{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:43:08Z","timestamp":1790959388975,"version":"4.1.0"},"reference-count":120,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.ejphar.2023.176289","type":"journal-article","created":{"date-parts":[[2023,12,27]],"date-time":"2023-12-27T11:30:26Z","timestamp":1703676626000},"page":"176289","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":52,"special_numbering":"C","title":["Anti-diarrheal effect of piperine possibly through the interaction with inflammation inducing enzymes: In vivo and in silico studies"],"prefix":"10.1016","volume":"965","author":[{"given":"Meher","family":"Afroz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6179-9720","authenticated-orcid":false,"given":"Md. Shimul","family":"Bhuia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Anisur","family":"Rahman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rubel","family":"Hasan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tawhida","family":"Islam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Rakibul","family":"Islam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raihan","family":"Chowdhury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Ali","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davi","family":"Antas e Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrique Douglas","family":"Melo Coutinho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Torequl","family":"Islam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2023.176289_bib1","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jare.2016.10.004","article-title":"Quantitative structure-activity relationship and molecular docking studies of a series of quinazolinonyl analogues as inhibitors of gamma amino butyric acid aminotransferase","volume":"8","author":"Abdulfatai","year":"2017","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.ejphar.2023.176289_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113430","article-title":"Microbiota alteration and modulation in Alzheimer's disease by gerobiotics: the gut-health axis for a good mind","volume":"153","author":"A\u011fag\u00fcnd\u00fcz","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ejphar.2023.176289_bib3","series-title":"Synergistic Hypnotic Effects of Sesamol and Thymol Possibly through GABAergic Interaction Pathway: in Vivo and in Silico Studies","author":"Akbor","year":"2023"},{"key":"10.1016\/j.ejphar.2023.176289_bib4","doi-asserted-by":"crossref","DOI":"10.1002\/cbdv.202300392","article-title":"Mikania micrantha Kunth: an ethnopharmacological treasure trove of therapeutic potential","volume":"20","author":"Ali Khan","year":"2023","journal-title":"Chem. Biodivers."},{"key":"10.1016\/j.ejphar.2023.176289_bib5","doi-asserted-by":"crossref","DOI":"10.1080\/21688370.2018.1463897","article-title":"Pathophysiology of IBD associated diarrhea","volume":"6","author":"Anbazhagan","year":"2018","journal-title":"Tissue Barriers"},{"key":"10.1016\/j.ejphar.2023.176289_bib6","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/S0002-9343(99)00128-X","article-title":"Acute diarrhea: a practical review","volume":"106","author":"Aranda-Michel","year":"1999","journal-title":"Am. J. Med."},{"key":"10.1016\/j.ejphar.2023.176289_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines10010154","article-title":"Piperine and its metabolite's pharmacology in neurodegenerative and neurological diseases","volume":"10","author":"Azam","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.ejphar.2023.176289_bib8","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1093\/bioinformatics\/btq112","article-title":"A machine learning approach to predicting protein-ligand binding affinity with applications to molecular docking","volume":"26","author":"Ballester","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ejphar.2023.176289_bib9","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1186\/s12889-020-08595-8","article-title":"Cost of illness for childhood diarrhea in low- and middle-income countries: a systematic review of evidence and modelled estimates","volume":"20","author":"Baral","year":"2020","journal-title":"BMC Publ. Health"},{"key":"10.1016\/j.ejphar.2023.176289_bib10","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1056\/NEJMcp011603","article-title":"Clinical practice. Antibiotic-associated diarrhea","volume":"346","author":"Bartlett","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejphar.2023.176289_bib11","doi-asserted-by":"crossref","first-page":"e44","DOI":"10.1017\/S0950268818002972","article-title":"Diarrhoea, enteric pathogen detection and nutritional indicators among controls in the Global Enteric Multicenter Study, Kenya site: an opportunity to understand reference populations in case-control studies of diarrhoea","volume":"147","author":"Berendes","year":"2018","journal-title":"Epidemiol. Infect."