{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:57:24Z","timestamp":1782953844102,"version":"3.54.5"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T00:00:00Z","timestamp":1707436800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003787","name":"Natural Science Foundation of Hebei Province","doi-asserted-by":"publisher","award":["H2020206631"],"award-info":[{"award-number":["H2020206631"]}],"id":[{"id":"10.13039\/501100003787","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003787","name":"Natural Science Foundation of Hebei Province","doi-asserted-by":"publisher","award":["2020-397"],"award-info":[{"award-number":["2020-397"]}],"id":[{"id":"10.13039\/501100003787","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.ejphar.2024.176402","type":"journal-article","created":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T20:41:11Z","timestamp":1707252071000},"page":"176402","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Pentoxifylline protects against cerebral ischaemia-reperfusion injury through ferroptosis regulation via the Nrf2\/SLC7A11\/GPX4 signalling pathway"],"prefix":"10.1016","volume":"967","author":[{"given":"Pei","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Min","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-Hao","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei-Lin","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Dong","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le-Le","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Peng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2024.176402_bib1","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.yhbeh.2015.07.007","article-title":"Lipoic acid and pentoxifylline mitigate nandrolone decanoate-induced neurobehavioral perturbations in rats via re-balance of brain neurotransmitters, up-regulation of Nrf2\/HO-1 pathway, and down-regulation of TNFR1 expression","volume":"73","author":"Ahmed","year":"2015","journal-title":"Horm. Behav."},{"key":"10.1016\/j.ejphar.2024.176402_bib2","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.brainresbull.2018.03.009","article-title":"Pentoxifylline prevents post-traumatic stress disorder induced memory impairment","volume":"139","author":"Alzoubi","year":"2018","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.ejphar.2024.176402_bib3","article-title":"Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal","volume":"360438","author":"Ayala","year":"2014","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"12","key":"10.1016\/j.ejphar.2024.176402_bib4","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1161\/01.STR.20.12.1662","article-title":"Pentoxifylline increases cerebral blood flow in patients with cerebrovascular disease","volume":"20","author":"Bowton","year":"1989","journal-title":"Stroke"},{"key":"10.1016\/j.ejphar.2024.176402_bib5","doi-asserted-by":"crossref","DOI":"10.1177\/17590914211037505","article-title":"Emerging role of ferroptosis in the pathogenesis of ischemic stroke: a new therapeutic target?","volume":"13","author":"Bu","year":"2021","journal-title":"ASN Neuro"},{"issue":"12","key":"10.1016\/j.ejphar.2024.176402_bib6","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1177\/0271678X18793324","article-title":"Sex differences in stroke: challenges and opportunities","volume":"38","author":"Bushnell","year":"2018","journal-title":"J. Cerebr. Blood Flow Metabol.: official journal of the International Society of Cerebral Blood Flow and Metabolism"},{"key":"10.1016\/j.ejphar.2024.176402_bib7","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1056\/NEJMoa1414792","article-title":"Endovascular therapy for ischemic stroke with perfusion-imaging selection","volume":"372","author":"Campbell","year":"2015","journal-title":"J. NEJM."},{"key":"10.1016\/j.ejphar.2024.176402_bib8","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/978-94-007-5881-0_2","article-title":"Nrf2 and antioxidant defense against CYP2E1 toxicity","volume":"67","author":"Cederbaum","year":"2013","journal-title":"Subcell. Biochem."},{"issue":"9","key":"10.1016\/j.ejphar.2024.176402_bib9","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1080\/15548627.2020.1810918","article-title":"Ferroptosis: machinery and regulation","volume":"17","author":"Chen","year":"2021","journal-title":"Autophagy"},{"issue":"5","key":"10.1016\/j.ejphar.2024.176402_bib10","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.ejphar.2024.176402_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101107","article-title":"NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis","volume":"23","author":"Dodson","year":"2019","journal-title":"Redox Biol."