{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T05:34:14Z","timestamp":1757309654567,"version":"3.37.3"},"reference-count":89,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002923","name":"CONICET","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005363","name":"University of Buenos Aires","doi-asserted-by":"publisher","award":["UBACyT 20020190100180BA"],"award-info":[{"award-number":["UBACyT 20020190100180BA"]}],"id":[{"id":"10.13039\/501100005363","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.ejphar.2024.176768","type":"journal-article","created":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T22:06:18Z","timestamp":1720735578000},"page":"176768","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Baclofen prevents morphine rewarding effects and associated biochemical alterations in male and female mice"],"prefix":"10.1016","volume":"979","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7564-3516","authenticated-orcid":false,"given":"Valeria T.","family":"Pedr\u00f3n","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eliana M.","family":"Canero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4227-5785","authenticated-orcid":false,"given":"Andr\u00e9s P.","family":"Varani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amira J.","family":"Aon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Maldonado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graciela N.","family":"Balerio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2024.176768_bib1","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0006-8993(89)90103-0","article-title":"Feline subthalamic nucleus neurons contain glutamate-like but not GABA-like or glycine-like immunoreactivity","volume":"491","author":"Albin","year":"1989","journal-title":"Brain Res."},{"issue":"6","key":"10.1016\/j.ejphar.2024.176768_bib2","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1111\/adb.12547","article-title":"Association of contextual cues with morphine reward increases neural and synaptic plasticity in the ventral hippocampus of rats","volume":"22","author":"Alvandi","year":"2017","journal-title":"Addiction Biol."},{"key":"10.1016\/j.ejphar.2024.176768_bib3","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S1043-6618(02)00147-0","article-title":"Baclofen analgesia: Involvement of the GABAergic system","volume":"46","author":"Balerio","year":"2002","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.ejphar.2024.176768_bib4","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/S0091-3057(99)00168-9","article-title":"Gender differences in dopaminergic function in striatum and nucleus accumbens","volume":"64","author":"Becker","year":"1999","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.ejphar.2024.176768_bib5","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.yfrne.2007.07.003","article-title":"Sex differences in drug abuse","volume":"29","author":"Becker","year":"2008","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.ejphar.2024.176768_bib6","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/2042-6410-3-14","article-title":"Sex differences in the neural mechanisms mediating addiction: a new synthesis and hypothesis","volume":"3","author":"Becker","year":"2012","journal-title":"Biol. Sex Differ."},{"key":"10.1016\/j.ejphar.2024.176768_bib7","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/j.1749-6632.2010.05896.x","article-title":"Hippocampus, amygdala and stress: interacting systems that affect susceptibility to addiction","volume":"1216","author":"Belujon","year":"2011","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.ejphar.2024.176768_bib8","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1007\/s00213-003-1769-3","article-title":"GABAB receptor agonists reduce operant ethanol self-administration and enhance ethanol sedation in C57BL\/6J mice","volume":"174","author":"Besheer","year":"2004","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.ejphar.2024.176768_bib9","doi-asserted-by":"crossref","DOI":"10.1523\/JNEUROSCI.21-03-01039.2001","article-title":"The NK1 receptor is essential for the Full expression of Noxious inhibitory controls in the mouse","author":"Bester","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2024.176768_bib11","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.gde.2009.02.009","article-title":"Emerging pathogenic pathways in the spinocerebellar ataxias","volume":"19","author":"Carlson","year":"2009","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.ejphar.2024.176768_bib12","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/0006-8993(93)91225-H","article-title":"Sex differences in striatal dopamine: in vivo microdialysis and behavioral studies","volume":"610","author":"Castner","year":"1993","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2024.176768_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s002130050911","article-title":"Sex