},{"key":"10.1016\/j.ejphar.2023.176289_bib12","article-title":"Therapeutic potentials of ononin with mechanistic insights: a comprehensive review","volume":"56","author":"Bhuia","year":"2023","journal-title":"Food Biosci."},{"key":"10.1016\/j.ejphar.2023.176289_bib13","doi-asserted-by":"crossref","DOI":"10.1002\/cbdv.202300847","article-title":"Anticancer potential of the plant-derived saponin gracillin: a comprehensive review of mechanistic approaches","volume":"20","author":"Bhuia","year":"2023","journal-title":"Chem. Biodivers."},{"key":"10.1016\/j.ejphar.2023.176289_bib14","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1007\/s13205-023-03520-3","article-title":"Modulatory effects of phytol on the antiemetic property of domperidone, possibly through the D(2) receptor interaction pathway: in vivo and in silico studies","volume":"13","author":"Bhuia","year":"2023","journal-title":"3 Biotech"},{"key":"10.1016\/j.ejphar.2023.176289_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.rechem.2023.101014","article-title":"Antiemetic activity of trans-ferulic acid possibly through muscarinic receptors interaction pathway: in vivo and in silico study","author":"Bhuia","year":"2023","journal-title":"Results Chem."},{"key":"10.1016\/j.ejphar.2023.176289_bib16","doi-asserted-by":"crossref","DOI":"10.3390\/ph16091271","article-title":"Anxiolytic-like effects by trans-ferulic acid possibly occur through GABAergic interaction pathways","volume":"16","author":"Bhuia","year":"2023","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.ejphar.2023.176289_bib17","doi-asserted-by":"crossref","DOI":"10.3390\/molecules28093671","article-title":"Anticancer potentials of the lignan magnolin: a systematic review","volume":"28","author":"Bhuia","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.ejphar.2023.176289_bib18","doi-asserted-by":"crossref","DOI":"10.3390\/molecules28166141","article-title":"Hirsutine, an emerging natural product with promising therapeutic benefits: a systematic review","volume":"28","author":"Bhuia","year":"2023","journal-title":"Molecules"},{"issue":"Suppl. 1","key":"10.1016\/j.ejphar.2023.176289_bib19","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1093\/clinids\/12.Supplement_1.S3","article-title":"Bismuth subsalicylate: history, chemistry, and safety","volume":"12","author":"Bierer","year":"1990","journal-title":"Rev. Infect. Dis."},{"key":"10.1016\/j.ejphar.2023.176289_bib20","series-title":"Bismuth Subsalicylate, StatPearls [Internet]","author":"Budisak","year":"2023"},{"key":"10.1016\/j.ejphar.2023.176289_bib21","doi-asserted-by":"crossref","first-page":"210b","DOI":"10.1016\/0002-9149(85)90633-2","article-title":"Calcium-channel blocking agents for gastrointestinal disorders","volume":"55","author":"Castell","year":"1985","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.ejphar.2023.176289_bib22","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.3748\/wjg.v18.i12.1391","article-title":"Opiate-induced constipation related to activation of small intestine opioid \u03bc2-receptors","volume":"18","author":"Chen","year":"2012","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.ejphar.2023.176289_bib23","doi-asserted-by":"crossref","first-page":"3","DOI":"10.12788\/jcso.0099","article-title":"Use of atropine-diphenoxylate compared with hyoscyamine to decrease rates of irinotecan-related cholinergic syndrome","volume":"13","author":"Cheng","year":"2015","journal-title":"J. Community Support. Oncol."},{"key":"10.1016\/j.ejphar.2023.176289_bib24","doi-asserted-by":"crossref","first-page":"2711","DOI":"10.3748\/wjg.v22.i9.2711","article-title":"Calcium-sensing receptor: a new target for therapy of diarrhea","volume":"22","author":"Cheng","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.ejphar.2023.176289_bib25","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1007\/BF01295716","article-title":"Effect of nifedipine on mouth-to-cecum transit of liquid meal in normal subjects","volume":"38","author":"Chiarioni","year":"1993","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.ejphar.2023.176289_bib26","series-title":"Assessment of Quercetin Antiemetic Properties: in Vivo and in Silico Investigations on Receptor Binding Affinity and Synergistic Effects","author":"Chowdhury","year":"2023"},{"key":"10.1016\/j.ejphar.2023.176289_bib27","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1111\/j.1469-7793.2001.0609e.x","article-title":"Nifedipine blocks Ca2+ store refilling through a pathway not involving L-type Ca2+ channels in rabbit arteriolar smooth muscle","volume":"532","author":"Curtis","year":"2001","journal-title":"J. Physiol."