{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T10:53:09Z","timestamp":1768560789852,"version":"3.49.0"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["2021R1A2C1011583"],"award-info":[{"award-number":["2021R1A2C1011583"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.ejphar.2023.176218","type":"journal-article","created":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T00:17:39Z","timestamp":1700525859000},"page":"176218","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Ibuprofen modulates tetrodotoxin-resistant persistent Na+ currents at acidic pH in rat trigeminal ganglion neurons"],"prefix":"10.1016","volume":"961","author":[{"given":"Jin-Hwa","family":"Cho","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0054-9680","authenticated-orcid":false,"given":"Il-Sung","family":"Jang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2023.176218_bib1","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/sj.bdj.4811721","article-title":"Relative efficacy of oral analgesics after third molar extraction","volume":"197","author":"Barden","year":"2004","journal-title":"Br. Dent. J."},{"key":"10.1016\/j.ejphar.2023.176218_bib2","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1056\/NEJM199106133242407","article-title":"Nonsteroidal antiinflammatory drugs--differences and similarities","volume":"324","author":"Brooks","year":"1991","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejphar.2023.176218_bib3","doi-asserted-by":"crossref","first-page":"2985","DOI":"10.1185\/030079907X242584","article-title":"Persistence of NSAIDs at effect sites and rapid disappearance from side-effect compartments contributes to tolerability","volume":"23","author":"Brune","year":"2007","journal-title":"Curr. Med. Res. Opin."},{"key":"10.1016\/j.ejphar.2023.176218_bib4","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/BF01958153","article-title":"Aspirin-like drugs may block pain independently of prostaglandin synthesis inhibition","volume":"47","author":"Brune","year":"1991","journal-title":"Experientia"},{"key":"10.1016\/j.ejphar.2023.176218_bib5","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/39807","article-title":"The capsaicin receptor: a heat-activated ion channel in the pain pathway","volume":"389","author":"Caterina","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2023.176218_bib6","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1152\/jn.00184.2010","article-title":"An increase in persistent sodium current contributes to intrinsic neuronal bursting after status epilepticus","volume":"105","author":"Chen","year":"2011","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.ejphar.2023.176218_bib7","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0014-2999(94)90700-5","article-title":"Antinociceptive effects of non-steroidal anti-inflammatory drugs in a rat model of unilateral hindpaw inflammation","volume":"257","author":"Clarke","year":"1994","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2023.176218_bib8","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.neuroscience.2004.06.066","article-title":"Characterization and function of TWIK-related acid sensing K+ channels in a rat nociceptive cell","volume":"129","author":"Cooper","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.ejphar.2023.176218_bib9","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1146\/annurev.ph.58.030196.002025","article-title":"Persistent sodium current in mammalian central neurons","volume":"58","author":"Crill","year":"1996","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.ejphar.2023.176218_bib10","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1472-6904-9-19","article-title":"Bioavailability of ibuprofen following oral administration of standard ibuprofen, sodium ibuprofen or ibuprofen acid incorporating poloxamer in healthy volunteers","volume":"9","author":"Dewland","year":"2009","journal-title":"BMC Clin. Pharmacol."},{"key":"10.1016\/j.ejphar.2023.176218_bib11","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1146\/annurev-neuro-070918-050144","article-title":"Sodium channels in human pain disorders: genetics and pharmacogenomics","volume":"42","author":"Dib-Hajj","year":"2019","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.ejphar.2023.176218_bib12","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1113\/jphysiol.1996.sp021604","article-title":"PGE2 modulates the tetrodotoxin-resistant sodium current in neonatal rat dorsal root ganglion neurones via the cyclic AMP-protein kinase A cascade","volume":"495","author":"England","year":"1996","journal-title":"J. Physiol."