{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T03:58:07Z","timestamp":1783137487414,"version":"3.54.6"},"reference-count":110,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81972313"],"award-info":[{"award-number":["81972313"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82203547"],"award-info":[{"award-number":["82203547"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.ejphar.2024.176996","type":"journal-article","created":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T16:55:42Z","timestamp":1726160142000},"page":"176996","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Mesenchymal stem cells alleviate inflammatory responses through regulation of T-cell subsets"],"prefix":"10.1016","volume":"983","author":[{"given":"Weimeng","family":"Ji","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deqiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5237-1992","authenticated-orcid":false,"given":"Wei","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.ejphar.2024.176996_bib1","doi-asserted-by":"crossref","DOI":"10.3390\/cells10113006","article-title":"Mesenchymal stem cell induced Foxp3(+) Tregs suppress effector T Cells and protect against retinal ischemic injury","volume":"10","author":"Agrawal","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.ejphar.2024.176996_bib2","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s13287-022-03219-x","article-title":"Transfer of mesenchymal stem cell mitochondria to CD4+ T cells contributes to repress Th1 differentiation by downregulating T-bet expression","volume":"14","author":"Akhter","year":"2023","journal-title":"Stem Cell Res. Ther."},{"issue":"8","key":"10.1016\/j.ejphar.2024.176996_bib3","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1002\/stem.3185","article-title":"Mesenchymal stromal cells induce regulatory T cells via epigenetic conversion of human conventional CD4 T cells in vitro","volume":"38","author":"Azevedo","year":"2020","journal-title":"Stem Cell."},{"issue":"4","key":"10.1016\/j.ejphar.2024.176996_bib4","doi-asserted-by":"crossref","DOI":"10.1111\/sji.12857","article-title":"Th9 cells in allergic diseases: a role for the microbiota?","volume":"91","author":"Badolati","year":"2020","journal-title":"Scand. J. Immunol."},{"issue":"Pt B","key":"10.1016\/j.ejphar.2024.176996_bib5","article-title":"Metformin potentiates immunosuppressant activity and adipogenic differentiation of human umbilical cord-mesenchymal stem cells","volume":"124","author":"Bajetto","year":"2023","journal-title":"Int. Immunopharm."},{"issue":"1","key":"10.1016\/j.ejphar.2024.176996_bib6","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1038\/s41467-024-45213-2","article-title":"Single-cell insights into immune dysregulation in rheumatoid arthritis flare versus drug-free remission","volume":"15","author":"Baker","year":"2024","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.ejphar.2024.176996_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2022.103236","article-title":"Autoimmune pre-disease","volume":"22","author":"Bieber","year":"2023","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.ejphar.2024.176996_bib8","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.cytogfr.2019.05.006","article-title":"Mesenchymal stem cells immunomodulation: the road to IFN-\u03b3 licensing and the path ahead","volume":"47","author":"Carvalho","year":"2019","journal-title":"Cytokine Growth Factor Rev."},{"issue":"2","key":"10.1016\/j.ejphar.2024.176996_bib9","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13363","article-title":"Nestin+ Peyer's patch resident MSCs enhance healing of inflammatory bowel disease through IL\u201022\u2010mediated intestinal epithelial repair","volume":"56","author":"Chen","year":"2022","journal-title":"Cell Prolif."},{"key":"10.1016\/j.ejphar.2024.176996_bib10","article-title":"Th22 cells and the intestinal mucosal barrier","volume":"14","author":"Chen","year":"2023","journal-title":"Front. Immunol."},{"issue":"12","key":"10.1016\/j.ejphar.2024.176996_bib11","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1084\/jem.20030152","article-title":"Conversion of peripheral CD4+CD25\u2212 naive T Cells to CD4+CD25+ regulatory T cells by TGF-\u03b2 induction of transcription factor Foxp3","volume":"198","author":"Chen","year":"2003","journal-title":"J. Exp. Med."