{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T02:13:11Z","timestamp":1780107191479,"version":"3.54.0"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,26]],"date-time":"2025-07-26T00:00:00Z","timestamp":1753488000000},"content-version":"am","delay-in-days":328,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["AARG-NTF-23-1145090"],"award-info":[{"award-number":["AARG-NTF-23-1145090"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006181","name":"FAPESB","doi-asserted-by":"publisher","award":["APP0024\/2023 \\u2013 UNIVERSAL"],"award-info":[{"award-number":["APP0024\/2023 \\u2013 UNIVERSAL"]}],"id":[{"id":"10.13039\/501100006181","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R00GM118885"],"award-info":[{"award-number":["R00GM118885"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01HL149762"],"award-info":[{"award-number":["R01HL149762"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["DK-132948"],"award-info":[{"award-number":["DK-132948"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","award":["309986\/2020-6"],"award-info":[{"award-number":["309986\/2020-6"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","award":["310719\/2023-2"],"award-info":[{"award-number":["310719\/2023-2"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.ejphar.2024.176822","type":"journal-article","created":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T23:00:22Z","timestamp":1721689222000},"page":"176822","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["NONO2P, a novel nitric oxide donor, causes vasorelaxation through NO\/sGC\/PKG pathway, K+ channels opening and SERCA activation"],"prefix":"10.1016","volume":"979","author":[{"given":"Raiana A.","family":"Moraes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele S.","family":"Brito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6063-1299","authenticated-orcid":false,"given":"F\u00eanix A.","family":"Araujo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2674-2024","authenticated-orcid":false,"given":"Rafael L.C.","family":"Jesus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliane B.","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise S.","family":"S\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos D.","family":"Silva da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laena","family":"Pernomian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla F.","family":"Wenceslau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6022-2081","authenticated-orcid":false,"given":"Fernanda","family":"Priviero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Clinton","family":"Webb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darizy F.","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2024.176822_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173525","article-title":"Inhibition of intracellular Ca2+ mobilization and potassium channels activation are involved in the vasorelaxation induced by 7-hydroxycoumarin","volume":"887","author":"Alves","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2024.176822_bib2","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.niox.2019.02.004","article-title":"NO donors induce vascular relaxation by different cellular mechanisms in hypertensive and normotensive rats","volume":"86","author":"Ara\u00fajo","year":"2019","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.ejphar.2024.176822_bib3","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1097\/00000542-198409000-00004","article-title":"Photodegradation of sodium nitroprusside","volume":"61","author":"Arnold","year":"1984","journal-title":"Anesthesiology"},{"key":"10.1016\/j.ejphar.2024.176822_bib4","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1038\/368850a0","article-title":"Nitric oxide directly activates calcium-dependent potassium channels in vascular smooth muscle","volume":"368","author":"Bolotina","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2024.176822_bib5","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.vph.2006.10.002","article-title":"Comparison of the mechanisms underlying the relaxation induced by two nitric oxide donors: sodium nitroprusside and a new ruthenium complex","volume":"46","author":"Bonaventura","year":"2007","journal-title":"Vasc. Pharmacol."},{"key":"10.1016\/j.ejphar.2024.176822_bib6","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1016\/j.jinorgbio.2009.07.015","article-title":"Endothelium negatively modulates the vascular relaxation induced by nitric oxide donor, due to uncoupling NO synthase","volume":"103","author":"Bonaventura","year":"2009","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.ejphar.2024.176822_bib7","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.niox.2004.03.004","article-title":"A macrocyclic nitrosyl ruthenium complex is a NO donor that induces rat aorta relaxation","volume":"10","author":"Bonaventura","year":"2004","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.ejphar.2024.176822_bib8","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.niox.2006.04.260","article-title":"Characterization