{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:35:39Z","timestamp":1786988139529,"version":"build-2736575974"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100010023","name":"Natural Science Research of Jiangsu Higher Education Institutions of China","doi-asserted-by":"publisher","award":["23KJB350002"],"award-info":[{"award-number":["23KJB350002"]}],"id":[{"id":"10.13039\/501100010023","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","award":["2022JSPAPD006"],"award-info":[{"award-number":["2022JSPAPD006"]}],"id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013280","name":"Major Basic Research Project of the Natural Science Foundation of the Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013280","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82304275"],"award-info":[{"award-number":["82304275"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.ejphar.2024.176738","type":"journal-article","created":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T09:05:48Z","timestamp":1718269548000},"page":"176738","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["The synergistic anti-nociceptive effects of nefopam and gabapentinoids in inflammatory, osteoarthritis, and neuropathic pain mouse models"],"prefix":"10.1016","volume":"977","author":[{"given":"Xin-Yi","family":"Xiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Ming","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Yue","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao-Nan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Min","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Xian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heng-Wei","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2024.176738_bib1","doi-asserted-by":"crossref","first-page":"4076","DOI":"10.1523\/JNEUROSCI.0356-09.2009","article-title":"The increased trafficking of the calcium channel subunit alpha2delta-1 to presynaptic terminals in neuropathic pain is inhibited by the alpha2delta ligand pregabalin","volume":"29","author":"Bauer","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2024.176738_bib2","doi-asserted-by":"crossref","first-page":"e98","DOI":"10.1016\/j.bja.2018.10.058","article-title":"Multicentre, prospective, double-blind, randomised controlled clinical trial comparing different non-opioid analgesic combinations with morphine for postoperative analgesia: the OCTOPUS study","volume":"122","author":"Beloeil","year":"2019","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.ejphar.2024.176738_bib4","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1097\/ACO.0b013e328330373a","article-title":"Multimodal analgesia for controlling acute postoperative pain","volume":"22","author":"Buvanendran","year":"2009","journal-title":"Curr. Opin. Anaesthesiol."},{"key":"10.1016\/j.ejphar.2024.176738_bib5","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0304-3959(01)00410-9","article-title":"Attenuation of hyperalgesia in a rat model of neuropathic pain after intrathecal pre- or post-treatment with a neurokinin-1 antagonist","volume":"95","author":"Cahill","year":"2002","journal-title":"Pain"},{"key":"10.1016\/j.ejphar.2024.176738_bib6","first-page":"17","article-title":"Treatment of postherpetic neuralgia: focus on pregabalin","volume":"4","author":"Cappuzzo","year":"2009","journal-title":"Clin. Interv. Aging"},{"key":"10.1016\/j.ejphar.2024.176738_bib7","doi-asserted-by":"crossref","first-page":"3939","DOI":"10.1111\/bph.14794","article-title":"Sigma-1 receptor modulates neuroinflammation associated with mechanical hypersensitivity and opioid tolerance in a mouse model of osteoarthritis pain","volume":"176","author":"Carcol\u00e9","year":"2019","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2024.176738_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2020.135057","article-title":"Antinociceptive effects of nefopam modulating serotonergic, adrenergic, and glutamatergic neurotransmission in the spinal cord","volume":"731","author":"Chae","year":"2020","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ejphar.2024.176738_bib9","doi-asserted-by":"crossref","first-page":"7204","DOI":"10.18632\/oncotarget.23208","article-title":"Inflammatory responses and inflammation-associated diseases in organs","volume":"9","author":"Chen","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.ejphar.2024.176738_bib10","doi-asserted-by":"crossref","first-page":"31111","DOI":"10.1074\/jbc.M114.600320","article-title":"Increased spinal cord Na\u207a-K\u207a-2Cl\u207b cotransporter-1 (NKCC1) activity contributes to impairment of synaptic inhibition in paclitaxel-induced neuropathic pain","volume":"289","author":"Chen","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2024.176738_bib11","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1007\/s00213-023-06329-3","article-title":"Flupirtine and antihistamines exert synergistic anti-nociceptive effects in mice","volume":"240","author":"Chen","year":"2023","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.ejphar.2024.176738_bib12","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1097\/00000542-200506000-00022","article-title":"Median effective dose (ED50) of nefopam and ketoprofen in postoperative patients: a study of interaction using sequential analysis and isobolographic