},{"issue":"2","key":"10.1016\/j.ejphar.2024.176996_bib12","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.3390\/ijms24021564","article-title":"Exploring mast cell\u2013CD8 T cell interactions in inflammatory skin diseases","volume":"24","author":"Chen","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.ejphar.2024.176996_bib13","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41584-018-0109-2","article-title":"Anti-inflammatory and immune-regulatory cytokines in rheumatoid arthritis","volume":"15","author":"Chen","year":"2019","journal-title":"Nat. Rev. Rheumatol."},{"issue":"1","key":"10.1016\/j.ejphar.2024.176996_bib14","doi-asserted-by":"crossref","first-page":"e8","DOI":"10.4110\/in.2024.24.e8","article-title":"Cytokines in follicular helper T cell biology in physiologic and pathologic conditions","volume":"24","author":"Choi","year":"2024","journal-title":"Immune Netw"},{"issue":"1","key":"10.1016\/j.ejphar.2024.176996_bib15","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jaci.2022.10.011","article-title":"From thymus to tissues and tumors: a review of T cell biology","volume":"151","author":"Chopp","year":"2022","journal-title":"J. Allergy Clin. Immunol."},{"issue":"11","key":"10.1016\/j.ejphar.2024.176996_bib16","doi-asserted-by":"crossref","first-page":"2698","DOI":"10.3390\/ijms20112698","article-title":"Mesenchymal stem cells for spinal cord injury: current options, limitations, and future of cell therapy","volume":"20","author":"Cofano","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.ejphar.2024.176996_bib17","doi-asserted-by":"crossref","DOI":"10.15252\/embr.201948052","article-title":"Mitochondrial transfer from MSCs to T cells induces Treg differentiation and restricts inflammatory response","volume":"21","author":"Court","year":"2020","journal-title":"EMBO Rep."},{"issue":"1","key":"10.1016\/j.ejphar.2024.176996_bib18","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1146\/annurev-immunol-061020-053702","article-title":"Cytokine regulation and function in T cells","volume":"39","author":"Dong","year":"2021","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.ejphar.2024.176996_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2021.155749","article-title":"The role of Th22 cells, from tissue repair to cancer progression","volume":"149","author":"Doulabi","year":"2022","journal-title":"Cytokine"},{"issue":"4","key":"10.1016\/j.ejphar.2024.176996_bib20","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/scrt75","article-title":"Mesenchymal stem cell effects on T-cell effector pathways","volume":"2","author":"Duffy","year":"2011","journal-title":"Stem Cell Res. Ther."},{"issue":"19","key":"10.1016\/j.ejphar.2024.176996_bib21","doi-asserted-by":"crossref","first-page":"7015","DOI":"10.3390\/ijms21197015","article-title":"Treg enhancing therapies to treat autoimmune diseases","volume":"21","author":"Eggenhuizen","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.ejphar.2024.176996_bib22","doi-asserted-by":"crossref","first-page":"8509","DOI":"10.1002\/jcp.27782","article-title":"CD8+ cytotoxic T lymphocytes in cancer immunotherapy: a review","volume":"234","author":"Farhood","year":"2019","journal-title":"J. Cell. Physiol."},{"issue":"5","key":"10.1016\/j.ejphar.2024.176996_bib23","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1007\/s13555-023-00920-4","article-title":"Emerging systemic treatments for atopic dermatitis","volume":"13","author":"Ferrucci","year":"2023","journal-title":"Dermatol. Ther."},{"key":"10.1016\/j.ejphar.2024.176996_bib24","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.bbrc.2023.05.088","article-title":"Three-dimensional culture conditioned bone marrow MSC secretome accelerates wound healing in a burn injury mouse model","volume":"673","author":"Gangadaran","year":"2023","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.ejphar.2024.176996_bib25","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s11658-022-00325-9","article-title":"Interleukin-10 genetically modified clinical-grade mesenchymal stromal cells markedly reinforced functional recovery after spinal cord injury via directing alternative activation of macrophages","volume":"27","author":"Gao","year":"2022","journal-title":"Cell. Mol. Biol. Lett."