{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T19:04:04Z","timestamp":1789758244470,"version":"4.0.1"},"reference-count":65,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100011790","name":"Xiangya Hospital Central South University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011790","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82100788"],"award-info":[{"award-number":["82100788"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81974090"],"award-info":[{"award-number":["81974090"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82230023"],"award-info":[{"award-number":["82230023"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["BX2021382"],"award-info":[{"award-number":["BX2021382"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2021M693571"],"award-info":[{"award-number":["2021M693571"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["kq2209005"],"award-info":[{"award-number":["kq2209005"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.ejphar.2024.176703","type":"journal-article","created":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T20:36:54Z","timestamp":1717447014000},"page":"176703","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["The PP2A inhibitor LB-100 mitigates lupus nephritis by suppressing tertiary lymphoid structure formation"],"prefix":"10.1016","volume":"977","author":[{"given":"Hongyu","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhilan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifei","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Cong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8608-2219","authenticated-orcid":false,"given":"Weiru","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2024.176703_bib1","doi-asserted-by":"crossref","DOI":"10.1002\/cpbi.27","article-title":"Searching online mendelian inheritance in man (OMIM): a knowledgebase of human genes and genetic phenotypes","volume":"58","author":"Amberger","year":"2017","journal-title":"Curr Protoc Bioinformatics"},{"key":"10.1016\/j.ejphar.2024.176703_bib2","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41572-019-0141-9","article-title":"Lupus nephritis","volume":"6","author":"Anders","year":"2020","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.ejphar.2024.176703_bib3","article-title":"NCBI GEO: archive for functional genomics data sets\u2014update","volume":"D991-D995","author":"Barrett","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ejphar.2024.176703_bib4","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/s41586-022-04642-z","article-title":"TLR7 gain-of-function genetic variation causes human lupus","volume":"605","author":"Brown","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2024.176703_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13123087","article-title":"Review of PP2A tumor Biology and antitumor effects of PP2A inhibitor LB100 in the nervous system","volume":"13","author":"Bryant","year":"2021","journal-title":"Cancers"},{"key":"10.1016\/j.ejphar.2024.176703_bib6","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/s41586-019-1914-8","article-title":"Tertiary lymphoid structures improve immunotherapy and survival in melanoma","volume":"577","author":"Cabrita","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2024.176703_bib7","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.4049\/jimmunol.1001983","article-title":"In situ B cell-mediated immune responses and tubulointerstitial inflammation in human lupus nephritis","volume":"186","author":"Chang","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.ejphar.2024.176703_bib8","doi-asserted-by":"crossref","first-page":"3277","DOI":"10.1158\/1078-0432.CCR-16-2299","article-title":"Safety, tolerability, and preliminary activity of LB-100, an inhibitor of protein phosphatase 2A, in patients with relapsed solid tumors: an open-label, dose escalation, first-in-human, phase I trial","volume":"23","author":"Chung","year":"2017","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.ejphar.2024.176703_bib9","doi-asserted-by":"crossref","first-page":"3567","DOI":"10.4049\/jimmunol.1200143","article-title":"Cutting edge: protein phosphatase 2A confers susceptibility to autoimmune disease through an IL-17-dependent mechanism","volume":"188","author":"Crispin","year":"2012","journal-title":"J. Immunol."},{"key":"10.1016\/j.ejphar.2024.176703_bib10","doi-asserted-by":"crossref","first-page":"7861","DOI":"10.1038\/s41598-018-26265-z","article-title":"Mesenchymal stem cells and T cells in the formation of tertiary lymphoid structures in lupus nephritis","volume":"8","author":"Dorraji","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejphar.2024.176703_bib11","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.1016\/j.ajpath.2020.07.015","article-title":"Kidney tertiary lymphoid structures in lupus nephritis develop into large interconnected networks and resemble lymph nodes in gene signature","volume":"190","author":"Dorraji","year":"2020","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.ejphar.2024.176703_bib12","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1136\/annrheumdis-2020-216924","article-title":"2019 update of the joint European league against rheumatism and European renal association\u2013European dialysis and transplant association (EULAR\/ERA\u2013EDTA) recommendations for the management of lupus nephritis","volume":"79","author":"Fanouriakis","year":"2020","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.ejphar.2024.176703_bib13","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1136\/annrheumdis-2020-218272","article-title":"Update