{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T05:46:11Z","timestamp":1780983971089,"version":"3.54.1"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.ejphar.2024.176817","type":"journal-article","created":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T02:55:03Z","timestamp":1722394503000},"page":"176817","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Pre-treatment with tocilizumab reduces lipopolysaccharide-induced acute lung injury in biliary cirrhotic rats"],"prefix":"10.1016","volume":"980","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4884-634X","authenticated-orcid":false,"given":"Shao-Jung","family":"Hsu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuang-Yao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Chun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiao-Lin","family":"Chuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5526-5389","authenticated-orcid":false,"given":"Ching-Chih","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3125-4495","authenticated-orcid":false,"given":"Chon-Kit","family":"Pun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Chih","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fa-Yauh","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.ejphar.2024.176817_bib1","doi-asserted-by":"crossref","first-page":"G980","DOI":"10.1152\/ajpgi.00336.2005","article-title":"Mild increases in portal pressure upregulate vascular endothelial growth factor and endothelial nitric oxide synthase in the intestinal microcirculatory bed, leading to a hyperdynamic state","volume":"290","author":"Abraldes","year":"2006","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"issue":"3","key":"10.1016\/j.ejphar.2024.176817_bib2","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/0016-5085(92)90179-3","article-title":"Vasodilatation and sodium retention in prehepatic portal hypertension","volume":"102","author":"Albillos","year":"1992","journal-title":"Gastroenterology"},{"issue":"12","key":"10.1016\/j.ejphar.2024.176817_bib3","doi-asserted-by":"crossref","first-page":"3363","DOI":"10.1111\/jgh.15633","article-title":"Mortality, sepsis, and organ failure in hospitalized patients with cirrhosis vary by type of infection","volume":"36","author":"Atteberry","year":"2021","journal-title":"J. Gastroenterol. Hepatol."},{"issue":"6","key":"10.1016\/j.ejphar.2024.176817_bib4","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1136\/gut.47.6.838","article-title":"Treatment with neutralising antibody against cytokine induced neutrophil chemoattractant (CINC) protects rats against acute pancreatitis associated lung injury","volume":"47","author":"Bhatia","year":"2000","journal-title":"Gut"},{"issue":"3","key":"10.1016\/j.ejphar.2024.176817_bib5","doi-asserted-by":"crossref","first-page":"670","DOI":"10.3350\/cmh.2022.0103","article-title":"Acute-on-chronic liver failure: terminology, mechanisms and management","volume":"29","author":"Br","year":"2023","journal-title":"Clin. Mol. Hepatol."},{"issue":"2","key":"10.1016\/j.ejphar.2024.176817_bib6","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1002\/path.1700750212","article-title":"Disturbances of structure and function in the liver as the result of biliary obstruction","volume":"75","author":"Cameron","year":"1958","journal-title":"J. Pathol. Bacteriol."},{"issue":"7","key":"10.1016\/j.ejphar.2024.176817_bib7","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1042\/CS20120052","article-title":"Sorafenib treatment improves hepatopulmonary syndrome in rats with biliary cirrhosis","volume":"124","author":"Chang","year":"2013","journal-title":"Clin. Sci."},{"issue":"4","key":"10.1016\/j.ejphar.2024.176817_bib8","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1002\/hep.28740","article-title":"Systemic inflammation in decompensated cirrhosis: characterization and role in acute-on-chronic liver failure","volume":"64","author":"Cl\u00e0ria","year":"2016","journal-title":"Hepatology"},{"issue":"2","key":"10.1016\/j.ejphar.2024.176817_bib9","doi-asserted-by":"crossref","first-page":"e132","DOI":"10.1002\/mco2.132","article-title":"Blockade of mIL-6R alleviated lipopolysaccharide-induced systemic inflammatory response syndrome by suppressing NF-\u03baB-mediated Ccl2 expression and inflammasome activation","volume":"3","author":"Dai","year":"2022","journal-title":"MedComm"},{"issue":"4 Pt 1","key":"10.1016\/j.ejphar.2024.176817_bib10","first-page":"G779","article-title":"Common bile duct ligation in the rat: a model of intrapulmonary vasodilatation and hepatopulmonary syndrome","volume":"272","author":"Fallon","year":"1997","journal-title":"Am. J. Physiol."