},{"issue":"3","key":"10.1016\/j.ejphar.2024.176996_bib26","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/cmi.2018.1","article-title":"MicroRNA-663 induces immune dysregulation by inhibiting TGF-\u03b21 production in bone marrow-derived mesenchymal stem cells in patients with systemic lupus erythematosus","volume":"16","author":"Geng","year":"2019","journal-title":"Cell. Mol. Immunol."},{"issue":"1","key":"10.1016\/j.ejphar.2024.176996_bib27","doi-asserted-by":"crossref","first-page":"302","DOI":"10.4049\/jimmunol.0902007","article-title":"Mesenchymal stem cells inhibit human Th17 cell differentiation and function and induce a T regulatory cell phenotype","volume":"185","author":"Ghannam","year":"2010","journal-title":"J. Immunol."},{"issue":"10","key":"10.1016\/j.ejphar.2024.176996_bib28","doi-asserted-by":"crossref","first-page":"2744","DOI":"10.1002\/stem.1755","article-title":"Mesenchymal stem cells differentially modulate effector CD8+ T cell subsets and exacerbate experimental autoimmune encephalomyelitis","volume":"32","author":"Glenn","year":"2014","journal-title":"Stem Cell."},{"issue":"3","key":"10.1016\/j.ejphar.2024.176996_bib29","doi-asserted-by":"crossref","first-page":"2696","DOI":"10.3390\/ijms24032696","article-title":"CD4 T-cell subsets and the pathophysiology of inflammatory bowel disease","volume":"24","author":"Gomez-Bris","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.ejphar.2024.176996_bib30","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1002\/art.24405","article-title":"Treatment of experimental arthritis by inducing immune tolerance with human adipose-derived mesenchymal stem cells","volume":"60","author":"Gonz\u00e1lez","year":"2009","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.ejphar.2024.176996_bib31","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.734040","article-title":"Tnfaip6 secreted by bone marrow\u2013derived mesenchymal stem cells attenuates TNBS-induced colitis by modulating follicular helper T cells and follicular regulatory T cells balance in mice","volume":"12","author":"Gu","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"14","key":"10.1016\/j.ejphar.2024.176996_bib32","doi-asserted-by":"crossref","first-page":"7447","DOI":"10.3390\/ijms22147447","article-title":"Mesenchymal stem cells therapies on fibrotic heart diseases","volume":"22","author":"Gubert","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2024.176996_bib33","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.coi.2017.08.008","article-title":"Atopic dermatitis and psoriasis: two different immune diseases or one spectrum?","volume":"48","author":"Guttman-Yassky","year":"2017","journal-title":"Curr. Opin. Immunol."},{"issue":"3","key":"10.1016\/j.ejphar.2024.176996_bib34","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1136\/jim-2019-001160","article-title":"Indoleamine 2,3-dioxgenase-transfected mesenchymal stem cells suppress heart allograft rejection by increasing the production and activity of dendritic cells and regulatory T cells","volume":"68","author":"He","year":"2020","journal-title":"J. Invest. Med."},{"key":"10.1016\/j.ejphar.2024.176996_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.109699","article-title":"Dysregulated balance in Th17\/Treg axis of pristane-induced lupus mouse model, are mesenchymal stem cells therapeutic?","volume":"117","author":"Hoseinzadeh","year":"2023","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.ejphar.2024.176996_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.111306","article-title":"Lupus mice derived mesenchymal stromal cells: beneficial or detrimental on SLE disease outcome","volume":"126","author":"Hosseini","year":"2024","journal-title":"Int. Immunopharm."},{"issue":"1","key":"10.1016\/j.ejphar.2024.176996_bib37","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1186\/s12967-023-04028-3","article-title":"Mesenchymal stem cells can prevent or promote the progression of colon cancer based on their timing of administration","volume":"21","author":"Hu","year":"2023","journal-title":"J. Transl. Med."},{"issue":"1","key":"10.1016\/j.ejphar.2024.176996_bib38","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-50258-2","article-title":"Embryonic-stem-cell-derived mesenchymal stem cells relieve experimental contact urticaria by regulating the functions of mast cells and T cells","volume":"13","author":"Hyun","year":"2023","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.ejphar.2024.176996_bib39","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12712","article-title":"Immune modulation by mesenchymal stem cells","volume":"53","author":"Jiang","year":"2019","journal-title":"Cell Prolif."