{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T19:15:51Z","timestamp":1791573351480,"version":"4.3.4"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2022J01017"],"award-info":[{"award-number":["2022J01017"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81,603,093"],"award-info":[{"award-number":["81,603,093"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008865","name":"Xiamen University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008865","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.ejphar.2023.175982","type":"journal-article","created":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T04:08:34Z","timestamp":1691640514000},"page":"175982","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["URB597 exerts neuroprotective effects against transient brain ischemia injury in mice by regulating autophagic flux and necroptosis"],"prefix":"10.1016","volume":"957","author":[{"given":"Xiaoqian","family":"Yuan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxuan","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doudou","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rengong","family":"Zhuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lichao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2023.175982_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2021.108935","article-title":"Role of PI3K\/Akt axis in mitigating hippocampal ischemia-reperfusion injury via CB1 receptor stimulation by paracetamol and FAAH inhibitor in rat","volume":"207","author":"Abdel Mageed","year":"2022","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ejphar.2023.175982_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173360","article-title":"Anthocyanin ameliorates hypoxia and ischemia induced inflammation and apoptosis by increasing autophagic flux in SH-SY5Y cells","volume":"883","author":"Cai","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2023.175982_bib3","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.neuroscience.2017.12.007","article-title":"Necrostatin-1 improves long-term functional recovery through protecting oligodendrocyte precursor cells after transient focal cerebral ischemia in mice","volume":"371","author":"Chen","year":"2018","journal-title":"Neuroscience"},{"issue":"11","key":"10.1016\/j.ejphar.2023.175982_bib4","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1248\/bpb.b19-00394","article-title":"N-linoleyltyrosine protects against transient cerebral ischemia in gerbil via CB2 receptor involvement in PI3K\/akt signaling pathway","volume":"42","author":"Cheng","year":"2019","journal-title":"Biol. Pharm. Bull."},{"issue":"6","key":"10.1016\/j.ejphar.2023.175982_bib5","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.phrs.2012.08.003","article-title":"A novel CB2 agonist, COR167, potently protects rat brain cortical slices against OGD and reperfusion injury","volume":"66","author":"Contartese","year":"2012","journal-title":"Pharmacol. Res."},{"issue":"5","key":"10.1016\/j.ejphar.2023.175982_bib6","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1111\/j.1471-4159.2007.04892.x","article-title":"Changes in brain levels of N-monoethanolamines and 2-arachidonoylglycerol in focal cerebral ischemia in mice","volume":"103","author":"Degn","year":"2007","journal-title":"J. Neurochem."},{"issue":"2","key":"10.1016\/j.ejphar.2023.175982_bib7","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nchembio711","article-title":"Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury","volume":"1","author":"Degterev","year":"2005","journal-title":"Nat. Chem. Biol."},{"issue":"4","key":"10.1016\/j.ejphar.2023.175982_bib8","doi-asserted-by":"crossref","first-page":"807","DOI":"10.14336\/AD.2018.0728","article-title":"Necrostatin-1 prevents necroptosis in brains after ischemic stroke via inhibition of RIPK1-mediated RIPK3\/MLKL signaling","volume":"10","author":"Deng","year":"2019","journal-title":"Aging Dis"},{"issue":"5","key":"10.1016\/j.ejphar.2023.175982_bib9","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1080\/15548627.2019.1644076","article-title":"ALS-FTLD-linked mutations of SQSTM1\/p62 disrupt selective autophagy and NFE2L2\/NRF2 anti-oxidative stress pathway","volume":"16","author":"Deng","year":"2020","journal-title":"Autophagy"},{"issue":"1","key":"10.1016\/j.ejphar.2023.175982_bib10","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1186\/s12974-018-1235-0","article-title":"Necroptosis: a regulated inflammatory mode of cell death","volume":"15","author":"Dhuriya","year":"2018","journal-title":"J. Neuroinflammation"},{"issue":"1","key":"10.1016\/j.ejphar.2023.175982_bib11","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1124\/jpet.104.078980","article-title":"Characterization of the fatty acid amide hydrolase inhibitor cyclohexyl carbamic acid 3'-carbamoyl-biphenyl-3-yl ester (URB597): effects on anandamide and oleoylethanolamide deactivation","volume":"313","author":"Fegley","year":"2005","journal-title":"J. Pharmacol. Exp. Therapeut."