},{"issue":"13","key":"10.1016\/j.ejphar.2024.176402_bib12","doi-asserted-by":"crossref","first-page":"12943","DOI":"10.18632\/aging.103378","article-title":"Nrf2 inhibits ferroptosis and protects against acute lung injury due to intestinal ischemia reperfusion via regulating SLC7A11 and HO-1","volume":"12","author":"Dong","year":"2020","journal-title":"Aging (Albany NY)"},{"issue":"1","key":"10.1016\/j.ejphar.2024.176402_bib13","first-page":"1141","article-title":"Pentoxifylline exerts anti-inflammatory effects on cerebral ischemia reperfusion-induced injury in a rat model via the p38 mitogen-activated protein kinase signaling pathway","volume":"17","author":"Dong","year":"2018","journal-title":"Mol. Med. Rep."},{"issue":"10","key":"10.1016\/j.ejphar.2024.176402_bib14","doi-asserted-by":"crossref","first-page":"3411","DOI":"10.1016\/j.celrep.2020.02.049","article-title":"Transferrin receptor is a specific ferroptosis marker","volume":"30","author":"Feng","year":"2020","journal-title":"Cell Rep. 10"},{"key":"10.1016\/j.ejphar.2024.176402_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115021","article-title":"Rehmannioside A improves cognitive impairment and alleviates ferroptosis via activating PI3K\/AKT\/Nrf2 and SLC7A11\/GPX4 signaling pathway after ischemia","volume":"289","author":"Fu","year":"2022","journal-title":"J. Ethnopharmacol."},{"issue":"9","key":"10.1016\/j.ejphar.2024.176402_bib16","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1111\/cns.13657","article-title":"Zinc attenuates ferroptosis and promotes functional recovery in contusion spinal cord injury by activating nrf2\/gpx4 defense pathway","volume":"27","author":"Ge","year":"2021","journal-title":"CNS Neurosci. Ther."},{"issue":"1","key":"10.1016\/j.ejphar.2024.176402_bib17","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/s12931-015-0266-7","article-title":"Role of pulmonary microvascular endothelial cell apoptosis in murine sepsis-induced lung injury in vivo","volume":"16","author":"Gill","year":"2015","journal-title":"Respir. Res."},{"key":"10.1016\/j.ejphar.2024.176402_bib18","first-page":"264","article-title":"Galangin attenuated cerebral ischemia-reperfusion injury by inhibition of ferroptosis through activating the SLC7A11\/GPX4 axis in gerbils","volume":"1","author":"Guan","year":"2021","journal-title":"Life Sci."},{"issue":"3","key":"10.1016\/j.ejphar.2024.176402_bib19","doi-asserted-by":"crossref","first-page":"388","DOI":"10.9758\/cpn.2019.17.3.388","article-title":"Differential effects of pentoxifylline on learning and memory impairment induced by hypoxic-ischemic brain injury in rats","volume":"17","author":"Halis","year":"2019","journal-title":"Clin Psychopharmacol Neurosci"},{"issue":"Pt 1","key":"10.1016\/j.ejphar.2024.176402_bib20","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.freeradbiomed.2022.10.314","article-title":"Inhibition of ferroptosis attenuates oligospermia in male Nrf2 knockout mice","volume":"193","author":"Han","year":"2022","journal-title":"Free Radic. Biol. Med."},{"issue":"1","key":"10.1016\/j.ejphar.2024.176402_bib21","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s12028-021-01278-1","article-title":"Intracerebral iron accumulation may be associated with secondary brain injury in patients with poor grade subarachnoid hemorrhage","volume":"36","author":"Helbok","year":"2022","journal-title":"Neurocrit Care. Feb"},{"issue":"11","key":"10.1016\/j.ejphar.2024.176402_bib22","doi-asserted-by":"crossref","first-page":"e915","DOI":"10.1212\/WNL.0000000000005123","article-title":"Blood-ocular barrier disruption in patients with acute stroke","volume":"90","author":"Hitomi","year":"2018","journal-title":"Neurology"},{"key":"10.1016\/j.ejphar.2024.176402_bib23","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.tox.2019.02.011","article-title":"NADPH oxidase regulates paraquat and maneb-induced dopaminergic neurodegeneration through ferroptosis","volume":"417","author":"Hou","year":"2021","journal-title":"Toxicology"},{"key":"10.1016\/j.ejphar.2024.176402_bib24","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/4776243","article-title":"Melatonin alleviates