},{"key":"10.1016\/j.ejphar.2024.176996_bib40","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1238647","article-title":"Platelet activation: a promoter for psoriasis and its comorbidity, cardiovascular disease","volume":"14","author":"Jiang","year":"2023","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.ejphar.2024.176996_bib41","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/s13287-021-02173-4","article-title":"Intrapancreatic MSC transplantation facilitates pancreatic islet regeneration","volume":"12","author":"Khatri","year":"2021","journal-title":"Stem Cell Res. Ther."},{"issue":"2","key":"10.1016\/j.ejphar.2024.176996_bib42","doi-asserted-by":"crossref","first-page":"e1022","DOI":"10.1002\/term.2423","article-title":"Tonsil-derived mesenchymal stem cells (T-MSCs) prevent Th17-mediated autoimmune response via regulation of the programmed death-1\/programmed death ligand-1 (PD-1\/PD-L1) pathway","volume":"12","author":"Kim","year":"2018","journal-title":"J Tissue Eng Regen Med"},{"issue":"1","key":"10.1016\/j.ejphar.2024.176996_bib43","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1186\/s13287-023-03599-8","article-title":"Mesenchymal stem cells lose the senescent phenotype under 3D cultivation","volume":"14","author":"Krasnova","year":"2023","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.ejphar.2024.176996_bib44","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s40364-019-0156-0","article-title":"Novel insights into MSC-EVs therapy for immune diseases","volume":"7","author":"Lai","year":"2019","journal-title":"Biomark. Res."},{"key":"10.1016\/j.ejphar.2024.176996_bib45","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.cellimm.2017.08.009","article-title":"Immunomodulatory mechanisms of mesenchymal stem cells and their therapeutic applications","volume":"326","author":"Lee","year":"2018","journal-title":"Cell. Immunol."},{"issue":"3","key":"10.1016\/j.ejphar.2024.176996_bib46","doi-asserted-by":"crossref","first-page":"730","DOI":"10.3390\/ijms19030730","article-title":"The balance of Th17 versus Treg cells in autoimmunity","volume":"19","author":"Lee","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2024.176996_bib47","article-title":"Mesenchymal stem cell therapy: hope for patients with systemic lupus erythematosus","volume":"12","author":"Li","year":"2021","journal-title":"Front. Immunol."},{"issue":"7","key":"10.1016\/j.ejphar.2024.176996_bib48","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1002\/stem.2638","article-title":"Human iPSC-MSC-derived xenografts modulate immune responses by inhibiting the cleavage of caspases","volume":"35","author":"Li","year":"2017","journal-title":"Stem Cell."},{"key":"10.1016\/j.ejphar.2024.176996_bib49","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/8459281","article-title":"Bone marrow mesenchymal stem cells decrease the expression of RANKL in collagen-induced arthritis rats via reducing the levels of IL-22","volume":"2019","author":"Li","year":"2019","journal-title":"J Immunol Res"},{"issue":"1","key":"10.1016\/j.ejphar.2024.176996_bib50","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1515\/biol-2021-0118","article-title":"TGF-\u03b21-overexpressing mesenchymal stem cells reciprocally regulate Th17\/Treg cells by regulating the expression of IFN-\u03b3","volume":"16","author":"Li","year":"2021","journal-title":"Open Life Sci."},{"issue":"1","key":"10.1016\/j.ejphar.2024.176996_bib51","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1186\/s13287-019-1384-9","article-title":"Intercellular adhesion molecule-1 enhances the therapeutic effects of MSCs in a dextran sulfate sodium-induced colitis models by promoting MSCs homing to murine colons and spleens","volume":"10","author":"Li","year":"2019","journal-title":"Stem Cell Res. Ther."