{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T18:26:20Z","timestamp":1772821580780,"version":"3.50.1"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T00:00:00Z","timestamp":1718323200000},"content-version":"am","delay-in-days":318,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20K07827"],"award-info":[{"award-number":["20K07827"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004330","name":"Smoking Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004330","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.ejphar.2023.175839","type":"journal-article","created":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T02:06:07Z","timestamp":1686276367000},"page":"175839","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Possible involvement of brain hydrogen sulphide in the inhibition of the rat micturition reflex induced by activation of brain alpha7 nicotinic acetylcholine receptors"],"prefix":"10.1016","volume":"953","author":[{"given":"Nobutaka","family":"Shimizu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1555-2284","authenticated-orcid":false,"given":"Takahiro","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youichirou","family":"Higashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suo","family":"Zou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideo","family":"Fukuhara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Karashima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiji","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motoaki","family":"Saito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2023.175839_bib1","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1523\/JNEUROSCI.16-03-01066.1996","article-title":"The possible role of hydrogen sulfide as an endogenous neuromodulator","volume":"16","author":"Abe","year":"1996","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2023.175839_bib2","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1152\/physrev.00015.2008","article-title":"Mammalian nicotinic acetylcholine receptors: from structure to function","volume":"89","author":"Albuquerque","year":"2009","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ejphar.2023.175839_bib3","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1111\/bph.12171","article-title":"Selectivity of commonly used pharmacological inhibitors for cystathionine \u03b2 synthase (CBS) and cystathionine \u03b3 lyase (CSE)","volume":"169","author":"Asimakopoulou","year":"2013","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2023.175839_bib4","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1113\/jphysiol.2011.226860","article-title":"Differential expression and function of nicotinic acetylcholine receptors in the urinary bladder epithelium of the rat","volume":"590","author":"Beckel","year":"2012","journal-title":"J. Physiol."},{"key":"10.1016\/j.ejphar.2023.175839_bib5","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1111\/j.1476-5381.2010.01124.x","article-title":"Central nicotinic acetylcholine receptor involved in Ca2+-calmodulin-endothelial nitric oxide synthase pathway modulated hypotensive effects","volume":"163","author":"Cheng","year":"2011","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2023.175839_bib6","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1146\/annurev.pharmtox.47.120505.105214","article-title":"Nicotinic acetylcholine receptors and nicotinic cholinergic mechanisms of the central nervous system","volume":"47","author":"Dani","year":"2007","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.ejphar.2023.175839_bib7","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0014-2999(00)00008-X","article-title":"Nicotinic acetylcholine receptors in the autonomic control of bladder function","volume":"393","author":"De Biasi","year":"2000","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2023.175839_bib8","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1002\/j.2040-4603.2015.tb00596.x","article-title":"Neural control of the lower urinary tract","volume":"5","author":"de Groat","year":"2015","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.ejphar.2023.175839_bib9","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1146\/annurev.pharmtox.41.1.691","article-title":"Pharmacology of the lower urinary tract","volume":"41","author":"de Groat","year":"2001","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.ejphar.2023.175839_bib10","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.pharmthera.2015.12.007","article-title":"Effects of hydrogen sulphide in smooth muscle","volume":"158","author":"Dunn","year":"2016","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.ejphar.2023.175839_bib11","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0071962","article-title":"Enhanced synthesis and diminished degradation of hydrogen sulfide in experimental colitis: a site-specific, pro-resolution mechanism","volume":"8","author":"Flannigan","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2023.175839_bib12","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.tips.2006.07.004","article-title":"Brain nicotinic acetylcholine receptors: native subtypes and their relevance","volume":"27","author":"Gotti","year":"2006","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.ejphar.2023.175839_bib13","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.eururo.2019.07.010","article-title":"Efficacy and safety of combination pharmacotherapy for patients with overactive bladder: a rapid evidence assessment","volume":"76","author":"Gratzke","year":"2019","journal-title":"Eur. Urol."},{"key":"10.1016\/j.ejphar.2023.175839_bib14","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.autneu.2004.05.008","article-title":"Nicotinic acetylcholine receptor subtypes in nociceptive dorsal root ganglion neurons of the adult rat","volume":"113","author":"Haberberger","year":"2004","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.ejphar.2023.175839_bib15","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s00418-003-0550-3","article-title":"Nicotinic receptor alpha 7-subunits are coupled to the stimulation of nitric oxide synthase in rat dorsal root ganglion neurons","volume":"120","author":"Haberberger","year":"2003","journal-title":"Histochem. Cell Biol."