemic injury and influence of aging","volume":"157","author":"Ham","year":"2017","journal-title":"Prog. Neurobiol."},{"issue":"11","key":"10.1016\/j.ejphar.2023.175801_bib18","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1097\/CCM.0000000000004597","article-title":"Management of acute ischemic stroke","volume":"48","author":"Herpich","year":"2020","journal-title":"Crit. Care Med."},{"issue":"8","key":"10.1016\/j.ejphar.2023.175801_bib19","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/aps.2015.31","article-title":"The edaravone and 3-n-butylphthalide ring-opening derivative 10b effectively attenuates cerebral ischemia injury in rats","volume":"36","author":"Hua","year":"2015","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.ejphar.2023.175801_bib20","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.neuroscience.2019.06.020","article-title":"Dl-3-N-butylphthalide alleviates the blood-brain barrier permeability of focal cerebral ischemia reperfusion in mice","volume":"413","author":"Li","year":"2019","journal-title":"Neuroscience"},{"issue":"9","key":"10.1016\/j.ejphar.2023.175801_bib21","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.4103\/1673-5374.191224","article-title":"Effects of triptolide on hippocampal microglial cells and astrocytes in the APP\/PS1 double transgenic mouse model of Alzheimer's disease","volume":"11","author":"Li","year":"2016","journal-title":"Neural Regen. Res."},{"issue":"1","key":"10.1016\/j.ejphar.2023.175801_bib22","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1186\/s12974-020-01946-7","article-title":"Cottonseed oil alleviates ischemic stroke injury by inhibiting the inflammatory activation of microglia and astrocyte","volume":"17","author":"Liu","year":"2020","journal-title":"J. Neuroinflammation"},{"issue":"1","key":"10.1016\/j.ejphar.2023.175801_bib23","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1161\/01.STR.20.1.84","article-title":"Reversible middle cerebral artery occlusion without craniectomy in rats","volume":"20","author":"Longa","year":"1989","journal-title":"Stroke"},{"issue":"10","key":"10.1016\/j.ejphar.2023.175801_bib24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0186700","article-title":"Chronic administration of fluoxetine and pro-inflammatory cytokine change in a rat model of depression","volume":"12","author":"Lu","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2023.175801_bib25","article-title":"Novel object recognition test for the investigation of learning and memory in mice","volume":"126","author":"Lueptow","year":"2017","journal-title":"J. Vis. Exp."},{"issue":"18","key":"10.1016\/j.ejphar.2023.175801_bib26","doi-asserted-by":"crossref","first-page":"6454","DOI":"10.3390\/ijms21186454","article-title":"Neuroinflammatory mechanisms in ischemic stroke: focus on cardioembolic stroke, background, and therapeutic approaches","volume":"21","author":"Maida","year":"2020","journal-title":"Int. J. Mol. Sci. Sep."},{"issue":"3","key":"10.1016\/j.ejphar.2023.175801_bib27","doi-asserted-by":"crossref","first-page":"817","DOI":"10.3233\/JAD-190861","article-title":"Can social cognition measurements differentiate behavioral variant frontotemporal dementia from Alzheimer's disease regardless of apathy?","volume":"74","author":"Mariano","year":"2020","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.ejphar.2023.175801_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.nlm.2020.107301","article-title":"The critical role of the hippocampal NLRP3 inflammasome in social isolation-induced cognitive impairment in male mice","volume":"175","author":"Niu","year":"2020","journal-title":"Neurobiol. Learn. Mem."},{"issue":"34","key":"10.1016\/j.ejphar.2023.175801_bib29","doi-asserted-by":"crossref","first-page":"4246","DOI":"10.2174\/1381612826666200708133912","article-title":"Pathophysiology of ischemic stroke: role of oxidative stress","volume":"26","author":"Orellana-Urz\u00faa","year":"2020","journal-title":"Curr. Pharmaceut. Des."},{"key":"10.1016\/j.ejphar.2023.175801_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2020.113518","article-title":"Emerging neuroprotective strategies for the treatment of ischemic stroke: an overview of clinical and preclinical studies","volume":"335","author":"Paul","year":"2021","journal-title":"Exp. Neurol."},{"issue":"4","key":"10.1016\/j.ejphar.2023.175801_bib31","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.jstrokecerebrovasdis.2006.04.002","article-title":"Use of an optimized transient occlusion of the middle cerebral artery protocol for the mouse stroke model","volume":"15","author":"Shah","year":"2006","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"10.1016\/j.ejphar.2023.175801_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2020.113308","article-title":"Neuroprotective and neuro-rehabilitative effects of acute purinergic receptor P2X4 (P2X4R) blockade after ischemic stroke","volume":"329","author":"Srivastava","year":"2020","journal-title":"Exp. Neurol."