{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:24:54Z","timestamp":1792801494317,"version":"4.5.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.ejphar.2023.176067","type":"journal-article","created":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T17:44:11Z","timestamp":1695577451000},"page":"176067","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["Novel HDAC inhibitors provide neuroprotection in MPTP-induced Parkinson's disease model of rats"],"prefix":"10.1016","volume":"959","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-8190-3722","authenticated-orcid":false,"given":"Sai Teja","family":"Meka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sree Lalitha","family":"Bojja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gautam","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumit Raosaheb","family":"Birangal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3744-8135","authenticated-orcid":false,"given":"C. Mallikarjuna","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2023.176067_bib34","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1007\/s11011-018-0201-y","article-title":"Interplay between adenosine receptor antagonist and cyclooxygenase inhibitor in haloperidol-induced extrapyramidal effects in mice","volume":"33","author":"Arora","year":"2018","journal-title":"Metab. Brain Dis."},{"issue":"10291","key":"10.1016\/j.ejphar.2023.176067_bib1","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1016\/S0140-6736(21)00218-X","article-title":"Parkinson's disease","volume":"397","author":"Bloem","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.ejphar.2023.176067_bib33","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s10787-020-00782-8","article-title":"Metformin ameliorates the status epilepticus- induced hippocampal pathology through possible mTOR modulation","volume":"29","author":"Bojja","year":"2021","journal-title":"Inflammopharmacology"},{"issue":"9","key":"10.1016\/j.ejphar.2023.176067_bib2","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1016\/j.drudis.2019.05.003","article-title":"The current status of pharmacotherapy for the treatment of Parkinson's disease: transition from single-target to multitarget therapy","volume":"24","author":"Cheong","year":"2019","journal-title":"Drug Discov. Today"},{"issue":"4","key":"10.1016\/j.ejphar.2023.176067_bib3","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1093\/hmg\/ddu526","article-title":"PINK1 positively regulates HDAC3 to suppress dopaminergic neuronal cell death","volume":"24","author":"Choi","year":"2015","journal-title":"Hum. Mol. Genet."},{"issue":"8","key":"10.1016\/j.ejphar.2023.176067_bib4","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0202770","article-title":"Charting the onset of Parkinson-like motor and non-motor symptoms in nonhuman primate model of Parkinson's disease","volume":"13","author":"Choudhury","year":"2018","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.ejphar.2023.176067_bib5","first-page":"1","article-title":"Signaling pathways in Parkinson's disease: molecular mechanisms and therapeutic interventions","volume":"8","author":"Dong-Chen","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"issue":"Suppl. 1","key":"10.1016\/j.ejphar.2023.176067_bib6","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.3233\/JPD-181474","article-title":"The emerging evidence of the Parkinson pandemic","volume":"8","author":"Dorsey","year":"2018","journal-title":"J. Parkinsons Dis."},{"key":"10.1016\/j.ejphar.2023.176067_bib7","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.pnpbp.2015.03.010","article-title":"The potential use of histone deacetylase inhibitors in the treatment of depression","volume":"64","author":"Fuchikami","year":"2016","journal-title":"Prog. Neuro Psychopharmacol. Biol. Psychiatr."},{"issue":"16","key":"10.1016\/j.ejphar.2023.176067_bib8","doi-asserted-by":"crossref","first-page":"4200","DOI":"10.1111\/bph.13208","article-title":"Neurorestoration induced by the HDAC inhibitor sodium valproate in the lactacystin model of Parkinson's is associated with histone acetylation and up-regulation of neurotrophic factors","volume":"172","author":"Harrison","year":"2015","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2023.176067_bib9","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/8797206","article-title":"HDAC inhibitors as epigenetic regulators of the immune system: impacts on cancer therapy and inflammatory diseases","author":"Hull","year":"2016","journal-title":"BioMed Res. Int."},{"issue":"2","key":"10.1016\/j.ejphar.2023.176067_bib10","doi-asserted-by":"crossref","first-page":"190","DOI":"10.2174\/1871527319999201113102852","article-title":"Histone deacetylase inhibitors prevented the development of morphine tolerance by decreasing IL6 production and upregulating \u03bc-opioid receptors","volume":"20","author":"Jindal","year":"2021","journal-title":"CNS Neurol. Disord. - Drug Targets"},{"issue":"38","key":"10.1016\/j.ejphar.2023.176067_bib11","doi-asserted-by":"crossref","first-page":"4934","DOI":"10.2174\/1381612826666200625101442","article-title":"Cinnamyl sulfonamide hydroxamate derivatives inhibited LPS-stimulated NF-kB expression in RAW 264.7 cells in vitro and mitigated experimental colitis in wistar rats in vivo","volume":"26","author":"Joshi","year":"2020","journal-title":"Curr. Pharmaceut. Des."},{"issue":"4","key":"10.1016\/j.ejphar.2023.176067_bib12","doi-asserted-by":"crossref","first-page":"504","DOI":"10.5607\/en.2019.28.4.504","article-title":"HDAC inhibition by valproic acid induces neuroprotection and improvement of PD-like behaviors in LRRK2 R1441G transgenic mice","volume":"28","author":"Kim","year":"2019","journal-title":"Exp. Neurobiol."},{"issue":"20","key":"10.1016\/j.ejphar.2023.176067_bib13","doi-asserted-by":"crossref","first-page":"3012","DOI":"10.1093\/hmg\/ddl243","article-title":"Alpha-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicity","volume":"15","author":"Kontopoulos","year":"2006","journal-title":"Hum. Mol. Genet."},{"issue":"3","key":"10.1016\/j.ejphar.2023.176067_bib14","doi-asserted-by":"crossref","first-page":"309","DOI":"10.4103\/0253-7613.132180","article-title":"Hesperidin potentiates the neuroprotective effects of diazepam and gabapentin against pentylenetetrazole-induced convulsions in mice: possible behavioral, biochemical and mitochondrial alterations","volume":"46","author":"Kumar","year":"2014","journal-title":"Indian J. Pharmacol."