},{"issue":"3","key":"10.1016\/j.ejphar.2023.175982_bib12","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/s00213-012-2927-2","article-title":"Effects of glutamate NMDA and TRPV1 receptor antagonists on the biphasic responses to anandamide injected into the dorsolateral periaqueductal grey of Wistar rats","volume":"226","author":"Foga\u00e7a","year":"2013","journal-title":"Psychopharmacology (Berl)"},{"issue":"6","key":"10.1016\/j.ejphar.2023.175982_bib13","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1111\/jnc.14789","article-title":"Post-ischemic salubrinal administration reduces necroptosis in a rat model of global cerebral ischemia","volume":"151","author":"Font-Belmonte","year":"2019","journal-title":"J. Neurochem."},{"issue":"2","key":"10.1016\/j.ejphar.2023.175982_bib14","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1152\/jn.00570.2019","article-title":"Endocannabinoid degradation inhibitors ameliorate neuronal and synaptic alterations following traumatic brain injury","volume":"123","author":"Fucich","year":"2020","journal-title":"J. Neurophysiol."},{"issue":"27","key":"10.1016\/j.ejphar.2023.175982_bib15","doi-asserted-by":"crossref","first-page":"27849","DOI":"10.1074\/jbc.M404087200","article-title":"Oleoylethanolamide stimulates lipolysis by activating the nuclear receptor peroxisome proliferator-activated receptor alpha (PPAR-alpha)","volume":"279","author":"Guzm\u00e1n","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2023.175982_bib16","first-page":"1","article-title":"Restoration of CTSD (cathepsin D) and lysosomal function in stroke is neuroprotective","author":"Hossain","year":"2020","journal-title":"Autophagy"},{"issue":"6","key":"10.1016\/j.ejphar.2023.175982_bib17","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1080\/15548627.2020.1761219","article-title":"Restoration of CTSD (cathepsin D) and lysosomal function in stroke is neuroprotective","volume":"17","author":"Hossain","year":"2021","journal-title":"Autophagy"},{"issue":"3","key":"10.1016\/j.ejphar.2023.175982_bib18","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1161\/STROKEAHA.120.031792","article-title":"Whole-genome sequencing association analyses of stroke and its subtypes in ancestrally diverse populations from trans-omics for precision medicine Project","volume":"53","author":"Hu","year":"2022","journal-title":"Stroke"},{"issue":"1","key":"10.1016\/j.ejphar.2023.175982_bib19","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.neuropharm.2008.04.018","article-title":"Inhibition of fatty acid amide hydrolase and cyclooxygenase-2 increases levels of endocannabinoid related molecules and produces analgesia via peroxisome proliferator-activated receptor-alpha in a model of inflammatory pain","volume":"55","author":"Jhaveri","year":"2008","journal-title":"Neuropharmacology"},{"issue":"19","key":"10.1016\/j.ejphar.2023.175982_bib20","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2021108863","article-title":"Autophagy in major human diseases","volume":"40","author":"Klionsky","year":"2021","journal-title":"EMBO J."},{"key":"10.1016\/j.ejphar.2023.175982_bib21","doi-asserted-by":"crossref","first-page":"376","DOI":"10.3389\/fphar.2018.00376","article-title":"Arylpropyl sulfamide reduces neurodegeneration and restores the memory deficits induced by hypoxia-ischemia in mice","volume":"9","author":"Kossatz","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejphar.2023.175982_bib22","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.brainres.2013.10.032","article-title":"Excitotoxic glutamate insults block autophagic flux in hippocampal neurons","volume":"1542","author":"Kulbe","year":"2014","journal-title":"Brain Res."},{"issue":"5","key":"10.1016\/j.ejphar.2023.175982_bib23","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/s41419-019-1558-5","article-title":"TRAF2 protects against cerebral ischemia-induced brain injury by suppressing necroptosis","volume":"10","author":"Li","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ejphar.2023.175982_bib24","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.neuroscience.2018.07.044","article-title":"Neuroprotective effects of dtio, A novel analog of nec-1, in acute and chronic stages after ischemic stroke","volume":"390","author":"Li","year":"2018","journal-title":"Neuroscience"},{"key":"10.1016\/j.ejphar.2023.175982_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2020.108629","article-title":"The possible roles of necroptosis during cerebral ischemia and ischemia\/reperfusion injury","volume":"695","author":"Liao","year":"2020","journal-title":"Arch. Biochem. Biophys."},{"issue":"5","key":"10.1016\/j.ejphar.2023.175982_bib26","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1161\/STROKEAHA.120.032749","article-title":"CAPN1 (Calpain 1)-Mediated impairment of autophagic flux contributes to cerebral ischemia-induced neuronal damage","volume":"52","author":"Liu","year":"2021","journal-title":"Stroke"},{"issue":"1","key":"10.1016\/j.ejphar.2023.175982_bib27","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1124\/mol.104.006353","article-title":"The nuclear receptor peroxisome proliferator-activated receptor-alpha mediates the anti-inflammatory actions of palmitoylethanolamide","volume":"67","author":"Lo Verme","year":"2005","journal-title":"Mol. Pharmacol."