{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T10:49:33Z","timestamp":1789469373535,"version":"build-2803163510"},"reference-count":65,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007128","name":"Natural Science Foundation of Shaanxi Province","doi-asserted-by":"publisher","award":["2019JQ-390"],"award-info":[{"award-number":["2019JQ-390"]}],"id":[{"id":"10.13039\/501100007128","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007128","name":"Natural Science Foundation of Shaanxi Province","doi-asserted-by":"publisher","award":["2023-JC-QN-0894"],"award-info":[{"award-number":["2023-JC-QN-0894"]}],"id":[{"id":"10.13039\/501100007128","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007128","name":"Natural Science Foundation of Shaanxi Province","doi-asserted-by":"publisher","award":["2020JO-508"],"award-info":[{"award-number":["2020JO-508"]}],"id":[{"id":"10.13039\/501100007128","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970050"],"award-info":[{"award-number":["81970050"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670051"],"award-info":[{"award-number":["81670051"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.ejphar.2024.176483","type":"journal-article","created":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T12:13:38Z","timestamp":1710159218000},"page":"176483","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Activation of CaMKII\/HDAC4 by SDF1 contributes to pulmonary arterial hypertension via stabilization Runx2"],"prefix":"10.1016","volume":"970","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3804-3714","authenticated-orcid":false,"given":"Yuqian","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limin","family":"Chai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danyang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanjie","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nirui","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingting","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinming","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaojun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manxiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2024.176483_bib1","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1093\/cvr\/cvz153","article-title":"Neutralization of CXCL12 attenuates established pulmonary hypertension in rats","volume":"116","author":"Bordenave","year":"2020","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ejphar.2024.176483_bib2","doi-asserted-by":"crossref","first-page":"4545","DOI":"10.3892\/mmr.2017.7211","article-title":"Lercanidipine attenuates angiotensin II-induced cardiomyocyte hypertrophy by blocking calcineurin-NFAT3 and CaMKII-HDAC4 signaling","volume":"16","author":"Chen","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.ejphar.2024.176483_bib3","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.tins.2012.05.003","article-title":"CaMKII regulation in information processing and storage","volume":"35","author":"Coultrap","year":"2012","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.ejphar.2024.176483_bib4","doi-asserted-by":"crossref","DOI":"10.3390\/antiox12010071","article-title":"Specificity protein 1-mediated promotion of CXCL12 Advances endothelial cell metabolism and proliferation in pulmonary hypertension","volume":"12","author":"DeVallance","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.ejphar.2024.176483_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamcr.2022.119329","article-title":"Combined role for YAP-TEAD and YAP-RUNX2 signalling in substrate-stiffness regulation of cardiac fibroblast proliferation","volume":"1869","author":"Ebrahimighaei","year":"2022","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"10.1016\/j.ejphar.2024.176483_bib6","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13048","article-title":"ERK\/Drp1-dependent mitochondrial fission contributes to HMGB1-induced autophagy in pulmonary arterial hypertension","volume":"54","author":"Feng","year":"2021","journal-title":"Cell Prolif."},{"key":"10.1016\/j.ejphar.2024.176483_bib7","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1186\/s13045-020-01009-7","article-title":"Abnormally activated OPN\/integrin \u03b1V\u03b23\/FAK signalling is responsible for EGFR-TKI resistance in EGFR mutant non-small-cell lung cancer","volume":"13","author":"Fu","year":"2020","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.ejphar.2024.176483_bib8","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/sj.cr.7310149","article-title":"HDACs, histone deacetylation and gene transcription: from molecular biology to cancer therapeutics","volume":"17","author":"Gallinari","year":"2007","journal-title":"Cell Res."