analysis","volume":"102","author":"Delage","year":"2005","journal-title":"Anesthesiology"},{"key":"10.1016\/j.ejphar.2024.176738_bib13","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.intimp.2014.02.004","article-title":"Ellagic acid protects against carrageenan-induced acute inflammation through inhibition of nuclear factor kappa B, inducible cyclooxygenase and proinflammatory cytokines and enhancement of interleukin-10 via an antioxidant mechanism","volume":"19","author":"El-Shitany","year":"2014","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.ejphar.2024.176738_bib14","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/j.1365-2249.2006.03261.x","article-title":"Chronic inflammation: importance of NOD2 and NALP3 in interleukin-1beta generation","volume":"147","author":"Ferrero-Miliani","year":"2007","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.ejphar.2024.176738_bib15","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/0028-3908(93)90064-A","article-title":"Evaluation of nefopam as a monoamine uptake inhibitor in vivo in mice","volume":"32","author":"Fuller","year":"1993","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ejphar.2024.176738_bib16","doi-asserted-by":"crossref","first-page":"29","DOI":"10.2165\/00023210-200115010-00004","article-title":"Glutamate receptors and nociception: implications for the drug treatment of pain","volume":"15","author":"Fundytus","year":"2001","journal-title":"CNS Drugs"},{"key":"10.1016\/j.ejphar.2024.176738_bib17","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.jpain.2012.03.009","article-title":"The economic costs of pain in the United States","volume":"13","author":"Gaskin","year":"2012","journal-title":"J. Pain"},{"key":"10.1016\/j.ejphar.2024.176738_bib18","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1186\/s13063-016-1268-6","article-title":"A clinical trial comparing Lanconone\u00ae with ibuprofen for rapid relief in acute joint pain","volume":"17","author":"Girandola","year":"2016","journal-title":"Trials"},{"key":"10.1016\/j.ejphar.2024.176738_bib19","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/1440-1681.12506","article-title":"Nefopam analgesia and its role in multimodal analgesia: a review of preclinical and clinical studies","volume":"43","author":"Girard","year":"2016","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.ejphar.2024.176738_bib20","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1111\/j.1440-1681.2011.05477.x","article-title":"Systematic evaluation of the nefopam-paracetamol combination in rodent models of antinociception","volume":"38","author":"Girard","year":"2011","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.ejphar.2024.176738_bib21","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.pbb.2004.01.018","article-title":"Nefopam potentiates morphine antinociception in allodynia and hyperalgesia in the rat","volume":"77","author":"Girard","year":"2004","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.ejphar.2024.176738_bib61","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.ejphar.2008.02.012","article-title":"Nefopam and ketoprofen synergy in rodent models of antinociception","volume":"584","author":"Girard","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2024.176738_bib62","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/S0140-6736(14)60802-3","article-title":"Osteoarthritis","volume":"386","author":"Glyn-Jones","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.ejphar.2024.176738_bib22","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1124\/jpet.104.067264","article-title":"Isobolographic analysis for combinations of a full and partial agonist: curved isoboles","volume":"310","author":"Grabovsky","year":"2004","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.ejphar.2024.176738_bib23","doi-asserted-by":"crossref","first-page":"249","DOI":"10.2165\/00003495-198019040-00001","article-title":"Nefopam: a review of its pharmacological properties and therapeutic efficacy","volume":"19","author":"Heel","year":"1980","journal-title":"Drugs"},{"key":"10.1016\/j.ejphar.2024.176738_bib24","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/S0140-6736(20)31693-7","article-title":"Gabapentin for chronic pelvic pain in women (GaPP2): a multicentre, randomised, double-blind, placebo-controlled trial","volume":"396","author":"Horne","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.ejphar.2024.176738_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2023.175870","article-title":"Pregabalin can interact synergistically with Kv7 channel openers to exert antinociception in mice","volume":"954","author":"Huang","year":"2023","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2024.176738_bib26","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1097\/00000542-200211000-00033","article-title":"Gabapentin and pregabalin can interact synergistically with naproxen to produce antihyperalgesia","volume":"97","author":"Hurley","year":"2002","journal-title":"Anesthesiology"},{"key":"10.1016\/j.ejphar.2024.176738_bib27","series-title":"Relieving Pain in America: A Blueprint for Transforming Prevention, Care, Education, and Research","article-title":"Committee on advancing pain research, Care, and education","year":"2011"},{"key":"10.1016\/j.ejphar.2024.176738_bib28","first-page":"CD007442","article-title":"Single dose oral nefopam for acute postoperative pain in adults","author":"Kakkar","year":"2009","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.ejphar.2024.176738_bib29","first-page":"156","article-title":"Pregabalin attenuates carrageenan-induced acute inflammation in rats by inhibiting proinflammatory cytokine levels. Eurasian","volume":"50","author":"Kilic","year":"2018","journal-title":"J. Med."