{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T17:19:51Z","timestamp":1788542391074,"version":"build-2803163510"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100012542","name":"Sichuan Province Science and Technology Support Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019649","name":"Chengdu Medical College Sichuan Provincial Key Laboratory of Development and Regeneration","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019649","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.ejphar.2024.176562","type":"journal-article","created":{"date-parts":[[2024,4,6]],"date-time":"2024-04-06T21:14:45Z","timestamp":1712438085000},"page":"176562","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Toosendanin inhibits T-cell proliferation through the P38 MAPK signalling pathway"],"prefix":"10.1016","volume":"973","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1755-2994","authenticated-orcid":false,"given":"Ting","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingyan","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Jing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunfen","family":"Mo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijie","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuxia","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yantang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ketian","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2024.176562_bib1","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/cyto.a.23964","article-title":"An evaluation of T-cell functionality after flow cytometry sorting revealed p38 MAPK activation","volume":"97","author":"Andr\u00e4","year":"2020","journal-title":"Cytometry Part A : the journal of the International Society for Analytical Cytology"},{"key":"10.1016\/j.ejphar.2024.176562_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2021.152804","article-title":"Redox-sensitive Nrf2 and MAPK signaling pathways contribute to trichloroethene-mediated autoimmune disease progression","volume":"457","author":"Banerjee","year":"2021","journal-title":"Toxicology"},{"key":"10.1016\/j.ejphar.2024.176562_bib3","doi-asserted-by":"crossref","first-page":"4070","DOI":"10.4049\/jimmunol.168.8.4070","article-title":"Anti-inflammatory effects of a p38 mitogen-activated protein kinase inhibitor during human endotoxemia","volume":"168","author":"Branger","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.ejphar.2024.176562_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.jns.2019.116602","article-title":"Ingested ACTH blocks Th17 production by inhibiting GALT IL-6","volume":"409","author":"Dittel","year":"2020","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.ejphar.2024.176562_bib5","doi-asserted-by":"crossref","first-page":"2684","DOI":"10.7150\/ijbs.71041","article-title":"Toosendanin, a novel potent vacuolar-type H(+)-translocating ATPase inhibitor, sensitizes cancer cells to chemotherapy by blocking protective autophagy","volume":"18","author":"Dong","year":"2022","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.ejphar.2024.176562_bib6","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1186\/s13287-018-1073-0","article-title":"Autophagy induces G0\/G1 arrest and apoptosis in menstrual blood-derived endometrial stem cells via GSK3-\u03b2\/\u03b2-catenin pathway","volume":"9","author":"Du","year":"2018","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.ejphar.2024.176562_bib7","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1007\/s10571-011-9716-z","article-title":"The anti-botulism triterpenoid toosendanin elicits calcium increase and exocytosis in rat sensory neurons","volume":"31","author":"Fang","year":"2011","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.ejphar.2024.176562_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jaut.2018.11.001","article-title":"Systemic lupus erythematosus: diagnosis and clinical management","volume":"96","author":"Fava","year":"2019","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.ejphar.2024.176562_bib9","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1204231","article-title":"T memory stem cell characteristics in autoimmune diseases and their promising therapeutic values","volume":"14","author":"Fazeli","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejphar.2024.176562_bib10","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.taap.2017.08.006","article-title":"Staphylococcal enterotoxin C2 mutant drives T lymphocyte activation through PI3K\/mTOR and NF-\u0138B signaling pathways","volume":"333","author":"Fu","year":"2017","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.ejphar.2024.176562_bib11","article-title":"Therapeutic potential of toosendanin: novel applications of an old ascaris repellent as a drug candidate","volume":"167","author":"Hu","year":"2023","journal-title":"Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie"},{"key":"10.1016\/j.ejphar.2024.176562_bib12","article-title":"Network pharmacology to identify the pharmacological mechanisms of a traditional Chinese medicine derived from trachelospermum jasminoides in patients with rheumatoid arthritis","volume":"26","author":"Jiang","year":"2020","journal-title":"Med. Sci. Mon. Int. Med. J. Exp. Clin. Res. : international medical journal of experimental and clinical