{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:35:35Z","timestamp":1786988135278,"version":"build-2736575974"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.ejphar.2023.175806","type":"journal-article","created":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T15:42:38Z","timestamp":1684856558000},"page":"175806","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Identification of protein kinase C domains involved in its translocation induced by propofol"],"prefix":"10.1016","volume":"955","author":[{"given":"Soshi","family":"Narasaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soma","family":"Noguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoaki","family":"Urabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kana","family":"Harada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izumi","family":"Hide","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhki","family":"Yanase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taketoshi","family":"Kajimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazue","family":"Uchida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuo M.","family":"Tsutsumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6648-8761","authenticated-orcid":false,"given":"Norio","family":"Sakai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2023.175806_bib1","doi-asserted-by":"crossref","first-page":"46886","DOI":"10.1074\/jbc.M307853200","article-title":"Activation mechanisms of conventional protein kinase C isoforms are determined by the ligand affinity and conformational flexibility of their C1 domains","volume":"278","author":"Ananthanarayanan","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2023.175806_bib2","doi-asserted-by":"crossref","first-page":"617","DOI":"10.4103\/0253-7613.194845","article-title":"Pain on propofol injection: causes and remedies","volume":"48","author":"Desousa","year":"2016","journal-title":"Indian J. Pharmacol."},{"issue":"Suppl. 1","key":"10.1016\/j.ejphar.2023.175806_bib3","first-page":"S72","article-title":"Molecular targets underlying general anaesthesia","volume":"147","author":"Franks","year":"2006","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2023.175806_bib4","doi-asserted-by":"crossref","first-page":"4277","DOI":"10.1074\/jbc.M106302200","article-title":"Localization of endothelial nitric-oxide synthase phosphorylated on serine 1179 and nitric oxide in Golgi and plasma membrane defines the existence of two pools of active enzyme","volume":"277","author":"Fulton","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2023.175806_bib5","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0361-9230(02)00755-4","article-title":"Translocation of protein kinase C by halothane in cholinergic cells","volume":"58","author":"Gomez","year":"2002","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.ejphar.2023.175806_bib6","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1097\/ALN.0000000000001015","article-title":"Propofol-induced inhibition of catecholamine release is reversed by maintaining calcium influx","volume":"124","author":"Han","year":"2016","journal-title":"Anesthesiology"},{"key":"10.1016\/j.ejphar.2023.175806_bib7","first-page":"1216","article-title":"Biochemical characterization of the stimulatory effects of halothane and propofol on purified brain protein kinase C","volume":"81","author":"Hemmings","year":"1995","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.ejphar.2023.175806_bib8","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.bja.2018.12.025","article-title":"Propofol infusion syndrome: a structured literature review and analysis of published case reports","volume":"122","author":"Hemphill","year":"2019","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.ejphar.2023.175806_bib9","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/0896-6273(90)90211-W","article-title":"Regulation of neurotransmitter receptor desensitization by protein phosphorylation","volume":"5","author":"Huganir","year":"1990","journal-title":"Neuron"},{"key":"10.1016\/j.ejphar.2023.175806_bib10","doi-asserted-by":"crossref","first-page":"4953","DOI":"10.1021\/acs.biochem.5b00565","article-title":"Dynamics and membrane interactions of protein kinase C","volume":"54","author":"Igumenova","year":"2015","journal-title":"Biochemistry"},{"key":"10.1016\/j.ejphar.2023.175806_bib11","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1128\/MCB.21.5.1769-1783.2001","article-title":"Subtype-specific translocation of the \u03b4 subtype of protein kinase C and its activation by tyrosine phosphorylation induced by ceramide in HeLa cells","volume":"21","author":"Kajimoto","year":"2001","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.ejphar.2023.175806_bib12","doi-asserted-by":"crossref","first-page":"12668","DOI":"10.1074\/jbc.M312350200","article-title":"Ceramide-induced apoptosis by translocation, phosphorylation, and activation of protein kinase c\u03b4 in the Golgi complex","volume":"279","author":"Kajimoto","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2023.175806_bib13","doi-asserted-by":"crossref","first-page":"18037","DOI":"10.1074\/jbc.M111761200","article-title":"Importance of C1B domain for lipid messenger-induced targeting of protein kinase C","volume":"277","author":"Kashiwagi","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2023.175806_bib14","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.3390\/pharmaceutics13111748","article-title":"Activators and inhibitors of protein kinase C (PKC): their applications in clinical trials","volume":"13","author":"Kawano","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ejphar.2023.175806_bib15","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/0006-291X(89)90028-4","article-title":"Calphostin C (UCN-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C","volume":"159","author":"Kobayashi","year":"1989","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejphar.2023.175806_bib16","doi-asserted-by":"crossref","DOI":"10.1186\/s13054-015-1112-5","article-title":"Propofol infusion syndrome: a structured review of experimental studies and 153 published case reports","volume":"19","author":"Kraj\u010dov\u00e1","year":"2015","journal-title":"Crit. Care"},{"key":"10.1016\/j.ejphar.2023.175806_bib17","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1083\/jcb.109.2.685","article-title":"Type 3 protein kinase C localization to the nuclear envelope of phorbol ester-treated NIH 3T3 cells","volume":"109","author":"Leach","year":"1989","journal-title":"JCB (J. Cell Biol.)"},{"key":"10.1016\/j.ejphar.2023.175806_bib18","doi-asserted-by":"crossref","first-page":"a004556","DOI":"10.1101\/cshperspect.a004556","article-title":"Protein kinase C: the \"masters\" of calcium and lipid","volume":"3","author":"Lipp","year":"2011","journal-title":"Cold Spring Harbor Perspect. Biol."