},{"key":"10.1016\/j.ejphar.2023.176289_bib28","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/978-1-4939-2269-7_19","article-title":"Small-molecule library screening by docking with PyRx","volume":"1263","author":"Dallakyan","year":"2015","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.ejphar.2023.176289_bib29","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0163-7258(95)02053-5","article-title":"Insights into opioid action in the intestinal tract","volume":"69","author":"De Luca","year":"1996","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.ejphar.2023.176289_bib30","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1111\/j.2042-7158.1993.tb07185.x","article-title":"Do antidiarrhoeal opiates accumulate in the rat intestinal lumen?","volume":"45","author":"De Luca","year":"1993","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.ejphar.2023.176289_bib31","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1113\/jphysiol.2001.013258","article-title":"Nitric oxide inhibits capacitative Ca2+ entry and enhances endoplasmic reticulum Ca2+ uptake in bovine vascular endothelial cells","volume":"539","author":"Dedkova","year":"2002","journal-title":"J. Physiol."},{"key":"10.1016\/j.ejphar.2023.176289_bib32","article-title":"Evaluation of analgesic, anti-inflammatory, and antipyretic activity of piperine: an experimental study","volume":"12","author":"Dhargawe","year":"2021","journal-title":"Pharmacogn. Res."},{"key":"10.1016\/j.ejphar.2023.176289_bib33","first-page":"529","article-title":"Targeting nitric oxide in the gastrointestinal tract","volume":"5","author":"Dijkstra","year":"2004","journal-title":"Curr. Opin. Invest. Drugs"},{"key":"10.1016\/j.ejphar.2023.176289_bib34","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.jnutbio.2012.05.009","article-title":"Piperine, a dietary phytochemical, inhibits angiogenesis","volume":"24","author":"Doucette","year":"2013","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.ejphar.2023.176289_bib35","doi-asserted-by":"crossref","DOI":"10.3390\/nu14224744","article-title":"Protective effects of piperine on ethanol-induced gastric mucosa injury by oxidative stress inhibition","volume":"14","author":"Duan","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.ejphar.2023.176289_bib36","doi-asserted-by":"crossref","first-page":"24s","DOI":"10.1016\/0002-9343(90)90272-F","article-title":"Over-the-counter antidiarrheal medications used for the self-treatment of acute nonspecific diarrhea","volume":"88","author":"Dukes","year":"1990","journal-title":"Am. J. Med."},{"key":"10.1016\/j.ejphar.2023.176289_bib37","article-title":"Hand-washing promotion for preventing diarrhoea","volume":"12","author":"Ejemot-Nwadiaro","year":"2021","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.ejphar.2023.176289_bib38","volume":"36","author":"Elkanzi","year":"2022","journal-title":"Appl. Organomet. Chem."},{"key":"10.1016\/j.ejphar.2023.176289_bib39","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/612403","article-title":"Role of antidiarrhoeal drugs as adjunctive therapies for acute diarrhoea in children","volume":"2013","author":"Faure","year":"2013","journal-title":"Int. J. Pediatr."},{"key":"10.1016\/j.ejphar.2023.176289_bib40","series-title":"Castor Oil","author":"FC","year":"2000"},{"key":"10.1016\/j.ejphar.2023.176289_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110247","article-title":"A novel piperine analogue exerts in vivo antitumor effect by inducing oxidative, antiangiogenic and immunomodulatory actions","volume":"128","author":"Ferreira","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ejphar.2023.176289_bib42","doi-asserted-by":"crossref","first-page":"S128","DOI":"10.1002\/(SICI)1099-1573(1998)12:1+<S128::AID-PTR272>3.0.CO;2-I","article-title":"Castor oil: new lessons from an ancient oil","volume":"12","author":"Gaginella","year":"1998","journal-title":"Phytother Res."},{"key":"10.1016\/j.ejphar.2023.176289_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.113664","article-title":"Pharmacological insights on the antidepressant, anxiolytic and aphrodisiac potentials of Aglaonema hookerianum Schott","volume":"268","author":"Goni","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.ejphar.2023.176289_bib44","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/0016-5085(90)90983-8","article-title":"Bismuth therapy in gastrointestinal diseases","volume":"99","author":"Gorbach","year":"1990","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ejphar.2023.176289_bib45","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s12551-013-0130-2","article-title":"Receptor-ligand molecular docking","volume":"6","author":"Guedes","year":"2014","journal-title":"Biophys. Rev."