{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T18:32:46Z","timestamp":1789583566483,"version":"build-2803163510"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T00:00:00Z","timestamp":1695340800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82000230"],"award-info":[{"award-number":["82000230"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82104197"],"award-info":[{"award-number":["82104197"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.ejphar.2023.176071","type":"journal-article","created":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T19:29:38Z","timestamp":1695324578000},"page":"176071","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["SOX4 as a potential therapeutic target for pathological cardiac hypertrophy"],"prefix":"10.1016","volume":"958","author":[{"given":"Shen","family":"Bin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"xinyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Huan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhang","family":"xiaoqin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wu","family":"Jiming","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Ziyue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zou","family":"Xiaochun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"zhouqi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhou","family":"Bangwei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Jing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu","family":"Shihui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0106-1451","authenticated-orcid":false,"given":"Gao","family":"Jinlai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.ejphar.2023.176071_bib1","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s00018-021-04097-x","article-title":"PRMT7 ablation in cardiomyocytes causes cardiac hypertrophy and fibrosis through beta-catenin dysregulation","volume":"79","author":"Ahn","year":"2022","journal-title":"Cell. Mol. Life Sci."},{"issue":"17","key":"10.1016\/j.ejphar.2023.176071_bib2","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1089\/ars.2018.7703","article-title":"Sirt3 deficiency shortens life span and impairs cardiac mitochondrial function rescued by Opa1 gene transfer","volume":"31","author":"Benigni","year":"2019","journal-title":"Antioxidants Redox Signal."},{"issue":"1","key":"10.1016\/j.ejphar.2023.176071_bib3","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.pharmthera.2010.04.005","article-title":"Molecular distinction between physiological and pathological cardiac hypertrophy: experimental findings and therapeutic strategies","volume":"128","author":"Bernardo","year":"2010","journal-title":"Pharmacol. Ther."},{"issue":"3","key":"10.1016\/j.ejphar.2023.176071_bib4","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/s41440-019-0354-z","article-title":"Inhibition of UCHL1 by LDN-57444 attenuates Ang II-Induced atrial fibrillation in mice","volume":"43","author":"Bi","year":"2020","journal-title":"Hypertens. Res."},{"issue":"9","key":"10.1016\/j.ejphar.2023.176071_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19092592","article-title":"Dihydromyricetin attenuates myocardial hypertrophy induced by transverse aortic constriction via oxidative stress inhibition and SIRT3 pathway enhancement","volume":"19","author":"Chen","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.ejphar.2023.176071_bib6","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s12943-019-1006-2","article-title":"Circular RNA circ-DONSON facilitates gastric cancer growth and invasion via NURF complex dependent activation of transcription factor SOX4","volume":"18","author":"Ding","year":"2019","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.ejphar.2023.176071_bib7","first-page":"718","article-title":"lncRNA BG981369 inhibits cell proliferation, migration, and invasion, and promotes cell apoptosis by SRY-related high-mobility group box 4 (SOX4) signaling pathway in human gastric cancer","volume":"24","author":"Dong","year":"2018","journal-title":"Med. Sci. Mon. Int. Med. J. Exp. Clin. Res."