{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T15:39:30Z","timestamp":1793979570825,"version":"4.8.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T00:00:00Z","timestamp":1712188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013143","name":"National Natural Science Foundation of China-Shandong Joint Fund for Marine Science Research Centers","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013143","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.ejphar.2024.176553","type":"journal-article","created":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T15:20:45Z","timestamp":1712071245000},"page":"176553","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"special_numbering":"C","title":["N6022 attenuates cerebral ischemia\/reperfusion injury-induced microglia ferroptosis by promoting Nrf2 nuclear translocation and inhibiting the GSNOR\/GSTP1 axis"],"prefix":"10.1016","volume":"972","author":[{"given":"Wan-Li","family":"Duan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Ping","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Jie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Sheng","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Mei","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Ying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8712-3147","authenticated-orcid":false,"given":"P. Andy","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bao-Gang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9443-690X","authenticated-orcid":false,"given":"Mao-Tao","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2024.176553_bib1","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1016\/j.cell.2019.03.032","article-title":"Selenium drives a transcriptional adaptive program to block ferroptosis and treat stroke","volume":"177","author":"Alim","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.ejphar.2024.176553_bib2","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1080\/10409238.2017.1304353","article-title":"The role of S-nitrosoglutathione reductase (GSNOR) in human disease and therapy","volume":"52","author":"Barnett","year":"2017","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"10.1016\/j.ejphar.2024.176553_bib3","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.pharmthera.2015.11.003","article-title":"Nrf2-ARE pathway: an emerging target against oxidative stress and neuroinflammation in neurodegenerative diseases","volume":"157","author":"Buendia","year":"2016","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.ejphar.2024.176553_bib4","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.freeradbiomed.2022.01.012","article-title":"Mitochondrial oxidative stress mediated Fe-induced ferroptosis via the NRF2-ARE pathway","volume":"180","author":"Chen","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ejphar.2024.176553_bib5","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s12975-022-01122-4","article-title":"Netrin-1 alleviates early brain injury by regulating ferroptosis via the ppar\u03b3\/nrf2\/GPX4 signaling pathway following subarachnoid hemorrhage","volume":"15","author":"Chen","year":"2023","journal-title":"Transl Stroke Res"},{"key":"10.1016\/j.ejphar.2024.176553_bib6","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1152\/japplphysiol.01302.2012","article-title":"Pharmacological inhibition of S-nitrosoglutathione reductase improves endothelial vasodilatory function in rats in vivo","volume":"114","author":"Chen","year":"2013","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.ejphar.2024.176553_bib7","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/s41418-022-01051-7","article-title":"SOCS2-enhanced ubiquitination of SLC7A11 promotes ferroptosis and radiosensitization in hepatocellular carcinoma","volume":"30","author":"Chen","year":"2023","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.ejphar.2024.176553_bib8","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1111\/cns.14130","article-title":"Srs11-92, a ferrostatin-1 analog, improves oxidative stress and neuroinflammation via Nrf2 signal following cerebral ischemia\/reperfusion injury","volume":"29","author":"Chen","year":"2023","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.ejphar.2024.176553_bib9","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.yrtph.2011.12.012","article-title":"A nonclinical safety and pharmacokinetic evaluation of N6022: a first-in-class S-nitrosoglutathione reductase inhibitor for the treatment of asthma","volume":"62","author":"Colagiovanni","year":"2012","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.ejphar.2024.176553_bib10","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.bbi.2021.01.003","article-title":"ACSL4 exacerbates ischemic stroke by promoting ferroptosis-induced brain injury and neuroinflammation","volume":"93","author":"Cui","year":"2021","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.ejphar.2024.176553_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101107","article-title":"NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis","volume":"23","author":"Dodson","year":"2019","journal-title":"Redox Biol."