},{"key":"10.1016\/j.ejphar.2023.176067_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101338","article-title":"Pharmacological inhibition of histone deacetylase reduces NADPH oxidase expression, oxidative stress and the progression of atherosclerotic lesions in hypercholesterolemic apolipoprotein E-deficient mice; potential implications for human atherosclerosis","volume":"28","author":"Manea","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.ejphar.2023.176067_bib16","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.bbi.2022.02.025","article-title":"Peripheral administration of the Class-IIa HDAC inhibitor MC1568 partially protects against nigrostriatal neurodegeneration in the striatal 6-OHDA rat model of Parkinson's disease","volume":"102","author":"Mazzocchi","year":"2022","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.ejphar.2023.176067_bib17","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.neuropharm.2016.03.012","article-title":"The HDAC inhibitor SAHA improves depressive-like behavior of CRTC1-deficient mice: possible relevance for treatment-resistant depression","volume":"107","author":"Meylan","year":"2016","journal-title":"Neuropharmacology"},{"issue":"5","key":"10.1016\/j.ejphar.2023.176067_bib18","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1007\/s43440-021-00252-0","article-title":"Antidepressant-like effect of dehydrozingerone from Zingiber officinale by elevating monoamines in brain: in silico and in vivo studies","volume":"73","author":"Moorkoth","year":"2021","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.ejphar.2023.176067_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2023.175625","article-title":"Usmarapride (SUVN-D4010), a 5-HT4 receptor partial agonist for the potential treatment of Alzheimer's disease: behavioural, neurochemical and pharmacological profiling","volume":"947","author":"Nirogi","year":"2023","journal-title":"Eur. J. Pharmacol."},{"issue":"7","key":"10.1016\/j.ejphar.2023.176067_bib20","doi-asserted-by":"crossref","DOI":"10.3390\/cells9071687","article-title":"Inflammation in Parkinson's disease: mechanisms and therapeutic implications","volume":"9","author":"Pajares","year":"2020","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.ejphar.2023.176067_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13041-017-0340-9","article-title":"Oxidative stress and cellular pathologies in Parkinson's disease","volume":"10","author":"Puspita","year":"2017","journal-title":"Mol. Brain"},{"issue":"7","key":"10.1016\/j.ejphar.2023.176067_bib22","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1007\/s11064-021-03334-w","article-title":"Epigenetic modulation in Parkinson's disease and potential treatment therapies","volume":"46","author":"Rathore","year":"2021","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.ejphar.2023.176067_bib23","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.cbi.2015.03.015","article-title":"In vitro and in vivo evaluation of novel cinnamyl sulfonamide hydroxamate derivative against colon adenocarcinoma","volume":"233","author":"Reddy","year":"2015","journal-title":"Chem. Biol. Interact."},{"issue":"8","key":"10.1016\/j.ejphar.2023.176067_bib24","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1007\/s00210-021-02096-0","article-title":"Pharmacokinetic and pharmacodynamic evaluation of nasal liposome and nanoparticle based rivastigmine formulations in acute and chronic models of Alzheimer's disease","volume":"394","author":"Rompicherla","year":"2021","journal-title":"Naunyn-Schmiedeberg\u2019s Arch. Pharmacol."},{"key":"10.1016\/j.ejphar.2023.176067_bib25","series-title":"Drug treatment strategies for depression in Parkinson disease","author":"Ryan","year":"2019"},{"issue":"7","key":"10.1016\/j.ejphar.2023.176067_bib26","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/nrn.2017.62","article-title":"Non-motor features of Parkinson disease","volume":"18","author":"Schapira","year":"2017","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.ejphar.2023.176067_bib27","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.bbr.2015.05.052","article-title":"Beneficial effects of sodium butyrate in 6-OHDA induced neurotoxicity and behavioral abnormalities: modulation of histone deacetylase activity","volume":"291","author":"Sharma","year":"2015","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ejphar.2023.176067_bib28","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.00537","article-title":"Histone deacetylases inhibitors in neurodegenerative diseases, neuroprotection and neuronal differentiation","volume":"11","author":"Shukla","year":"2020","journal-title":"Front. Pharmacol."},{"issue":"11","key":"10.1016\/j.ejphar.2023.176067_bib29","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/s41577-022-00684-6","article-title":"Inflammation and immune dysfunction in Parkinson disease","volume":"22","author":"Tansey","year":"2022","journal-title":"Nat. Rev. Immunol."},{"issue":"3","key":"10.1016\/j.ejphar.2023.176067_bib30","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1007\/s12035-021-02711-4","article-title":"Pharmacological modulation of TRPM2 channels via PARP pathway leads to neuroprotection in MPTP-induced Parkinson's disease in sprague dawley rats","volume":"59","author":"Vaidya","year":"2022","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.ejphar.2023.176067_bib31","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2019.00277","article-title":"Entanglement of genetics and epigenetics in Parkinson's disease","volume":"13","author":"van Heesbeen","year":"2019","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.ejphar.2023.176067_bib32","article-title":"Inhibition of histone deacetylase promotes a neuroprotective mechanism in an experimental model of Parkinson's disease","author":"Wang","year":"2021","journal-title":"Arch. Med. Sci."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299923005794?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299923005794?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T04:26:18Z","timestamp":1762143978000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299923005794"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":34,"alternative-id":["S0014299923005794"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2023.176067","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel HDAC inhibitors provide neuroprotection in MPTP-induced Parkinson's disease model of rats","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2023.176067","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"176067"}}