},{"issue":"9","key":"10.1016\/j.ejphar.2024.176817_bib11","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1001\/archsurg.1979.01370330086016","article-title":"Portal hypertension after bile duct obstruction: effect of bile diversion on portal pressure in the rat","volume":"114","author":"Franco","year":"1979","journal-title":"Arch. Surg."},{"issue":"2","key":"10.1016\/j.ejphar.2024.176817_bib12","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1513\/AnnalsATS.202301-056OC","article-title":"Tocilizumab in patients with systemic sclerosis-associated interstitial lung disease: a systematic review and meta-analysis","volume":"21","author":"Ghazipura","year":"2024","journal-title":"Ann. Am. Thorac. Soc."},{"issue":"9","key":"10.1016\/j.ejphar.2024.176817_bib13","doi-asserted-by":"crossref","first-page":"4056","DOI":"10.1111\/jcmm.13673","article-title":"Circulating monocytes accelerate acute liver failure by IL-6 secretion in monkey","volume":"22","author":"Guo","year":"2018","journal-title":"J. Cell Mol. Med."},{"issue":"1","key":"10.1016\/j.ejphar.2024.176817_bib14","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1165\/rcmb.2011-0353OC","article-title":"Proinflammatory cytokines induce bronchial hyperplasia and squamous metaplasia in smokers: implications for chronic obstructive pulmonary disease therapy","volume":"47","author":"Herfs","year":"2012","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"1","key":"10.1016\/j.ejphar.2024.176817_bib15","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1124\/jpet.122.001289","article-title":"Sodium-glucose cotransporter-2 inhibition exacerbates hepatic encephalopathy in biliary cirrhotic rats","volume":"383","author":"Hsu","year":"2022","journal-title":"J. Pharmacol. Exp. Therapeut."},{"issue":"1","key":"10.1016\/j.ejphar.2024.176817_bib16","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1093\/intimm\/dxu081","article-title":"Therapeutic uses of anti-interleukin-6 receptor antibody","volume":"27","author":"Kang","year":"2015","journal-title":"Int. Immunol."},{"issue":"11","key":"10.1016\/j.ejphar.2024.176817_bib17","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.3390\/pharmaceutics13111851","article-title":"Aerosol delivery of surfactant liposomes for management of pulmonary fibrosis: an approach supporting pulmonary mechanics","volume":"13","author":"Kotta","year":"2021","journal-title":"Pharmaceutics"},{"issue":"10","key":"10.1016\/j.ejphar.2024.176817_bib18","doi-asserted-by":"crossref","first-page":"2945","DOI":"10.3390\/jcm11102945","article-title":"Comparative study of cytokine storm treatment in patients with COVID-19 pneumonia using immunomodulators","volume":"11","author":"Marc","year":"2022","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.ejphar.2024.176817_bib19","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1254\/jjp.82.261","article-title":"Effects of nitric oxide scavenger, carboxy-PTIO on endotoxin-induced alterations in systemic hemodynamics in rats","volume":"82","author":"Miura","year":"2000","journal-title":"Jpn. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.ejphar.2024.176817_bib20","doi-asserted-by":"crossref","DOI":"10.1002\/rmv.2372","article-title":"The role of cytokines and their antagonists in the treatment of COVID-19 patients","volume":"33","author":"Mohseni Afshar","year":"2023","journal-title":"Rev. Med. Virol."},{"issue":"3","key":"10.1016\/j.ejphar.2024.176817_bib21","doi-asserted-by":"crossref","first-page":"401","DOI":"10.3109\/14397595.2014.973659","article-title":"The effect of tocilizumab on preventing relapses in adult-onset Still\u2019s disease: a retrospective, single-center study","volume":"25","author":"Nishina","year":"2015","journal-title":"Mod. Rheumatol."