of the mechanisms of action and nitric oxide species involved in the relaxation induced by the ruthenium complex","volume":"15","author":"Bonaventura","year":"2006","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.ejphar.2024.176822_bib9","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1111\/j.1440-1681.1996.tb01172.x","article-title":"Potassium channels in vascular smooth muscle","volume":"23","author":"Brayden","year":"1996","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.ejphar.2024.176822_bib10","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1161\/01.RES.84.2.210","article-title":"Mechanism of nitric oxide\u2013induced vasodilatation","volume":"84","author":"Cohen","year":"1999","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2024.176822_bib11","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.3390\/biology10101041","article-title":"Nitric oxide as a central molecule in hypertension: focus on the vasorelaxant activity of new nitric oxide donors","volume":"10","author":"da Silva","year":"2021","journal-title":"Biology"},{"key":"10.1016\/j.ejphar.2024.176822_bib12","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1089\/ars.2015.6376","article-title":"Organic nitrate therapy, nitrate tolerance, and nitrate-induced endothelial dysfunction: emphasis on redox biology and oxidative stress","volume":"23","author":"Daiber","year":"2015","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.ejphar.2024.176822_bib13","doi-asserted-by":"crossref","first-page":"9628","DOI":"10.3390\/molecules19079628","article-title":"Ruthenium complexes as NO donors for vascular relaxation induction","volume":"19","author":"de Lima","year":"2014","journal-title":"Molecules"},{"key":"10.1016\/j.ejphar.2024.176822_bib14","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/S0005-2728(99)00024-9","article-title":"Guanylate cyclase and the \u22c5NO\/cGMP signaling pathway","volume":"1411","author":"Denninger","year":"1999","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ejphar.2024.176822_bib15","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1124\/jpet.116.234153","article-title":"Endothelium-dependent contractions of isolated arteries to thymoquinone require biased activity of soluble guanylyl cyclase with subsequent cyclic IMP production","volume":"358","author":"Detremmerie","year":"2016","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.ejphar.2024.176822_bib16","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/sj.bjp.0703058","article-title":"Differential actions of L-cysteine on responses to nitric oxide, nitroxyl anions and EDRF in the rat aorta","volume":"129","author":"Ellis","year":"2000","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2024.176822_bib17","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/sj.bjp.0704287","article-title":"Effects of agents that inactivate free radical NO(NO \u2022)on nitroxyl anion-mediated relaxations, and on the detection of NO \u2022 released from the nitroxyl anion donor Angeli's salt","volume":"134","author":"Ellis","year":"2001","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2024.176822_bib18","doi-asserted-by":"crossref","first-page":"H1274","DOI":"10.1152\/ajpheart.00008.2009","article-title":"Redox variants of NO (NO and HNO) elicit vasorelaxation of resistance arteries via distinct mechanisms","volume":"296","author":"Favaloro","year":"2009","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.ejphar.2024.176822_bib19","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.ejphar.2012.06.043","article-title":"The 2-nitrate-1,3-dibuthoxypropan, a new nitric oxide donor, induces vasorelaxation in mesenteric arteries of the rat","volume":"690","author":"Fran\u00e7a-Silva","year":"2012","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2024.176822_bib20","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1124\/pr.110.002907","article-title":"cGMP-dependent protein kinases and cGMP phosphodiesterases in nitric oxide and cGMP action","volume":"62","author":"Francis","year":"2010","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.ejphar.2024.176822_bib21","first-page":"152","article-title":"Sodium nitroprusside: twenty years and counting","volume":"81","author":"Friederich","year":"1995","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.ejphar.2024.176822_bib22","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1021\/ic50097a006","article-title":"The preparation of ruthenium nitrosyl complexes containing 2,2\u2019-bipyridine and 1,10-phenanthroline","volume":"10","author":"Godwin","year":"1971","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.ejphar.2024.176822_bib23","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1161\/01.RES.79.4.881","article-title":"Role of Ca2+-activated K+ channels in the regulation of membrane potential and tone of smooth muscle in human pial arteries","volume":"79","author":"Gokina","year":"1996","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2024.176822_bib24","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1161\/01.HYP.0000072010.54901.DE","article-title":"NO- activates