{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T22:03:50Z","timestamp":1777586630178,"version":"3.51.4"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2013\/07467-1"],"award-info":[{"award-number":["2013\/07467-1"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2015\/50040\\u20134"],"award-info":[{"award-number":["2015\/50040\\u20134"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2020\/04998-0"],"award-info":[{"award-number":["2020\/04998-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004330","name":"GlaxoSmithKline","doi-asserted-by":"publisher","award":["2020\/13139-0"],"award-info":[{"award-number":["2020\/13139-0"]}],"id":[{"id":"10.13039\/100004330","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.ejphar.2023.176058","type":"journal-article","created":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T20:45:59Z","timestamp":1695242759000},"page":"176058","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Wnt signaling is involved in crotalphine-induced analgesia in a rat model of neuropathic pain"],"prefix":"10.1016","volume":"959","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2940-9059","authenticated-orcid":false,"given":"Nat\u00e1lia G.","family":"H\u00f6sch","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2304-2142","authenticated-orcid":false,"given":"B\u00e1rbara B.","family":"Martins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Queren A.","family":"Alcantara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle Cristiane","family":"Bufalo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5917-5559","authenticated-orcid":false,"given":"Beatriz S.","family":"Neto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Marisa","family":"Chudzinki-Tavassi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fl\u00e1via V.","family":"Santa-Cecilia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yara","family":"Cury","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0890-9561","authenticated-orcid":false,"given":"Vanessa O.","family":"Zambelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2023.176058_bib1","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0304-3959(88)90209-6","article-title":"A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man","volume":"33","author":"Bennett","year":"1988","journal-title":"Pain"},{"key":"10.1016\/j.ejphar.2023.176058_bib2","doi-asserted-by":"crossref","first-page":"46","DOI":"10.4161\/cib.2.1.7503","article-title":"Mitogen-activated protein kinases and Wnt\/\u03b2-catenin signaling: molecular conversations among signaling pathways","volume":"2","author":"Bikkavilli","year":"2009","journal-title":"Commun. Integr. Biol."},{"key":"10.1016\/j.ejphar.2023.176058_bib3","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.ejphar.2023.176058_bib4","doi-asserted-by":"crossref","first-page":"2504","DOI":"10.1097\/j.pain.0000000000000669","article-title":"Crotalphine desensitizes TRPA1 ion channels to alleviate inflammatory hyperalgesia","volume":"157","author":"Bressan","year":"2016","journal-title":"Pain"},{"key":"10.1016\/j.ejphar.2023.176058_bib5","first-page":"346","article-title":"An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control","volume":"80","author":"Clevers","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2023.176058_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/cells11193143","article-title":"Axon guidance molecules and pain","volume":"11","author":"Damo","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.ejphar.2023.176058_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/toxins13120912","article-title":"Pkc\u03b6-mitogen-activated protein kinase signaling mediates crotalphine-induced antinociception","volume":"13","author":"de Freitas","year":"2021","journal-title":"Toxins"},{"key":"10.1016\/j.ejphar.2023.176058_bib8","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1152\/ajpgi.90455.2008","article-title":"The endocannabinoid anandamide inhibits cholangiocarcinoma growth via activation of the noncanonical Wnt signaling pathway","volume":"295","author":"DeMorrow","year":"2008","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.ejphar.2023.176058_bib9","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.2147\/JPR.S127014","article-title":"The prevalence of probable neuropathic pain in the US: results from a multimodal general-population health survey","volume":"10","author":"DiBonaventura","year":"2017","journal-title":"J. Pain Res."