differences in development of morphine tolerance and dependence in the rat","volume":"143","author":"Craft","year":"1999","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.ejphar.2024.176768_bib14","doi-asserted-by":"crossref","DOI":"10.1038\/nprot.2006.279","article-title":"Drug-induced conditioned place preference and aversion in mice","author":"Cunningham","year":"2006","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.ejphar.2024.176768_bib15","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1007\/s002130050148","article-title":"GABAergic influences on plus-maze behaviour in mice","volume":"128","author":"Dalvi","year":"1996","journal-title":"Psychopharmacology (Berl)"},{"issue":"1","key":"10.1016\/j.ejphar.2024.176768_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41398-021-01589-z","article-title":"Differential dopamine release by psychosis-generating and non-psychosis-generating addictive substances in the nucleus accumbens and dorsomedial striatum","volume":"11","author":"Danielsson","year":"2021","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.ejphar.2024.176768_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2003.10.009","article-title":"Behavioral sensitization to different dopamine agonists in a parkinsonian rodent model of drug-induced dyskinesias","author":"Delfino","year":"2004","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ejphar.2024.176768_bib18","first-page":"1067","article-title":"Opposite effects of mu and kappa opiate agonists on dopamine release in the nucleus accumbens and in the dorsal caudate of freely moving rats","volume":"244","author":"Di Chiara","year":"1988","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.ejphar.2024.176768_bib19","first-page":"1624","article-title":"Reciprocal changes in prefrontal and limbic dopamine responsiveness to aversive and rewarding stimuli after chronic mild stress: implications for the psychobiology of depression. Biol","volume":"46","author":"Di Chiara","year":"1999","journal-title":"Psychiatry"},{"key":"10.1016\/j.ejphar.2024.176768_bib20","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1002\/syn.20279","article-title":"Morphine withdrawal syndrome and its prevention with baclofen : autoradiographic study of l -opioid receptors in prepubertal male and female mice","volume":"140","author":"Diaz","year":"2006","journal-title":"Synapse"},{"key":"10.1016\/j.ejphar.2024.176768_bib21","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1002\/bdd.554","article-title":"Pharmacokinetic aspects of naloxone-precipitated morphine withdrawal in male and female prepubertal mice","volume":"28","author":"Diaz","year":"2007","journal-title":"Biopharm. Drug Dispos."},{"key":"10.1016\/j.ejphar.2024.176768_bib22","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1097\/00008877-200102000-00009","article-title":"Lack of sex-related differences in the prevention by baclofen of the morphine withdrawal syndrome in mice","volume":"12","author":"Diaz","year":"2001","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.ejphar.2024.176768_bib23","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1002\/syn.20061","article-title":"Baclofen reestablishes micro-opioid receptor levels modified by morphine withdrawal syndrome in either sex","volume":"54","author":"Diaz","year":"2004","journal-title":"Synapse"},{"key":"10.1016\/j.ejphar.2024.176768_bib24","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1081\/ADA-100103705","article-title":"Gender differences in cocaine craving among non-treatment-seeking individuals with cocaine dependence","volume":"27","author":"Elman","year":"2001","journal-title":"Am. J. Drug Alcohol Abuse"},{"key":"10.1016\/j.ejphar.2024.176768_bib25","doi-asserted-by":"crossref","first-page":"3312","DOI":"10.1523\/JNEUROSCI.22-09-03312.2002","article-title":"Psychomotor stimulant addiction: a neural systems perspective","volume":"22","author":"Everitt","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2024.176768_bib26","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.euroneuro.2009.01.007","article-title":"Baclofen prevents drug-induced reinstatement of extinguished nicotine-seeking behaviour and nicotine place preference in rodents","volume":"19","author":"Fattore","year":"2009","journal-title":"Eur. Neuropsychopharmacol"},{"issue":"6","key":"10.1016\/j.ejphar.2024.176768_bib27","doi-asserted-by":"crossref","DOI":"10.1002\/dev.22186","article-title":"Morphine exposure alters Fos expression in a sex\u2010, age\u2010, and brain region\u2010specific manner during adolescence","volume":"63","author":"Figueroa","year":"2021","journal-title":"Dev. Psychobiol."