soluble guanylate cyclase and Kv channels to vasodilate resistance arteries","volume":"41","author":"Irvine","year":"2003","journal-title":"Hypertension"},{"key":"10.1016\/j.ejphar.2024.176822_bib25","series-title":"Advances in Pharmacology","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/bs.apha.2016.07.001","article-title":"Potassium channels in regulation of vascular smooth muscle contraction and growth","author":"Jackson","year":"2017"},{"key":"10.1016\/j.ejphar.2024.176822_bib26","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s11658-023-00423-2","article-title":"Endothelial dysfunction due to eNOS uncoupling: molecular mechanisms as potential therapeutic targets","volume":"28","author":"Janaszak-Jasiecka","year":"2023","journal-title":"Cell. Mol. Biol. Lett."},{"key":"10.1016\/j.ejphar.2024.176822_bib27","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1540\/jsmr.44.65","article-title":"Physiological roles of K+ channels in vascular smooth muscle cells","volume":"44","author":"Ko","year":"2008","journal-title":"J. Smooth Muscle Res."},{"key":"10.1016\/j.ejphar.2024.176822_bib28","doi-asserted-by":"crossref","first-page":"H927","DOI":"10.1152\/ajpheart.1991.260.3.H927","article-title":"Block of calcium-activated potassium channels in mammalian arterial myocytes by tetraethylammonium ions","volume":"260","author":"Langton","year":"1991","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.ejphar.2024.176822_bib29","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1161\/01.CIR.94.9.2241","article-title":"In vivo nitrate tolerance is not associated with reduced bioconversion of nitroglycerin to nitric oxide","volume":"94","author":"Laursen","year":"1996","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2024.176822_bib30","doi-asserted-by":"crossref","first-page":"fso54","DOI":"10.4155\/fso.15.54","article-title":"Nitric oxide generating\/releasing materials","volume":"1","author":"Liang","year":"2015","journal-title":"Future Sci OA"},{"key":"10.1016\/j.ejphar.2024.176822_bib31","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1152\/jappl.2001.91.3.1421","article-title":"cGMP-dependent protein kinase signaling mechanisms in smooth muscle: from the regulation of tone to gene expression","volume":"91","author":"Lincoln","year":"2001","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.ejphar.2024.176822_bib32","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1515\/revic-2018-0017","article-title":"Nitric oxide-releasing molecules at the interface of inorganic chemistry and biology: a concise overview","volume":"39","author":"Mir","year":"2019","journal-title":"Rev. Inorg. Chem."},{"key":"10.1016\/j.ejphar.2024.176822_bib33","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1038\/sj.bjp.0701940","article-title":"Nitric oxide (NO)-induced activation of large conductance Ca 2+ -dependent K + channels (BK Ca) in smooth muscle cells isolated from the rat mesenteric artery","volume":"124","author":"Mistry","year":"1998","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2024.176822_bib34","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1007\/s43440-019-00051-8","article-title":"Itaconimides derivatives induce relaxation in mesenteric artery and negative inotropism by inhibition of CA2+ influx","volume":"72","author":"Moraes","year":"2020","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.ejphar.2024.176822_bib35","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.mam.2004.09.003","article-title":"The role of nitric oxide in cardiovascular diseases","volume":"26","author":"Naseem","year":"2005","journal-title":"Mol. Aspect. Med."},{"key":"10.1016\/j.ejphar.2024.176822_bib36","doi-asserted-by":"crossref","first-page":"825","DOI":"10.4155\/fmc.14.26","article-title":"Enhancing vascular relaxing effects of nitric oxide-donor ruthenium complexes","volume":"6","author":"Paulo","year":"2014","journal-title":"Future Med. Chem."},{"key":"10.1016\/j.ejphar.2024.176822_bib37","doi-asserted-by":"crossref","first-page":"3748","DOI":"10.2174\/1381612826666200519114442","article-title":"Nitric oxide donors as potential drugs for the treatment of vascular diseases due to endothelium dysfunction","volume":"26","author":"Paulo","year":"2020","journal-title":"Curr. Pharmaceut. Des."},{"key":"10.1016\/j.ejphar.2024.176822_bib38","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.niox.2016.11.001","article-title":"Hypotensive effect and vascular relaxation in different arteries induced by the nitric oxide donor RuBPY","volume":"62","author":"Pereira","year":"2017","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.ejphar.2024.176822_bib39","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.ejps.2013.01.003","article-title":"Nitric oxide generated by the compound RuBPY promotes the vascular smooth cell membrane hyperpolarization","volume":"48","author":"Pereira","year":"2013","journal-title":"Eur. J. Pharmaceut. Sci."