},{"key":"10.1016\/j.ejphar.2023.176218_bib13","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1152\/jn.1996.76.3.2125","article-title":"Kinetics of slow inactivation of persistent sodium current in layer V neurons of mouse neocortical slices","volume":"76","author":"Fleidervish","year":"1996","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.ejphar.2023.176218_bib14","doi-asserted-by":"crossref","first-page":"18994","DOI":"10.1073\/pnas.0803464105","article-title":"Endogenous polyamines regulate cortical neuronal excitability by blocking voltage-gated Na+ channels","volume":"105","author":"Fleidervish","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ejphar.2023.176218_bib15","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1038\/nm.2235","article-title":"Nociceptor sensitization in pain pathogenesis","volume":"16","author":"Gold","year":"2010","journal-title":"Nat. Med."},{"key":"10.1016\/j.ejphar.2023.176218_bib16","doi-asserted-by":"crossref","first-page":"10345","DOI":"10.1523\/JNEUROSCI.18-24-10345.1998","article-title":"Modulation of TTX-R INa by PKC and PKA and their role in PGE2-induced sensitization of rat sensory neurons in vitro","volume":"18","author":"Gold","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2023.176218_bib17","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1073\/pnas.93.3.1108","article-title":"Hyperalgesic agents increase a tetrodotoxin-resistant Na+ current in nociceptors","volume":"93","author":"Gold","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ejphar.2023.176218_bib18","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1007\/BF02358871","article-title":"Acidic nonsteroid anti-inflammatory drugs accumulating in inflamed tissue","volume":"31","author":"Graf","year":"1975","journal-title":"Experientia"},{"key":"10.1016\/j.ejphar.2023.176218_bib19","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1046\/j.1460-9568.1999.00503.x","article-title":"Immunocytochemical localization of the vanilloid receptor 1 (VR1): relationship to neuropeptides, the P2X3 purinoceptor and IB4 binding sites","volume":"11","author":"Guo","year":"1999","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.ejphar.2023.176218_bib20","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1111\/j.2042-7158.2012.01479.x","article-title":"Insights into the effects of diclofenac and other non-steroidal anti-inflammatory agents on ion channels","volume":"64","author":"Gwanyanya","year":"2012","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.ejphar.2023.176218_bib21","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1212\/WNL.0000000000002333","article-title":"Sodium channel Nav1.8: emerging links to human disease","volume":"86","author":"Han","year":"2016","journal-title":"Neurology"},{"key":"10.1016\/j.ejphar.2023.176218_bib22","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1126\/science.1094925","article-title":"GlyR \u03b13: an essential target for spinal PGE2-mediated inflammatory pain sensitization","volume":"304","author":"Harvey","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2023.176218_bib23","doi-asserted-by":"crossref","first-page":"7985","DOI":"10.1523\/JNEUROSCI.2146-04.2004","article-title":"Mechanism of spontaneous firing in dorsomedial suprachiasmatic nucleus neurons","volume":"24","author":"Jackson","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2023.176218_bib24","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.ejphar.2018.09.006","article-title":"Modulation of tetrodotoxin-resistant Na+ channels by amitriptyline in dural afferent neurons","volume":"838","author":"Kang","year":"2018","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2023.176218_bib25","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1113\/jphysiol.2002.021014","article-title":"Role of outer ring carboxylates of the rat skeletal muscle sodium channel pore in proton block","volume":"543","author":"Khan","year":"2002","journal-title":"J. Physiol."},{"key":"10.1016\/j.ejphar.2023.176218_bib26","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1002\/cne.20794","article-title":"Distinct expression of TRPM8, TRPA1, and TRPV1 mRNAs in rat primary afferent neurons with A\u03b4\/C-fibers and colocalization with Trk receptors","volume":"493","author":"Kobayashi","year":"2005","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.ejphar.2023.176218_bib27","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1146\/annurev.pharmtox.44.101802.121627","article-title":"Voltage-gated sodium channels and hyperalgesia","volume":"44","author":"Lai","year":"2004","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.ejphar.2023.176218_bib28","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1152\/jn.1990.63.4.887","article-title":"Chemosensitivity of fine afferents from rat skin in vitro","volume":"63","author":"Lang","year":"1990","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.ejphar.2023.176218_bib29","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.brainres.2003.08.048","article-title":"Diclofenac inhibition of sodium currents in rat dorsal root ganglion neurons","volume":"992","author":"Lee","year":"2003","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2023.176218_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2023.137427","article-title":"Menthol