acute kidney injury by inhibiting NRF2\/slc7a11 axis-mediated ferroptosis","volume":"2022","author":"Huang","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.ejphar.2024.176402_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154112","article-title":"\u03b2-Caryophyllene suppresses ferroptosis induced by cerebral ischemia reperfusion via activation of the NRF2\/HO-1 signaling pathway in MCAO\/R rats","volume":"102","author":"Hu","year":"2022","journal-title":"Phytomedicine"},{"issue":"7","key":"10.1016\/j.ejphar.2024.176402_bib26","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.1016\/S0041-1345(02)03372-9","article-title":"Beneficial effects of pentoxifylline and propentofylline on the warm ischemic injury of rat livers","volume":"34","author":"Iwamoto","year":"2002","journal-title":"Transplant. Proc."},{"key":"10.1016\/j.ejphar.2024.176402_bib27","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.601572","article-title":"Neuroprotective effects of the anti-cancer drug lapatinib against epileptic seizures via suppressing glutathione peroxidase 4-dependent ferroptosis","volume":"11","author":"Jia","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejphar.2024.176402_bib28","article-title":"Neuroprotective effects of irisin against cerebral ischemia\/reperfusion injury via Notch signaling pathway","volume":"120","author":"Jin","year":"2019","journal-title":"J. Biomed Pharmacother."},{"issue":"6","key":"10.1016\/j.ejphar.2024.176402_bib29","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1081\/JDI-100108187","article-title":"Effect of pentoxifylline on ischemic acute renal failure in rabbits","volume":"23","author":"Kim","year":"2001","journal-title":"Ren. Fail."},{"issue":"1","key":"10.1016\/j.ejphar.2024.176402_bib30","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s40880-018-0288-x","article-title":"Amino acid transporter SLC7A11\/xCT at the crossroads of regulating redox homeostasis and nutrient dependency of cancer","volume":"38","author":"Koppula","year":"2018","journal-title":"Cancer Commun."},{"issue":"8","key":"10.1016\/j.ejphar.2024.176402_bib31","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1016\/j.bbagen.2017.05.019","article-title":"Ferroptosis: role of lipid peroxidation, iron and ferritinophagy","volume":"1861","author":"Latunde-Dada","year":"2017","journal-title":"Biochim Biophys Acta Gen Subj. Aug"},{"key":"10.1016\/j.ejphar.2024.176402_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101644","article-title":"A novel compound DBZ ameliorates neuroinflammation in LPS-stimulated microglia and ischemic stroke rats: role of Akt(Ser 473)\/GSK3\u03b2(Ser 9)-mediated Nrf2 activation","volume":"36","author":"Liao","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.ejphar.2024.176402_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2022.110137","article-title":"Baicalein ameliorates cerebral ischemia-reperfusion injury by inhibiting ferroptosis via regulating GPX4\/ACSL4\/ACSL3 axis","volume":"366","author":"Li","year":"2022","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.ejphar.2024.176402_bib34","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/1587922","article-title":"Targeting ferroptosis: pathological mechanism and treatment of ischemia-reperfusion injury","volume":"2021","author":"Li","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"11","key":"10.1016\/j.ejphar.2024.176402_bib35","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1038\/s41418-019-0299-4","article-title":"Ischemia-induced ACSL4 activation contributes to ferroptosis-mediated tissue injury in intestinal ischemia\/reperfusion","volume":"26","author":"Li","year":"2019","journal-title":"Cell Death Differ."},{"issue":"10","key":"10.1016\/j.ejphar.2024.176402_bib36","doi-asserted-by":"crossref","first-page":"153","DOI":"10.3389\/fphar.2019.00153","article-title":"Critical role of Nrf2 in experimental ischemic stroke","volume":"5","author":"Liu","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejphar.2024.176402_bib37","article-title":"SLC7A11\/GPX4 inactivation-mediated ferroptosis contributes to the pathogenesis of triptolide-induced cardiotoxicity","volume":"2022","author":"Liu","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"8","key":"10.1016\/j.ejphar.2024.176402_bib38","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1158\/0008-5472.CAN-18-3037","article-title":"The deubiquitylase OTUB1 mediates ferroptosis via stabilization of SLC7A11","volume":"79","author":"Liu","year":"2019","journal-title":"Cancer Res."