},{"key":"10.1016\/j.ejphar.2023.176071_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.174614","article-title":"Anthelmintic niclosamide attenuates pressure-overload induced heart failure in mice","volume":"912","author":"Fu","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2023.176071_bib9","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.freeradbiomed.2018.06.020","article-title":"Characterizations of mitochondrial uncoupling induced by chemical mitochondrial uncouplers in cardiomyocytes","volume":"124","author":"Gao","year":"2018","journal-title":"Free Radic. Biol. Med."},{"issue":"1","key":"10.1016\/j.ejphar.2023.176071_bib10","doi-asserted-by":"crossref","first-page":"82","DOI":"10.3892\/or.2017.5641","article-title":"MicroRNA-212 inhibits the metastasis of nasopharyngeal carcinoma by targeting SOX4","volume":"38","author":"Jiang","year":"2017","journal-title":"Oncol. Rep."},{"issue":"6","key":"10.1016\/j.ejphar.2023.176071_bib11","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1172\/JCI44824","article-title":"Pivotal role of cardiomyocyte TGF-beta signaling in the murine pathological response to sustained pressure overload","volume":"121","author":"Koitabashi","year":"2011","journal-title":"J. Clin. Invest."},{"issue":"15","key":"10.1016\/j.ejphar.2023.176071_bib12","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1161\/CIRCULATIONAHA.117.027832","article-title":"Tomo-seq identifies SOX9 as a key regulator of cardiac fibrosis during ischemic injury","volume":"136","author":"Lacraz","year":"2017","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.ejphar.2023.176071_bib13","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/sj.bjp.0707372","article-title":"Good statistical practice in pharmacology. Problem 2","volume":"152","author":"Lew","year":"2007","journal-title":"Br. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.ejphar.2023.176071_bib14","doi-asserted-by":"crossref","first-page":"226","DOI":"10.3349\/ymj.2018.59.2.226","article-title":"Long non-coding RNA TUG1 promotes proliferation and inhibits apoptosis of osteosarcoma cells by sponging miR-132-3p and upregulating SOX4 expression","volume":"59","author":"Li","year":"2018","journal-title":"Yonsei Med. J."},{"issue":"2","key":"10.1016\/j.ejphar.2023.176071_bib15","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21020682","article-title":"STVNa attenuates isoproterenol-induced cardiac hypertrophy response through the HDAC4 and Prdx2\/ROS\/Trx1 pathways","volume":"21","author":"Liu","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2023.176071_bib16","doi-asserted-by":"crossref","first-page":"2475","DOI":"10.2147\/OTT.S160192","article-title":"UCA1 promotes cell proliferation and invasion and inhibits apoptosis through regulation of the miR129-SOX4 pathway in renal cell carcinoma","volume":"11","author":"Liu","year":"2018","journal-title":"OncoTargets Ther."},{"issue":"8","key":"10.1016\/j.ejphar.2023.176071_bib17","doi-asserted-by":"crossref","first-page":"e593","DOI":"10.1038\/bcj.2017.74","article-title":"Overexpression of SOX4 correlates with poor prognosis of acute myeloid leukemia and is leukemogenic in zebrafish","volume":"7","author":"Lu","year":"2017","journal-title":"Blood Cancer J."},{"issue":"11","key":"10.1016\/j.ejphar.2023.176071_bib18","doi-asserted-by":"crossref","first-page":"2887","DOI":"10.1084\/jem.20172021","article-title":"SOX4 controls invariant NKT cell differentiation by tuning TCR signaling","volume":"215","author":"Malhotra","year":"2018","journal-title":"J. Exp. Med."},{"issue":"8","key":"10.1016\/j.ejphar.2023.176071_bib19","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1111\/bph.13861","article-title":"Hydrogen sulfide pretreatment improves mitochondrial function in myocardial hypertrophy via a SIRT3-dependent manner","volume":"175","author":"Meng","year":"2018","journal-title":"Br. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.ejphar.2023.176071_bib20","first-page":"359","article-title":"SOX4 regulates invasion of bladder cancer cells via repression of WNT5a","volume":"55","author":"Moran","year":"2019","journal-title":"Int. J. Oncol."},{"issue":"Pt 1","key":"10.1016\/j.ejphar.2023.176071_bib21","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.semcancer.2019.08.027","article-title":"SOX4: the unappreciated oncogene","volume":"67","author":"Moreno","year":"2020","journal-title":"Semin. Cancer Biol."