},{"key":"10.1016\/j.ejphar.2023.176289_bib46","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1002\/ptr.6855","article-title":"Piperine: a review of its biological effects","volume":"35","author":"Haq","year":"2021","journal-title":"Phytother Res."},{"key":"10.1016\/j.ejphar.2023.176289_bib47","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1016\/j.crfs.2022.08.018","article-title":"Effect of piperine on the mitigation of obesity associated with gut microbiota alteration","volume":"5","author":"He","year":"2022","journal-title":"Curr. Res. Food Sci."},{"key":"10.1016\/j.ejphar.2023.176289_bib48","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.1093\/ajcn\/33.11.2365","article-title":"Breast-feeding and food intake among children with acute diarrheal disease","volume":"33","author":"Hoyle","year":"1980","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.ejphar.2023.176289_bib49","series-title":"Pharmacological Sciences: Perspectives for Research and Therapy in the Late 1990s","first-page":"117","article-title":"Calcium channels, calcium channel antagonists and the functioning of the gastrointestinal tract","author":"Huizinga","year":"1995"},{"key":"10.1016\/j.ejphar.2023.176289_bib50","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms11092177","article-title":"Revisiting the intestinal microbiome and its role in diarrhea and constipation","volume":"11","author":"Iancu","year":"2023","journal-title":"Microorganisms"},{"key":"10.1016\/j.ejphar.2023.176289_bib51","doi-asserted-by":"crossref","DOI":"10.3390\/nu13082727","article-title":"Malnutrition and gut microbiota in children","volume":"13","author":"Iddrisu","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.ejphar.2023.176289_bib52","first-page":"145","article-title":"Citrate can effectively replace bicarbonate in oral rehydration salts for cholera and infantile diarrhoea","volume":"64","author":"Islam","year":"1986","journal-title":"Bull. World Health Organ."},{"key":"10.1016\/j.ejphar.2023.176289_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114900","article-title":"Therapeutic strategies for rheumatic diseases and disorders: targeting redox imbalance and oxidative stress","volume":"164","author":"Islam","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ejphar.2023.176289_bib54","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s12974-020-1703-1","article-title":"Molecular mechanisms underlying the actions of arachidonic acid-derived prostaglandins on peripheral nociception","volume":"17","author":"Jang","year":"2020","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.ejphar.2023.176289_bib55","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1093\/trstmh\/trab042","article-title":"Gastrointestinal manifestations in COVID-19","volume":"115","author":"Kariyawasam","year":"2021","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.ejphar.2023.176289_bib56","first-page":"589","article-title":"Antibacterial and antidiarrhoeal effects of alkaloids of Holarrhena antidysenterica WALL","volume":"42","author":"Kavitha","year":"2004","journal-title":"Indian J. Exp. Biol."},{"key":"10.1016\/j.ejphar.2023.176289_bib57","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1016\/S1473-3099(18)30424-9","article-title":"Old and new challenges related to global burden of diarrhoea","volume":"18","author":"Keddy","year":"2018","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.ejphar.2023.176289_bib58","doi-asserted-by":"crossref","first-page":"G405","DOI":"10.1152\/ajpgi.00316.2021","article-title":"Intestinal secretory mechanisms and diarrhea","volume":"322","author":"Keely","year":"2022","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.ejphar.2023.176289_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110774","article-title":"Pharmacological insights and prediction of lead bioactive isolates of Dita bark through experimental and computer-aided mechanism","volume":"131","author":"Khan","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ejphar.2023.176289_bib60","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.niox.2011.07.002","article-title":"The role of nitric oxide in prostaglandin biology; update","volume":"25","author":"Kim","year":"2011","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.ejphar.2023.176289_bib61","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1517\/14656566.2013.815725","article-title":"Screening of antidiabetic and antihyperlipidemic potential of oil from Piper longum and piperine with their possible mechanism","volume":"14","author":"Kumar","year":"2013","journal-title":"Expet Opin. Pharmacother."