},{"key":"10.1016\/j.ejphar.2023.176058_bib10","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.tins.2009.11.005","article-title":"Ryks: new partners for Wnts in the developing and regenerating nervous system","volume":"33","author":"Fradkin","year":"2010","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.ejphar.2023.176058_bib11","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.ejphar.2008.07.053","article-title":"Crotalphine induces potent antinociception in neuropathic pain by acting at peripheral opioid receptors","volume":"594","author":"Gutierrez","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2023.176058_bib12","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/glia.21081","article-title":"WNT signaling in activated microglia is proinflammatory","volume":"59","author":"Halleskog","year":"2011","journal-title":"Glia"},{"key":"10.1016\/j.ejphar.2023.176058_bib13","doi-asserted-by":"crossref","first-page":"10529","DOI":"10.1073\/pnas.1834309100","article-title":"Activation of CB2 cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: pain inhibition by receptors not present in the CNS","volume":"100","author":"Ibrahim","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejphar.2023.176058_bib14","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.neures.2013.12.002","article-title":"Involvement of Wnt\/\u03b2-catenin signaling in the development of neuropathic pain","volume":"79","author":"Itokazu","year":"2014","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.ejphar.2023.176058_bib15","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2202-11-33","article-title":"Interaction of the mu-opioid receptor with GPR177 (Wntless) inhibits Wnt secretion: Potential implications for opioid dependence","volume":"11","author":"Jin","year":"2010","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.ejphar.2023.176058_bib16","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics13040450","article-title":"Topical treatments and their molecular\/cellular mechanisms in patients with peripheral neuropathic pain\u2014narrative review","volume":"13","author":"Kocot-K\u0119pska","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ejphar.2023.176058_bib17","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1016\/j.peptides.2008.04.003","article-title":"Crotalphine, a novel potent analgesic peptide from the venom of the South American rattlesnake Crotalus durissus terrificus","volume":"29","author":"Konno","year":"2008","journal-title":"Peptides"},{"key":"10.1016\/j.ejphar.2023.176058_bib18","doi-asserted-by":"crossref","first-page":"3112","DOI":"10.1016\/j.ejca.2012.02.062","article-title":"Anandamide inhibits the Wnt\/\u03b2-catenin signalling pathway in human breast cancer MDA MB 231 cells","volume":"48","author":"Laezza","year":"2012","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.ejphar.2023.176058_bib19","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1007\/s12035-015-9138-x","article-title":"Role of Wnt signaling in central nervous system injury","volume":"53","author":"Lambert","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.ejphar.2023.176058_bib20","doi-asserted-by":"crossref","first-page":"2572","DOI":"10.1097\/j.pain.0000000000000366","article-title":"Wnt\/Ryk signaling contributes to neuropathic pain by regulating sensory neuron excitability and spinal synaptic plasticity in rats","volume":"156","author":"Liu","year":"2015","journal-title":"Pain"},{"key":"10.1016\/j.ejphar.2023.176058_bib21","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1146\/annurev.cellbio.20.010403.113126","article-title":"The Wnt signaling pathway in development and disease","volume":"20","author":"Logan","year":"2004","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.ejphar.2023.176058_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms231911571","article-title":"Crotalphine Modulates microglia M1\/M2 Phenotypes and induces spinal analgesia mediated by opioid-cannabinoid systems","volume":"23","author":"Lopes","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2023.176058_bib23","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.devcel.2008.10.004","article-title":"Cleavage of the Wnt receptor Ryk regulates neuronal differentiation during Cortical Neurogenesis","volume":"15","author":"Lyu","year":"2008","journal-title":"Dev. Cell"},{"key":"10.1016\/j.ejphar.2023.176058_bib24","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.devcel.2009.06.016","article-title":"Wnt\/\u03b2-Catenin signaling: components, mechanisms, and diseases","volume":"17","author":"MacDonald","year":"2009","journal-title":"Dev. Cell"},{"key":"10.1016\/j.ejphar.2023.176058_bib25","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1111\/bph.12488","article-title":"Peripheral interactions between cannabinoid and opioid systems contribute to the antinociceptive effect of crotalphine","volume":"171","author":"Machado","year":"2014","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2023.176058_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/biom11121798","article-title":"Activation of PKC\u03b5-ALDH2 axis prevents 4-HNE-induced pain in mice","volume":"11","author":"Martins","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.ejphar.2023.176058_bib27","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0104420","article-title":"Delta-opioid receptor analgesia is independent of microglial activation in a rat model of neuropathic pain","volume":"9","author":"Mika","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2023.176058_bib28","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/B978-0-12-394311-8.00017-0","article-title":"Beta-catenin versus the other armadillo catenins: Assessing our current view of canonical Wnt