},{"issue":"1","key":"10.1016\/j.ejphar.2024.176996_bib52","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1186\/s13287-022-02985-y","article-title":"Mesenchymal stem cells and their microenvironment","volume":"13","author":"Liu","year":"2022","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.ejphar.2024.176996_bib53","article-title":"Autoreactive lymphocytes in multiple sclerosis: pathogenesis and treatment target","volume":"13","author":"Liu","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejphar.2024.176996_bib54","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.intimp.2019.05.009","article-title":"Recent advances in the study of regulatory T cells in gastric cancer","volume":"73","author":"Liu","year":"2019","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.ejphar.2024.176996_bib55","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.804919","article-title":"Th17\/Treg imbalance in chronic obstructive pulmonary disease: clinical and experimental evidence","volume":"12","author":"Louren\u00e7o","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejphar.2024.176996_bib56","doi-asserted-by":"crossref","first-page":"798","DOI":"10.3389\/fimmu.2019.00798","article-title":"Mesenchymal stem cells improve rheumatoid arthritis progression by controlling memory T Cell response","volume":"10","author":"Luque-Campos","year":"2019","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.ejphar.2024.176996_bib57","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/scrt216","article-title":"Mesenchymal stem cells generate a CD4+CD25+Foxp3+ regulatory T cell population during the differentiation process of Th1 and Th17 cells","volume":"4","author":"Luz-Crawford","year":"2013","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.ejphar.2024.176996_bib58","doi-asserted-by":"crossref","first-page":"995","DOI":"10.3389\/fimmu.2018.00995","article-title":"Transcriptional control of Th9 cells: role of Foxo1 in interleukin-9 induction","volume":"9","author":"Malik","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejphar.2024.176996_bib59","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1222170","article-title":"Effect of antiviral and immunomodulatory treatment on a cytokine profile in patients with COVID-19","volume":"14","author":"Martonik","year":"2023","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.ejphar.2024.176996_bib60","doi-asserted-by":"crossref","DOI":"10.1002\/eji.202149675","article-title":"Targeting B cells and plasma cells in autoimmune diseases: from established treatments to novel therapeutic approaches","volume":"53","author":"Merino-Vico","year":"2023","journal-title":"Eur. J. Immunol."},{"issue":"31","key":"10.1016\/j.ejphar.2024.176996_bib61","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.aat5943","article-title":"Human \u201cTH9\u201d cells are a subpopulation of PPAR-\u03b3+ TH2 cells","volume":"4","author":"Micoss\u00e9","year":"2019","journal-title":"Sci Immunol"},{"issue":"10","key":"10.1016\/j.ejphar.2024.176996_bib62","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/nrd3794","article-title":"Targeting IL-17 and Th17 cells in chronic inflammation","volume":"11","author":"Miossec","year":"2012","journal-title":"Nat. Rev. Drug Discov."},{"issue":"10","key":"10.1016\/j.ejphar.2024.176996_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2023.103410","article-title":"Immune-mediated inflammatory diseases: common and different pathogenic and clinical features","volume":"22","author":"Monteleone","year":"2023","journal-title":"Autoimmun. Rev."},{"issue":"10","key":"10.1016\/j.ejphar.2024.176996_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2020.102647","article-title":"The role of Th17 cells in multiple sclerosis: therapeutic implications","volume":"19","author":"Moser","year":"2020","journal-title":"Autoimmun. Rev."},{"issue":"1","key":"10.1016\/j.ejphar.2024.176996_bib65","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1080\/08916934.2019.1693545","article-title":"Th1, Th2, and Th17 cytokines in systemic lupus erythematosus","volume":"53","author":"Muhammad Yusoff","year":"2020","journal-title":"Autoimmunity"},{"issue":"3","key":"10.1016\/j.ejphar.2024.176996_bib66","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s00011-018-1205-0","article-title":"Immunological modulation following bone marrow-derived mesenchymal stromal cells and Th17 lymphocyte co-cultures","volume":"68","author":"Najar","year":"2019","journal-title":"Inflamm. Res."},{"issue":"11","key":"10.1016\/j.ejphar.2024.176996_bib67","doi-asserted-by":"crossref","first-page":"21145","DOI":"10.1002\/jcp.28717","article-title":"Th17 immune response to adipose tissue\u2010derived mesenchymal stromal cells","volume":"234","author":"Najar","year":"2019","journal-title":"J. Cell. Physiol."