},{"key":"10.1016\/j.ejphar.2024.176738_bib30","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.3390\/ijms23052583","article-title":"Substance P, A Promising therapeutic target in musculoskeletal disorders","volume":"23","author":"Ko","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2024.176738_bib31","doi-asserted-by":"crossref","first-page":"323","DOI":"10.2147\/JPR.S224478","article-title":"The antiallodynic effect of nefopam on vincristine-induced neuropathy in mice","volume":"13","author":"Lee","year":"2020","journal-title":"J. Pain Res."},{"key":"10.1016\/j.ejphar.2024.176738_bib32","doi-asserted-by":"crossref","first-page":"5335","DOI":"10.1007\/s11033-011-0684-7","article-title":"Osteoarthritic tissues modulate functional properties of sensory neurons associated with symptomatic OA pain","volume":"38","author":"Li","year":"2011","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.ejphar.2024.176738_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.ehb.2022.101200","article-title":"Pain trends and pain growth disparities, 2009-2021","volume":"47","author":"Macchia","year":"2022","journal-title":"Econ. Hum. Biol."},{"key":"10.1016\/j.ejphar.2024.176738_bib34","doi-asserted-by":"crossref","first-page":"184","DOI":"10.3390\/cells8020184","article-title":"Astrocytes maintain glutamate homeostasis in the CNS by controlling the balance between glutamate uptake and release","volume":"8","author":"Mahmoud","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.ejphar.2024.176738_bib35","doi-asserted-by":"crossref","DOI":"10.5812\/aapm.95776","article-title":"Predicting factors of pain duration in patients with chronic pain: a large population-based study","volume":"10","author":"Majedi","year":"2020","journal-title":"Anesthesiol. Pain Med."},{"key":"10.1016\/j.ejphar.2024.176738_bib36","doi-asserted-by":"crossref","first-page":"4060","DOI":"10.12998\/wjcc.v11.i17.4060","article-title":"Pregabalin induced balance disorder, asthenia, edema, and constipation in an elderly adult: a case report","volume":"11","author":"Ma","year":"2023","journal-title":"World J. Clin. Cases"},{"key":"10.1016\/j.ejphar.2024.176738_bib37","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.3390\/biomedicines10061413","article-title":"Synergistic anti-nociceptive effects of indomethacin-pregabalin and meloxicam-pregabalin in paclitaxel-induced neuropathic pain","volume":"10","author":"Ma","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.ejphar.2024.176738_bib38","series-title":"Nonopioid Pharmacologic Treatments for Chronic Pain","author":"McDonagh","year":"2020"},{"key":"10.1016\/j.ejphar.2024.176738_bib39","doi-asserted-by":"crossref","first-page":"9","DOI":"10.21037\/atm-22-3323","article-title":"The interplay between the nerves and skeleton: a 30-year bibliometric analysis","volume":"11","author":"Mei","year":"2023","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.ejphar.2024.176738_bib40","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1111\/cns.12486","article-title":"Preclinical assessment of inflammatory pain","volume":"22","author":"Muley","year":"2016","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.ejphar.2024.176738_bib41","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/s41380-018-0345-5","article-title":"Towards precision medicine for pain: diagnostic biomarkers and repurposed drugs","volume":"24","author":"Niculescu","year":"2019","journal-title":"Mol. Psychiatr."},{"key":"10.1016\/j.ejphar.2024.176738_bib42","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1007\/s12272-010-1020-9","article-title":"The combination of naproxen and citral reduces nociception and gastric damage in rats","volume":"33","author":"Ortiz","year":"2010","journal-title":"Arch Pharm. Res. (Seoul)"},{"key":"10.1016\/j.ejphar.2024.176738_bib43","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.ejphar.2017.03.021","article-title":"Low doses of tizanidine synergize the anti-nociceptive and anti-inflammatory effects of ketorolac or naproxen while reducing of side effects","volume":"805","author":"Pati\u00f1o-Camacho","year":"2017","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2024.176738_bib44","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.3390\/ph14111091","article-title":"Opioid analgesia and opioid-induced adverse effects: a review","volume":"14","author":"Paul","year":"2021","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.ejphar.2024.176738_bib45","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0304-3959(01)00363-3","article-title":"A painful peripheral neuropathy in the rat produced by the chemotherapeutic drug, paclitaxel","volume":"94","author":"Polomano","year":"2001","journal-title":"Pain"},{"key":"10.1016\/j.ejphar.2024.176738_bib46","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1001\/jama.280.21.1837","article-title":"Gabapentin for the treatment of postherpetic neuralgia: a randomized controlled trial","volume":"280","author":"Rowbotham","year":"1998","journal-title":"JAMA"},{"key":"10.1016\/j.ejphar.2024.176738_bib47","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3344\/kjp.2012.25.1.7","article-title":"Enhancement of antinociception by co-administrations of nefopam, morphine, and nimesulide in a rat model of neuropathic pain","volume":"25","author":"Saghaei","year":"2012","journal-title":"Korean J. Pain"},{"key":"10.1016\/j.ejphar.2024.176738_bib48","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1186\/s12882-019-1401-3","article-title":"Pregabalin-induced urticarial rash and neutropenia in a renal transplant recipient: a case report","volume":"20","author":"Sahota","year":"2019","journal-title":"BMC Nephrol."