},{"key":"10.1016\/j.ejphar.2024.176822_bib40","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1590\/S0100-879X2011007500084","article-title":"Nitric oxide synthesis and biological functions of nitric oxide released from ruthenium compounds","volume":"44","author":"Pereira","year":"2011","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.ejphar.2024.176822_bib41","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.niox.2011.03.001","article-title":"Ruthenium-nitrite complex as pro-drug releases NO in a tissue and enzyme-dependent way","volume":"24","author":"Pereira","year":"2011","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.ejphar.2024.176822_bib42","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/sj.bjp.0704127","article-title":"Relaxation to authentic nitric oxide and SIN\u20101 in rat isolated mesenteric arteries: variable role for smooth muscle hyperpolarization","volume":"133","author":"Plane","year":"2001","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2024.176822_bib43","series-title":"Rat Mesenteric Artery. Evidence-Based Complementary and Alternative Medicine","first-page":"1","article-title":"Involvement of potassium channels in vasorelaxant effect induced by valeriana prionophylla standl","author":"Reis","year":"2013"},{"key":"10.1016\/j.ejphar.2024.176822_bib44","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1097\/FJC.0b013e31825bacc4","article-title":"Long-lasting hypotensive effect in renal hypertensive rats induced by nitric oxide released from a ruthenium complex","volume":"60","author":"Rodrigues","year":"2012","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.ejphar.2024.176822_bib45","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.toxicon.2017.04.010","article-title":"NO production and potassium channels activation induced by Crotalus durissus cascavella underlie mesenteric artery relaxation","volume":"133","author":"Santos","year":"2017","journal-title":"Toxicon"},{"key":"10.1016\/j.ejphar.2024.176822_bib46","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s00210-020-01985-0","article-title":"Braylin induces a potent vasorelaxation, involving distinct mechanisms in superior mesenteric and iliac arteries of rats","volume":"394","author":"Santos","year":"2021","journal-title":"Naunyn-Schmiedeberg\u2019s Arch. Pharmacol."},{"key":"10.1016\/j.ejphar.2024.176822_bib47","article-title":"Ru(II) based dual nitric oxide donors: electrochemical and photochemical reactivities and vasorelaxant effect with no cytotoxicity","author":"Silva da Silva","year":"2023","journal-title":"Dalton Trans."},{"key":"10.1016\/j.ejphar.2024.176822_bib48","doi-asserted-by":"crossref","first-page":"21330","DOI":"10.1074\/jbc.M117.794453","article-title":"Conformational memory in the association of the transmembrane protein phospholamban with the sarcoplasmic reticulum calcium pump SERCA","volume":"292","author":"Smeazzetto","year":"2017","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2024.176822_bib49","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1161\/01.ATV.21.1.28","article-title":"Potassium channel function in vascular disease","volume":"21","author":"Sobey","year":"2001","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.ejphar.2024.176822_bib50","doi-asserted-by":"crossref","first-page":"H272","DOI":"10.1152\/ajpheart.00216.2007","article-title":"Decreased function of voltage-gated potassium channels contributes to augmented myogenic tone of uterine arteries in late pregnancy","volume":"294","author":"Telezhkin","year":"2008","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.ejphar.2024.176822_bib51","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.ejphar.2007.10.009","article-title":"Vasorelaxant effect of isopropyl 3-(3, 4-dihydroxyphenyl)-2-hydroxypropanoate, a novel metabolite from Salvia miltiorrhiza, on isolated rat mesenteric artery","volume":"579","author":"Wang","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2024.176822_bib52","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/sj.bjp.0704269","article-title":"Vascular smooth muscle relaxation mediated by nitric oxide donors: a comparison with acetylcholine, nitric oxide and nitroxyl ion","volume":"134","author":"Wanstall","year":"2001","journal-title":"Br. J. Pharmacol."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299924005119?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299924005119?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T20:03:33Z","timestamp":1728504213000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299924005119"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":52,"alternative-id":["S0014299924005119"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2024.176822","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"NONO2P, a novel nitric oxide donor, causes vasorelaxation through NO\/sGC\/PKG pathway, K+ channels opening and SERCA activation","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2024.176822","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"176822"}}