},{"issue":"7","key":"10.1016\/j.ejphar.2023.176071_bib22","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/s41569-018-0007-y","article-title":"Mechanisms of physiological and pathological cardiac hypertrophy","volume":"15","author":"Nakamura","year":"2018","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.ejphar.2023.176071_bib23","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.actbio.2020.02.010","article-title":"Computational modeling of cardiac growth and remodeling in pressure overloaded hearts-Linking microstructure to organ phenotype","volume":"106","author":"Niestrawska","year":"2020","journal-title":"Acta Biomater."},{"issue":"2","key":"10.1016\/j.ejphar.2023.176071_bib24","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1139\/cjpp-2019-0566","article-title":"Mechanisms for the transition from physiological to pathological cardiac hypertrophy","volume":"98","author":"Oldfield","year":"2020","journal-title":"Can. J. Physiol. Pharmacol."},{"issue":"1","key":"10.1016\/j.ejphar.2023.176071_bib25","first-page":"441","article-title":"miR-188 suppresses tumor progression by targeting SOX4 in pediatric osteosarcoma","volume":"18","author":"Pan","year":"2018","journal-title":"Mol. Med. Rep."},{"issue":"10","key":"10.1016\/j.ejphar.2023.176071_bib26","doi-asserted-by":"crossref","first-page":"3788","DOI":"10.1073\/pnas.0810147106","article-title":"Induction of SOX4 by DNA damage is critical for p53 stabilization and function","volume":"106","author":"Pan","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"15","key":"10.1016\/j.ejphar.2023.176071_bib27","doi-asserted-by":"crossref","first-page":"2931","DOI":"10.1007\/s00018-013-1523-x","article-title":"Cardiac outflow tract development relies on the complex function of Sox4 and Sox11 in multiple cell types","volume":"71","author":"Paul","year":"2014","journal-title":"Cell. Mol. Life Sci."},{"issue":"1","key":"10.1016\/j.ejphar.2023.176071_bib28","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.gendis.2017.12.005","article-title":"SOX4 contributes to TGF-beta-induced epithelial-mesenchymal transition and stem cell characteristics of gastric cancer cells","volume":"5","author":"Peng","year":"2018","journal-title":"Genes Dis"},{"issue":"2","key":"10.1016\/j.ejphar.2023.176071_bib29","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.ydbio.2015.05.012","article-title":"Transcription factors SOX4 and SOX9 cooperatively control development of bile ducts","volume":"404","author":"Poncy","year":"2015","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ejphar.2023.176071_bib30","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.freeradbiomed.2021.02.040","article-title":"Oxidative stress in cardiac hypertrophy: from molecular mechanisms to novel therapeutic targets","volume":"166","author":"Ramachandra","year":"2021","journal-title":"Free Radic. Biol. Med."},{"issue":"8","key":"10.1016\/j.ejphar.2023.176071_bib31","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1161\/CIRCRESAHA.118.314438","article-title":"Protective effects of activated myofibroblasts in the pressure-overloaded myocardium are mediated through smad-dependent activation of a matrix-preserving Program","volume":"124","author":"Russo","year":"2019","journal-title":"Circ. Res."},{"issue":"5","key":"10.1016\/j.ejphar.2023.176071_bib32","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/j.jhep.2017.01.004","article-title":"The microRNA-449 family inhibits TGF-beta-mediated liver cancer cell migration by targeting SOX4","volume":"66","author":"Sandbothe","year":"2017","journal-title":"J. Hepatol."},{"key":"10.1016\/j.ejphar.2023.176071_bib33","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ijcard.2019.01.078","article-title":"Loss of Sox9 in cardiomyocytes delays the onset of cardiac hypertrophy and fibrosis","volume":"282","author":"Schauer","year":"2019","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.ejphar.2023.176071_bib34","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.yjmcc.2016.06.001","article-title":"Physiological and pathological cardiac hypertrophy","volume":"97","author":"Shimizu","year":"2016","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"4","key":"10.1016\/j.ejphar.2023.176071_bib35","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1017\/S1047951116001116","article-title":"The role of echocardiography in the evaluation of cardiac re-modelling and differentiation between physiological and pathological hypertrophy in teenagers engaged in competitive amateur sports","volume":"27","author":"Sulovic","year":"2017","journal-title":"Cardiol. Young"},{"issue":"20","key":"10.1016\/j.ejphar.2023.176071_bib36","doi-asserted-by":"crossref","first-page":"6384","DOI":"10.1128\/MCB.00426-08","article-title":"SIRT3 is a stress-responsive deacetylase in cardiomyocytes that protects cells from stress-mediated cell death by deacetylation of Ku70","volume":"28","author":"Sundaresan","year":"2008","journal-title":"Mol. Cell Biol."