{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:43:17Z","timestamp":1792597397846,"version":"4.5.0"},"reference-count":72,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T00:00:00Z","timestamp":1718323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.ejphar.2024.176718","type":"journal-article","created":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T06:39:49Z","timestamp":1717655989000},"page":"176718","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Nimodipine inhibits spreading depolarization, ischemic injury, and neuroinflammation in mouse live brain slice preparations"],"prefix":"10.1016","volume":"977","author":[{"given":"Rita","family":"Frank","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e9ter Archibald","family":"Szarvas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Istv\u00e1n","family":"Pesti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Zsigmond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9076-2177","authenticated-orcid":false,"given":"R\u00f3bert","family":"Berkecz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1kos","family":"Menyh\u00e1rt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferenc","family":"Bari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8478-9664","authenticated-orcid":false,"given":"Eszter","family":"Farkas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2024.176718_bib1","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1161\/01.STR.31.6.1250","article-title":"Effect of intravenous nimodipine on blood pressure and outcome after acute stroke","volume":"31","author":"Ahmed","year":"2000","journal-title":"Stroke"},{"key":"10.1016\/j.ejphar.2024.176718_bib2","doi-asserted-by":"crossref","DOI":"10.1007\/s41664-024-00316-z","article-title":"UHPLC-MS\/MS approach for following nimodipine saturation kinetics in acute rat brain slice","author":"Ali","year":"2024","journal-title":"J. Anal. Test"},{"key":"10.1016\/j.ejphar.2024.176718_bib3","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s12028-021-01431-w","article-title":"The critical role of spreading depolarizations in early brain injury: consensus and contention","volume":"37","author":"Andrew","year":"2022","journal-title":"Neurocritical Care"},{"key":"10.1016\/j.ejphar.2024.176718_bib4","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1152\/physrev.00027.2014","article-title":"Spreading depression, spreading depolarizations, and the cerebral vasculature","volume":"95","author":"Ayata","year":"2015","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ejphar.2024.176718_bib5","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1152\/jn.00090.2012","article-title":"A neuronal population in hypothalamus that dramatically resists acute ischemic injury compared to neocortex","volume":"108","author":"Brisson","year":"2012","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.ejphar.2024.176718_bib6","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.neuron.2013.12.034","article-title":"Reactive gliosis and the multicellular response to CNS damage and disease","volume":"81","author":"Burda","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.ejphar.2024.176718_bib7","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1097\/00004647-199611000-00002","article-title":"Potassium-induced cortical spreading depressions during focal cerebral ischemia in rats: contribution to lesion growth assessed by diffusion-weighted NMR and biochemical imaging","volume":"16","author":"Busch","year":"1996","journal-title":"J. Cerebr. Blood Flow Metabol. : Off. J. Int. Soc. Cerebr. Blood Flow Metabol."},{"key":"10.1016\/j.ejphar.2024.176718_bib8","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s12028-020-00935-1","article-title":"Effect of locally delivered nimodipine microparticles on spreading depolarization in aneurysmal subarachnoid hemorrhage","volume":"34","author":"Carlson","year":"2021","journal-title":"Neurocritical Care"},{"key":"10.1016\/j.ejphar.2024.176718_bib9","doi-asserted-by":"crossref","first-page":"65","DOI":"10.2174\/1570159X17666190927113021","article-title":"Nimodipine reappraised: an old drug with a future","volume":"18","author":"Carlson","year":"2020","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.ejphar.2024.176718_bib10","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1002\/glia.23013","article-title":"L-type voltage-operated calcium channels contribute to astrocyte activation in vitro","volume":"64","author":"Cheli","year":"2016","journal-title":"Glia"},{"key":"10.1016\/j.ejphar.2024.176718_bib11","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s12028-012-9670-8","article-title":"Acute effects of nimodipine on cerebral vasculature and brain metabolism in high grade subarachnoid hemorrhage patients","volume":"16","author":"Choi","year":"2012","journal-title":"Neurocritical Care"},{"key":"10.1016\/j.ejphar.2024.176718_bib12","doi-asserted-by":"crossref","first-page":"C1650","DOI":"10.1152\/ajpcell.1994.266.6.C1650","article-title":"K+ modulation of microglial superoxide production: involvement of voltage-gated Ca2+ channels","volume":"266","author":"Colton","year":"1994","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.ejphar.2024.176718_bib13","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1126\/science.1967852","article-title":"Glutamate induces calcium waves in cultured astrocytes: long-range glial signaling","volume":"247","author":"Cornell-Bell","year":"1990","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2024.176718_bib14","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1186\/s12974-023-02948-x","article-title":"Deletion of voltage-gated calcium channels in astrocytes decreases neuroinflammation and demyelination in a murine model of multiple sclerosis","volume":"20","author":"Denaroso","year":"2023","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.ejphar.2024.176718_bib15","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s11910-005-0052-x","article-title":"Role of microglia in multiple sclerosis","volume":"5","author":"Deng","year":"2005","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"10.1016\/j.ejphar.2024.176718_bib16","doi-asserted-by":"crossref","first-page":"8014","DOI":"10.1523\/JNEUROSCI.0765-08.2008","article-title":"Zn2+ influx is critical for some forms of spreading depression in brain slices","volume":"28","author":"Dietz","year":"2008","journal-title":"J. Neurosci. : Off. J. Soc. Neurosci."},{"key":"10.1016\/j.ejphar.2024.176718_bib17","first-page":"143","article-title":"Nimodipine in subarachnoid hemorrhage","volume":"40","author":"DiPalma","year":"1989","journal-title":"Am. Fam. Physician"},{"key":"10.1016\/j.ejphar.2024.176718_bib18","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/nm.2333","article-title":"The role of spreading depression, spreading depolarization and spreading ischemia in neurological disease","volume":"17","author":"Dreier","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.ejphar.2024.176718_bib19","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1177\/0271678X16654496","article-title":"Recording, analysis, and interpretation of spreading depolarizations in neurointensive care: review and recommendations of the COSBID research group","volume":"37","author":"Dreier","year":"2017","journal-title":"J. Cerebr. Blood Flow Metabol. : Off. J. Int. Soc. Cerebr. Blood Flow Metabol."},{"key":"10.1016\/j.ejphar.2024.176718_bib20","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1097\/00004647-199809000-00007","article-title":"Nitric oxide scavenging by hemoglobin or nitric oxide synthase inhibition by N-nitro-L-arginine induces cortical spreading ischemia when K+ is increased in the subarachnoid space","volume":"18","author":"Dreier","year":"1998","journal-title":"J. Cerebr. Blood Flow Metabol. : Off. J. Int. Soc. Cerebr. Blood Flow Metabol."},{"key":"10.1016\/j.ejphar.2024.176718_bib21","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/j.neuron.2015.04.004","article-title":"The stroke-migraine depolarization continuum","volume":"86","author":"Dreier","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.ejphar.2024.176718_bib22","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1097\/00006123-200212000-00017","article-title":"Ischemia triggered by red blood cell products in the subarachnoid space is inhibited by nimodipine administration or moderate volume expansion\/hemodilution in rats","volume":"51","author":"Dreier","year":"2002","journal-title":"Neurosurgery"},{"key":"10.1016\/j.ejphar.2024.176718_bib23","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.ibneur.2021.01.007","article-title":"Quantitative morphometric and cell-type-specific population analysis of microglia-enriched cultures subcloned to high purity from newborn rat brains","volume":"10","author":"Dulka","year":"2021","journal-title":"IBRO Neurosci Rep"},{"key":"10.1016\/j.ejphar.2024.176718_bib24","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1172\/JCI116573","article-title":"Astrocytes are the primary source of tissue factor in the murine central nervous system. A role for astrocytes in cerebral hemostasis","volume":"92","author":"Eddleston","year":"1993","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ejphar.2024.176718_bib25","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21051663","article-title":"Strategies for neuroprotection in multiple sclerosis and the role of calcium","volume":"21","author":"Enders","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2024.176718_bib26","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.mcn.2014.12.004","article-title":"The L-type voltage-gated calcium channel modulates microglial pro-inflammatory activity","volume":"64","author":"Espinosa-Parrilla","year":"2015","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.ejphar.2024.176718_bib27","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s12868-021-00637-0","article-title":"Comparative