},{"key":"10.1016\/j.ejphar.2024.176768_bib28","first-page":"755","article-title":"GABA(B) receptors in drug addiction","volume":"60","author":"Filip","year":"2008","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.ejphar.2024.176768_bib29","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0304-3959(99)00119-0","article-title":"The kappa opioid nalbuphine produces gender- and dose-dependent analgesia and antianalgesia in patients with postoperative pain","volume":"83","author":"Gear","year":"1999","journal-title":"Pain"},{"key":"10.1016\/j.ejphar.2024.176768_bib30","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1126\/science.2147780","article-title":"D1 and D2 dopamine receptor-regulated gene expression of striatonigral and striatopallidal neurons","volume":"250","author":"Gerfen","year":"1990","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2024.176768_bib33","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0006-8993(83)90913-7","article-title":"Morphine-induced activation of A10 dopamine neurons in the rat","volume":"277","author":"Gysling","year":"1983","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2024.176768_bib34","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.bbr.2009.10.013","article-title":"Baclofen enhances extinction of opiate conditioned place preference","volume":"207","author":"Heinrichs","year":"2010","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ejphar.2024.176768_bib35","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1038\/35094560","article-title":"Addiction and the brain: the neurobiology of compulsion and its persistence","volume":"2","author":"Hyman","year":"2001","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.ejphar.2024.176768_bib36","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1523\/JNEUROSCI.12-02-00483.1992","article-title":"Opioids excite dopamine neurons by hyperpolarization of local interneurons","volume":"12","author":"Johnson","year":"1992","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2024.176768_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.pbb.2021.173111","article-title":"Microinjection of the BDNF receptor antagonist ANA-12 into the nucleus accumbens and medial-prefrontal cortex attenuates morphine-induced reward memory, and alterations of BDNF levels and apoptotic cells in rats","volume":"201","author":"Jorjani","year":"2021","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.ejphar.2024.176768_bib38","first-page":"858","article-title":"Modulation of A10 dopamine neurons by gamma-aminobutyric acid agonists","volume":"253","author":"Kalivas","year":"1990","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.ejphar.2024.176768_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/S0006-8993(03)03218-9","article-title":"Baclofen inhibits opiate-induced conditioned place preference and associated induction of Fos in cortical and limbic regions","author":"Kaplan","year":"2003","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2024.176768_bib42","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0006-8993(00)02685-8","article-title":"A comparison of morphine analgesic tolerance in male and female mice","volume":"879","author":"Kest","year":"2000","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2024.176768_bib43","doi-asserted-by":"crossref","first-page":"2646","DOI":"10.1038\/npp.2014.118","article-title":"Loss of BDNF signaling in d1r-expressing NAc neurons enhances morphine reward by reducing GABA inhibition","volume":"39","author":"Koo","year":"2014","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.ejphar.2024.176768_bib44","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1126\/science.1222265","article-title":"BDNF is a negative modulator of morphine action","volume":"338","author":"Koo","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2024.176768_bib45","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/j.1749-6632.1992.tb25966.x","article-title":"Neural mechanisms of drug reinforcement","volume":"654","author":"Koob","year":"1992","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.ejphar.2024.176768_bib47","article-title":"Neurocircuitry of addiction","author":"Koob","year":"2010","journal-title":"Neuropsychopharmacology"},{"issue":"10","key":"10.1016\/j.ejphar.2024.176768_bib48","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1101\/lm.042192.116","article-title":"Effects of drugs of abuse on hippocampal plasticity and hippocampus-dependent learning and memory: contributions to development and maintenance of addiction","volume":"23","author":"Kutlu","year":"2016","journal-title":"Learn. Mem."