on the diagnosis and management of systemic lupus erythematosus","volume":"80","author":"Fanouriakis","year":"2021","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.ejphar.2024.176703_bib14","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/nrc3245","article-title":"The immune contexture in human tumours: impact on clinical outcome","volume":"12","author":"Fridman","year":"2012","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.ejphar.2024.176703_bib15","doi-asserted-by":"crossref","first-page":"W726","DOI":"10.1093\/nar\/gkac297","article-title":"SuperPred 3.0: drug classification and target prediction\u2014a machine learning approach","volume":"50","author":"Gallo","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ejphar.2024.176703_bib16","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1126\/science.1129139","article-title":"Type, density, and location of immune cells within human colorectal tumors predict clinical outcome","volume":"313","author":"Galon","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2024.176703_bib17","doi-asserted-by":"crossref","first-page":"D945","DOI":"10.1093\/nar\/gkw1074","article-title":"The ChEMBL database in 2017","volume":"45","author":"Gaulton","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ejphar.2024.176703_bib18","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1093\/rheumatology\/keaa491","article-title":"Assessing outcomes in a lupus nephritis cohort over a 40-year period","volume":"60","author":"Gisca","year":"2021","journal-title":"Rheumatology"},{"key":"10.1016\/j.ejphar.2024.176703_bib19","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.canlet.2017.11.035","article-title":"LB-100, a novel Protein Phosphatase 2A (PP2A) inhibitor, sensitizes malignant meningioma cells to the therapeutic effects of radiation","volume":"415","author":"Ho","year":"2018","journal-title":"Cancer Lett."},{"key":"10.1016\/j.ejphar.2024.176703_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2021.102980","article-title":"Interplay of immune and kidney resident cells in the formation of tertiary lymphoid structures in lupus nephritis","volume":"20","author":"Jamaly","year":"2021","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.ejphar.2024.176703_bib21","doi-asserted-by":"crossref","first-page":"20139","DOI":"10.1016\/S0021-9258(17)32138-5","article-title":"Comparison of heterotrimeric protein phosphatase 2A containing different B subunits","volume":"269","author":"Kamibayashi","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2024.176703_bib22","doi-asserted-by":"crossref","first-page":"2602","DOI":"10.4049\/jimmunol.1600281","article-title":"BAFF induces tertiary lymphoid structures and positions T cells within the glomeruli during lupus nephritis","volume":"198","author":"Kang","year":"2017","journal-title":"J. Immunol."},{"key":"10.1016\/j.ejphar.2024.176703_bib23","doi-asserted-by":"crossref","first-page":"3193","DOI":"10.1172\/JCI24895","article-title":"Protein phosphatase 2A is a negative regulator of IL-2 production in patients with systemic lupus erythematosus","volume":"115","author":"Katsiari","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ejphar.2024.176703_bib24","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1161\/CIRCRESAHA.121.319519","article-title":"Renal AT2 receptors mediate natriuresis via protein phosphatase PP2A","volume":"130","author":"Kemp","year":"2022","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2024.176703_bib25","doi-asserted-by":"crossref","first-page":"D1388","DOI":"10.1093\/nar\/gkaa971","article-title":"PubChem in 2021: new data content and improved web interfaces","volume":"49","author":"Kim","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ejphar.2024.176703_bib26","doi-asserted-by":"crossref","first-page":"ITC81","DOI":"10.7326\/AITC202006020","article-title":"Systemic lupus erythematosus","volume":"172","author":"Kiriakidou","year":"2020","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.ejphar.2024.176703_bib27","doi-asserted-by":"crossref","DOI":"10.1001\/jamainternmed.2015.3528","article-title":"Familial aggregation of systemic lupus erythematosus and coaggregation of autoimmune diseases in affected families","volume":"175","author":"Kuo","year":"2015","journal-title":"JAMA Intern. Med."},{"key":"10.1016\/j.ejphar.2024.176703_bib64","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1681\/ASN.2013010026","article-title":"The pathogenesis of lupus nephritis","volume":"24","author":"Lech","year":"2013","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.ejphar.2024.176703_bib28","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.125503","article-title":"Resident macrophages reprogram toward a developmental state after acute kidney injury","volume":"4","author":"Lever","year":"2019","journal-title":"JCI Insight"},{"key":"10.1016\/j.ejphar.2024.176703_bib29","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1097\/BOR.0000000000000412","article-title":"An update on lupus animal models","volume":"29","author":"Li","year":"2017","journal-title":"Curr. Opin. Rheumatol."},{"key":"10.1016\/j.ejphar.2024.176703_bib30","doi-asserted-by":"crossref","first-page":"2728","DOI":"10.1038\/s41418-021-00780-5","article-title":"PP2Acalpha promotes macrophage accumulation and activation to exacerbate tubular cell death and kidney fibrosis through activating Rap1 and TNFalpha production","volume":"28","author":"Liang","year":"2021","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.ejphar.2024.176703_bib63","article-title":"Autoantibodies in systemic lupus erythematosus: From immunopathology to therapeutic target","volume":"102861","author":"Lou","year":"2022","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.ejphar.2024.176703_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2021.110187","article-title":"PP2A Catalytic Subunit alpha promotes fibroblast activation and kidney fibrosis via ERK pathway","volume":"90","author":"Lu","year":"2022","journal-title":"Cell. Signal."