},{"key":"10.1016\/j.ejphar.2024.176483_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.117389","article-title":"Regulation of Runx2 by post-translational modifications in osteoblast differentiation","volume":"245","author":"Gomathi","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2024.176483_bib10","doi-asserted-by":"crossref","first-page":"L936","DOI":"10.1152\/ajplung.00256.2016","article-title":"TGF-\u03b2(1) stimulates HDAC4 nucleus-to-cytoplasm translocation and NADPH oxidase 4-derived reactive oxygen species in normal human lung fibroblasts","volume":"312","author":"Guo","year":"2017","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.ejphar.2024.176483_bib11","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.1056\/NEJMra2000348","article-title":"Pulmonary arterial hypertension","volume":"385","author":"Hassoun","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejphar.2024.176483_bib12","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232315328","article-title":"Osteopontin splicing isoforms contribute to endometriotic proliferation, migration, and epithelial-mesenchymal transition in endometrial epithelial cells","volume":"23","author":"Ho","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2024.176483_bib13","doi-asserted-by":"crossref","first-page":"4005","DOI":"10.1038\/s41598-017-04198-3","article-title":"Chemokine receptor CXCR4 regulates CaMKII\/CREB pathway in spinal neurons that underlies cancer-induced bone pain","volume":"7","author":"Hu","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejphar.2024.176483_bib14","doi-asserted-by":"crossref","first-page":"16502","DOI":"10.1074\/jbc.M512494200","article-title":"Bone morphogenetic protein-2 stimulates Runx2 acetylation","volume":"281","author":"Jeon","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2024.176483_bib15","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1177\/0022034509341629","article-title":"Post-translational regulation of Runx2 in bone and cartilage","volume":"88","author":"Jonason","year":"2009","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.ejphar.2024.176483_bib16","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1080\/09537104.2018.1457780","article-title":"Increased platelet content of SDF-1alpha is associated with worse prognosis in patients with pulmonary prterial hypertension","volume":"30","author":"Kazimierczyk","year":"2019","journal-title":"Platelets"},{"key":"10.1016\/j.ejphar.2024.176483_bib17","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1097\/HJH.0000000000001081","article-title":"Histone deacetylase and GATA-binding factor 6 regulate arterial remodeling in angiotensin II-induced hypertension","volume":"34","author":"Kim","year":"2016","journal-title":"J. Hypertens."},{"key":"10.1016\/j.ejphar.2024.176483_bib18","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20071694","article-title":"Regulation of proliferation, differentiation and functions of osteoblasts by Runx2","volume":"20","author":"Komori","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2024.176483_bib19","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/nrcardio.2017.84","article-title":"Epidemiology and treatment of pulmonary arterial hypertension","volume":"14","author":"Lau","year":"2017","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.ejphar.2024.176483_bib20","doi-asserted-by":"crossref","first-page":"H688","DOI":"10.1152\/ajpheart.01014.2009","article-title":"Calmodulin kinase II is required for angiotensin II-mediated vascular smooth muscle hypertrophy","volume":"298","author":"Li","year":"2010","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.ejphar.2024.176483_bib21","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1038\/s41467-019-09653-5","article-title":"TMCO1-mediated Ca(2+) leak underlies osteoblast functions via CaMKII signaling","volume":"10","author":"Li","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejphar.2024.176483_bib22","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1161\/01.RES.74.2.214","article-title":"Osteopontin promotes vascular cell adhesion and spreading and is chemotactic for smooth muscle cells in vitro","volume":"74","author":"Liaw","year":"1994","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2024.176483_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.117328","article-title":"Osteopontin induces atrial fibrosis by activating Akt\/GSK-3\u03b2\/\u03b2-catenin pathway and suppressing autophagy","volume":"245","author":"Lin","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2024.176483_bib24","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12783","article-title":"Alteration of calcium signalling in cardiomyocyte induced by simulated microgravity and hypergravity","volume":"53","author":"Liu","year":"2020","journal-title":"Cell Prolif."