signaling","volume":"116","author":"Miller","year":"2013","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"10.1016\/j.ejphar.2023.176058_bib29","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1523\/JNEUROSCI.23-03-01026.2003","article-title":"Spinal glia and proinflammatory cytokines mediate mirror-image neuropathic pain in rats","volume":"23","author":"Milligan","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2023.176058_bib30","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/j.bmcl.2019.03.013","article-title":"Analyzing the role of cannabinoids as modulators of Wnt\/\u03b2-catenin signaling pathway for their use in the management of neuropathic pain","volume":"29","author":"Nalli","year":"2019","journal-title":"Bioorganic Med. Chem. Lett."},{"key":"10.1016\/j.ejphar.2023.176058_bib31","doi-asserted-by":"crossref","DOI":"10.3390\/cells8080826","article-title":"WNT signaling in disease","volume":"8","author":"Ng","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.ejphar.2023.176058_bib32","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.brainresbull.2017.07.004","article-title":"Identifying novel members of the Wntless interactome through genetic and candidate gene approaches","volume":"138","author":"Petko","year":"2018","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.ejphar.2023.176058_bib33","first-page":"209","article-title":"A method for measurement of analgesia activity on inflamed tissue","volume":"111","author":"Randall","year":"1957","journal-title":"Arch. Inst. Pharmacodyn."},{"key":"10.1016\/j.ejphar.2023.176058_bib34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fncel.2013.00103","article-title":"WNT signalling in neuronal maturation and synaptogenesis","volume":"7","author":"Rosso","year":"2013","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.ejphar.2023.176058_bib35","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/nature04334","article-title":"Wnt-Ryk signalling mediates medial-lateral retinotectal topographic mapping","volume":"439","author":"Schmitt","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2023.176058_bib36","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1080\/17460441.2020.1746266","article-title":"Targeting the Wnt\/\u03b2-catenin pathway in neurodegenerative diseases: recent approaches and current challenges","volume":"15","author":"Serafino","year":"2020","journal-title":"Expert Opin. Drug Discov."},{"key":"10.1016\/j.ejphar.2023.176058_bib37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1744-8069-8-47","article-title":"Regulation of Wnt signaling by nociceptive input in animal models","volume":"8","author":"Shi","year":"2012","journal-title":"Mol. Pain"},{"key":"10.1016\/j.ejphar.2023.176058_bib38","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1007\/978-3-319-05161-1_3","article-title":"TRPs as chemosensors (ROS, RNS, RCS, gasotransmitters)","volume":"223","author":"Shimizu","year":"2014","journal-title":"Handb. Exp. Pharmacol."},{"key":"10.1016\/j.ejphar.2023.176058_bib39","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.neuron.2014.05.037","article-title":"Wnt-fzd signaling sensitizes peripheral sensory neurons via distinct noncanonical pathways","volume":"83","author":"Simonetti","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.ejphar.2023.176058_bib40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1242\/dev.146589","article-title":"Wnt signaling in development and tissue homeostasis","volume":"145","author":"Steinhart","year":"2018","journal-title":"Development"},{"key":"10.1016\/j.ejphar.2023.176058_bib41","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1037\/bne0000104","article-title":"Low expression of D2R and wntless correlates with high motivation for heroin","volume":"129","author":"Tacelosky","year":"2015","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.ejphar.2023.176058_bib42","first-page":"185","article-title":"Wnt signaling pathway in development and cancer","volume":"69","author":"Taciak","year":"2018","journal-title":"J. Physiol. Pharmacol."},{"key":"10.1016\/j.ejphar.2023.176058_bib43","doi-asserted-by":"crossref","first-page":"737","DOI":"10.2174\/1871527312666131223114457","article-title":"Synaptic activity-regulated Wnt signaling in synaptic plasticity, glial function and chronic pain","volume":"13","author":"Tang","year":"2014","journal-title":"CNS Neurol. Disord. - Drug Targets"},{"key":"10.1016\/j.ejphar.2023.176058_bib44","doi-asserted-by":"crossref","DOI":"10.1007\/s12017-021-08700-z","article-title":"Wnt signaling pathways: a role in pain processing","author":"Tang","year":"2022","journal-title":"NeuroMolecular Med."