excites dural afferent neurons by inhibiting leak K+ conductance in rats","volume":"813","author":"Lee","year":"2023","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ejphar.2023.176218_bib31","doi-asserted-by":"crossref","first-page":"6081","DOI":"10.1523\/JNEUROSCI.18-16-06081.1998","article-title":"The cAMP transduction cascade mediates the prostaglandin E2 enhancement of the capsaicin-elicited current in rat sensory neurons: whole-cell and single-channel studies","volume":"18","author":"Lopshire","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2023.176218_bib32","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/S0896-6273(02)00714-6","article-title":"Molecular basis of an inherited epilepsy","volume":"34","author":"Lossin","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.ejphar.2023.176218_bib33","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1085\/jgp.114.4.491","article-title":"Biophysical properties and slow voltage-dependent inactivation of a sustained sodium current in entorhinal cortex layer-II principal neurons: a whole-cell and single-channel study","volume":"114","author":"Magistretti","year":"1999","journal-title":"J. Gen. Physiol."},{"key":"10.1016\/j.ejphar.2023.176218_bib34","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S1474-4422(10)70059-4","article-title":"Voltage-gated sodium channels as therapeutic targets in epilepsy and other neurological disorders","volume":"9","author":"Mantegazza","year":"2010","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.ejphar.2023.176218_bib35","doi-asserted-by":"crossref","first-page":"3341","DOI":"10.1523\/JNEUROSCI.0104-05.2005","article-title":"Molecular determinants for modulation of persistent sodium current by G-protein \u03b2\u03b3 subunits","volume":"25","author":"Mantegazza","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2023.176218_bib36","first-page":"533","article-title":"Dissociation between the antinociceptive and anti-inflammatory effects of the nonsteroidal anti-inflammatory drugs","volume":"41","author":"McCormack","year":"1991","journal-title":"Surv. Analg.Eff. Drugs"},{"key":"10.1016\/j.ejphar.2023.176218_bib37","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1002\/cpdd.433","article-title":"Pharmacokinetic drug interaction study of bazedoxifene and ibuprofen","volume":"7","author":"McKeand","year":"2018","journal-title":"Clin. Pharmacol. Drug Dev."},{"key":"10.1016\/j.ejphar.2023.176218_bib38","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1744-8069-1-3","article-title":"Sensitization of TRPV1 by EP1 and IP reveals peripheral nociceptive mechanism of prostaglandins","volume":"1","author":"Moriyama","year":"2005","journal-title":"Mol. Pain"},{"key":"10.1016\/j.ejphar.2023.176218_bib39","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/0304-3940(89)90485-0","article-title":"Excitatory and inhibitory amino acids and peptide-induced responses in acutely isolated rat spinal dorsal horn neurons","volume":"103","author":"Murase","year":"1989","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ejphar.2023.176218_bib40","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.pnpbp.2015.07.003","article-title":"pH-dependent inhibition of tetrodotoxin-resistant Na+ channels by diclofenac in rat nociceptive neurons","volume":"64","author":"Nakamura","year":"2016","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.ejphar.2023.176218_bib41","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.neuropharm.2016.02.017","article-title":"Indomethacin inhibits tetrodotoxin-resistant Na+ channels at acidic pH in rat nociceptive neurons","volume":"105","author":"Nakamura","year":"2016","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ejphar.2023.176218_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.174449","article-title":"Propranolol modulation of tetrodotoxin-resistant Na+ channels in dural afferent neurons","volume":"910","author":"Nakamura","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2023.176218_bib43","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s10194-022-01443-7","article-title":"Contribution of tetrodotoxin-resistant persistent Na+ currents to the excitability of C-type dural afferent neurons in rats","volume":"23","author":"Nakamura","year":"2022","journal-title":"J. Headache Pain"},{"key":"10.1016\/j.ejphar.2023.176218_bib44","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1124\/mol.104.007112","article-title":"Meclofenamic acid and diclofenac, novel templates of KCNQ2\/Q3 potassium channel openers, depress cortical neuron activity and exhibit anticonvulsant properties","volume":"67","author":"Peretz","year":"2005","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.ejphar.2023.176218_bib45","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s10787-009-0016-x","article-title":"Ibuprofen: pharmacology, efficacy and