analysis of spreading depolarizations in brain slices exposed to osmotic or metabolic stress","volume":"22","author":"Frank","year":"2021","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.ejphar.2024.176718_bib28","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/0959-4388(95)80050-6","article-title":"Calcium regulation of gene expression in neurons: the mode of entry matters","volume":"5","author":"Gallin","year":"1995","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.ejphar.2024.176718_bib29","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1152\/jn.1956.19.2.154","article-title":"Mechanism of spreading cortical depression","volume":"19","author":"Grafstein","year":"1956","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.ejphar.2024.176718_bib30","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.clineuro.2008.05.001","article-title":"Feasibility and safety of intrathecal nimodipine on posthaemorrhagic cerebral vasospasm refractory to medical and endovascular therapy","volume":"110","author":"Hanggi","year":"2008","journal-title":"Clin. Neurol. Neurosurg."},{"key":"10.1016\/j.ejphar.2024.176718_bib31","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1007\/s12028-015-0112-2","article-title":"Newton: nimodipine microparticles to enhance recovery while reducing toxicity after subarachnoid hemorrhage","volume":"23","author":"Hanggi","year":"2015","journal-title":"Neurocritical Care"},{"key":"10.1016\/j.ejphar.2024.176718_bib32","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1001\/jamaneurol.2019.4476","article-title":"Prognostic value of spreading depolarizations in patients with severe traumatic brain injury","volume":"77","author":"Hartings","year":"2020","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.ejphar.2024.176718_bib33","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1177\/0271678X16654495","article-title":"The continuum of spreading depolarizations in acute cortical lesion development: examining Leao's legacy","volume":"37","author":"Hartings","year":"2017","journal-title":"J. Cerebr. Blood Flow Metabol. : Off. J. Int. Soc. Cerebr. Blood Flow Metabol."},{"key":"10.1016\/j.ejphar.2024.176718_bib34","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1093\/cercor\/11.3.249","article-title":"Anoxic depolarization mediates acute damage independent of glutamate in neocortical brain slices","volume":"11","author":"Jarvis","year":"2001","journal-title":"Cerebr. Cortex"},{"key":"10.1016\/j.ejphar.2024.176718_bib35","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s12028-022-01469-4","article-title":"Microglia modulate cortical spreading depolarizations after ischemic stroke: a narrative review","volume":"37","author":"Kearns","year":"2022","journal-title":"Neurocritical Care"},{"key":"10.1016\/j.ejphar.2024.176718_bib36","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2023.1175281","article-title":"Nimodipine augments cerebrovascular reactivity in aging but runs the risk of local perfusion reduction in acute cerebral ischemia","volume":"15","author":"Kecskes","year":"2023","journal-title":"Front. Aging Neurosci."},{"issue":"Pt 1","key":"10.1016\/j.ejphar.2024.176718_bib37","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1113\/jphysiol.1995.sp020566","article-title":"Activation of P2-purinoreceptors triggered Ca2+ release from InsP3-sensitive internal stores in mammalian oligodendrocytes","volume":"483","author":"Kirischuk","year":"1995","journal-title":"J. Physiol."},{"key":"10.1016\/j.ejphar.2024.176718_bib38","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1002\/glia.10162","article-title":"Expression of voltage-gated Ca2+ channel subtypes in cultured astrocytes","volume":"41","author":"Latour","year":"2003","journal-title":"Glia"},{"key":"10.1016\/j.ejphar.2024.176718_bib39","doi-asserted-by":"crossref","DOI":"10.1177\/1759091415605115","article-title":"Osmotic edema rapidly increases neuronal excitability through activation of NMDA receptor-dependent slow inward currents in juvenile and adult Hippocampus","volume":"7","author":"Lauderdale","year":"2015","journal-title":"ASN neuro"},{"key":"10.1016\/j.ejphar.2024.176718_bib40","article-title":"L-type Ca(2+) channels mediate regulation of glutamate release by subthreshold potential changes","volume":"120","author":"Lee","year":"2023","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejphar.2024.176718_bib41","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1161\/STROKEAHA.120.032766","article-title":"Microglial calcium waves during the hyperacute phase of ischemic stroke","volume":"52","author":"Liu","year":"2021","journal-title":"Stroke"},{"key":"10.1016\/j.ejphar.2024.176718_bib42","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3171\/2019.9.JNS191366","article-title":"Nimodipine pharmacokinetics after intraventricular injection of sustained-release nimodipine for subarachnoid hemorrhage","volume":"134","author":"Macdonald","year":"2019","journal-title":"J. Neurosurg."