{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T18:22:06Z","timestamp":1770142926688,"version":"3.49.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,7,13]],"date-time":"2023-07-13T00:00:00Z","timestamp":1689206400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008373","name":"Takeda Pharmaceutical Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008373","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007723","name":"Takeda Pharmaceuticals USA Inc","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007723","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.ejphar.2023.175906","type":"journal-article","created":{"date-parts":[[2023,7,8]],"date-time":"2023-07-08T23:10:35Z","timestamp":1688857835000},"page":"175906","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Characterization of rat gastric myogenic contractions and modulation by oxytocin and arginine-vasopressin"],"prefix":"10.1016","volume":"955","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2175-3530","authenticated-orcid":false,"given":"Raj","family":"Makwana","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4231-1945","authenticated-orcid":false,"given":"Gareth J.","family":"Sanger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2023.175906_bib1","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.ejphar.2013.09.072","article-title":"Nausea and the quest for the perfect anti-emetic","volume":"722","author":"Andrews","year":"2014","journal-title":"Eur. J. Pharmacol."},{"issue":"18","key":"10.1016\/j.ejphar.2023.175906_bib2","doi-asserted-by":"crossref","first-page":"4567","DOI":"10.1113\/jphysiol.2013.254292","article-title":"The bioelectrical basis and validity of gastrointestinal extracellular slow wave recordings","volume":"591","author":"Angeli","year":"2013","journal-title":"J. Physiol."},{"key":"10.1016\/j.ejphar.2023.175906_bib3","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/s12576-017-0550-z","article-title":"Possible involvement of central oxytocin in cisplatin-induced anorexia in rats","volume":"68","author":"Arase","year":"2018","journal-title":"J. Physiol. Sci."},{"key":"10.1016\/j.ejphar.2023.175906_bib4","doi-asserted-by":"crossref","first-page":"G895","DOI":"10.1152\/ajpgi.00255.2016","article-title":"Functional physiology of the human terminal antrum defined by high-resolution electrical mapping and computational modeling","volume":"311","author":"Berry","year":"2016","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.ejphar.2023.175906_bib5","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1111\/bph.15685","article-title":"Evidence for tetrodotoxin-resistant spontaneous myogenic contractions of mouse isolated stomach that are dependent on acetylcholine","volume":"179","author":"Cai","year":"2022","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2023.175906_bib6","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0165-1838(92)90144-6","article-title":"Distributions of interstitial cells of Cajal in stomach and colon of cat, dog, ferret, opossum, rat, Guinea pig and rabbit","volume":"37","author":"Christensen","year":"1992","journal-title":"J. Auton. Nerv. Syst."},{"issue":"9","key":"10.1016\/j.ejphar.2023.175906_bib7","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1113\/EP085697","article-title":"Simultaneous anterior and posterior serosal mapping of gastric slow-wave dysrhythmias induced by vasopressin","volume":"101","author":"Du","year":"2016","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.ejphar.2023.175906_bib8","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1530\/eje.0.1360531","article-title":"Oxytocin induced changes in single cell K+ currents and smooth muscle contraction of Guinea-pig gastric antrum","volume":"136","author":"Duridanova","year":"1997","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.ejphar.2023.175906_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0939-8600(02)80002-5","article-title":"The forestomach of rats and mice, an effective device supporting digestive metabolism in muridae","volume":"42","author":"G\u00e4rtner","year":"2001","journal-title":"J. Exp. Anim. Sci."},{"key":"10.1016\/j.ejphar.2023.175906_bib10","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1038\/sj.bjp.0706383","article-title":"Selectivity of d[Cha4]AVP and SSR149415 at human vasopressin and oxytocin receptors: evidence that SSR149415 is a mixed vasopressin V1b\/oxytocin receptor antagonist","volume":"146","author":"Griffante","year":"2005","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2023.175906_bib11","first-page":"547","article-title":"Comparative study in the effect of C-type natriuretic peptide on gastric motility in various animals","volume":"9","author":"Guo","year":"2003","journal-title":"Wld. J. Gastroenterol."