research"},{"key":"10.1016\/j.ejphar.2024.176562_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2022.103185","article-title":"T cell abnormalities in systemic sclerosis","volume":"21","author":"Jin","year":"2022","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.ejphar.2024.176562_bib14","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/bs.ircmb.2018.05.008","article-title":"T lymphocytes and autoimmunity","volume":"341","author":"Khan","year":"2018","journal-title":"International review of cell and molecular biology"},{"key":"10.1016\/j.ejphar.2024.176562_bib15","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1002\/eji.201040391","article-title":"IL-6: regulator of Treg\/Th17 balance","volume":"40","author":"Kimura","year":"2010","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.ejphar.2024.176562_bib16","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1111\/bph.14926","article-title":"PO-322 exerts potent immunosuppressive effects in vitro and in vivo by selectively inhibiting SGK1 activity","volume":"177","author":"Lai","year":"2020","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2024.176562_bib17","doi-asserted-by":"crossref","first-page":"8241","DOI":"10.1096\/fj.201900146R","article-title":"Artesunate prevents type 1 diabetes in NOD mice mainly by inducing protective IL-4-producing T cells and regulatory T cells","volume":"33","author":"Li","year":"2019","journal-title":"Faseb. J. : official publication of the Federation of American Societies for Experimental Biology"},{"key":"10.1016\/j.ejphar.2024.176562_bib18","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.toxlet.2023.02.006","article-title":"Toosendanin induced hepatotoxicity via triggering PERK-eIF2\u03b1-ATF4 mediated ferroptosis","volume":"377","author":"Liang","year":"2023","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.ejphar.2024.176562_bib19","first-page":"237","article-title":"Early diagnosis and treatment of rheumatoid arthritis","volume":"45","author":"Littlejohn","year":"2018","journal-title":"PrimaryCare"},{"key":"10.1016\/j.ejphar.2024.176562_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhepr.2023.100856","article-title":"Circadian control of ConA-induced acute liver injury and inflammatory response via Bmal1 regulation of Junb","volume":"5","author":"Liu","year":"2023","journal-title":"JHEP reports : innovation in hepatology"},{"key":"10.1016\/j.ejphar.2024.176562_bib21","doi-asserted-by":"crossref","first-page":"758","DOI":"10.3389\/fimmu.2018.00758","article-title":"NOD-like receptor protein 3 inflammasome-dependent IL-1\u03b2 accelerated ConA-induced hepatitis","volume":"9","author":"Luan","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejphar.2024.176562_bib22","doi-asserted-by":"crossref","first-page":"9193","DOI":"10.1002\/jcb.28195","article-title":"A benzoxazole derivative PO-296 inhibits T lymphocyte proliferation by the JAK3\/STAT5 signal pathway","volume":"120","author":"Luo","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.ejphar.2024.176562_bib23","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1238171","article-title":"The role of ion channels in T cell function and disease","volume":"14","author":"Manolios","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejphar.2024.176562_bib24","doi-asserted-by":"crossref","first-page":"821","DOI":"10.17219\/acem\/35771","article-title":"The effects of anti-CD3\/CD28 coated beads and IL-2 on expanded T cell for immunotherapy","volume":"25","author":"Martkamchan","year":"2016","journal-title":"Adv. Clin. Exp. Med. : official organ Wroclaw Medical University"},{"key":"10.1016\/j.ejphar.2024.176562_bib25","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1229516","article-title":"Cytokine profile characterization of na\u00efve patients with psoriasis and psoriatic arthritis: implications for a pathogenic disease continuum","volume":"14","author":"Ruscitti","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejphar.2024.176562_bib26","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-72148-7","article-title":"Elevated IL-6R on CD4(+) T cells promotes IL-6 driven Th17 cell responses in patients with T1R leprosy reactions","volume":"10","author":"Saini","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejphar.2024.176562_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2019.102376","article-title":"Treg cells in health and autoimmune diseases: new insights from single cell analysis","volume":"110","author":"Scheinecker","year":"2020","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.ejphar.2024.176562_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.109745","article-title":"Toosendanin inhibits osteoclast formation and alleviate postmenopausal osteoporosis by regulating the p38 signaling pathway","volume":"116","author":"Tan","year":"2023","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.ejphar.2024.176562_bib29","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/cmi.2015.89","article-title":"The regulation of the Treg\/Th17 balance by mesenchymal stem cells in human systemic lupus erythematosus","volume":"14","author":"Wang","year":"2017","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.ejphar.2024.176562_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154571","article-title":"Toosendanin reduces cisplatin resistance in ovarian