},{"issue":"1","key":"10.1016\/j.ejphar.2024.176817_bib22","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jbspin.2014.07.010","article-title":"Efficacy and safety of tocilizumab in elderly patients with rheumatoid arthritis","volume":"82","author":"Pers","year":"2015","journal-title":"Joint Bone Spine"},{"key":"10.1016\/j.ejphar.2024.176817_bib23","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.935160","article-title":"The immune pathogenesis of acute-on-chronic liver failure and the danger hypothesis","volume":"13","author":"Qiang","year":"2022","journal-title":"Front. Immunol."},{"issue":"4","key":"10.1016\/j.ejphar.2024.176817_bib24","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1164\/rccm.200201-027OC","article-title":"Prevention of gram-negative translocation reduces the severity of hepatopulmonary syndrome","volume":"166","author":"Rabiller","year":"2002","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.ejphar.2024.176817_bib25","first-page":"349","article-title":"Tocilizumab in the treatment of rheumatoid arthritis and beyond","volume":"8","author":"Shetty","year":"2014","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.ejphar.2024.176817_bib26","doi-asserted-by":"crossref","DOI":"10.1038\/srep32341","article-title":"Characterization of inflammatory response in acute-on-chronic liver failure and relationship with prognosis","volume":"6","author":"Sol\u00e9","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejphar.2024.176817_bib27","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1172\/JCI11830","article-title":"NF-kappaB: a key role in inflammatory diseases","volume":"107","author":"Tak","year":"2001","journal-title":"J. Clin. Invest."},{"issue":"20","key":"10.1016\/j.ejphar.2024.176817_bib28","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1182\/blood-2018-07-862334","article-title":"International, evidence-based consensus treatment guidelines for idiopathic multicentric Castleman disease","volume":"132","author":"van Rhee","year":"2018","journal-title":"Blood"},{"issue":"5","key":"10.1016\/j.ejphar.2024.176817_bib29","doi-asserted-by":"crossref","first-page":"432","DOI":"10.4161\/mabs.1.5.9497","article-title":"Tocilizumab","volume":"1","author":"Venkiteshwaran","year":"2009","journal-title":"mAbs"},{"issue":"8","key":"10.1016\/j.ejphar.2024.176817_bib30","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1002\/hep4.1949","article-title":"Soluble factors and suppressive monocytes can predict early development of sepsis in acute-on-chronic liver failure","volume":"6","author":"Yadav","year":"2022","journal-title":"Hepatol. Commun."},{"issue":"22","key":"10.1016\/j.ejphar.2024.176817_bib31","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.21037\/atm-21-5476","article-title":"Knockdown of phosphoinositide-dependent kinase 1 (PDK1) inhibits fibrosis and inflammation in lipopolysaccharide-induced acute lung injury rat model by attenuating NF-\u03baB\/p65 pathway activation","volume":"9","author":"Yang","year":"2021","journal-title":"Ann. Transl. Med."},{"issue":"7","key":"10.1016\/j.ejphar.2024.176817_bib32","doi-asserted-by":"crossref","first-page":"6120","DOI":"10.18632\/aging.103010","article-title":"Alveolar macrophage - derived exosomes modulate severity and outcome of acute lung injury","volume":"12","author":"Ye","year":"2020","journal-title":"Aging (Albany NY)"},{"issue":"5","key":"10.1016\/j.ejphar.2024.176817_bib33","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/S0168-8278(03)00430-6","article-title":"Intrapulmonary vascular dilatation and nitric oxide in hypoxemic rats with chronic bile duct ligation","volume":"39","author":"Zhang","year":"2003","journal-title":"J. Hepatol."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299924005065?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299924005065?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T13:30:17Z","timestamp":1742391017000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299924005065"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":33,"alternative-id":["S0014299924005065"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2024.176817","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pre-treatment with tocilizumab reduces lipopolysaccharide-induced acute lung injury in biliary cirrhotic rats","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2024.176817","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"176817"}}