},{"key":"10.1016\/j.ejphar.2024.176553_bib12","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/s41586-019-1707-0","article-title":"FSP1 is a glutathione-independent ferroptosis suppressor","volume":"575","author":"Doll","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2024.176553_bib13","doi-asserted-by":"crossref","DOI":"10.3390\/molecules26165001","article-title":"The Nrf2 pathway in ischemic stroke: a review","volume":"26","author":"Farina","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.ejphar.2024.176553_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115021","article-title":"Rehmannioside A improves cognitive impairment and alleviates ferroptosis via activating PI3K\/AKT\/Nrf2 and SLC7A11\/GPX4 signaling pathway after ischemia","volume":"289","author":"Fu","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.ejphar.2024.176553_bib15","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1089\/ars.2020.8175","article-title":"Ferroptosis: biological rust of lipid membranes","volume":"35","author":"Hassannia","year":"2021","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.ejphar.2024.176553_bib16","doi-asserted-by":"crossref","first-page":"2268","DOI":"10.1093\/carcin\/bgm135","article-title":"Differential effects of glutathione S-transferase pi (GSTP1) haplotypes on cell proliferation and apoptosis","volume":"28","author":"Holley","year":"2007","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.ejphar.2024.176553_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154112","article-title":"\u03b2-Caryophyllene suppresses ferroptosis induced by cerebral ischemia reperfusion via activation of the NRF2\/HO-1 signaling pathway in MCAO\/R rats","volume":"102","author":"Hu","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.ejphar.2024.176553_bib18","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: mechanisms, biology and role in disease","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ejphar.2024.176553_bib19","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/s41568-022-00459-0","article-title":"Targeting ferroptosis as a vulnerability in cancer","volume":"22","author":"Lei","year":"2022","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.ejphar.2024.176553_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105933","article-title":"Nuclear receptor coactivator 4-mediated ferritinophagy contributes to cerebral ischemia-induced ferroptosis in ischemic stroke","volume":"174","author":"Li","year":"2021","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.ejphar.2024.176553_bib21","article-title":"System X(c) (-)\/GSH\/GPX4 axis: an important antioxidant system for the ferroptosis in drug-resistant solid tumor therapy","volume":"13","author":"Li","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejphar.2024.176553_bib22","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/s12967-021-02745-1","article-title":"Panaxydol attenuates ferroptosis against LPS-induced acute lung injury in mice by Keap1-Nrf2\/HO-1 pathway","volume":"19","author":"Li","year":"2021","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.ejphar.2024.176553_bib23","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1161\/STROKEAHA.119.028484","article-title":"Trends in stroke incidence in high-income countries in the 21st century: population-based study and systematic review","volume":"51","author":"Li","year":"2020","journal-title":"Stroke"},{"key":"10.1016\/j.ejphar.2024.176553_bib24","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1038\/s41418-019-0299-4","article-title":"Ischemia-induced ACSL4 activation contributes to ferroptosis-mediated tissue injury in intestinal ischemia\/reperfusion","volume":"26","author":"Li","year":"2019","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.ejphar.2024.176553_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101644","article-title":"A novel compound DBZ ameliorates neuroinflammation in LPS-stimulated microglia and ischemic stroke rats: role of Akt(Ser473)\/GSK3\u03b2(Ser9)-mediated Nrf2 activation","volume":"36","author":"Liao","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.ejphar.2024.176553_bib26","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.2147\/IJGM.S341502","article-title":"Pan-cancer analyses confirmed the ferroptosis-related gene SLC7A11 as a prognostic biomarker for cancer","volume":"15","author":"Lin","year":"2022","journal-title":"Int. J. Gen. Med."},{"key":"10.1016\/j.ejphar.2024.176553_bib27","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1111\/jnc.15351","article-title":"Ferroptosis: an emerging therapeutic target in stroke","volume":"160","author":"Liu","year":"2022","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ejphar.2024.176553_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154729","article-title":"Loureirin C inhibits ferroptosis after cerebral ischemia reperfusion through regulation of the Nrf2 pathway in mice","volume":"113","author":"Liu","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.ejphar.2024.176553_bib29","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1001\/jama.2020.26867","article-title":"Diagnosis and management of transient ischemic attack and acute ischemic stroke: a review","volume":"325","author":"Mendelson","year":"2021","journal-title":"JAMA"},{"key":"10.1016\/j.ejphar.2024.176553_bib30","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/pros.23111","article-title":"GSTP1 Loss results in accumulation of oxidative DNA base damage and promotes prostate cancer cell survival following exposure to protracted oxidative stress","volume":"76","author":"Mian","year":"2016","journal-title":"Prostate"},{"key":"10.1016\/j.ejphar.2024.176553_bib31","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.neuron.2010.07.002","article-title":"The science of stroke: mechanisms in search of treatments","volume":"67","author":"Moskowitz","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.ejphar.2024.176553_bib32","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1002\/iid3.220","article-title":"Effect of the S-nitrosoglutathione reductase inhibitor