},{"key":"10.1016\/j.ejphar.2024.176738_bib49","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1097\/j.pain.0000000000000905","article-title":"Neuropathic pain-induced enhancement of spontaneous and pain-evoked neuronal activity in the periaqueductal gray that is attenuated by gabapentin","volume":"158","author":"Samineni","year":"2017","journal-title":"Pain"},{"key":"10.1016\/j.ejphar.2024.176738_bib50","doi-asserted-by":"crossref","first-page":"213","DOI":"10.11604\/pamj.2022.41.213.33365","article-title":"Nefopam prescribing preferences in French hospitals: results of a survey","volume":"41","author":"Schulz","year":"2022","journal-title":"Pan Afr. Med J"},{"key":"10.1016\/j.ejphar.2024.176738_bib51","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1016\/j.pain.2014.09.020","article-title":"Incidence, prevalence, and predictors of chemotherapy-induced peripheral neuropathy: a systematic review and meta-analysis","volume":"155","author":"Seretny","year":"2014","journal-title":"Pain"},{"key":"10.1016\/j.ejphar.2024.176738_bib52","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.carbpol.2018.06.042","article-title":"Chemical structure and anti-inflammatory effect of polysaccharide extracted from Morinda citrifolia Linn (Noni)","volume":"197","author":"Sousa","year":"2018","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ejphar.2024.176738_bib53","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.pharmthera.2010.04.011","article-title":"The application of drug dose equivalence in the quantitative analysis of receptor occupation and drug combinations","volume":"127","author":"Tallarida","year":"2010","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.ejphar.2024.176738_bib54","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1001\/jama.2018.22039","article-title":"Effect of combination of paracetamol (acetaminophen) and ibuprofen vs either alone on patient-controlled morphine consumption in the first 24 hours after total hip arthroplasty: the PANSAID randomized clinical trial","volume":"321","author":"Thybo","year":"2019","journal-title":"JAMA"},{"key":"10.1016\/j.ejphar.2024.176738_bib55","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jtcme.2022.10.003","article-title":"Cinnamic aldehyde, an anti-inflammatory component in Du-Huo-Ji-Sheng-Tang, ameliorates arthritis in II collagenase and monosodium iodoacetate induced osteoarthritis rat models","volume":"13","author":"Tseng","year":"2022","journal-title":"J. Tradit. Complement Med."},{"key":"10.1016\/j.ejphar.2024.176738_bib56","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.brainres.2004.04.035","article-title":"Nefopam blocks voltage-sensitive sodium channels and modulates glutamatergic transmission in rodents","volume":"1013","author":"Verleye","year":"2004","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2024.176738_bib57","first-page":"CD007938","article-title":"Gabapentin for chronic neuropathic pain in adults","volume":"6","author":"Wiffen","year":"2017","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.ejphar.2024.176738_bib58","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.2174\/092986712799462630","article-title":"The role of glutamate signaling in pain processes and its regulation by GCP II inhibition","volume":"19","author":"Wozniak","year":"2012","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.ejphar.2024.176738_bib59","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.12998\/wjcc.v9.i9.2100","article-title":"Expert consensus of the Chinese Association for the Study of Pain on ion channel drugs for neuropathic pain","volume":"9","author":"Xiao","year":"2021","journal-title":"World J. Clin. Cases"},{"key":"10.1016\/j.ejphar.2024.176738_bib60","article-title":"Osteoarthritis pain model induced by intra-articular injection of mono-iodoacetate in rats","volume":"159","author":"Xu","year":"2020","journal-title":"J. Vis. Exp."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299924004266?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299924004266?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,29]],"date-time":"2024-06-29T15:05:50Z","timestamp":1719673550000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299924004266"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":61,"alternative-id":["S0014299924004266"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2024.176738","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The synergistic anti-nociceptive effects of nefopam and gabapentinoids in inflammatory, osteoarthritis, and neuropathic pain mouse models","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2024.176738","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"176738"}}