},{"key":"10.1016\/j.ejphar.2024.176768_bib49","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.bbr.2013.12.041","article-title":"Extinction of opiate reward reduces dendritic arborization and c-Fos expression in the nucleus accumbens core","volume":"263","author":"Leite-Morris","year":"2014","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ejphar.2024.176768_bib50","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/S0024-3205(01)01397-2","article-title":"GABA(B) receptor agonist baclofen attenuates the development and expression of d-methamphetamine-induced place preference in rats","volume":"70","author":"Li","year":"2001","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2024.176768_bib51","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1007\/s002130000488","article-title":"Effects of sex and the estrous cycle on regulation of intravenously self-administered cocaine in rats","volume":"152","author":"Lynch","year":"2000","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.ejphar.2024.176768_bib52","doi-asserted-by":"crossref","DOI":"10.1042\/AN20110063","article-title":"Regional and cell-type-specific effects of DAMGO on striatal D1 and D2 dopamine receptor-expressing medium-sized spiny neurons","author":"Ma","year":"2012","journal-title":"ASN Neuro"},{"key":"10.1016\/j.ejphar.2024.176768_bib53","doi-asserted-by":"crossref","DOI":"10.1038\/41567","article-title":"Absence of opiate, rewarding effects in mice lacking dopamine D2 receptors","author":"Maldonado","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2024.176768_bib54","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0166-2236(95)80024-V","article-title":"Opioid receptors: past, present and future","volume":"18","author":"Mansour","year":"1995","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.ejphar.2024.176768_bib55","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0031-9384(95)02007-1","article-title":"Dietary compensation by humans for supplemental energy provided as ethanol or carbohydrate in fluids","volume":"59","author":"Mattes","year":"1996","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.ejphar.2024.176768_bib56","doi-asserted-by":"crossref","DOI":"10.1038\/383819a0","article-title":"Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the \u03bc-opioid-receptor gene","author":"Matthes","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2024.176768_bib57","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.brainres.2013.04.031","article-title":"Region-specific expression of brain-derived neurotrophic factor splice variants in morphine conditioned place preference in mice","volume":"1519","author":"Meng","year":"2013","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2024.176768_bib58","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/j.1749-6632.1999.tb09266.x","article-title":"The synaptic framework for chemical signaling in nucleus accumbens","volume":"877","author":"Meredith","year":"1999","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"36","key":"10.1016\/j.ejphar.2024.176768_bib59","doi-asserted-by":"crossref","first-page":"9721","DOI":"10.1523\/JNEUROSCI.2993-07.2007","article-title":"Compartment-specific modulation of GABAergic synaptic transmission by mu-opioid receptor in the mouse striatum with green fluorescent protein-expressing dopamine islands","volume":"27","author":"Miura","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2024.176768_bib60","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1038\/sj.npp.1300413","article-title":"Genetic and pharmacological evidence of a role for GABAB receptors in the modulation of anxiety- and antidepressant-like behavior","volume":"29","author":"Mombereau","year":"2004","journal-title":"Neuropsychopharmacology"},{"issue":"4","key":"10.1016\/j.ejphar.2024.176768_bib61","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1111\/j.1369-1600.2010.00249.x","article-title":"Implication of dopaminergic projection from the ventral tegmental area to the anterior cingulate cortex in \u03bc\u2010opioid\u2010induced place preference","volume":"15","author":"Narita","year":"2010","journal-title":"Addiction Biol."},{"key":"10.1016\/j.ejphar.2024.176768_bib62","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.brainresbull.2017.06.019","article-title":"Alterations in nociception and morphine antinociception in mice fed a high-fat diet","volume":"138","author":"Nealon","year":"2018","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.ejphar.2024.176768_bib64","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0896-6273(02)00653-0","article-title":"Neurobiology of depression","volume":"34","author":"Nestler","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.ejphar.2024.176768_bib65","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1126\/science.1094285","article-title":"Dissociable roles of ventral and dorsal striatum in instrumental conditioning","volume":"304","author":"O'Doherty","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2024.176768_bib67","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/0006-8993(82)90454-1","article-title":"Reinforcing effects of morphine in the nucleus accumbens","volume":"237","author":"Olds","year":"1982","journal-title":"Brain Res."