N6022 on bronchial hyperreactivity in asthma","volume":"6","author":"Que","year":"2018","journal-title":"Immun Inflamm Dis"},{"key":"10.1016\/j.ejphar.2024.176553_bib33","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.freeradbiomed.2018.09.014","article-title":"Role of GPX4 in ferroptosis and its pharmacological implication","volume":"133","author":"Seibt","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ejphar.2024.176553_bib34","doi-asserted-by":"crossref","first-page":"776","DOI":"10.3389\/fnins.2020.00776","article-title":"Cross talk between ferroptosis and cerebral ischemia","volume":"14","author":"She","year":"2020","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.ejphar.2024.176553_bib35","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1016\/j.cell.2022.06.003","article-title":"Ferroptosis turns 10: emerging mechanisms, physiological functions, and therapeutic applications","volume":"185","author":"Stockwell","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.ejphar.2024.176553_bib36","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.cell.2017.09.021","article-title":"Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease","volume":"171","author":"Stockwell","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.ejphar.2024.176553_bib37","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1021\/ml200045s","article-title":"Discovery of s-nitrosoglutathione reductase inhibitors: potential agents for the treatment of asthma and other inflammatory diseases","volume":"2","author":"Sun","year":"2011","journal-title":"ACS Med. Chem. Lett."},{"key":"10.1016\/j.ejphar.2024.176553_bib38","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2022.1102158","article-title":"Targeting GSTP1-dependent ferroptosis in lung cancer radiotherapy: existing evidence and future directions","volume":"9","author":"Tan","year":"2022","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.ejphar.2024.176553_bib39","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.freeradbiomed.2020.02.027","article-title":"Lipid peroxidation and ferroptosis: the role of GSH and GPx4","volume":"152","author":"Ursini","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ejphar.2024.176553_bib40","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1161\/CIRCULATIONAHA.116.025250","article-title":"Prevalence, incidence, and mortality of stroke in China: results from a nationwide population-based survey of 480 687 adults","volume":"135","author":"Wang","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2024.176553_bib41","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1038\/s41418-022-00990-5","article-title":"PRMT4 promotes ferroptosis to aggravate doxorubicin-induced cardiomyopathy via inhibition of the Nrf2\/GPX4 pathway","volume":"29","author":"Wang","year":"2022","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.ejphar.2024.176553_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154790","article-title":"15, 16-Dihydrotanshinone I protects against ischemic stroke by inhibiting ferroptosis via the activation of nuclear factor erythroid 2-related factor 2","volume":"114","author":"Wu","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.ejphar.2024.176553_bib43","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s10571-022-01196-6","article-title":"Role of ferroptosis in stroke","volume":"43","author":"Xu","year":"2023","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.ejphar.2024.176553_bib44","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1152\/physrev.00023.2017","article-title":"The KEAP1-NRF2 system: a thiol-based sensor-effector apparatus for maintaining redox homeostasis","volume":"98","author":"Yamamoto","year":"2018","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ejphar.2024.176553_bib45","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1161\/STROKEAHA.118.021590","article-title":"Mitophagy reduces oxidative stress via Keap1 (Kelch-Like epichlorohydrin-associated protein 1)\/nrf2 (nuclear factor-E2-related factor 2)\/PHB2 (prohibitin 2) pathway after subarachnoid hemorrhage in rats","volume":"50","author":"Zhang","year":"2019","journal-title":"Stroke"},{"key":"10.1016\/j.ejphar.2024.176553_bib46","doi-asserted-by":"crossref","first-page":"4352","DOI":"10.1016\/j.molcel.2023.10.042","article-title":"SMURF2 predisposes cancer cell toward ferroptosis in GPX4-independent manners by promoting GSTP1 degradation","volume":"83","author":"Zhang","year":"2023","journal-title":"Mol Cell"},{"key":"10.1016\/j.ejphar.2024.176553_bib47","doi-asserted-by":"crossref","first-page":"5650","DOI":"10.7150\/thno.55482","article-title":"Endogenous glutamate determines ferroptosis sensitivity via ADCY10-dependent YAP suppression in lung adenocarcinoma","volume":"11","author":"Zhang","year":"2021","journal-title":"Theranostics"}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299924002413?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299924002413?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T20:54:43Z","timestamp":1717188883000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299924002413"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":47,"alternative-id":["S0014299924002413"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2024.176553","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"N6022 attenuates cerebral ischemia\/reperfusion injury-induced microglia ferroptosis by promoting Nrf2 nuclear translocation and inhibiting the GSNOR\/GSTP1 axis","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2024.176553","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"176553"}}