},{"issue":"21","key":"10.1016\/j.ejphar.2023.176071_bib37","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1161\/CIRCULATIONAHA.117.028728","article-title":"SIRT2 acts as a cardioprotective deacetylase in pathological cardiac hypertrophy","volume":"136","author":"Tang","year":"2017","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.ejphar.2023.176071_bib38","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.jacc.2006.02.075","article-title":"EUK-8, a superoxide dismutase and catalase mimetic, reduces cardiac oxidative stress and ameliorates pressure overload-induced heart failure in the harlequin mouse mutant","volume":"48","author":"van Empel","year":"2006","journal-title":"J. Am. Coll. Cardiol."},{"issue":"18","key":"10.1016\/j.ejphar.2023.176071_bib39","doi-asserted-by":"crossref","first-page":"9578","DOI":"10.1093\/nar\/gky755","article-title":"SOX4 can redirect TGF-beta-mediated SMAD3-transcriptional output in a context-dependent manner to promote tumorigenesis","volume":"46","author":"Vervoort","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ejphar.2023.176071_bib40","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.ejphar.2017.12.013","article-title":"Rosuvastatin improves myocardial hypertrophy after hemodynamic pressure overload via regulating the crosstalk of Nrf2\/ARE and TGF-beta\/smads pathways in rat heart","volume":"820","author":"Wang","year":"2018","journal-title":"Eur. J. Pharmacol."},{"issue":"11","key":"10.1016\/j.ejphar.2023.176071_bib41","first-page":"663","article-title":"Lidocaine sensitizes the cytotoxicity of 5-fluorouacil in melanoma cells via upregulation of microRNA-493","volume":"72","author":"Wang","year":"2017","journal-title":"Pharmazie"},{"issue":"5","key":"10.1016\/j.ejphar.2023.176071_bib42","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aau0495","article-title":"The immunoproteasome catalytic beta5i subunit regulates cardiac hypertrophy by targeting the autophagy protein ATG5 for degradation","volume":"5","author":"Xie","year":"2019","journal-title":"Sci. Adv."},{"issue":"2","key":"10.1016\/j.ejphar.2023.176071_bib43","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1002\/jcp.29918","article-title":"Suppression of Sox4 protects against myocardial ischemic injury by reduction of cardiac apoptosis in mice","volume":"236","author":"Zhang","year":"2021","journal-title":"J. Cell. Physiol."},{"issue":"1","key":"10.1016\/j.ejphar.2023.176071_bib44","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s11658-022-00349-1","article-title":"METTL3 mediates Ang-II-induced cardiac hypertrophy through accelerating pri-miR-221\/222 maturation in an m6A-dependent manner","volume":"27","author":"Zhang","year":"2022","journal-title":"Cell. Mol. Biol. Lett."},{"issue":"5","key":"10.1016\/j.ejphar.2023.176071_bib45","doi-asserted-by":"crossref","first-page":"5488","DOI":"10.1002\/jcp.27329","article-title":"The novel relationship between Sirt3 and autophagy in myocardial ischemia-reperfusion","volume":"234","author":"Zheng","year":"2019","journal-title":"J. Cell. Physiol."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299923005836?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299923005836?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T04:23:14Z","timestamp":1762143794000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299923005836"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":45,"alternative-id":["S0014299923005836"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2023.176071","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"SOX4 as a potential therapeutic target for pathological cardiac hypertrophy","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2023.176071","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"176071"}}