},{"key":"10.1016\/j.ejphar.2023.175906_bib12","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.bpa.2006.02.002","article-title":"The physiology of gastric emptying","volume":"20","author":"Hellstr\u00f6m","year":"2006","journal-title":"Best Pract. Res. Clin. Anaesthesiol."},{"key":"10.1016\/j.ejphar.2023.175906_bib13","doi-asserted-by":"crossref","DOI":"10.1371\/annotation\/1c75cd5d-9dde-4ace-8524-a4980745e804","article-title":"Why Can't Rodents Vomit? A comparative behavioral, anatomical, and physiological study","volume":"8","author":"Horn","year":"2013","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.ejphar.2023.175906_bib14","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1113\/jphysiol.2006.116491","article-title":"Electrical events underlying organized myogenic contractions of the Guinea pig stomach","volume":"576","author":"Hirst","year":"2006","journal-title":"J. Physiol."},{"key":"10.1016\/j.ejphar.2023.175906_bib15","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1292\/jvms.66.951","article-title":"Involvement of endogenous vasopressin in high plasma osmolality-induced anorexia via V1 receptor-mediated mechanism","volume":"66","author":"Ikemura","year":"2004","journal-title":"J. Vet. Med. Sci."},{"key":"10.1016\/j.ejphar.2023.175906_bib16","doi-asserted-by":"crossref","first-page":"G814","DOI":"10.1152\/ajpgi.00118.2009","article-title":"Interstitial cells of Cajal generate spontaneous transient depolarizations in the rat gastric fundus","volume":"297","author":"Kito","year":"2009","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.ejphar.2023.175906_bib17","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1046\/j.1365-2982.1997.d01-44.x","article-title":"A noxious trio: nausea, gastric dysrhythmias and vasopressin","volume":"9","author":"Koch","year":"1997","journal-title":"Neurogastroenterol. Motil."},{"issue":"1","key":"10.1016\/j.ejphar.2023.175906_bib18","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0031-9384(91)90251-I","article-title":"Mechanisms of vasopressin's anorectic effect","volume":"49","author":"Langhans","year":"1991","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.ejphar.2023.175906_bib19","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1111\/j.1365-2982.2007.00953.x","article-title":"Systemic oxytocin and vasopressin excite gastrointestinal motility through oxytocin receptor in rabbits","volume":"19","author":"Li","year":"2007","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1016\/j.ejphar.2023.175906_bib20","doi-asserted-by":"crossref","first-page":"5305","DOI":"10.1111\/bph.15943","article-title":"Synergistic augmentation of rhythmic myogenic contractions of human stomach by arginine vasopressin and adrenaline: implications for induction of nausea","volume":"179","author":"Makwana","year":"2022","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2023.175906_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173740","article-title":"Copeptin, a surrogate marker of arginine vasopressin, has no ability to modulate human gastric motility","volume":"892","author":"Makwana","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2023.175906_bib22","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1006\/phrs.1998.0313","article-title":"Differences in the effects of vasopressin and oxytocin on feline gastric corpus motility: selective action of vasopressin on longitudinal muscle","volume":"37","author":"Mir\u010di\u0107","year":"1998","journal-title":"Pharmacol. Res."},{"issue":"1\u20132","key":"10.1016\/j.ejphar.2023.175906_bib23","first-page":"71","article-title":"Gastric stimulation is effective in reversing vasopressin induced gastroparesis","volume":"45","author":"Nowak","year":"2004","journal-title":"Folia Med. Cracov."},{"key":"10.1016\/j.ejphar.2023.175906_bib24","first-page":"G585","article-title":"Origin and propagation of human gastric slow wave activity defined by high-resolution mapping","volume":"299","author":"O'Grady","year":"2010","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.ejphar.2023.175906_bib25","doi-asserted-by":"crossref","first-page":"G527","DOI":"10.1152\/ajpgi.00065.2021","article-title":"The gastric conduction system in health and disease: a translational review","volume":"321","author":"O'Grady","year":"2021","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.ejphar.2023.175906_bib26","article-title":"The ARRIVE guidelines 2.0: updated guidelines for reporting animal research","volume":"18","author":"Percie du Sert","year":"2020","journal-title":"PLoS Biol."