{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T01:16:28Z","timestamp":1788138988820,"version":"build-2803163510"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Zhejiang Province Natural Science Foundation","doi-asserted-by":"publisher","award":["LY18H170001"],"award-info":[{"award-number":["LY18H170001"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971304"],"award-info":[{"award-number":["81971304"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013807","name":"Wuhan University School of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013290","name":"National Key Research and Development Program of China Stem Cell and Translational Research","doi-asserted-by":"publisher","award":["2018YFA0507700"],"award-info":[{"award-number":["2018YFA0507700"]}],"id":[{"id":"10.13039\/501100013290","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.ejphar.2024.176377","type":"journal-article","created":{"date-parts":[[2024,2,10]],"date-time":"2024-02-10T11:02:17Z","timestamp":1707562937000},"page":"176377","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["PARP-1 inhibitor alleviates cerebral ischemia\/reperfusion injury by reducing PARylation of HK-1 and LDH in mice"],"prefix":"10.1016","volume":"967","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3158-3424","authenticated-orcid":false,"given":"Ya-Ling","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6905-7126","authenticated-orcid":false,"given":"Qiu-Yu","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0764-3079","authenticated-orcid":false,"given":"Tong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0204-1669","authenticated-orcid":false,"given":"Cong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong-Yao","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Ping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6539-4798","authenticated-orcid":false,"given":"Yun-Bi","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.ejphar.2024.176377_bib1","first-page":"255","article-title":"Protective effects of PJ34, a novel, potent inhibitor of poly(ADP-ribose) polymerase (PARP) in in vitro and in vivo models of stroke","volume":"7","author":"Abdelkarim","year":"2001","journal-title":"Int. J. Mol. Med."},{"issue":"7","key":"10.1016\/j.ejphar.2024.176377_bib2","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1073\/pnas.70.7.1968","article-title":"Structure-function relationships in lactate dehydrogenase","volume":"70","author":"Adams","year":"1973","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"8","key":"10.1016\/j.ejphar.2024.176377_bib3","doi-asserted-by":"crossref","first-page":"3811","DOI":"10.1093\/nar\/gkz120","article-title":"Poly(ADP-ribosyl)ation by PARP1: reaction mechanism and regulatory proteins","volume":"47","author":"Alemasova","year":"2019","journal-title":"Nucleic Acids Res."},{"issue":"28","key":"10.1016\/j.ejphar.2024.176377_bib4","doi-asserted-by":"crossref","first-page":"10209","DOI":"10.1073\/pnas.1405158111","article-title":"Poly(ADP-ribose) polymerase-dependent energy depletion occurs through inhibition of glycolysis","volume":"111","author":"Andrabi","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"7","key":"10.1016\/j.ejphar.2024.176377_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/cells10071714","article-title":"Brain protection after anoxic brain injury: is lactate supplementation helpful?","volume":"10","author":"Annoni","year":"2021","journal-title":"Cells"},{"issue":"6","key":"10.1016\/j.ejphar.2024.176377_bib6","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.cmet.2011.08.016","article-title":"Brain energy metabolism: focus on astrocyte-neuron metabolic cooperation","volume":"14","author":"Belanger","year":"2011","journal-title":"Cell Metabol."},{"issue":"1","key":"10.1016\/j.ejphar.2024.176377_bib7","doi-asserted-by":"crossref","first-page":"301","DOI":"10.3390\/cimb43010025","article-title":"Poly(ADP-Ribose) polymerase inhibitor PJ34 reduces brain damage after stroke in the neonatal mouse brain","volume":"43","author":"Bonnin","year":"2021","journal-title":"Curr. Issues Mol. Biol."},{"issue":"8","key":"10.1016\/j.ejphar.2024.176377_bib8","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1016\/j.cmet.2021.07.006","article-title":"Astrocyte-neuron metabolic cooperation shapes brain activity","volume":"33","author":"Bonvento","year":"2021","journal-title":"Cell Metabol."},{"issue":"10244","key":"10.1016\/j.ejphar.2024.176377_bib9","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0140-6736(20)31179-X","volume":"396","author":"Campbell","year":"2020","journal-title":"Stroke. Lancet."