},{"key":"10.1016\/j.ejphar.2024.176703_bib32","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1189\/jlb.0413240","article-title":"The role of viruses in autoreactive B cell activation within tertiary lymphoid structures in autoimmune diseases","volume":"94","author":"Lucchesi","year":"2013","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.ejphar.2024.176703_bib33","doi-asserted-by":"crossref","first-page":"117","DOI":"10.7150\/thno.48624","article-title":"Tertiary lymphoid organs are associated with the progression of kidney damage and regulated by interleukin-17A","volume":"11","author":"Luo","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.ejphar.2024.176703_bib34","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.kint.2021.10.028","article-title":"Dephosphorylation of AMP-activated protein kinase exacerbates ischemia\/reperfusion-induced acute kidney injury via mitochondrial dysfunction","volume":"101","author":"Ma","year":"2022","journal-title":"Kidney Int."},{"key":"10.1016\/j.ejphar.2024.176703_bib35","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.autrev.2017.01.007","article-title":"Gender balance in patients with systemic lupus erythematosus","volume":"16","author":"Margery-Muir","year":"2017","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.ejphar.2024.176703_bib36","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.130655","article-title":"Serine\/threonine phosphatase PP2A is essential for optimal B cell function","volume":"5","author":"Meidan","year":"2020","journal-title":"JCI Insight"},{"key":"10.1016\/j.ejphar.2024.176703_bib37","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1681\/ASN.2010101073","article-title":"The inflammatory cytokines TWEAK and TNFalpha reduce renal klotho expression through NFkappaB","volume":"22","author":"Moreno","year":"2011","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.ejphar.2024.176703_bib38","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1093\/rheumatology\/ket462","article-title":"Rituximab vs mycophenolate and vs cyclophosphamide pulses for induction therapy of active lupus nephritis: a clinical observational study","volume":"53","author":"Moroni","year":"2014","journal-title":"Rheumatology"},{"key":"10.1016\/j.ejphar.2024.176703_bib39","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-03523-1","article-title":"PP2A phosphatase inhibition is anti-fibrotic through Ser77 phosphorylation-mediated ARNT\/ARNT homodimer formation","volume":"11","author":"Nyamsuren","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejphar.2024.176703_bib61","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.138215","article-title":"PPP2R2D suppresses IL-2 production and Treg function","volume":"5","author":"Pan","year":"2020","journal-title":"JCI Insight"},{"key":"10.1016\/j.ejphar.2024.176703_bib40","doi-asserted-by":"crossref","first-page":"609","DOI":"10.2337\/db12-0187","article-title":"Deregulation of protein phosphatase 2A and hyperphosphorylation of tau protein following onset of diabetes in NOD mice","volume":"62","author":"Papon","year":"2013","journal-title":"Diabetes"},{"key":"10.1016\/j.ejphar.2024.176703_bib41","doi-asserted-by":"crossref","first-page":"D833","DOI":"10.1093\/nar\/gkw943","article-title":"DisGeNET: a comprehensive platform integrating information on human disease-associated genes and variants","volume":"45","author":"Pi\u00f1ero","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ejphar.2024.176703_bib42","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/nri3700","article-title":"Ectopic lymphoid-like structures in infection, cancer and autoimmunity","volume":"14","author":"Pitzalis","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.ejphar.2024.176703_bib65","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.160251","article-title":"Glucocorticoids target the CXCL9\/CXCL10-CXCR3 axis and confer protection against immune-mediated kidney injury","volume":"8","author":"Riedel","year":"2023","journal-title":"JCI Insight"},{"key":"10.1016\/j.ejphar.2024.176703_bib43","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1182\/blood-2017-11-814681","article-title":"Antiphospholipid antibodies induce thrombosis by PP2A activation via apoER2-Dab2-SHC1 complex formation in endothelium","volume":"131","author":"Sacharidou","year":"2018","journal-title":"Blood"},{"key":"10.1016\/j.ejphar.2024.176703_bib44","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/s41568-019-0144-6","article-title":"Tertiary lymphoid structures in the era of cancer immunotherapy","volume":"19","author":"Saut\u00e8s-Fridman","year":"2019","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.ejphar.2024.176703_bib45","doi-asserted-by":"crossref","DOI":"10.1126\/science.abf9419","article-title":"Tertiary lymphoid structures in cancer","volume":"375","author":"Schumacher","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2024.176703_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115876","article-title":"Mechanism of Sijunzi Decoction in the treatment of colorectal cancer based on network pharmacology and experimental validation","volume":"302","author":"Shang","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.ejphar.2024.176703_bib62","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0898-6568(00)00123-6","article-title":"Protein phosphatase 2A: the Trojan Horse of cellular signaling","volume":"13","author":"Sontag","year":"2001","journal-title":"Cell. Signal."