},{"key":"10.1016\/j.ejphar.2023.176289_bib62","doi-asserted-by":"crossref","first-page":"38","DOI":"10.2174\/1872213X13666190514105054","article-title":"Travelers' diarrhea: a clinical review","volume":"13","author":"Leung","year":"2019","journal-title":"Recent Pat. Inflamm. Allergy Drug Discov."},{"key":"10.1016\/j.ejphar.2023.176289_bib63","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0009266","article-title":"Derivation of the first clinical diagnostic models for dehydration severity in patients over five years with acute diarrhea","volume":"15","author":"Levine","year":"2021","journal-title":"PLoS Neglected Trop. Dis."},{"key":"10.1016\/j.ejphar.2023.176289_bib64","doi-asserted-by":"crossref","first-page":"137","DOI":"10.31083\/j.fbl2704137","article-title":"Piperine: an anticancer and senostatic drug","volume":"27","author":"Lim","year":"2022","journal-title":"Front. Biosci."},{"key":"10.1016\/j.ejphar.2023.176289_bib65","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1177\/0115426505020006618","article-title":"Enteral nutrition and drug administration, interactions, and complications","volume":"20","author":"Magnuson","year":"2005","journal-title":"Nutr. Clin. Pract."},{"key":"10.1016\/j.ejphar.2023.176289_bib66","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.phrs.2017.08.001","article-title":"Probiotics and antibiotic-associated diarrhea in children: a review and new evidence on Lactobacillus rhamnosus GG during and after antibiotic treatment","volume":"128","author":"Mantegazza","year":"2018","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.ejphar.2023.176289_bib67","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1111\/j.1476-5381.1993.tb13478.x","article-title":"Inhibitors of nitric oxide synthetase prevent castor-oil-induced diarrhoea in the rat","volume":"108","author":"Mascolo","year":"1993","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2023.176289_bib68","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1002\/ptr.4972","article-title":"Piper nigrum and piperine: an update","volume":"27","author":"Meghwal","year":"2013","journal-title":"Phytother Res."},{"key":"10.1016\/j.ejphar.2023.176289_bib69","doi-asserted-by":"crossref","first-page":"290","DOI":"10.5455\/jice.20160426094553","article-title":"Therapeutic significance and pharmacological activities of antidiarrheal medicinal plants mention in Ayurveda: a review","volume":"5","author":"Mishra","year":"2016","journal-title":"J. Intercult. Ethnopharmacol."},{"key":"10.1016\/j.ejphar.2023.176289_bib70","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1358\/mf.2000.22.5.796644","article-title":"In vitro antioxidant activity of piperine","volume":"22","author":"Mittal","year":"2000","journal-title":"Methods Find Exp. Clin. Pharmacol."},{"key":"10.1016\/j.ejphar.2023.176289_bib71","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.phrs.2015.08.024","article-title":"Drug-induced secretory diarrhea: a role for CFTR","volume":"102","author":"Moon","year":"2015","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.ejphar.2023.176289_bib72","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0260667","article-title":"A worldwide systematic review and meta-analysis of bacteria related to antibiotic-associated diarrhea in hospitalized patients","volume":"16","author":"Motamedi","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2023.176289_bib73","article-title":"Antibiotic treatment for Clostridium difficile-associated diarrhoea in adults","volume":"3","author":"Nelson","year":"2017","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.ejphar.2023.176289_bib74","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph18116043","article-title":"Diarrhoea among children aged under five years and risk factors in informal settlements: a cross-sectional study in cape town, South Africa","volume":"18","author":"Nguyen","year":"2021","journal-title":"Int. J. Environ. Res. Publ. Health"},{"key":"10.1016\/j.ejphar.2023.176289_bib75","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/j.1365-2036.1990.tb00461.x","article-title":"The absorption of bismuth and salicylate from oral doses of Pepto-Bismol (bismuth salicylate)","volume":"4","author":"Nwokolo","year":"1990","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.ejphar.2023.176289_bib76","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/S0889-8553(05)70212-0","article-title":"The role of antibiotics in the treatment of infectious diarrhea","volume":"30","author":"Oldfield","year":"2001","journal-title":"Gastroenterol. Clin. N. Am."