{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T17:42:53Z","timestamp":1776015773555,"version":"3.50.1"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T00:00:00Z","timestamp":1749600000000},"content-version":"am","delay-in-days":314,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["R01AA027660"],"award-info":[{"award-number":["R01AA027660"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R61 NS124923"],"award-info":[{"award-number":["R61 NS124923"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R14NS135658"],"award-info":[{"award-number":["R14NS135658"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.ejphar.2024.176722","type":"journal-article","created":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T16:25:55Z","timestamp":1717691155000},"page":"176722","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Inhibition of TRPC3 channels suppresses seizure susceptibility in the genetically-epilepsy prone rats"],"prefix":"10.1016","volume":"977","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6528-1534","authenticated-orcid":false,"given":"Gleice K.","family":"Silva-Cardoso","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7299-2369","authenticated-orcid":false,"given":"Vijay K.","family":"Boda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9522-4474","authenticated-orcid":false,"given":"Wei","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7829-7292","authenticated-orcid":false,"given":"Prosper","family":"N'Gouemo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2024.176722_bib1","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1159\/000503831","article-title":"The Epidemiology of epilepsy","volume":"54","author":"Beghi","year":"2020","journal-title":"Neuroepidemiology"},{"key":"10.1016\/j.ejphar.2024.176722_bib43","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/0014-2999(89)90077-0","article-title":"Anticonvulsant profile of the progesterone metabolite 5 alpha-pregnan-3alpha-o1-20-one","volume":"166","author":"Belelli","year":"1989","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2024.176722_bib2","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.1007\/s00018-013-1550-7","article-title":"Neuronal calcium signaling: function and dysfunction","volume":"71","author":"Brini","year":"2014","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.ejphar.2024.176722_bib3","doi-asserted-by":"crossref","first-page":"282","DOI":"10.30802\/AALAS-JAALAS-19-000112","article-title":"Using vaginal impedance measurement to identify proestrus in rats given luteinizing hormone releasing hormone (LHRH) agonist","volume":"59","author":"Chesney","year":"2020","journal-title":"J. Am. Assoc. Lab. Anim. Sci. JAALAS"},{"key":"10.1016\/j.ejphar.2024.176722_bib4","first-page":"18","article-title":"Inhibition of transient potential receptor vanilloid type 1 suppresses seizure susceptibility in genetically epilepsy-prone rats. CNS Neurosci","volume":"24","author":"Cho","year":"2018","journal-title":"Therapy"},{"key":"10.1016\/j.ejphar.2024.176722_bib5","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0920-1211(89)90063-6","article-title":"Neurobiology of seizure predisposition in the genetically epilepsy-prone rat","volume":"3","author":"Dailey","year":"1989","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.ejphar.2024.176722_bib6","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/0306-3623(90)91032-M","article-title":"Anticonvulsant properties of some calcium antagonists on sound-induced seizures in genetically epilepsy prone rats","volume":"21","author":"De Sarro","year":"1990","journal-title":"Gen. Pharmacol."},{"key":"10.1016\/j.ejphar.2024.176722_bib7","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s00210-005-1052-8","article-title":"Functional characterization and physiological relevance of the TRPC3\/6\/7 subfamily of cation channels","volume":"371","author":"Dietrich","year":"2005","journal-title":"Naunyn Schmieledebergs Arch. Pharmacol."},{"key":"10.1016\/j.ejphar.2024.176722_bib8","first-page":"5","article-title":"Classification of reflex epilepsies and reflex seizures","volume":"75","author":"Dreifuss","year":"1998","journal-title":"Adv. Neurol."},{"key":"10.1016\/j.ejphar.2024.176722_bib9","first-page":"311","article-title":"Neuronal networks in the genetically epilepsy-prone rat","volume":"79","author":"Faingold","year":"1999","journal-title":"Adv. Neurol."},{"key":"10.1016\/j.ejphar.2024.176722_bib10","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.914499","article-title":"Review on the role of TRP channels and their potential as drug targets - an insight into the TRP channel drug discovery Methodologies","volume":"13","author":"Fallah","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejphar.2024.176722_bib11","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.36852","article-title":"Structure of the human lipid-gated cation channel TRPC3","volume":"7","author":"Fan","year":"2018","journal-title":"Elife"},{"key":"10.1016\/j.ejphar.2024.176722_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2021.107980","article-title":"Contribution of non-selective membrane channels and receptors in epilepsy","volume":"231","author":"Garc\u00eda-Rodr\u00edguez","year":"2022","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.ejphar.2024.176722_bib13","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.3390\/ijms19041256","article-title":"Ca2+ regulation of TRP ion channels","volume":"19","author":"Hasan","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2024.176722_bib14","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.584388","article-title":"The role of TRP channels and PMCA in brain disorders: intracellular and Ph homeostasis","volume":"9","author":"Hwang","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.ejphar.2024.176722_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2019.107790","article-title":"Pharmacoresistance - epidemiology, mechanisms, and impact on epilepsy treatment","volume":"168","author":"Janmohamed","year":"2020","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ejphar.2024.176722_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2023.108384","article-title":"Pharmacologically targeting transient receptor potential channels for seizures and epilepsy: emerging preclinical evidence of druggability","volume":"244","author":"Jiang","year":"2023","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.ejphar.2024.176722_bib17","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/j.1527-3458.2000.tb00150.x","article-title":"Genetically epilepsy-prone rats (GEPRs) in drug research","volume":"6","author":"Jobe","year":"2000","journal-title":"CNS Drug Rev."