},{"issue":"3","key":"10.1016\/j.ejphar.2023.175982_bib28","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines11030973","article-title":"PPAR\u03b1 inhibits astrocyte inflammation activation by restoring autophagic flux after transient brain ischemia","volume":"11","author":"Luo","year":"2023","journal-title":"Biomedicines"},{"key":"10.1016\/j.ejphar.2023.175982_bib29","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.phrs.2019.01.027","article-title":"Oleoylethanolamide inhibits glial activation via demodulating PPAR\u03b1 and promotes motor function recovery after brain ischemia","volume":"141","author":"Luo","year":"2019","journal-title":"Pharmacol. Res."},{"issue":"5","key":"10.1016\/j.ejphar.2023.175982_bib30","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1101\/lm.1145209","article-title":"Fatty acid amide hydrolase (FAAH) inhibition enhances memory acquisition through activation of PPAR-alpha nuclear receptors","volume":"16","author":"Mazzola","year":"2009","journal-title":"Learn. Mem."},{"issue":"2","key":"10.1016\/j.ejphar.2023.175982_bib31","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23020735","article-title":"Inhibition of neuronal necroptosis mediated by RIPK1 provides neuroprotective effects on hypoxia and ischemia in vitro and in vivo","volume":"23","author":"Mitroshina","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.ejphar.2023.175982_bib32","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1161\/STROKEAHA.122.038466","article-title":"Clinically ineffective reperfusion after endovascular therapy in acute ischemic stroke","volume":"54","author":"Nie","year":"2023","journal-title":"Stroke"},{"key":"10.1016\/j.ejphar.2023.175982_bib33","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/5879548","article-title":"Futile recanalization after endovascular therapy in acute ischemic stroke","volume":"2018","author":"Nie","year":"2018","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.ejphar.2023.175982_bib34","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.yjmcc.2017.06.008","article-title":"Suppression of autophagic flux contributes to cardiomyocyte death by activation of necroptotic pathways","volume":"108","author":"Ogasawara","year":"2017","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"1","key":"10.1016\/j.ejphar.2023.175982_bib35","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.pharmthera.2013.01.003","article-title":"Inhibition of FAAH and activation of PPAR: new approaches to the treatment of cognitive dysfunction and drug addiction","volume":"138","author":"Panlilio","year":"2013","journal-title":"Pharmacol. Ther."},{"issue":"1","key":"10.1016\/j.ejphar.2023.175982_bib36","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1527-3458.2006.00021.x","article-title":"Pharmacological profile of the selective FAAH inhibitor KDS-4103 (URB597)","volume":"12","author":"Piomelli","year":"2006","journal-title":"CNS Drug Rev."},{"issue":"6","key":"10.1016\/j.ejphar.2023.175982_bib37","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1097\/FBP.0000000000000154","article-title":"Biphasic effects of anandamide on behavioural responses: emphasis on copulatory behaviour","volume":"26","author":"Rodr\u00edguez-Manzo","year":"2015","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.ejphar.2023.175982_bib38","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.bbr.2016.07.009","article-title":"Cannabinoid receptor agonist WIN55,212-2 and fatty acid amide hydrolase inhibitor URB597 may protect against cognitive impairment in rats of chronic cerebral hypoperfusion via PI3K\/AKT signaling","volume":"313","author":"Su","year":"2016","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ejphar.2023.175982_bib39","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.neuroscience.2015.03.021","article-title":"Cannabinoid receptor agonist WIN55,212-2 and fatty acid amide hydrolase inhibitor URB597 suppress chronic cerebral hypoperfusion-induced neuronal apoptosis by inhibiting c-Jun N-terminal kinase signaling","volume":"301","author":"Su","year":"2015","journal-title":"Neuroscience"},{"issue":"7","key":"10.1016\/j.ejphar.2023.175982_bib40","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1038\/s41419-018-0755-y","article-title":"Inhibition of excessive autophagy and mitophagy mediates neuroprotective effects of URB597 against chronic cerebral hypoperfusion","volume":"9","author":"Su","year":"2018","journal-title":"Cell Death Dis."},{"issue":"2","key":"10.1016\/j.ejphar.2023.175982_bib41","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S0091-3057(97)00422-X","article-title":"Biphasic effects of anandamide","volume":"59","author":"Sulcova","year":"1998","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.ejphar.2023.175982_bib42","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.nbd.2014.04.002","article-title":"Ischemic insults induce necroptotic cell death in hippocampal neurons through the up-regulation of endogenous RIP3","volume":"68","author":"Vieira","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.ejphar.2023.175982_bib43","doi-asserted-by":"crossref","first-page":"3661","DOI":"10.2147\/IJN.S307335","article-title":"Neuroprotective effects of VEGF-A nanofiber membrane and FAAH inhibitor URB597 against oxygen-glucose deprivation-induced ischemic neuronal injury","volume":"16","author":"Wang","year":"2021","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.ejphar.2023.175982_bib44","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.pneurobio.2018.01.001","article-title":"Autophagy in ischemic stroke","volume":"163\u2013164","author":"Wang","year":"2018","journal-title":"Prog. Neurobiol. (Oxf.)"