},{"key":"10.1016\/j.ejphar.2023.176289_bib77","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.fct.2013.08.007","article-title":"Piperine inhibits the proliferation of human prostate cancer cells via induction of cell cycle arrest and autophagy","volume":"60","author":"Ouyang","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.ejphar.2023.176289_bib78","doi-asserted-by":"crossref","first-page":"31","DOI":"10.2147\/JEP.S70568","article-title":"New insights into therapeutic activity and anticancer properties of curcumin","volume":"9","author":"Panda","year":"2017","journal-title":"J. Exp. Pharmacol."},{"key":"10.1016\/j.ejphar.2023.176289_bib79","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.coph.2018.08.008","article-title":"Opioid receptors in the GI tract: targets for treatment of both diarrhea and constipation in functional bowel disorders?","volume":"43","author":"Pannemans","year":"2018","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.ejphar.2023.176289_bib80","doi-asserted-by":"crossref","first-page":"7146","DOI":"10.1021\/acs.jmedchem.7b00835","article-title":"Hydrophilic, potent, and selective 7-substituted 2-aminoquinolines as improved human neuronal nitric oxide synthase inhibitors","volume":"60","author":"Pensa","year":"2017","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejphar.2023.176289_bib81","doi-asserted-by":"crossref","first-page":"2926","DOI":"10.1097\/MIB.0000000000000504","article-title":"Mechanisms underlying dysregulation of electrolyte absorption in inflammatory bowel disease-associated diarrhea","volume":"21","author":"Priyamvada","year":"2015","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.ejphar.2023.176289_bib82","article-title":"Sclareol exerts an anti-inflammatory effect, possibly through COXs inhibition pathway: in vivo and in silico studies","author":"Prottay","year":"2023","journal-title":"Pharm. Sci. Adv."},{"key":"10.1016\/j.ejphar.2023.176289_bib83","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/s13105-012-0167-x","article-title":"The role of nitric oxide and L-type calcium channel blocker in the contractility of rabbit ileum in vitro","volume":"68","author":"Ragy","year":"2012","journal-title":"J. Physiol. Biochem."},{"key":"10.1016\/j.ejphar.2023.176289_bib84","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1016\/j.biopha.2017.11.147","article-title":"Evidence based traditional anti-diarrheal medicinal plants and their phytocompounds","volume":"96","author":"Rawat","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ejphar.2023.176289_bib85","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.jpainsymman.2011.06.001","article-title":"Loperamide","volume":"42","author":"Regnard","year":"2011","journal-title":"J. Pain Symptom Manag."},{"key":"10.1016\/j.ejphar.2023.176289_bib86","doi-asserted-by":"crossref","first-page":"158","DOI":"10.3389\/fphar.2017.00158","article-title":"An introduction to terminology and methodology of chemical synergy-perspectives from across disciplines","volume":"8","author":"Roell","year":"2017","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejphar.2023.176289_bib87","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1097\/00004836-198304000-00008","article-title":"Development of new antidiarrheal medications","volume":"5","author":"Rosenthal","year":"1983","journal-title":"J. Clin. Gastroenterol."},{"key":"10.1016\/j.ejphar.2023.176289_bib88","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/S0749-0720(15)31081-1","article-title":"Treatment of diarrhea of neonatal calves","volume":"7","author":"Roussel","year":"1991","journal-title":"Vet. Clin. North Am. Food Anim. Pract."},{"key":"10.1016\/j.ejphar.2023.176289_bib89","first-page":"218","article-title":"Ileostomy diarrhea: pathophysiology and management","volume":"33","author":"Rowe","year":"2020","journal-title":"SAVE Proc."},{"key":"10.1016\/j.ejphar.2023.176289_bib90","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1002\/ibra.12050","article-title":"Potential natural products for the management of autism spectrum disorder","volume":"8","author":"Sachdeva","year":"2022","journal-title":"Ibrain"},{"issue":"1985","key":"10.1016\/j.ejphar.2023.176289_bib91","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1152\/jappl.2001.91.3.1438","article-title":"Invited review: mechanisms of calcium handling in smooth muscles","volume":"91","author":"Sanders","year":"2001","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.ejphar.2023.176289_bib92","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1016\/S0025-7125(05)70286-8","article-title":"Diarrhea","volume":"84","author":"Schiller","year":"2000","journal-title":"Med. Clin. North Am."