},{"key":"10.1016\/j.ejphar.2024.176483_bib25","doi-asserted-by":"crossref","first-page":"15534","DOI":"10.1021\/acs.jmedchem.1c01145","article-title":"Chromosome region maintenance 1 (XPO1\/CRM1) as an anticancer target and discovery of its inhibitor","volume":"64","author":"Liu","year":"2021","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejphar.2024.176483_bib26","doi-asserted-by":"crossref","first-page":"9345","DOI":"10.1002\/jcb.28210","article-title":"alpha1A-adrenoceptor is involved in norepinephrine-induced proliferation of pulmonary artery smooth muscle cells via CaMKII signaling","volume":"120","author":"Luo","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.ejphar.2024.176483_bib27","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1196\/annals.1378.042","article-title":"SDF-1 controls pituitary cell proliferation through the activation of ERK1\/2 and the Ca2+-dependent, cytosolic tyrosine kinase Pyk2","volume":"1090","author":"Massa","year":"2006","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.ejphar.2024.176483_bib28","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0123709","article-title":"Elevated plasma CXCL12\u03b1 is associated with a poorer prognosis in pulmonary arterial hypertension","volume":"10","author":"McCullagh","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2024.176483_bib29","doi-asserted-by":"crossref","first-page":"6312","DOI":"10.1128\/MCB.21.18.6312-6321.2001","article-title":"Identification of a signal-responsive nuclear export sequence in class II histone deacetylases","volume":"21","author":"McKinsey","year":"2001","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.ejphar.2024.176483_bib30","doi-asserted-by":"crossref","first-page":"L706","DOI":"10.1152\/ajplung.90598.2008","article-title":"Thrombin induces fibronectin-specific migration of pulmonary microvascular endothelial cells: requirement of calcium\/calmodulin-dependent protein kinase II","volume":"297","author":"Meoli","year":"2009","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.ejphar.2024.176483_bib31","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1111\/resp.13557","article-title":"Osteopontin lung gene expression is a marker of disease severity in pulmonary arterial hypertension","volume":"24","author":"Mura","year":"2019","journal-title":"Respirology"},{"key":"10.1016\/j.ejphar.2024.176483_bib32","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1111\/jcmm.17081","article-title":"CaMKII inhibitor KN-93 impaired angiogenesis and aggravated cardiac remodelling and heart failure via inhibiting NOX2\/mtROS\/p-VEGFR2 and STAT3 pathways","volume":"26","author":"Ni","year":"2022","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.ejphar.2024.176483_bib33","doi-asserted-by":"crossref","first-page":"23","DOI":"10.5551\/jat.9753","article-title":"Runx2\/Smad3 complex negatively regulates TGF-\u03b2-induced connective tissue growth factor gene expression in vascular smooth muscle cells","volume":"19","author":"Ohyama","year":"2012","journal-title":"J. Atherosclerosis Thromb."},{"key":"10.1016\/j.ejphar.2024.176483_bib34","doi-asserted-by":"crossref","first-page":"2804","DOI":"10.1091\/mbc.e03-08-0624","article-title":"Caspase-dependent regulation of histone deacetylase 4 nuclear-cytoplasmic shuttling promotes apoptosis","volume":"15","author":"Paroni","year":"2004","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.ejphar.2024.176483_bib35","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/cyto.a.10008","article-title":"Evaluation of SDF-1\/CXCR4-induced Ca2+ signaling by fluorometric imaging plate reader (FLIPR) and flow cytometry","volume":"51","author":"Princen","year":"2003","journal-title":"Cytometry"},{"key":"10.1016\/j.ejphar.2024.176483_bib36","doi-asserted-by":"crossref","first-page":"921","DOI":"10.7150\/thno.22182","article-title":"Cancer-associated fibroblast-derived IL-6 promotes head and neck cancer progression via the osteopontin-NF-kappa B signaling pathway","volume":"8","author":"Qin","year":"2018","journal-title":"Theranostics"},{"key":"10.1016\/j.ejphar.2024.176483_bib37","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1182\/blood-2002-03-0978","article-title":"Role of the intracellular domains of CXCR4 in SDF-1-mediated signaling","volume":"101","author":"Roland","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.ejphar.2024.176483_bib38","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1164\/rccm.201512-2380OC","article-title":"Role for runt-related transcription factor 2 in