},{"key":"10.1016\/j.ejphar.2023.175806_bib19","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.jphs.2018.03.008","article-title":"Propofol induced diverse and subtype-specific translocation of PKC families","volume":"137","author":"Miyahara","year":"2018","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.ejphar.2023.175806_bib20","doi-asserted-by":"crossref","first-page":"13216","DOI":"10.1021\/bi010761u","article-title":"Membrane binding kinetics of protein kinase C \u03b2II mediated by the C2 domain","volume":"40","author":"Nalefski","year":"2001","journal-title":"Biochemistry"},{"key":"10.1016\/j.ejphar.2023.175806_bib21","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0304-4157(98)00003-3","article-title":"Protein kinase C: a paradigm for regulation of protein function by two membrane-targeting modules","volume":"1376","author":"Newton","year":"1998","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ejphar.2023.175806_bib22","doi-asserted-by":"crossref","first-page":"F197","DOI":"10.1152\/ajprenal.00364.2010","article-title":"Protein kinase C-epsilon activation induces mitochondrial dysfunction and fragmentation in renal proximal tubules","volume":"301","author":"Nowak","year":"2011","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.ejphar.2023.175806_bib23","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0092-8674(00)81763-8","article-title":"Protein kinase C as a molecular machine for decoding calcium and diacylglycerol signals","volume":"95","author":"Oancea","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.ejphar.2023.175806_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2022.103936","article-title":"Direct visualization of general anesthetic propofol on neurons by stimulated Raman scattering microscopy","volume":"25","author":"Oda","year":"2022","journal-title":"iScience"},{"key":"10.1016\/j.ejphar.2023.175806_bib25","doi-asserted-by":"crossref","first-page":"5263","DOI":"10.1128\/MCB.18.9.5263","article-title":"Three distinct mechanisms for translocation and activation of the delta subspecies of protein kinase C","volume":"18","author":"Ohmori","year":"1998","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.ejphar.2023.175806_bib26","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.pharmthera.2008.08.003","article-title":"The role of nitric oxide (NO) in migraine, tension-type headache and cluster headache","volume":"120","author":"Olesen","year":"2008","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.ejphar.2023.175806_bib27","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/BF02935541","article-title":"The role of protein kinase C and its neuronal substrates dephosphin, B-50, and MARCKS in neurotransmitter release","volume":"5","author":"Robinson","year":"1991","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.ejphar.2023.175806_bib28","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1007\/s40262-018-0672-3","article-title":"Clinical pharmacokinetics and pharmacodynamics of propofol","volume":"57","author":"Sahinovic","year":"2018","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.ejphar.2023.175806_bib29","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1083\/jcb.139.6.1465","article-title":"Direct visualization of the translocation of the \u03b3-subspecies of protein kinase C in living cells using fusion proteins with green fluorescent protein","volume":"139","author":"Sakai","year":"1997","journal-title":"JCB (J. Cell Biol.)"},{"key":"10.1016\/j.ejphar.2023.175806_bib30","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1242\/jcs.111.13.1823","article-title":"Nuclear import of protein kinase C occurs by a mechanism distinct from the mechanism used by proteins with a classical nuclear localization signal","volume":"111","author":"Schmalz","year":"1998","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.ejphar.2023.175806_bib31","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1083\/jcb.143.2.511","article-title":"Distinct effects of fatty acids on translocation of \u03b3- and \u03b5-subspecies of protein kinase C","volume":"143","author":"Shirai","year":"1998","journal-title":"JCB (J. Cell Biol.)"},{"key":"10.1016\/j.ejphar.2023.175806_bib32","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1093\/oxfordjournals.jbchem.a003271","article-title":"Activation mechanisms of protein kinase C: maturation, catalytic activation, and targeting","volume":"132","author":"Shirai","year":"2002","journal-title":"J. Biochem."},{"key":"10.1016\/j.ejphar.2023.175806_bib33","doi-asserted-by":"crossref","first-page":"29501","DOI":"10.1074\/jbc.M403191200","article-title":"Mechanism of diacylglycerol-induced membrane targeting and activation of protein kinase c\u03b4","volume":"279","author":"Stahelin","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2023.175806_bib34","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.bbrc.2020.11.036","article-title":"Role of the E3 ubiquitin ligase HRD1 in the regulation of serotonin transporter function","volume":"534","author":"Taguchi","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejphar.2023.175806_bib35","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1146\/annurev.ne.17.030194.003003","article-title":"The protein kinase C family for neuronal signaling","volume":"17","author":"Tanaka","year":"1994","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.ejphar.2023.175806_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173303","article-title":"Propofol induces the elevation of intracellular calcium via morphological changes in intracellular organelles, including the endoplasmic reticulum and mitochondria","volume":"884","author":"Urabe","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2023.175806_bib37","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1093\/bja\/aeq064","article-title":"Translocation of protein kinase C isoforms is involved in propofol-induced endothelial nitric oxide synthase activation","volume":"104","author":"Wang","year":"2010","journal-title":"Br. J. Anaesth."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299923003175?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299923003175?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T09:18:53Z","timestamp":1736327933000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299923003175"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":37,"alternative-id":["S0014299923003175"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2023.175806","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification of protein kinase C domains involved in its translocation induced by propofol","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2023.175806","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"175806"}}