},{"issue":"5","key":"10.1016\/j.ejphar.2024.176718_bib43","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1111\/jnc.15792","article-title":"Nimodipine accelerates the restoration of functional hyperemia during spreading oligemia","volume":"168","author":"Menyh\u00e1rt","year":"2024","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ejphar.2024.176718_bib44","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.nbd.2018.07.026","article-title":"Large-conductance Ca(2+)-activated potassium channels are potently involved in the inverse neurovascular response to spreading depolarization","volume":"119","author":"Menyhart","year":"2018","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.ejphar.2024.176718_bib45","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1177\/0271678X211040056","article-title":"Malignant astrocyte swelling and impaired glutamate clearance drive the expansion of injurious spreading depolarization foci","volume":"42","author":"Menyhart","year":"2022","journal-title":"J. Cerebr. Blood Flow Metabol. : Off. J. Int. Soc. Cerebr. Blood Flow Metabol."},{"key":"10.1016\/j.ejphar.2024.176718_bib46","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1097\/00001756-199306000-00027","article-title":"Correlation between peri-infarct DC shifts and ischaemic neuronal damage in rat","volume":"4","author":"Mies","year":"1993","journal-title":"Neuroreport"},{"key":"10.1016\/j.ejphar.2024.176718_bib47","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1742-2094-10-4","article-title":"A quantitative spatiotemporal analysis of microglia morphology during ischemic stroke and reperfusion","volume":"10","author":"Morrison","year":"2013","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.ejphar.2024.176718_bib48","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1152\/jn.1999.82.4.1818","article-title":"Intrinsic optical signals in rat hippocampal slices during hypoxia-induced spreading depression-like depolarization","volume":"82","author":"Muller","year":"1999","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.ejphar.2024.176718_bib49","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/0006-8993(88)91062-1","article-title":"Spreading depression is not associated with neuronal injury in the normal brain","volume":"449","author":"Nedergaard","year":"1988","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2024.176718_bib50","article-title":"Tissue acidosis associated with ischemic stroke to guide neuroprotective drug delivery","volume":"9","author":"O","year":"2020","journal-title":"Biology"},{"key":"10.1016\/j.ejphar.2024.176718_bib51","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.neuron.2020.11.018","article-title":"Non-canonical glutamate signaling in a genetic model of migraine with aura","volume":"109","author":"Parker","year":"2021","journal-title":"Neuron"},{"key":"10.1016\/j.ejphar.2024.176718_bib52","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1159\/000096326","article-title":"Volume changes in neurons: hyperexcitability and neuronal death","volume":"152","author":"Pasantes-Morales","year":"2006","journal-title":"Contrib. Nephrol."},{"key":"10.1016\/j.ejphar.2024.176718_bib53","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/nrneurol.2010.17","article-title":"Microglia in neurodegenerative disease","volume":"6","author":"Perry","year":"2010","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.ejphar.2024.176718_bib54","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/nrn3770","article-title":"Chaos and commotion in the wake of cortical spreading depression and spreading depolarizations","volume":"15","author":"Pietrobon","year":"2014","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.ejphar.2024.176718_bib55","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1002\/glia.23183","article-title":"TRPV4 channels contribute to calcium transients in astrocytes and neurons during peri-infarct depolarizations in a stroke model","volume":"65","author":"Rakers","year":"2017","journal-title":"Glia"},{"key":"10.1016\/j.ejphar.2024.176718_bib56","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1111\/j.1476-5381.2012.02112.x","article-title":"Nimodipine inhibits IL-1 beta release stimulated by amyloid beta from microglia","volume":"167","author":"Sanz","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2024.176718_bib57","doi-asserted-by":"crossref","first-page":"E3295","DOI":"10.1073\/pnas.1620052114","article-title":"Nimodipine fosters remyelination in a mouse model of multiple sclerosis and induces microglia-specific apoptosis","volume":"114","author":"Schampel","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejphar.2024.176718_bib58","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1111\/j.1749-6632.1988.tb33415.x","article-title":"Pharmacology of nimodipine. A review","volume":"522","author":"Scriabine","year":"1988","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.ejphar.2024.176718_bib59","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.tcb.2016.01.003","article-title":"Probing