},{"key":"10.1016\/j.ejphar.2023.175906_bib27","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.regpep.2009.06.003","article-title":"V1 receptor in ENS mediates the excitatory effect of vasopressin on circular muscle strips of gastric body in vitro in rats","volume":"157","author":"Qin","year":"2009","journal-title":"Regul. Pept."},{"key":"10.1016\/j.ejphar.2023.175906_bib28","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1111\/j.1365-2982.2009.01282.x","article-title":"Oxytocin receptor expressed on the smooth muscle mediates the excitatory effect of oxytocin on gastric motility in rats","volume":"21","author":"Qin","year":"2009","journal-title":"Neurogastroenterol. Motil."},{"issue":"24","key":"10.1016\/j.ejphar.2023.175906_bib29","doi-asserted-by":"crossref","first-page":"6105","DOI":"10.1113\/jphysiol.2011.217497","article-title":"Analysis of pacemaker activity in the human stomach","volume":"589","author":"Rhee","year":"2011","journal-title":"J. Physiol."},{"key":"10.1016\/j.ejphar.2023.175906_bib30","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1146\/annurev.physiol.68.040504.094718","article-title":"Interstitial cells of Cajal as pacemakers in the gastrointestinal tract","volume":"68","author":"Sanders","year":"2006","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.ejphar.2023.175906_bib31","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.tips.2011.03.009","article-title":"The translational value of rodent gastrointestinal functions: a cautionary tale","volume":"32","author":"Sanger","year":"2011","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.ejphar.2023.175906_bib32","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1172\/JCI116554","article-title":"Biochemical and pharmacological properties of SR 49059, a new, potent, nonpeptide antagonist of rat and human vasopressin V1a receptors","volume":"92","author":"Serradeil-Le Gal","year":"1993","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ejphar.2023.175906_bib33","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1136\/gut.29.1.85","article-title":"Biphasic nature of gastric emptying","volume":"29","author":"Siegel","year":"1998","journal-title":"Gut"},{"key":"10.1016\/j.ejphar.2023.175906_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106247","article-title":"A multi-parameter approach to measurement of spontaneous myogenic contractions in human stomach: utilization to assess potential modulators of myogenic contractions","volume":"180","author":"Straface","year":"2022","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.ejphar.2023.175906_bib35","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1126\/science.3715453","article-title":"Oxytocin secretion in response to cholecystokinin and food: differentiation of nausea from satiety","volume":"232","author":"Verbalis","year":"1986","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2023.175906_bib36","doi-asserted-by":"crossref","first-page":"200","DOI":"10.5056\/jnm14120","article-title":"Regulation of gastric electrical and mechanical activity by cholinesterases in mice","volume":"21","author":"Worth","year":"2015","journal-title":"J. Neurogastroenterol. Motil."},{"key":"10.1016\/j.ejphar.2023.175906_bib37","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s00424-002-0925-7","article-title":"Involvement of cholecystokinin receptor in the inhibition of gastric emptying by oxytocin in male rats","volume":"445","author":"Wu","year":"2002","journal-title":"Pfl\u00fcgers Archiv"}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299923004181?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299923004181?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T14:19:39Z","timestamp":1736345979000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299923004181"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":37,"alternative-id":["S0014299923004181"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2023.175906","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characterization of rat gastric myogenic contractions and modulation by oxytocin and arginine-vasopressin","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2023.175906","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"175906"}}