proliferative and calcified vascular lesions in pulmonary arterial hypertension","volume":"194","author":"Ruffenach","year":"2016","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.ejphar.2024.176483_bib39","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0136247","article-title":"Identification of the acetylation and ubiquitin-modified proteome during the progression of skeletal muscle atrophy","volume":"10","author":"Ryder","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2024.176483_bib40","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1164\/rccm.201202-0335OC","article-title":"Immune and inflammatory cell involvement in the pathology of idiopathic pulmonary arterial hypertension","volume":"186","author":"Savai","year":"2012","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.ejphar.2024.176483_bib41","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1161\/ATVBAHA.116.308606","article-title":"Olfactomedin 2 regulates smooth muscle phenotypic modulation and vascular remodeling through mediating runt-related transcription factor 2 binding to serum response factor","volume":"37","author":"Shi","year":"2017","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.ejphar.2024.176483_bib42","doi-asserted-by":"crossref","first-page":"4694","DOI":"10.1002\/jcp.30193","article-title":"Activation of yes-associated protein mediates sphingosine-1-phosphate-induced proliferation and migration of pulmonary artery smooth muscle cells and its potential mechanisms","volume":"236","author":"Shi","year":"2021","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.ejphar.2024.176483_bib43","doi-asserted-by":"crossref","first-page":"2927","DOI":"10.1158\/1078-0432.CCR-09-2329","article-title":"CXCL12 (SDF-1)\/CXCR4 pathway in cancer","volume":"16","author":"Teicher","year":"2010","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.ejphar.2024.176483_bib44","doi-asserted-by":"crossref","first-page":"C462","DOI":"10.1152\/ajpcell.00341.2015","article-title":"Vascular CaMKII: heart and brain in your arteries","volume":"311","author":"Toussaint","year":"2016","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.ejphar.2024.176483_bib45","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.omtn.2021.12.028","article-title":"miR-424\/322 protects against abdominal aortic aneurysm formation by modulating the Smad2\/3\/runt-related transcription factor 2 axis","volume":"27","author":"Tsai","year":"2022","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.ejphar.2024.176483_bib46","doi-asserted-by":"crossref","first-page":"500","DOI":"10.3389\/fphar.2018.00500","article-title":"Kinin and purine signaling contributes to neuroblastoma metastasis","volume":"9","author":"Ulrich","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejphar.2024.176483_bib47","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0232536","article-title":"Stromal cell-derived factor 1 regulates in vitro sperm migration towards the cumulus-oocyte complex in cattle","volume":"15","author":"Umezu","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2024.176483_bib48","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1161\/HYPERTENSIONAHA.113.01843","article-title":"Histone deacetylase 4 controls neointimal hyperplasia via stimulating proliferation and migration of vascular smooth muscle cells","volume":"63","author":"Usui","year":"2014","journal-title":"Hypertension"},{"key":"10.1016\/j.ejphar.2024.176483_bib49","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.cell.2004.10.024","article-title":"Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis","volume":"119","author":"Vega","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.ejphar.2024.176483_bib50","doi-asserted-by":"crossref","first-page":"5992","DOI":"10.1128\/MCB.21.17.5992-6005.2001","article-title":"Histone deacetylase 4 possesses intrinsic nuclear import and export signals","volume":"21","author":"Wang","year":"2001","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.ejphar.2024.176483_bib51","doi-asserted-by":"crossref","first-page":"139","DOI":"10.2217\/epi.13.73","article-title":"HDAC4: mechanism of regulation and biological functions","volume":"6","author":"Wang","year":"2014","journal-title":"Epigenomics"},{"key":"10.1016\/j.ejphar.2024.176483_bib52","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1111\/jpi.12226","article-title":"Melatonin induces apoptosis of colorectal cancer cells through HDAC4 nuclear import mediated by CaMKII inactivation","volume":"58","author":"Wei","year":"2015","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.ejphar.2024.176483_bib53","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0113867","article-title":"Specific