},{"issue":"1","key":"10.1016\/j.ejphar.2023.175801_bib33","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1002\/med.21817","article-title":"Mechanisms of neuronal cell death in ischemic stroke and their therapeutic implications","volume":"42","author":"Tuo","year":"2022","journal-title":"Med. Res. Rev."},{"issue":"4","key":"10.1016\/j.ejphar.2023.175801_bib34","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1007\/s13311-016-0458-y","article-title":"Clinical trials of immunomodulation in ischemic stroke","volume":"13","author":"Veltkamp","year":"2016","journal-title":"Neurotherapeutics"},{"issue":"11","key":"10.1016\/j.ejphar.2023.175801_bib35","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1089\/ars.2017.7440","article-title":"Dl-3-n-butylphthalide inhibits nlrp3 inflammasome and mitigates Alzheimer's-like pathology via Nrf2-TXNIP-TrX axis","volume":"30","author":"Wang","year":"2019","journal-title":"Antioxidants Redox Signal."},{"issue":"Pt B","key":"10.1016\/j.ejphar.2023.175801_bib36","article-title":"Pexidartinib (PLX3397) through restoring hippocampal synaptic plasticity ameliorates social isolation-induced mood disorders","volume":"113","author":"Wang","year":"2022","journal-title":"Int. Immunopharm."},{"issue":"5","key":"10.1016\/j.ejphar.2023.175801_bib37","doi-asserted-by":"crossref","first-page":"338","DOI":"10.2174\/1871527317666180612125843","article-title":"Dl-3-n-butylphthalide (NBP): a promising therapeutic agent for ischemic stroke","volume":"17","author":"Wang","year":"2018","journal-title":"CNS Neurol. Disord.: Drug Targets"},{"key":"10.1016\/j.ejphar.2023.175801_bib38","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.ejphar.2014.06.035","article-title":"The synergetic effect of edaravone and borneol in the rat model of ischemic stroke","volume":"740","author":"Wu","year":"2014","journal-title":"Eur. J. Pharmacol."},{"issue":"4","key":"10.1016\/j.ejphar.2023.175801_bib39","doi-asserted-by":"crossref","first-page":"3156","DOI":"10.18632\/aging.102790","article-title":"LncRNA MEG3 targeting miR-424-5p via MAPK signaling pathway mediates neuronal apoptosis in ischemic stroke","volume":"12","author":"Xiang","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.ejphar.2023.175801_bib40","doi-asserted-by":"crossref","first-page":"238","DOI":"10.3389\/fnagi.2017.00238","article-title":"Dl-3-n-butylphthalide treatment enhances hemodynamics and ameliorates memory deficits in rats with chronic cerebral hypoperfusion","volume":"9","author":"Xiong","year":"2017","journal-title":"Front. Aging Neurosci."},{"issue":"3","key":"10.1016\/j.ejphar.2023.175801_bib41","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1136\/svn-2018-000221","article-title":"Safety and efficacy of Edaravone Dexborneol versus edaravone for patients with acute ischaemic stroke: a phase II, multicentre, randomised, double-blind, multiple-dose, active-controlled clinical trial","volume":"4","author":"Xu","year":"2019","journal-title":"Stroke Vasc. Neurol."},{"issue":"9","key":"10.1016\/j.ejphar.2023.175801_bib42","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1111\/cns.12438","article-title":"L-3-n-butylphthalide promotes neurogenesis and neuroplasticity in cerebral ischemic rats","volume":"21","author":"Yang","year":"2015","journal-title":"CNS Neurosci. Ther. Sep."},{"issue":"1","key":"10.1016\/j.ejphar.2023.175801_bib43","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s12974-019-1693-z","article-title":"Dectin-1\/Syk signaling triggers neuroinflammation after ischemic stroke in mice","volume":"17","author":"Ye","year":"2020","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.ejphar.2023.175801_bib44","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.987293","article-title":"DL-3-n-butylphthalide (NBP) alleviates poststroke cognitive impairment (PSCI) by suppressing neuroinflammation and oxidative stress","volume":"13","author":"Zhang","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejphar.2023.175801_bib45","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.biopha.2016.07.040","article-title":"N-Butylphthalide (NBP) ameliorated cerebral ischemia reperfusion-induced brain injury via HGF-regulated TLR4\/NF-\u03baB signaling pathway","volume":"83","author":"Zhang","year":"2016","journal-title":"Biomed. Pharmacother."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299923003126?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299923003126?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T04:22:37Z","timestamp":1762143757000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299923003126"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":45,"alternative-id":["S0014299923003126"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2023.175801","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A comparative study of the neuroprotective effects of dl-3-n-butylphthalide and edaravone dexborneol on cerebral ischemic stroke rats","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2023.175801","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"175801"}}