},{"key":"10.1016\/j.ejphar.2024.176377_bib10","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0006-291X(63)90024-X","article-title":"Nicotinamide mononucleotide activation of new DNA-dependent polyadenylic acid synthesizing nuclear enzyme","volume":"11","author":"Chambon","year":"1963","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.ejphar.2024.176377_bib11","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.phrs.2005.02.018","article-title":"Poly(ADP-ribosyl)ation and stroke","volume":"52","author":"Chiarugi","year":"2005","journal-title":"Pharmacol. Res."},{"issue":"10","key":"10.1016\/j.ejphar.2024.176377_bib12","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1038\/s41573-020-0076-6","article-title":"Poly(ADP-ribose) polymerase inhibition: past, present and future","volume":"19","author":"Curtin","year":"2020","journal-title":"Nat. Rev. Drug Discov."},{"issue":"Web Server issue","key":"10.1016\/j.ejphar.2024.176377_bib13","doi-asserted-by":"crossref","first-page":"W665","DOI":"10.1093\/nar\/gkh381","article-title":"PDB2PQR: an automated pipeline for the setup of Poisson-Boltzmann electrostatics calculations","volume":"32","author":"Dolinsky","year":"2004","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.ejphar.2024.176377_bib14","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0304-3940(98)00224-9","article-title":"Role of peroxynitrite and neuronal nitric oxide synthase in the activation of poly(ADP-ribose) synthetase in a murine model of cerebral ischemia-reperfusion","volume":"248","author":"Endres","year":"1998","journal-title":"Neurosci. Lett."},{"issue":"6","key":"10.1016\/j.ejphar.2024.176377_bib15","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1016\/j.celrep.2014.08.036","article-title":"ARTD1\/PARP1 negatively regulates glycolysis by inhibiting hexokinase 1 independent of NAD+ depletion","volume":"8","author":"Fouquerel","year":"2014","journal-title":"Cell Rep."},{"issue":"16","key":"10.1016\/j.ejphar.2024.176377_bib16","doi-asserted-by":"crossref","first-page":"7788","DOI":"10.1093\/nar\/gks486","article-title":"Quantitative proteomics profiling of the poly(ADP-ribose)-related response to genotoxic stress","volume":"40","author":"Gagne","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ejphar.2024.176377_bib17","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ejphar.2014.10.006","article-title":"Neuroprotection by the PARP inhibitor PJ34 modulates cerebral and circulating RAGE levels in rats exposed to focal brain ischemia","volume":"744","author":"Greco","year":"2014","journal-title":"Eur. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.ejphar.2024.176377_bib18","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.ejphar.2008.04.013","article-title":"Reduction of hemorrhagic transformation by PJ34, a poly(ADP-ribose)polymerase inhibitor, after permanent focal cerebral ischemia in mice","volume":"588","author":"Haddad","year":"2008","journal-title":"Eur. J. Pharmacol."},{"issue":"10227","key":"10.1016\/j.ejphar.2024.176377_bib19","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/S0140-6736(20)30258-0","article-title":"Efficacy and safety of nerinetide for the treatment of acute ischaemic stroke (ESCAPE-NA1): a multicentre, double-blind, randomised controlled trial","volume":"395","author":"Hill","year":"2020","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.ejphar.2024.176377_bib20","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.14336\/AD.2021.0311","article-title":"Acute stroke management: overview and recent updates","volume":"12","author":"Hollist","year":"2021","journal-title":"Aging Dis"},{"issue":"1","key":"10.1016\/j.ejphar.2024.176377_bib21","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1002\/pro.3280","article-title":"Improvements to the APBS biomolecular solvation software suite","volume":"27","author":"Jurrus","year":"2018","journal-title":"Protein Sci."},{"issue":"9","key":"10.1016\/j.ejphar.2024.176377_bib22","doi-asserted-by":"crossref","first-page":"7153","DOI":"10.1007\/s12035-018-0910-6","article-title":"Early treatment with poly(ADP-ribose) polymerase-1 inhibitor (JPI-289) reduces infarct volume and improves long-term behavior in an animal model of ischemic stroke","volume":"55","author":"Kim","year":"2018","journal-title":"Mol. Neurobiol."},{"issue":"6","key":"10.1016\/j.ejphar.2024.176377_bib23","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/j.mam.2012.12.005","article-title":"Reprogramming cellular events by poly(ADP-ribose)-binding proteins","volume":"34","author":"Krietsch","year":"2013","journal-title":"Mol. Aspect. Med."