},{"key":"10.1016\/j.ejphar.2024.176703_bib47","doi-asserted-by":"crossref","DOI":"10.1002\/cpbi.5","article-title":"The GeneCards suite: from gene data mining to disease genome sequence analyses","volume":"54","author":"Stelzer","year":"2016","journal-title":"Curr Protoc Bioinformatics"},{"key":"10.1016\/j.ejphar.2024.176703_bib48","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1002\/art.39594","article-title":"Risk of end-stage renal disease in patients with lupus nephritis, 1971-2015: a systematic review and bayesian meta-analysis","volume":"68","author":"Tektonidou","year":"2016","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.ejphar.2024.176703_bib49","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s00395-017-0621-6","article-title":"Insufficient activation of Akt upon reperfusion because of its novel modification by reduced PP2A-B55alpha contributes to enlargement of infarct size by chronic kidney disease","volume":"112","author":"Tobisawa","year":"2017","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.ejphar.2024.176703_bib50","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.ctrv.2017.11.007","article-title":"CXCL9, CXCL10, CXCL11\/CXCR3 axis for immune activation \u2013 a target for novel cancer therapy","volume":"63","author":"Tokunaga","year":"2018","journal-title":"Cancer Treat Rev."},{"key":"10.1016\/j.ejphar.2024.176703_bib51","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1002\/art.41685","article-title":"Camptothecin and topotecan, inhibitors of transcription factor fli-1 and topoisomerase, markedly ameliorate lupus nephritis in (NZB x NZW)F1 mice and reduce the production of inflammatory mediators in human renal cells","volume":"73","author":"Wang","year":"2021","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.ejphar.2024.176703_bib52","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1161\/CIRCRESAHA.119.316298","article-title":"Erythrocyte metabolic reprogramming by sphingosine 1-phosphate in chronic kidney disease and therapies","volume":"127","author":"Xie","year":"2020","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2024.176703_bib53","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1073\/pnas.1807484116","article-title":"Phosphatase PP2A is essential for TH17 differentiation","volume":"116","author":"Xu","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejphar.2024.176703_bib54","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1681\/ASN.2021111465","article-title":"A novel pathological mechanism of tertiary lymphoid structure formation in the renal pelvis","volume":"33","author":"Yamamoto","year":"2022","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.ejphar.2024.176703_bib55","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1002\/art.38298","article-title":"Epicutaneous application of toll-like receptor 7 agonists leads to systemic autoimmunity in wild-type mice: a new model of systemic Lupus erythematosus","volume":"66","author":"Yokogawa","year":"2014","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.ejphar.2024.176703_bib56","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R Package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"OMICS A J. Integr. Biol."},{"key":"10.1016\/j.ejphar.2024.176703_bib57","doi-asserted-by":"crossref","first-page":"3281","DOI":"10.1681\/ASN.2004110917","article-title":"Effect of human anti-DNA antibodies on proximal renal tubular epithelial cell cytokine expression: implications on tubulointerstitial inflammation in lupus nephritis","volume":"16","author":"Yung","year":"2005","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.ejphar.2024.176703_bib58","doi-asserted-by":"crossref","first-page":"6481","DOI":"10.4049\/jimmunol.173.10.6481","article-title":"Decreased expression of the Ets family transcription factor Fli-1 markedly prolongs survival and significantly reduces renal disease in MRL\/lpr mice","volume":"173","author":"Zhang","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.ejphar.2024.176703_bib59","doi-asserted-by":"crossref","first-page":"12422","DOI":"10.1073\/pnas.1821116116","article-title":"Protein phosphatase 2A has an essential role in promoting thymocyte survival during selection","volume":"116","author":"Zheng","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejphar.2024.176703_bib60","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s12964-019-0402-y","article-title":"Protein phosphatase 2A modulates podocyte maturation and glomerular functional integrity in mice","volume":"17","author":"Zhu","year":"2019","journal-title":"Cell Commun. Signal."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299924003911?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299924003911?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T02:52:35Z","timestamp":1777431155000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299924003911"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":65,"alternative-id":["S0014299924003911"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2024.176703","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The PP2A inhibitor LB-100 mitigates lupus nephritis by suppressing tertiary lymphoid structure formation","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2024.176703","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"176703"}}