},{"year":"2008","series-title":"The Mouse Brain in Stereotaxic Coordinates","author":"Paxinos","key":"10.1016\/j.ejphar.2024.176768_bib68"},{"key":"10.1016\/j.ejphar.2024.176768_bib69","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1002\/syn.21620","article-title":"Baclofen did not modify sexually dimorphic c-Fos expression during morphine withdrawal syndrome","volume":"67","author":"Pedr\u00f3n","year":"2013","journal-title":"Synapse"},{"key":"10.1016\/j.ejphar.2024.176768_bib70","doi-asserted-by":"crossref","DOI":"10.1016\/j.pbb.2019.02.015","article-title":"GABA B receptors modulate morphine antinociception: pharmacological and genetic approaches","author":"Pedr\u00f3n","year":"2019","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.ejphar.2024.176768_bib71","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/0091-3057(80)90460-8","article-title":"Reinforcing effects of morphine microinjection into the ventral tegmental area","volume":"12","author":"Phillips","year":"1980","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.ejphar.2024.176768_bib73","doi-asserted-by":"crossref","first-page":"12304","DOI":"10.1073\/pnas.92.26.12304","article-title":"Intravenous cocaine, morphine, and amphetamine preferentially increase extracellular dopamine in the \u00abshell\u00bb as compared with the \u00abcore\u00bb of the rat nucleus accumbens","volume":"92","author":"Pontieri","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ejphar.2024.176768_bib74","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1097\/FBP.0b013e3283635ee9","article-title":"Role of dorsal hippocampal orexin-1 receptors in associating morphine reward with contextual stimuli","volume":"24","author":"Riahi","year":"2013","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.ejphar.2024.176768_bib77","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1002\/(SICI)1098-2396(199908)33:2<160::AID-SYN6>3.0.CO;2-S","article-title":"Morphine alters the structure of neurons in the nucleus accumbens and neocortex of rats","volume":"33","author":"Robinson","year":"1999","journal-title":"Synapse"},{"author":"Sahraei","key":"10.1016\/j.ejphar.2024.176768_bib78"},{"first-page":"17","year":"2002","series-title":"Resoluci\u00f3n (617\/2002): Requisitos, condiciones y procedimientos para la habilitaci\u00f3n t\u00e9cnica de laboratorios que posean bioterios de producci\u00f3n. mantenimiento y local de experimentaci\u00f3n","key":"10.1016\/j.ejphar.2024.176768_bib81"},{"key":"10.1016\/j.ejphar.2024.176768_bib82","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.ejphar.2004.01.012","article-title":"Estrous cycle stage-dependent expression of acute tolerance to morphine analgesia in rats","volume":"486","author":"Shekunova","year":"2004","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2024.176768_bib83","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/0006-8993(93)90107-X","article-title":"Effects of castration, estrogen replacement and estrus cycle on monoamine metabolism in the nucleus accumbens, measured by microdialysis","volume":"621","author":"Shimizu","year":"1993","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2024.176768_bib84","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S0166-2236(99)01447-2","article-title":"The dopamine hypothesis of reward: past and current status","volume":"22","author":"Spanagel","year":"1999","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.ejphar.2024.176768_bib85","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S0031-9384(00)00426-1","article-title":"Sex differences in relation to conditioned fear-induced enhancement of morphine analgesia","volume":"72","author":"Stock","year":"2001","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.ejphar.2024.176768_bib86","doi-asserted-by":"crossref","first-page":"743","DOI":"10.3389\/fphar.2020.00743","article-title":"Postretrieval microinjection of baclofen into the agranular insular cortex inhibits morphine-induced cpp by disrupting reconsolidation","volume":"11","author":"Sun","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejphar.2024.176768_bib87","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.tins.2007.03.008","article-title":"D1 and D2 dopamine-receptor modulation of striatal glutamatergic signaling in striatal medium spiny neurons","volume":"30","author":"Surmeier","year":"2007","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.ejphar.2024.176768_bib88","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0006-8993(95)00064-W","article-title":"Effects of the histaminergic system on the morphine-induced conditioned place preference in mice","volume":"675","author":"Suzuki","year":"1995","journal-title":"Brain Res."