},{"key":"10.1016\/j.ejphar.2024.176377_bib24","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.bcp.2019.04.028","article-title":"New insights of poly(ADP-ribosylation) in neurodegenerative diseases: a focus on protein phase separation and pathologic aggregation","volume":"167","author":"Liu","year":"2019","journal-title":"Biochem. Pharmacol."},{"issue":"1","key":"10.1016\/j.ejphar.2024.176377_bib25","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1111\/jnc.15464","article-title":"Emerging role of PARP-1 and PARthanatos in ischemic stroke","volume":"160","author":"Liu","year":"2022","journal-title":"J. Neurochem."},{"issue":"1","key":"10.1016\/j.ejphar.2024.176377_bib26","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1161\/01.STR.20.1.84","article-title":"Reversible middle cerebral artery occlusion without craniectomy in rats","volume":"20","author":"Longa","year":"1989","journal-title":"Stroke"},{"issue":"1","key":"10.1016\/j.ejphar.2024.176377_bib27","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1046\/j.1365-2990.2000.00218.x","article-title":"Neuronal death in brain infarcts in man","volume":"26","author":"Love","year":"2000","journal-title":"Neuropathol. Appl. Neurobiol."},{"issue":"3","key":"10.1016\/j.ejphar.2024.176377_bib28","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1021\/acs.chemrev.7b00122","article-title":"ADP-ribosylation, a multifaceted posttranslational modification involved in the control of cell physiology in health and disease","volume":"118","author":"Luscher","year":"2018","journal-title":"Chem. Rev."},{"issue":"1","key":"10.1016\/j.ejphar.2024.176377_bib29","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.ncl.2021.08.002","article-title":"Acute treatment of ischemic stroke","volume":"40","author":"Lyden","year":"2022","journal-title":"Neurol. Clin."},{"key":"10.1016\/j.ejphar.2024.176377_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.conb.2022.102575","article-title":"How neurons die in Alzheimer's disease: implications for neuroinflammation","volume":"75","author":"Mangalmurti","year":"2022","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.ejphar.2024.176377_bib31","doi-asserted-by":"crossref","DOI":"10.1007\/s12264-022-00859-0","article-title":"Neuronal death mechanisms and therapeutic strategy in ischemic stroke","author":"Mao","year":"2022","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.ejphar.2024.176377_bib32","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.mad.2015.04.001","article-title":"PARP-1 involvement in neurodegeneration: a focus on Alzheimer's and Parkinson's diseases","volume":"146\u2013148","author":"Martire","year":"2015","journal-title":"Mech. Ageing Dev."},{"issue":"3","key":"10.1016\/j.ejphar.2024.176377_bib33","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1529\/biophysj.105.062604","article-title":"The approach to the Michaelis complex in lactate dehydrogenase: the substrate binding pathway","volume":"89","author":"McClendon","year":"2005","journal-title":"Biophys. J."},{"issue":"5","key":"10.1016\/j.ejphar.2024.176377_bib34","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.molcel.2018.07.002","article-title":"Poly(ADP-Ribose) prevents pathological phase separation of TDP-43 by promoting liquid demixing and stress granule localization","volume":"71","author":"McGurk","year":"2018","journal-title":"Mol. Cell"},{"issue":"1","key":"10.1016\/j.ejphar.2024.176377_bib35","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.coph.2007.10.005","article-title":"Poly(ADP-ribose)polymerase 1 (PARP-1) and postischemic brain damage","volume":"8","author":"Moroni","year":"2008","journal-title":"Curr. Opin. Pharmacol."},{"issue":"16","key":"10.1016\/j.ejphar.2024.176377_bib36","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1002\/jcc.21256","article-title":"AutoDock4 and AutoDockTools4: automated docking with selective receptor flexibility","volume":"30","author":"Morris","year":"2009","journal-title":"J. Comput. Chem."},{"issue":"4\u20135","key":"10.1016\/j.ejphar.2024.176377_bib37","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1007\/s11064-006-9132-9","article-title":"Kinetic parameters and lactate dehydrogenase isozyme activities support possible lactate utilization by neurons","volume":"32","author":"O'Brien","year":"2007","journal-title":"Neurochem. Res."},{"issue":"Web Server issue","key":"10.1016\/j.ejphar.2024.176377_bib38","doi-asserted-by":"crossref","first-page":"W332","DOI":"10.1093\/nar\/gkh479","article-title":"MyHits: a new interactive resource for protein annotation and domain identification","volume":"32","author":"Pagni","year":"2004","journal-title":"Nucleic Acids Res."