},{"key":"10.1016\/j.ejphar.2024.176402_bib39","first-page":"193","article-title":"Reduction in ischemic brain injury following the administration of pentoxifylline after transient global ischemia\/reperfusion in a rat model","volume":"29","author":"Nadia Sharifi","year":"2015","journal-title":"Med. J. Islam. Repub. Iran"},{"issue":"47","key":"10.1016\/j.ejphar.2024.176402_bib40","doi-asserted-by":"crossref","first-page":"18578","DOI":"10.1073\/pnas.0804373105","article-title":"Divalent metal transporter 1 (DMT1) contributes to neurodegeneration in animal models of Parkinson's disease","volume":"105","author":"Salazar","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"9","key":"10.1016\/j.ejphar.2024.176402_bib41","article-title":"Pentoxifylline for intermittent claudication","volume":"9","author":"Salhiyyah","year":"2015","journal-title":"Cochrane Database Syst. Rev."},{"issue":"5","key":"10.1016\/j.ejphar.2024.176402_bib42","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/sj.sc.3101281","article-title":"Pentoxifylline reduces biochemical markers of ischemia-reperfusion induced spinal cord injury in rabbits","volume":"40","author":"Sava\u015f","year":"2002","journal-title":"Spinal Cord"},{"key":"10.1016\/j.ejphar.2024.176402_bib43","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.freeradbiomed.2018.09.014","article-title":"Role of GPX4 in ferroptosis and its pharmacological implication","volume":"133","author":"Seibt","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ejphar.2024.176402_bib44","doi-asserted-by":"crossref","first-page":"776","DOI":"10.3389\/fnins.2020.00776","article-title":"Cross talk between ferroptosis and cerebral ischemia","volume":"14","author":"She","year":"2020","journal-title":"Front. Neurosci."},{"issue":"8","key":"10.1016\/j.ejphar.2024.176402_bib45","first-page":"19","article-title":"Divalent metal transporter 1 (DMT1) in the brain: implications for a role in iron transport at the blood-brain barrier, and neuronal and glial pathology","volume":"8","author":"Skj\u00f8rringe","year":"2015","journal-title":"Front. Mol. Neurosci."},{"issue":"2","key":"10.1016\/j.ejphar.2024.176402_bib46","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.cell.2017.09.021","article-title":"Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease","volume":"171","author":"Stockwell","year":"2017","journal-title":"Cell"},{"issue":"9","key":"10.1016\/j.ejphar.2024.176402_bib47","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1097\/00007890-200105150-00019","article-title":"Preventive effect of inhaled nitric oxide and pentoxifylline on ischemia\/reperfusion injury after lung transplantation","volume":"71","author":"Thabut","year":"2001","journal-title":"Transplantation"},{"issue":"1","key":"10.1016\/j.ejphar.2024.176402_bib48","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/s41392-022-00917-z","article-title":"Thrombin induces ACSL4-dependent ferroptosis during cerebral ischemia\/reperfusion","volume":"7","author":"Tuo","year":"2022","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.ejphar.2024.176402_bib49","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.brainres.2011.01.001","article-title":"Pentoxifylline attenuates TNF-\u03b1 protein levels and brain edema following temporary focal cerebral ischemia in rats","volume":"1377","author":"Vakili","year":"2011","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2024.176402_bib50","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.brainres.2007.01.096","article-title":"Post-ischemic treatment of pentoxifylline reduces cortical not striatal infarct volume in transient model of focal cerebral ischemia in rat","volume":"1144","author":"Vakili","year":"2007","journal-title":"Brain Res."},{"issue":"12","key":"10.1016\/j.ejphar.2024.176402_bib51","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.3390\/antiox11122377","article-title":"Nrf2 regulates oxidative stress and its role in cerebral ischemic stroke","volume":"11","author":"Wang","year":"2022","journal-title":"Antioxidants"},{"issue":"10","key":"10.1016\/j.ejphar.2024.176402_bib52","first-page":"1933","article-title":"Iron and magnetic: new research direction of the ferroptosis-based cancer therapy","volume":"8","author":"Wang","year":"2018","journal-title":"Am. J. Cancer Res."