},{"issue":"22","key":"10.1016\/j.ejphar.2024.176768_bib89","doi-asserted-by":"crossref","first-page":"8442","DOI":"10.1523\/JNEUROSCI.4036-14.2015","article-title":"Microglia disrupt mesolimbic reward circuitry in chronic pain","volume":"35","author":"Taylor","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2024.176768_bib91","doi-asserted-by":"crossref","first-page":"3399","DOI":"10.1046\/j.1460-9568.2000.00214.x","article-title":"Suppression of c-fos induction in the nucleus accumbens prevents acquisition but not expression of morphine-conditioned place preference","volume":"12","author":"Tolliver","year":"2000","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.ejphar.2024.176768_bib92","first-page":"169","volume":"vol. 313","author":"Tsuji","year":"1996"},{"key":"10.1016\/j.ejphar.2024.176768_bib93","doi-asserted-by":"crossref","first-page":"2671","DOI":"10.1111\/j.1460-9568.1996.tb01562.x","article-title":"Protein kinases in the rat nucleus accumbens are involved in the aversive component of opiate withdrawal","volume":"8","author":"Valverde","year":"1996","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.ejphar.2024.176768_bib94","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.ejphar.2014.05.039","article-title":"Baclofen and 2-hydroxysaclofen modify acute hypolocomotive and antinociceptive effects of nicotine","volume":"738","author":"Varani","year":"2014","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2024.176768_bib95","doi-asserted-by":"crossref","first-page":"3031","DOI":"10.1007\/s00213-014-3469-6","article-title":"Attenuation by baclofen of nicotine rewarding properties and nicotine withdrawal manifestations","volume":"231","author":"Varani","year":"2014","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.ejphar.2024.176768_bib96","article-title":"Nicotine-induced molecular alterations are modulated by GABA(B) receptor activity","author":"Varani","year":"2017","journal-title":"Addiction Biol."},{"key":"10.1016\/j.ejphar.2024.176768_bib97","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1038\/sj.npp.1300915","article-title":"Sex differences in neurochemical effects of dopaminergic drugs in rat striatum","volume":"31","author":"Walker","year":"2006","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.ejphar.2024.176768_bib98","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/S0306-4522(99)00500-X","article-title":"Dopamine release and uptake are greater in female than male rat striatum as measured by fast cyclic voltammetry","volume":"95","author":"Walker","year":"1999","journal-title":"Neuroscience"},{"key":"10.1016\/j.ejphar.2024.176768_bib99","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.brainres.2011.07.045","article-title":"RACK1 affects morphine reward via BDNF","volume":"1416","author":"Wan","year":"2011","journal-title":"Brain Res."},{"issue":"2","key":"10.1016\/j.ejphar.2024.176768_bib100","first-page":"255","article-title":"Intra-nucleus accumbens shell injection of baclofen blocks the reconsolidation of conditioned place preference in morphine-addicted mice","volume":"72","author":"Wang","year":"2020","journal-title":"Sheng li xue bao:[Acta physiologica Sinica]"},{"key":"10.1016\/j.ejphar.2024.176768_bib101","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0376-8716(98)00063-5","article-title":"Drug-activation of brain reward pathways","volume":"51","author":"Wise","year":"1998","journal-title":"Drug Alcohol Depend."},{"key":"10.1016\/j.ejphar.2024.176768_bib103","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0304-3940(94)90510-X","article-title":"Quantitative microdialysis determination of extracellular striatal dopamine concentration in male and female rats: effects of estrous cycle and gonadectomy","volume":"180","author":"Xiao","year":"1994","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ejphar.2024.176768_bib104","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1254\/fpj.75.805","volume":"75","author":"Yoshimura","year":"1979","journal-title":"Nihon Yakurigaku Zasshi"}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299924004564?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299924004564?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T20:47:57Z","timestamp":1723668477000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299924004564"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":89,"alternative-id":["S0014299924004564"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2024.176768","relation":{},"ISSN":["0014-2999"],"issn-type":[{"type":"print","value":"0014-2999"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Baclofen prevents morphine rewarding effects and associated biochemical alterations in male and female mice","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2024.176768","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"176768"}}