},{"issue":"7","key":"10.1016\/j.ejphar.2024.176377_bib39","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1038\/jcbfm.2011.149","article-title":"Sweet sixteen for ANLS","volume":"32","author":"Pellerin","year":"2012","journal-title":"J. Cerebr. Blood Flow Metabol."},{"issue":"9","key":"10.1016\/j.ejphar.2024.176377_bib40","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17091450","article-title":"Lactate as a metabolite and a regulator in the central nervous System","volume":"17","author":"Proia","year":"2016","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.ejphar.2024.176377_bib41","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1007\/s00401-009-0559-3","article-title":"Neuronal caspase-3 and PARP-1 correlate differentially with apoptosis and necrosis in ischemic human stroke","volume":"118","author":"Sairanen","year":"2009","journal-title":"Acta Neuropathol."},{"issue":"12","key":"10.1016\/j.ejphar.2024.176377_bib42","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0015230","article-title":"Amyloid-beta triggers the release of neuronal hexokinase 1 from mitochondria","volume":"5","author":"Saraiva","year":"2010","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.ejphar.2024.176377_bib43","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.neulet.2012.05.052","article-title":"Aggravated chronic brain injury after focal cerebral ischemia in aquaporin-4-deficient mice","volume":"520","author":"Shi","year":"2012","journal-title":"Neurosci. Lett."},{"issue":"5","key":"10.1016\/j.ejphar.2024.176377_bib44","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.2337\/diabetes.54.5.1452","article-title":"Pyruvate administered after severe hypoglycemia reduces neuronal death and cognitive impairment","volume":"54","author":"Suh","year":"2005","journal-title":"Diabetes"},{"issue":"2","key":"10.1016\/j.ejphar.2024.176377_bib45","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/neup.12639","article-title":"Metabolic compartmentalization between astroglia and neurons in physiological and pathophysiological conditions of the neurovascular unit","volume":"40","author":"Takahashi","year":"2020","journal-title":"Neuropathology"},{"key":"10.1016\/j.ejphar.2024.176377_bib46","article-title":"Poly (ADP-ribose) polymerase-1 as a promising drug target for neurodegenerative diseases","volume":"267","author":"Thapa","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2024.176377_bib47","author":"Wang","year":"2022","journal-title":"Stroke Vasc. Neurol."},{"issue":"4","key":"10.1016\/j.ejphar.2024.176377_bib48","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1002128","article-title":"Beyond bar and line graphs: time for a new data presentation paradigm","volume":"13","author":"Weissgerber","year":"2015","journal-title":"PLoS Biol."},{"issue":"Pt 12","key":"10.1016\/j.ejphar.2024.176377_bib49","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1242\/jeb.00241","article-title":"Isozymes of mammalian hexokinase: structure, subcellular localization and metabolic function","volume":"206","author":"Wilson","year":"2003","journal-title":"J. Exp. Biol."},{"issue":"8","key":"10.1016\/j.ejphar.2024.176377_bib50","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1161\/CIRCRESAHA.121.319948","article-title":"Advances in acute ischemic stroke therapy","volume":"130","author":"Xiong","year":"2022","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.ejphar.2024.176377_bib51","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.nbd.2006.12.007","article-title":"Systemic pyruvate administration markedly reduces infarcts and motor deficits in rat models of transient and permanent focal cerebral ischemia","volume":"26","author":"Yi","year":"2007","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.ejphar.2024.176377_bib52","doi-asserted-by":"crossref","first-page":"30","DOI":"10.3389\/fnins.2019.00030","article-title":"Mitochondrial dysfunction in neural injury","volume":"13","author":"Zhao","year":"2019","journal-title":"Front. Neurosci."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299924000657?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299924000657?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T23:31:24Z","timestamp":1757979084000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299924000657"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":52,"alternative-id":["S0014299924000657"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2024.176377","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PARP-1 inhibitor alleviates cerebral ischemia\/reperfusion injury by reducing PARylation of HK-1 and LDH in mice","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2024.176377","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"176377"}}