},{"issue":"18","key":"10.1016\/j.ejphar.2024.176402_bib53","doi-asserted-by":"crossref","first-page":"9902","DOI":"10.3390\/ijms22189902","article-title":"Ferroptosis mechanisms involved in hippocampal-related diseases","volume":"22","author":"Wang","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"24","key":"10.1016\/j.ejphar.2024.176402_bib54","doi-asserted-by":"crossref","first-page":"25487","DOI":"10.18632\/aging.104155","article-title":"Pentoxifylline enhances antioxidative capability and promotes mitochondrial biogenesis for improving age-related behavioral deficits","volume":"12","author":"Wang","year":"2020","journal-title":"Aging (Albany NY)"},{"issue":"4","key":"10.1016\/j.ejphar.2024.176402_bib55","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/S1474-4422(18)30500-3","article-title":"China Stroke Study Collaboration. Stroke in China: advances and challenges in epidemiology, prevention, and management","volume":"18","author":"Wu","year":"2019","journal-title":"Lancet Neurol."},{"issue":"7","key":"10.1016\/j.ejphar.2024.176402_bib56","doi-asserted-by":"crossref","first-page":"3052","DOI":"10.7150\/thno.54113","article-title":"Ferroptosis as a novel therapeutic target for cardiovascular disease","volume":"11","author":"Wu","year":"2021","journal-title":"Theranostics. 1"},{"key":"10.1016\/j.ejphar.2024.176402_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154748","article-title":"Wenqingyin suppresses ferroptosis in the pathogenesis of sepsis-induced liver injury by activating the Nrf2-mediated signaling pathway","volume":"114","author":"Xie","year":"2023","journal-title":"Phytomedicine"},{"issue":"3","key":"10.1016\/j.ejphar.2024.176402_bib58","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/cdd.2015.158","article-title":"Ferroptosis: process and function","volume":"23","author":"Xie","year":"2016","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.ejphar.2024.176402_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113611","article-title":"The mechanism of ferroptosis regulating oxidative stress in ischemic stroke and the regulation mechanism of natural pharmacological active components","volume":"154","author":"Yang","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ejphar.2024.176402_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111303","article-title":"Anti-cerebral ischemia reperfusion injury of polysaccharides: a review of the mechanisms","volume":"137","author":"Yuan","year":"2021","journal-title":"Biomed. Pharmacother."},{"issue":"7","key":"10.1016\/j.ejphar.2024.176402_bib61","doi-asserted-by":"crossref","first-page":"923","DOI":"10.3390\/biom11070923","article-title":"Kaempferol ameliorates oxygen-glucose deprivation\/reoxygenation-induced neuronal ferroptosis by activating nrf2\/SLC7A11\/GPX4 Axis","volume":"11","author":"Yuan","year":"2021","journal-title":"Biomolecules"},{"issue":"366","key":"10.1016\/j.ejphar.2024.176402_bib62","first-page":"95","article-title":"Sirtuin 6 protects the brain from cerebral ischemia\/reperfusion injury through NRF2 activation","volume":"16","author":"Zhang","year":"2017","journal-title":"Neuroscience"},{"issue":"7","key":"10.1016\/j.ejphar.2024.176402_bib63","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1080\/00207454.2020.1797722","article-title":"Enriched environment improves post-stroke cognitive impairment and inhibits neuroinflammation and oxidative stress by activating Nrf2-ARE pathway","volume":"131","author":"Zhang","year":"2017","journal-title":"Int. J. Neurosci."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299924000906?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299924000906?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:27:36Z","timestamp":1777393656000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299924000906"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":63,"alternative-id":["S0014299924000906"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2024.176402","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pentoxifylline protects against cerebral ischaemia-reperfusion injury through ferroptosis regulation via the Nrf2\/SLC7A11\/GPX4 signalling pathway","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2024.176402","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Second Hospital of Hebei Medical University. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"176402"}}