},{"issue":"1","key":"10.1016\/j.ejphar.2023.175982_bib45","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1083\/jcb.201804165","article-title":"ATP13A2 facilitates HDAC6 recruitment to lysosome to promote autophagosome-lysosome fusion","volume":"218","author":"Wang","year":"2018","journal-title":"J. Cell Biol."},{"issue":"5","key":"10.1016\/j.ejphar.2023.175982_bib46","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1007\/s11064-020-02993-5","article-title":"The novel role of PPAR alpha in the brain: promising target in therapy of alzheimer's disease and other neurodegenerative disorders","volume":"45","author":"W\u00f3jtowicz","year":"2020","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.ejphar.2023.175982_bib47","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.nbd.2018.04.018","article-title":"The role of autophagy in acute brain injury: a state of flux?","volume":"122","author":"Wolf","year":"2019","journal-title":"Neurobiol. Dis."},{"issue":"37","key":"10.1016\/j.ejphar.2023.175982_bib48","doi-asserted-by":"crossref","first-page":"7369","DOI":"10.1523\/JNEUROSCI.0299-19.2019","article-title":"Circular RNA TLK1 aggravates neuronal injury and neurological deficits after ischemic stroke via miR-335-3p\/TIPARP","volume":"39","author":"Wu","year":"2019","journal-title":"J. Neurosci."},{"issue":"9","key":"10.1016\/j.ejphar.2023.175982_bib49","doi-asserted-by":"crossref","DOI":"10.3390\/life11090948","article-title":"Melibiose confers a neuroprotection against cerebral ischemia\/reperfusion injury by ameliorating autophagy flux via facilitation of TFEB nuclear translocation in neurons","volume":"11","author":"Wu","year":"2021","journal-title":"Life"},{"key":"10.1016\/j.ejphar.2023.175982_bib50","article-title":"RIP3 induces ischemic neuronal DNA degradation and programmed necrosis in rat via AIF","volume":"6","author":"Xu","year":"2016","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.ejphar.2023.175982_bib51","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1042\/BST20170102","article-title":"Evolution of tools and methods for monitoring autophagic flux in mammalian cells","volume":"46","author":"Yang","year":"2018","journal-title":"Biochem. Soc. Trans."},{"issue":"6","key":"10.1016\/j.ejphar.2023.175982_bib52","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1007\/s12975-021-00916-2","article-title":"Four decades of ischemic penumbra and its implication for ischemic stroke","volume":"12","author":"Yang","year":"2021","journal-title":"Transl Stroke Res"},{"issue":"2","key":"10.1016\/j.ejphar.2023.175982_bib53","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1080\/15548627.2017.1378838","article-title":"Autophagy pathway: cellular and molecular mechanisms","volume":"14","author":"Yu","year":"2018","journal-title":"Autophagy"},{"key":"10.1016\/j.ejphar.2023.175982_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2020.113915","article-title":"Necroptosis mediated by impaired autophagy flux contributes to adverse ventricular remodeling after myocardial infarction","volume":"175","author":"Zhang","year":"2020","journal-title":"Biochem. Pharmacol."},{"issue":"7","key":"10.1016\/j.ejphar.2023.175982_bib55","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/s41419-020-02770-w","article-title":"Catalytically inactive RIP1 and RIP3 deficiency protect against acute ischemic stroke by inhibiting necroptosis and neuroinflammation","volume":"11","author":"Zhang","year":"2020","journal-title":"Cell Death Dis."},{"issue":"2","key":"10.1016\/j.ejphar.2023.175982_bib56","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.neuropharm.2012.03.008","article-title":"Orally administered oleoylethanolamide protects mice from focal cerebral ischemic injury by activating peroxisome proliferator-activated receptor \u03b1","volume":"63","author":"Zhou","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ejphar.2023.175982_bib57","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.pbb.2015.06.009","article-title":"Orally administrated pterospilus attenuates acute cerebral ischemia-reperfusion injury in a dose- and time-dependent manner in mice","volume":"135","author":"Zhou","year":"2015","journal-title":"Pharmacol. Biochem. Behav."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299923004946?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299923004946?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T13:15:35Z","timestamp":1777382135000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299923004946"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":57,"alternative-id":["S0014299923004946"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2023.175982","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"URB597 exerts neuroprotective effects against transient brain ischemia injury in mice by regulating autophagic flux and necroptosis","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2023.175982","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"175982"}}