},{"key":"10.1016\/j.ejphar.2023.176289_bib93","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/jgh.12392","article-title":"Gastro 2013 APDW\/WCOG Shanghai working party report: chronic diarrhea: definition, classification, diagnosis","volume":"29","author":"Schiller","year":"2014","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.ejphar.2023.176289_bib94","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/s42003-021-01967-9","article-title":"Identification and characterization of piperine synthase from black pepper, Piper nigrum L","volume":"4","author":"Schnabel","year":"2021","journal-title":"Commun. Biol."},{"key":"10.1016\/j.ejphar.2023.176289_bib95","first-page":"47","article-title":"Antidiarrheal effects of anacardium occidentale L. Leaf powder on newborn chicks","volume":"29","author":"Sera","year":"2017","journal-title":"Rev. Prod. Anim."},{"key":"10.1016\/j.ejphar.2023.176289_bib96","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1007\/s10787-007-0013-x","article-title":"Role of nitric oxide in inflammatory diseases","volume":"15","author":"Sharma","year":"2007","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.ejphar.2023.176289_bib97","doi-asserted-by":"crossref","first-page":"41","DOI":"10.4103\/2231-4040.70521","article-title":"Antidiarrhoeal activity of leaf extract of celosia argentea in experimentally induced diarrhoea in rats","volume":"1","author":"Sharma","year":"2010","journal-title":"J. Adv. Pharm. Technol. Res."},{"key":"10.1016\/j.ejphar.2023.176289_bib98","first-page":"615","article-title":"Piperine-review of advances in pharmacology","volume":"2","author":"Singh","year":"2009","journal-title":"Int. J. Pharm. Sci. Nanotechnol. (IJPSN)"},{"key":"10.1016\/j.ejphar.2023.176289_bib99","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1007\/s00535-013-0753-x","article-title":"Physiology, signaling, and pharmacology of opioid receptors and their ligands in the gastrointestinal tract: current concepts and future perspectives","volume":"49","author":"Sobczak","year":"2014","journal-title":"J. Gastroenterol."},{"key":"10.1016\/j.ejphar.2023.176289_bib100","doi-asserted-by":"crossref","DOI":"10.3390\/nu13020575","article-title":"Impact of diet on symptoms of the irritable bowel syndrome","volume":"13","author":"Spiller","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.ejphar.2023.176289_bib101","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1177\/1947601912440575","article-title":"Quantitative methods for assessing drug synergism","volume":"2","author":"Tallarida","year":"2011","journal-title":"Genes Cancer"},{"key":"10.1016\/j.ejphar.2023.176289_bib102","doi-asserted-by":"crossref","first-page":"229","DOI":"10.3109\/10715769309056511","article-title":"Direct evidence for nitric oxide stimulation of electrolyte secretion in the rat colon","volume":"19","author":"Tamai","year":"1993","journal-title":"Free Radic. Res. Commun."},{"key":"10.1016\/j.ejphar.2023.176289_bib103","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1080\/13880200902918352","article-title":"Insight into the possible mechanism of antidiarrheal and antispasmodic activities of piperine","volume":"47","author":"Taqvi","year":"2009","journal-title":"Pharmaceut. Biol."},{"key":"10.1016\/j.ejphar.2023.176289_bib104","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.cgh.2013.12.001","article-title":"Discovery and development of antisecretory drugs for treating diarrheal diseases","volume":"12","author":"Thiagarajah","year":"2014","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.ejphar.2023.176289_bib105","first-page":"59","article-title":"Lactose intolerance: myths and facts. An update","volume":"120","author":"Toca","year":"2022","journal-title":"Arch. Argent. Pediatr."},{"key":"10.1016\/j.ejphar.2023.176289_bib106","doi-asserted-by":"crossref","DOI":"10.1016\/j.crtox.2023.100120","article-title":"Phytanic acid, an inconclusive phytol metabolite: a review","volume":"5","author":"Torequl Islam","year":"2023","journal-title":"Curr. Res. Toxicol."},{"key":"10.1016\/j.ejphar.2023.176289_bib107","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20184574","article-title":"Key topics in molecular docking for drug design","volume":"20","author":"Torres","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2023.176289_bib108","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1111\/jvp.13078","article-title":"Can diarrhea affect the pharmacokinetics of racecadotril in neonatal calves?","volume":"45","author":"Tras","year":"2022","journal-title":"J. Vet. Pharmacol. Therapeut."