inhibition of the nuclear exporter exportin-1 attenuates kidney cancer growth","volume":"9","author":"Wettersten","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2024.176483_bib54","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/s41419-022-04806-9","article-title":"Osteopontin promotes hepatocellular carcinoma progression through inducing JAK2\/STAT3\/NOX1-mediated ROS production","volume":"13","author":"Wu","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ejphar.2024.176483_bib55","first-page":"1458","article-title":"Inhibition of CXCR4 ameliorates hypoxia-induced pulmonary arterial hypertension in rats","volume":"13","author":"Xu","year":"2021","journal-title":"Am J Transl Res"},{"key":"10.1016\/j.ejphar.2024.176483_bib56","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.biopha.2016.09.031","article-title":"Iptakalim induces mitochondria-dependent apoptosis in hypoxic rat pulmonary arterial smooth muscle cells","volume":"84","author":"Xu","year":"2016","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ejphar.2024.176483_bib57","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.bbrc.2019.06.160","article-title":"S1P induces pulmonary artery smooth muscle cell proliferation by activating calcineurin\/NFAT\/OPN signaling pathway","volume":"516","author":"Yan","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejphar.2024.176483_bib58","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22063182","article-title":"Endothelial autocrine signaling through CXCL12\/CXCR4\/FoxM1 Axis contributes to severe pulmonary arterial hypertension","volume":"22","author":"Yi","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2024.176483_bib59","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1165\/rcmb.2019-0401OC","article-title":"Mural cell SDF1 signaling is associated with the pathogenesis of pulmonary arterial hypertension","volume":"62","author":"Yuan","year":"2020","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.ejphar.2024.176483_bib60","doi-asserted-by":"crossref","DOI":"10.1177\/1557988320945458","article-title":"Increased levels of runt-related transcription factor 2 are associated with poor survival of patients with idiopathic pulmonary arterial hypertension","volume":"14","author":"Yuan","year":"2020","journal-title":"Am. J. Men's Health"},{"key":"10.1016\/j.ejphar.2024.176483_bib61","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/j.biopha.2017.05.096","article-title":"miR-152 regulated glioma cell proliferation and apoptosis via Runx2 mediated by DNMT1","volume":"92","author":"Zhang","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ejphar.2024.176483_bib62","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12436","article-title":"The transient receptor potential vanilloid-3 regulates hypoxia-mediated pulmonary artery smooth muscle cells proliferation via PI3K\/AKT signaling pathway","volume":"51","author":"Zhang","year":"2018","journal-title":"Cell Prolif."},{"key":"10.1016\/j.ejphar.2024.176483_bib63","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1186\/s12931-023-02454-x","article-title":"HMGB1-induced activation of ER stress contributes to pulmonary artery hypertension in vitro and in vivo","volume":"24","author":"Zhang","year":"2023","journal-title":"Respir. Res."},{"key":"10.1016\/j.ejphar.2024.176483_bib64","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s12931-019-1041-y","article-title":"Silibinin efficacy in a rat model of pulmonary arterial hypertension using monocrotaline and chronic hypoxia","volume":"20","author":"Zhang","year":"2019","journal-title":"Respir. Res."},{"key":"10.1016\/j.ejphar.2024.176483_bib65","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1161\/CIRCULATIONAHA.121.054827","article-title":"Targeting E3 ubiquitin ligase WWP1 prevents cardiac hypertrophy through destabilizing DVL2 via inhibition of K27-linked ubiquitination","volume":"144","author":"Zhao","year":"2021","journal-title":"Circulation"}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299924001717?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299924001717?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T23:28:40Z","timestamp":1757978920000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299924001717"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":65,"alternative-id":["S0014299924001717"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2024.176483","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Activation of CaMKII\/HDAC4 by SDF1 contributes to pulmonary arterial hypertension via stabilization Runx2","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2024.176483","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"176483"}}