cancer through modulating the miR-195\/ERK\/\u03b2-catenin pathway","volume":"109","author":"Wang","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.ejphar.2024.176562_bib31","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.575572","article-title":"Regulatory T cells in autoimmune hepatitis: unveiling their roles in mouse models and patients","volume":"11","author":"Wang","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejphar.2024.176562_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2020.114014","article-title":"Toosendanin-induced apoptosis in colorectal cancer cells is associated with the \u03ba-opioid receptor\/\u03b2-catenin signaling axis","volume":"177","author":"Wang","year":"2020","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejphar.2024.176562_bib33","article-title":"Traditional Chinese medicine compound, Bu Sheng Hui Yang Fang, promotes the proliferation of lymphocytes in the immunosuppressed mice potentially by upregulating IL-4 signaling","volume":"134","author":"Wang","year":"2021","journal-title":"Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie"},{"key":"10.1016\/j.ejphar.2024.176562_bib34","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1080\/08923973.2022.2055565","article-title":"LY294002 attenuates inflammatory response in endotoxin-induced uveitis by downregulating JAK3 and inactivating the PI3K\/Akt signaling","volume":"44","author":"Wu","year":"2022","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"10.1016\/j.ejphar.2024.176562_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2020.102743","article-title":"An updated advance of autoantibodies in autoimmune diseases","volume":"20","author":"Xiao","year":"2021","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.ejphar.2024.176562_bib36","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abq3558","article-title":"Small-molecule toosendanin reverses macrophage-mediated immunosuppression to overcome glioblastoma resistance to immunotherapy","volume":"15","author":"Yang","year":"2023","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.ejphar.2024.176562_bib37","doi-asserted-by":"crossref","first-page":"4567","DOI":"10.1002\/ptr.7174","article-title":"Synergistic effect of toosendanin and regorafenib against cell proliferation and migration by regulating WWOX signaling pathway in hepatocellular carcinoma","volume":"35","author":"Yang","year":"2021","journal-title":"Phytother Res. : PT"},{"key":"10.1016\/j.ejphar.2024.176562_bib38","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1111\/vco.12889","article-title":"Toosendanin-induced apoptosis of CMT-U27 is mediated through the mitochondrial apoptotic pathway","volume":"21","author":"Yang","year":"2023","journal-title":"Vet. Comp. Oncol."},{"key":"10.1016\/j.ejphar.2024.176562_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2021.109739","article-title":"Toosendanin and isotoosendanin suppress triple-negative breast cancer growth via inducing necrosis, apoptosis and autophagy","volume":"351","author":"Zhang","year":"2022","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.ejphar.2024.176562_bib40","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1080\/10286020.2018.1451516","article-title":"Anti-cancer effect of toosendanin and its underlying mechanisms","volume":"21","author":"Zhang","year":"2019","journal-title":"J. Asian Nat. Prod. Res."},{"key":"10.1016\/j.ejphar.2024.176562_bib41","doi-asserted-by":"crossref","first-page":"69","DOI":"10.14503\/THIJ-18-6746","article-title":"Progress in immunosuppressive agents for solid-organ transplantation","volume":"46","author":"Zhang","year":"2019","journal-title":"Texas Heart Institute journal"},{"key":"10.1016\/j.ejphar.2024.176562_bib42","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/978-94-017-9487-9_2","article-title":"TH1\/TH2 cell differentiation and molecular signals","volume":"841","author":"Zhang","year":"2014","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.ejphar.2024.176562_bib43","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.bbrc.2018.09.093","article-title":"Toosendanin induces caspase-dependent apoptosis through the p38 MAPK pathway in human gastric cancer cells","volume":"505","author":"Zhou","year":"2018","journal-title":"Biochemical and biophysical research communications"},{"key":"10.1016\/j.ejphar.2024.176562_bib44","doi-asserted-by":"crossref","first-page":"4","DOI":"10.55563\/clinexprheumatol\/nolysy","article-title":"One year in review 2022: systemic lupus erythematosus","volume":"40","author":"Zucchi","year":"2022","journal-title":"Clin. Exp. Rheumatol."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299924002504?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299924002504?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,4]],"date-time":"2024-05-04T11:01:41Z","timestamp":1714820501000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299924002504"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":44,"alternative-id":["S0014299924002504"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2024.176562","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Toosendanin inhibits T-cell proliferation through the P38 MAPK signalling pathway","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2024.176562","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"176562"}}