},{"key":"10.1016\/j.ejphar.2023.176289_bib109","first-page":"5778","article-title":"Cyclooxygenase-2 inhibition with celecoxib enhances antitumor efficacy and reduces diarrhea side effect of CPT-11","volume":"62","author":"Trifan","year":"2002","journal-title":"Cancer Res."},{"key":"10.1016\/j.ejphar.2023.176289_bib110","first-page":"1679","article-title":"Antidiarrheal properties of aqueous leaf extract of cyathula prostrata on Castor oil-induced diarrhoea in Wistar rats","volume":"7","author":"Uahomo","year":"2022","journal-title":"Int. J. Pharmaceut. Res. Anal."},{"key":"10.1016\/j.ejphar.2023.176289_bib111","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1254\/jjp.82.168","article-title":"Involvement of nitric oxide from nerves on diarrhea induced by castor oil in rats","volume":"82","author":"Uchida","year":"2000","journal-title":"Jpn. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2023.176289_bib112","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114182","article-title":"Central and peripheral pain intervention by Ophiorrhiza rugosa leaves: potential underlying mechanisms and insight into the role of pain modulators","volume":"276","author":"Uddin Chy","year":"2021","journal-title":"J. Ethnopharmacol."},{"issue":"Suppl. 1","key":"10.1016\/j.ejphar.2023.176289_bib113","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/j.1471-0528.2005.00591.x","article-title":"Nifedipine trials: effectiveness and safety aspects","volume":"112","author":"van Geijn","year":"2005","journal-title":"BJOG"},{"key":"10.1016\/j.ejphar.2023.176289_bib114","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173524","article-title":"The protective effect of piperine against isoproterenol-induced inflammation in experimental models of myocardial toxicity","volume":"885","author":"Viswanadha","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2023.176289_bib115","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s41182-021-00389-x","article-title":"Herbal medicine used for the treatment of diarrhea and cough in Kampala city, Uganda","volume":"50","author":"Walusansa","year":"2022","journal-title":"Trop. Med. Health"},{"key":"10.1016\/j.ejphar.2023.176289_bib116","doi-asserted-by":"crossref","first-page":"772","DOI":"10.4251\/wjgo.v13.i8.772","article-title":"Immune checkpoint inhibitor-mediated colitis in gastrointestinal malignancies and inflammatory bowel disease","volume":"13","author":"Weingarden","year":"2021","journal-title":"World J. Gastrointest. Oncol."},{"key":"10.1016\/j.ejphar.2023.176289_bib117","doi-asserted-by":"crossref","first-page":"C832","DOI":"10.1152\/ajpcell.1996.270.3.C832","article-title":"Production and localization of cGMP and PGE2 in nitroprusside-stimulated rat colonic ion transport","volume":"270","author":"Wilson","year":"1996","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.ejphar.2023.176289_bib118","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1038\/s41422-022-00663-5","article-title":"Structural basis for pore blockade of human voltage-gated calcium channel Ca(v)1.3 by motion sickness drug cinnarizine","volume":"32","author":"Yao","year":"2022","journal-title":"Cell Res."},{"key":"10.1016\/j.ejphar.2023.176289_bib119","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.lwt.2012.07.036","article-title":"Antioxidant and antimicrobial activities of various solvent extracts, piperine and piperic acid from Piper nigrum","volume":"50","author":"Zarai","year":"2013","journal-title":"LWT-Food Sci. Technol."},{"key":"10.1016\/j.ejphar.2023.176289_bib120","doi-asserted-by":"crossref","first-page":"4361","DOI":"10.1016\/j.cell.2022.09.041","article-title":"Molecular recognition of morphine and fentanyl by the human \u03bc-opioid receptor","volume":"185","author":"Zhuang","year":"2022","journal-title":"Cell"}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299923008038?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299923008038?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T04:26:19Z","timestamp":1762143979000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299923008038"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":120,"alternative-id":["S0014299923008038"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2023.176289","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anti-diarrheal effect of piperine possibly through the interaction with inflammation inducing enzymes: In vivo and in silico studies","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2023.176289","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"176289"}}