},{"key":"10.1016\/j.ejphar.2023.176058_bib45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1124\/jpet.106.104463","article-title":"Functional selectivity and classical concepts of quantitative pharmacology","volume":"320","author":"Urban","year":"2007","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2023.176058_bib46","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.pain.2013.11.013","article-title":"Neuropathic pain in the general population: a systematic review of epidemiological studies","volume":"155","author":"Van Hecke","year":"2014","journal-title":"Pain"},{"key":"10.1016\/j.ejphar.2023.176058_bib47","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.neulet.2017.01.005","article-title":"Morphine administration induces change in anxiety-related behavior via Wnt\/\u03b2-catenin signaling","volume":"639","author":"Wang","year":"2017","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ejphar.2023.176058_bib48","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1124\/jpet.107.132142","article-title":"2-Methoxymethyl-salvinorin B is a potent \u03ba opioid receptor agonist with longer lasting action in vivo than salvinorin A","volume":"324","author":"Wang","year":"2008","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejphar.2023.176058_bib49","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1111\/j.1365-2567.2010.03281.x","article-title":"The anti-inflammatory effects of interleukin-4 are not mediated by suppressor of cytokine signalling-1 (SOCS1)","volume":"131","author":"Woodward","year":"2010","journal-title":"Immunology"},{"key":"10.1016\/j.ejphar.2023.176058_bib50","doi-asserted-by":"crossref","first-page":"10128","DOI":"10.1523\/JNEUROSCI.0800-16.2016","article-title":"Inhibition of YAP\/TAZ activity in spinal cord suppresses neuropathic pain","volume":"36","author":"Xu","year":"2016","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2023.176058_bib51","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s12031-015-0565-y","article-title":"TCF4 mediates the maintenance of neuropathic pain through Wnt\/\u03b2-catenin signaling following peripheral nerve injury in rats","volume":"56","author":"Xu","year":"2015","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.ejphar.2023.176058_bib52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/1744806917709372","article-title":"Ryk receptors on unmyelinated nerve fibers mediate excitatory synaptic transmission and CCL2 release during neuropathic pain induced by peripheral nerve injury","volume":"13","author":"Yang","year":"2017","journal-title":"Mol. Pain"},{"key":"10.1016\/j.ejphar.2023.176058_bib53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/2045-3701-2-14","article-title":"Wnt signaling in development and disease","volume":"2","author":"Yang","year":"2012","journal-title":"Cell Biosci."},{"key":"10.1016\/j.ejphar.2023.176058_bib54","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0090576","article-title":"Peripheral sensitization increases opioid receptor expression and activation by crotalphine in rats","volume":"9","author":"Zambelli","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2023.176058_bib55","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3009539","article-title":"Aldehyde dehydrogenase-2 regulates nociception in rodent models of acute inflammatory pain","volume":"6","author":"Zambelli","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.ejphar.2023.176058_bib56","doi-asserted-by":"crossref","first-page":"2268","DOI":"10.1172\/JCI65364","article-title":"WNT signaling underlies the pathogenesis of neuropathic pain in rodents","volume":"123","author":"Zhang","year":"2013","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ejphar.2023.176058_bib57","first-page":"3082","article-title":"Effect of Wnt signaling pathway on pathogenesis and intervention of neuropathic pain","volume":"16","author":"Zhao","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.ejphar.2023.176058_bib58","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/1744806920922100","article-title":"Wnt\/\u03b2-catenin signaling regulates brain-derived neurotrophic factor release from spinal microglia to mediate HIV1 gp120-induced neuropathic pain","volume":"16","author":"Zhou","year":"2020","journal-title":"Mol. Pain"},{"key":"10.1016\/j.ejphar.2023.176058_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2021.107984","article-title":"Wnt signaling: a prospective therapeutic target for chronic pain","volume":"231","author":"Zhou","year":"2022","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.ejphar.2023.176058_bib60","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0304-3959(83)90201-4","article-title":"Ethical guidelines for investigations of experimental pain in conscious animals","volume":"16","author":"Zimmermann","year":"1983","journal-title":"Pain"}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299923005708?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299923005708?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T20:07:17Z","timestamp":1777406837000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299923005708"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":60,"alternative-id":["S0014299923005708"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2023.176058","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Wnt signaling is involved in crotalphine-induced analgesia in a rat model of neuropathic pain","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2023.176058","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"176058"}}