the complexities of astrocyte calcium signaling","volume":"26","author":"Shigetomi","year":"2016","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.ejphar.2024.176718_bib60","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s12028-019-00776-7","article-title":"Which spreading depolarizations are deleterious to brain tissue?","volume":"32","author":"Shuttleworth","year":"2020","journal-title":"Neurocritical Care"},{"key":"10.1016\/j.ejphar.2024.176718_bib61","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1152\/physrev.2001.81.3.1065","article-title":"Mechanisms of spreading depression and hypoxic spreading depression-like depolarization","volume":"81","author":"Somjen","year":"2001","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ejphar.2024.176718_bib62","doi-asserted-by":"crossref","first-page":"110","DOI":"10.2174\/1874467208666150507105845","article-title":"Pharmacology of L-type calcium channels: novel drugs for old targets?","volume":"8","author":"Striessnig","year":"2015","journal-title":"Curr. Mol. Pharmacol."},{"key":"10.1016\/j.ejphar.2024.176718_bib63","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1161\/STROKEAHA.122.041351","article-title":"Optogenetic spreading depolarizations do not worsen acute ischemic stroke outcome","volume":"54","author":"Sugimoto","year":"2023","journal-title":"Stroke"},{"key":"10.1016\/j.ejphar.2024.176718_bib64","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1111\/bph.14611","article-title":"The impact of dihydropyridine derivatives on the cerebral blood flow response to somatosensory stimulation and spreading depolarization","volume":"176","author":"Szabo","year":"2019","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2024.176718_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2019.107850","article-title":"Chitosan nanoparticles release nimodipine in response to tissue acidosis to attenuate spreading depolarization evoked during forebrain ischemia","volume":"162","author":"Toth","year":"2020","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ejphar.2024.176718_bib66","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22073442","article-title":"Astrocyte Ca(2+) waves and subsequent non-synchronized Ca(2+) oscillations coincide with arteriole diameter changes in response to spreading depolarization","volume":"22","author":"Toth","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2024.176718_bib67","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1111\/j.1471-4159.1959.tb12636.x","article-title":"Compounds in brain extracts causing spreading depression of cerebral cortical activity and contraction of crustacean muscle","volume":"3","author":"Van Harreveld","year":"1959","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ejphar.2024.176718_bib68","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/0304-3940(90)90202-K","article-title":"Cultured glial precursor cells from mouse cortex express two types of calcium currents","volume":"112","author":"Verkhratsky","year":"1990","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ejphar.2024.176718_bib69","first-page":"539","article-title":"Nimodipine","volume":"52","author":"Whitfield","year":"1994","journal-title":"Br. J. Hosp. Med."},{"key":"10.1016\/j.ejphar.2024.176718_bib70","doi-asserted-by":"crossref","first-page":"3204","DOI":"10.1093\/cercor\/bhx192","article-title":"Spreading depression promotes astrocytic calcium oscillations and enhances gliotransmission to hippocampal neurons","volume":"28","author":"Wu","year":"2018","journal-title":"Cerebr. Cortex"},{"key":"10.1016\/j.ejphar.2024.176718_bib71","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1002\/glia.23537","article-title":"Morphological profile determines the frequency of spontaneous calcium events in astrocytic processes","volume":"67","author":"Wu","year":"2019","journal-title":"Glia"},{"key":"10.1016\/j.ejphar.2024.176718_bib72","first-page":"451","article-title":"Nimodipine in the treatment of subarachnoid hemorrhage","volume":"23","author":"Yasuda","year":"1989","journal-title":"Drug Intell. Clin. Pharm."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299924004060?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299924004060?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,29]],"date-time":"2024-06-29T15:03:46Z","timestamp":1719673426000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299924004060"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":72,"alternative-id":["S0014299924004060"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2024.176718","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nimodipine inhibits spreading depolarization, ischemic injury, and neuroinflammation in mouse live brain slice preparations","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2024.176718","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"176718"}}