},{"key":"10.1016\/j.ejphar.2024.176722_bib19","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2012.00061","article-title":"Physiology and pathology of calcium signaling in the brain","volume":"3","author":"Kawamoto","year":"2012","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejphar.2024.176722_bib20","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s10571-012-9875-6","article-title":"The reverse roles of transient receptor potential canonical channel-3 and -6 in neuronal death following pilocarpine-induced status epilepticus","volume":"33","author":"Kim","year":"2013","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.ejphar.2024.176722_bib22","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0896-6273(00)80838-7","article-title":"Activation of a TRPC3-dependent cation current through the neurotrophin BDNF","volume":"24","author":"Li","year":"1999","journal-title":"Neuron"},{"key":"10.1016\/j.ejphar.2024.176722_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2020.134880","article-title":"Expression of TRPC3 in cortical lesions from patients with focal cortical dysplasia","volume":"724","author":"Liang","year":"2020","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ejphar.2024.176722_bib24","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0920-1211(89)90023-5","article-title":"Audiogenic convulsions in moderate seizure genetically epilepsy-prone rats (GEPR-3s)","volume":"3","author":"Mishra","year":"1989","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.ejphar.2024.176722_bib26","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1111\/epi.17190","article-title":"Inhibition of TRPC3 channels by a novel pyrazole compound confers antiseizure effects","volume":"63","author":"Nagib","year":"2022","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejphar.2024.176722_bib27","series-title":"The National Academies Collection: Reports Funded by National Institutes of Health","article-title":"Guide for the Care and use of laboratory animals","year":"2011"},{"key":"10.1016\/j.ejphar.2024.176722_bib25","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.neuropharm.2008.11.005","article-title":"Calcium channel dysfunction in inferior colliculus neurons of the genetically epilepsy-prone rat","volume":"56","author":"N\u2019Gouemo","year":"2009","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ejphar.2024.176722_bib28","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.bbadis.2007.02.002","article-title":"TRP channels in disease","volume":"1772","author":"Nilus","year":"2007","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ejphar.2024.176722_bib29","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.ceca.2005.06.028","article-title":"TRP channels: an overview","volume":"38","author":"Pedersen","year":"2005","journal-title":"Cell Calcium"},{"key":"10.1016\/j.ejphar.2024.176722_bib30","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/epi.13648","article-title":"TRPC3 channels play a critical role in the theta component of pilocarpine-induced status epilepticus in mice","volume":"58","author":"Phelan","year":"2017","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejphar.2024.176722_bib31","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1146\/annurev.physiol.68.040204.100431","article-title":"An introduction to TRP channels","volume":"68","author":"Ramsey","year":"2006","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.ejphar.2024.176722_bib45","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.eplepsyres.2004.09.003","article-title":"Role of neurosteroids in catamenial epilepsy","volume":"62","author":"Reddy","year":"2004","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.ejphar.2024.176722_bib32","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1046\/j.1528-1157.2002.06702.x","article-title":"Models for epilepsy and epileptogenesis: report from the NIH workshop, Bethesda, Maryland","volume":"43","author":"Stables","year":"2002","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejphar.2024.176722_bib33","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1007\/s10571-018-0586-5","article-title":"Canonical Transient receptor potential channel 3 contributes to febrile seizure inducing neuronal cell death and neuroinflammation","volume":"38","author":"Sun","year":"2018","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.ejphar.2024.176722_bib44","first-page":"27","article-title":"TRPs in the brain","volume":"163","author":"Vennekens","year":"2012","journal-title":"Rev. Physiol. Biochem. Pharmacol."},{"key":"10.1016\/j.ejphar.2024.176722_bib34","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/7289194","article-title":"Roles of TRP channels in neurological diseases","volume":"2020","author":"Wang","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.ejphar.2024.176722_bib35","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.1152\/jn.2001.86.5.2520","article-title":"Effect of lamotrigine on the Ca2+-sensing cation current in cultured hippocampal neurons","volume":"86","author":"Xiong","year":"2001","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.ejphar.2024.176722_bib36","article-title":"Transient receptor potential (TRP) channels in pain, neuropsychiatric disorders, and epilepsy","volume":"24","author":"Yang","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2024.176722_bib37","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.tips.2022.06.007","article-title":"TRPC channels as emerging targets for seizure disorders","volume":"43","author":"Yu","year":"2022","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.ejphar.2024.176722_bib38","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1007\/s12035-014-8871-x","article-title":"Upregulation and diverse roles of TRPC3 and TRPC6 in synaptic reorganization of the mossy fiber pathway in temporal lobe epilepsy","volume":"52","author":"Zeng","year":"2015","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.ejphar.2024.176722_bib39","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1021\/acsmedchemlett.0c00571","article-title":"Discovery of a highly selective and potent TRPC3 inhibitor with high metabolic stability and low toxicity","volume":"12","author":"Zhang","year":"2021","journal-title":"ACS Med. Chem. Lett."},{"key":"10.1016\/j.ejphar.2024.176722_bib40","series-title":"Epilepsy","article-title":"Canonical transient receptor potential channels as novel targets for antiepileptic drugs","author":"Zheng","year":"2022"},{"key":"10.1016\/j.ejphar.2024.176722_bib41","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1152\/jn.00607.2013","article-title":"TRPC3 mediates hyperexcitability and epileptiform activity in immature cortex and experimental cortical dysplasia","volume":"111","author":"Zhou","year":"2014","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.ejphar.2024.176722_bib42","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1523\/JNEUROSCI.3978-07.2008","article-title":"Constitutively acrive TRPC3 channels regulate basal ganglia out put neurons","volume":"28","author":"Zhou","year":"2008","journal-title":"J. Neurosci."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299924004102?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299924004102?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,29]],"date-time":"2024-06-29T19:03:40Z","timestamp":1719687820000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299924004102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":43,"alternative-id":["S0014299924004102"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2024.176722","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibition of TRPC3 channels suppresses seizure susceptibility in the genetically-epilepsy prone rats","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2024.176722","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"176722"}}