},{"key":"10.1016\/j.ejphar.2023.175839_bib16","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.neures.2005.07.002","article-title":"Modulating effect of hydrogen sulfide on gamma-aminobutyric acid B receptor in recurrent febrile seizures in rats","volume":"53","author":"Han","year":"2005","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.ejphar.2023.175839_bib17","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.pharmthera.2012.08.012","article-title":"Nicotinic acetylcholine receptors: from basic science to therapeutics","volume":"137","author":"Hurst","year":"2013","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.ejphar.2023.175839_bib18","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.neuint.2013.09.003","article-title":"Physiological role of hydrogen sulfide and polysulfide in the central nervous system","volume":"63","author":"Kimura","year":"2013","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.ejphar.2023.175839_bib19","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1089\/ars.2014.5869","article-title":"Signaling molecules: hydrogen sulfide and polysulfide","volume":"22","author":"Kimura","year":"2015","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.ejphar.2023.175839_bib20","doi-asserted-by":"crossref","first-page":"R84","DOI":"10.1152\/ajpregu.00109.2003","article-title":"Effect of (+\/\u2212)-epibatidine, a nicotinic agonist, on the central pathways controlling voiding function in the rat","volume":"285","author":"Lee","year":"2003","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.ejphar.2023.175839_bib21","article-title":"The slow-releasing hydrogen sulfide donor, GYY4137, exhibits novel anti-cancer effects in vitro and in vivo","volume":"6","author":"Lee","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2023.175839_bib22","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1161\/CIRCULATIONAHA.107.753467","article-title":"Characterization of a novel, water-soluble hydrogen sulfide-releasing molecule (GYY4137): new insights into the biology of hydrogen sulfide","volume":"117","author":"Li","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2023.175839_bib23","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/S0022-5347(06)00581-7","article-title":"Roles of peripheral and central nicotinic receptors in the micturition reflex in rats","volume":"176","author":"Masuda","year":"2006","journal-title":"J. Urol."},{"key":"10.1016\/j.ejphar.2023.175839_bib24","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.neuroscience.2012.10.059","article-title":"Expression of nicotinic acetylcholine receptor subunit mRNA in mouse bladder afferent neurons","volume":"229","author":"Nandigama","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.ejphar.2023.175839_bib25","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0165-0270(80)90021-7","article-title":"AChE-stained horizontal sections of the rat brain in stereotaxic coordinates","volume":"3","author":"Paxinos","year":"1980","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.ejphar.2023.175839_bib26","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1113\/EP088870","article-title":"The ARRIVE guidelines 2.0. The ARRIVE guidelines 2.0: updated guidelines for reporting animal research","volume":"105","author":"Percie du Sert","year":"2020","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.ejphar.2023.175839_bib27","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1089\/ars.2008.2253","article-title":"3-Mercaptopyruvate sulfurtransferase produces hydrogen sulfide and bound sulfane sulfur in the brain","volume":"11","author":"Shibuya","year":"2009","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.ejphar.2023.175839_bib28","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1124\/jpet.115.230334","article-title":"A stress-related peptide bombesin centrally induces frequent urination through brain bombesin receptor Types 1 and 2 in the rat","volume":"356","author":"Shimizu","year":"2016","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.ejphar.2023.175839_bib29","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.bbrc.2021.02.051","article-title":"Stimulation of brain \u03b17-nicotinic acetylcholine receptors suppresses the rat micturition through brain GABAergic receptors","volume":"548","author":"Shimizu","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejphar.2023.175839_bib30","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1124\/pr.117.014050","article-title":"International union of basic and clinical pharmacology. CII: pharmacological modulation of H2S levels: H2S donors and H2S biosynthesis inhibitors. CII: pharmacological modulation of H2S levels: H2S donors and H2S biosynthesis inhibitors","volume":"69","author":"Szabo","year":"2017","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.ejphar.2023.175839_bib31","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/j.pharep.2019.05.009","article-title":"GABAA receptor, KATP channel and L-type Ca2+ channel is associated with facilitation effect of H2S on the baroreceptor reflex in spontaneous hypertensive rats","volume":"71","author":"Teng","year":"2019","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.ejphar.2023.175839_bib32","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1096\/fj.02-0211hyp","article-title":"Two's company, three's a crowd: can H2S be the third endogenous gaseous transmitter?","volume":"16","author":"Wang","year":"2002","journal-title":"Faseb. J."},{"key":"10.1016\/j.ejphar.2023.175839_bib33","first-page":"55","article-title":"Nicotine affects hydrogen sulfide concentrations in mouse kidney and heart but not in brain and liver tissues","volume":"57","author":"Wili\u0144ski","year":"2017","journal-title":"Folia Med. Cracov."},{"key":"10.1016\/j.ejphar.2023.175839_bib34","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.pharmthera.2018.04.010","article-title":"Basic and clinical aspects of antimuscarinic agents used to treat overactive bladder","volume":"189","author":"Yamada","year":"2018","journal-title":"Pharmacol. Ther."},{"issue":"105","key":"10.1016\/j.ejphar.2023.175839_bib35","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.niox.2020.08.006","article-title":"Brain hydrogen sulfide suppresses the micturition reflex via brain GABA receptors in rats","volume":"104","author":"Yamamoto","year":"2020","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.ejphar.2023.175839_bib36","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1021\/cn500185g","article-title":"Hydrogen sulfide: a neuromodulator and neuroprotectant in the central nervous system","volume":"5","author":"Zhang","year":"2014","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.ejphar.2023.175839_bib37","article-title":"Brain 3-mercaptopyruvate sulfurtransferase (3MST): cellular localization and downregulation after acute stroke","volume":"8","author":"Zhao","year":"2013","journal-title":"PLoS One"}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299923003503?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299923003503?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T04:23:29Z","timestamp":1762143809000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299923003503"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":37,"alternative-id":["S0014299923003503"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2023.175839","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Possible involvement of brain hydrogen sulphide in the inhibition of the rat micturition reflex induced by activation of brain alpha7 nicotinic acetylcholine receptors","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2023.175839","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"175839"}}