safety","volume":"17","author":"Rainsford","year":"2009","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.ejphar.2023.176218_bib46","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0079-6123(08)61085-7","article-title":"Tissue acidosis in nociception and pain","volume":"113","author":"Reeh","year":"1996","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.ejphar.2023.176218_bib47","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1152\/jn.2001.86.2.629","article-title":"Contribution of NaV1.8 sodium channels to action potential electrogenesis in DRG neurons","volume":"86","author":"Renganathan","year":"2001","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.ejphar.2023.176218_bib48","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1124\/pr.56.3.3","article-title":"Cyclooxygenase isozymes: the biology of prostaglandin synthesis and inhibition","volume":"56","author":"Simmons","year":"2004","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.ejphar.2023.176218_bib49","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1535-7511.2007.00156.x","article-title":"Persistent sodium current and its role in epilepsy","volume":"7","author":"Stafstrom","year":"2007","journal-title":"Epilepsy Curr."},{"key":"10.1016\/j.ejphar.2023.176218_bib50","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0304-3940(95)12002-L","article-title":"Pain due to experimental acidosis in human skin: evidence for non-adapting nociceptor excitation","volume":"199","author":"Steen","year":"1995","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ejphar.2023.176218_bib51","doi-asserted-by":"crossref","first-page":"3982","DOI":"10.1523\/JNEUROSCI.15-05-03982.1995","article-title":"A dominant role of acid pH in inflammatory excitation and sensitization of nociceptors in rat skin, in vitro","volume":"15","author":"Steen","year":"1995","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2023.176218_bib52","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1523\/JNEUROSCI.12-01-00086.1992","article-title":"Protons selectively induce lasting excitation and sensitization to mechanical stimulation of nociceptors in rat skin, in vitro","volume":"12","author":"Steen","year":"1992","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2023.176218_bib53","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/S0896-6273(02)00574-3","article-title":"Subthreshold sodium current from rapidly inactivating sodium channels drives spontaneous firing of tuberomammillary neurons","volume":"33","author":"Taddese","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.ejphar.2023.176218_bib54","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.tins.2013.12.002","article-title":"Opening paths to novel analgesics: the role of potassium channels in chronic pain","volume":"37","author":"Tsantoulas","year":"2014","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.ejphar.2023.176218_bib55","doi-asserted-by":"crossref","first-page":"8026","DOI":"10.1523\/JNEUROSCI.21-20-08026.2001","article-title":"Nonsteroid anti-inflammatory drugs inhibit both the activity and the inflammation-induced expression of acid-sensing ion channels in nociceptors","volume":"21","author":"Voilley","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2023.176218_bib56","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0018681","article-title":"Blockade of persistent sodium currents contributes to the riluzole-induced inhibition of spontaneous activity and oscillations in injured DRG neurons","volume":"6","author":"Xie","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2023.176218_bib57","doi-asserted-by":"crossref","first-page":"C577","DOI":"10.1152\/ajpcell.00125.2011","article-title":"NaV1.5-dependent persistent Na+ influx activates CaMKII in rat ventricular myocytes and N1325S mice","volume":"301","author":"Yao","year":"2011","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.ejphar.2023.176218_bib58","doi-asserted-by":"crossref","first-page":"253","DOI":"10.3389\/fnmol.2018.00253","article-title":"A-type KV channels in dorsal root ganglion neurons: diversity, function, and dysfunction","volume":"11","author":"Zemel","year":"2018","journal-title":"Front. Mol. Neurosci."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001429992300732X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001429992300732X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T23:26:21Z","timestamp":1757978781000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S001429992300732X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":58,"alternative-id":["S001429992300732X"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2023.176218","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ibuprofen modulates tetrodotoxin-resistant persistent Na+ currents at acidic pH in rat trigeminal ganglion neurons","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2023.176218","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"176218"}}