},{"issue":"10","key":"10.1016\/j.ejphar.2024.176996_bib68","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.3390\/pharmaceutics13101736","article-title":"In vitro cellular and molecular interplay between human foreskin-derived mesenchymal stromal\/stem cells and the Th17 cell pathway","volume":"13","author":"Najar","year":"2021","journal-title":"Pharmaceutics"},{"issue":"2","key":"10.1016\/j.ejphar.2024.176996_bib69","doi-asserted-by":"crossref","first-page":"169","DOI":"10.3390\/cells13020169","article-title":"Umbilical cord mesenchymal stromal\/stem cells and their interplay with Th-17 cell response pathway","volume":"13","author":"Najar","year":"2024","journal-title":"Cells"},{"issue":"17","key":"10.1016\/j.ejphar.2024.176996_bib70","doi-asserted-by":"crossref","first-page":"3323","DOI":"10.1007\/s00018-019-03125-1","article-title":"Biological functions of mesenchymal stem cells and clinical implications","volume":"76","author":"Naji","year":"2019","journal-title":"Cell. Mol. Life Sci."},{"issue":"15","key":"10.1016\/j.ejphar.2024.176996_bib71","doi-asserted-by":"crossref","first-page":"7785","DOI":"10.3390\/ijms22157785","article-title":"Mechanisms governing anaphylaxis: inflammatory cells, mediators, endothelial gap junctions and beyond","volume":"22","author":"Nguyen","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.ejphar.2024.176996_bib72","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1097\/JCMA.0000000000000202","article-title":"The expression of Th9 and Th22 cells in rats with cerebral palsy after Huc-MSC transplantation","volume":"83","author":"Niu","year":"2020","journal-title":"J. Chin. Med. Assoc."},{"issue":"5","key":"10.1016\/j.ejphar.2024.176996_bib73","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1080\/08923973.2022.2082977","article-title":"Investigation of the effect of IFN-\u03b3\/TNF-\u03b1-treated mesenchymal stem cells on Th9- and Treg cell-related parameters in a mouse model of ovalbumin-induced allergic asthma","volume":"44","author":"Nozari","year":"2022","journal-title":"Immunopharmacol. Immunotoxicol."},{"issue":"12","key":"10.1016\/j.ejphar.2024.176996_bib74","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2023.108483","article-title":"Amniotic MSC affect CD8 naive polarization toward SLEC\/MPEC subsets by down-modulating IL-12R\u03b21 and IL-2R\u03b1 signaling pathways","volume":"26","author":"Papait","year":"2023","journal-title":"iScience"},{"issue":"7","key":"10.1016\/j.ejphar.2024.176996_bib75","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1002\/eji.202149497","article-title":"Mesenchymal stromal cells\u2010derived small extracellular vesicles modulate DC function to suppress Th2 responses via IL\u201010 in patients with allergic rhinitis","volume":"52","author":"Peng","year":"2022","journal-title":"Eur. J. Immunol."},{"issue":"21","key":"10.1016\/j.ejphar.2024.176996_bib76","doi-asserted-by":"crossref","first-page":"7593","DOI":"10.3390\/molecules27217593","article-title":"Hydrolyzable tannins in the management of Th1, Th2 and Th17 inflammatory-related diseases","volume":"27","author":"Piazza","year":"2022","journal-title":"Molecules"},{"issue":"4","key":"10.1016\/j.ejphar.2024.176996_bib77","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2018.10.033","article-title":"Mesenchymal stem cells to treat type 1 diabetes","volume":"1866","author":"Pixley","year":"2020","journal-title":"Biochim. Biophys. Acta, Mol. Basis Dis."},{"key":"10.1016\/j.ejphar.2024.176996_bib78","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1178792","article-title":"T follicular helper cells and T follicular regulatory cells in autoimmune diseases","volume":"14","author":"Qi","year":"2023","journal-title":"Front. Immunol."},{"issue":"11","key":"10.1016\/j.ejphar.2024.176996_bib79","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1038\/s41577-021-00537-8","article-title":"CD8+ T cell metabolism in infection and cancer","volume":"21","author":"Reina-Campos","year":"2021","journal-title":"Nat. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.ejphar.2024.176996_bib80","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.arcmed.2020.08.006","article-title":"Mesenchymal stem cells current clinical applications: a systematic review","volume":"52","author":"Rodr\u00edguez-Fuentes","year":"2021","journal-title":"Arch. Med. Res."},{"key":"10.1016\/j.ejphar.2024.176996_bib81","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.3389\/fimmu.2020.01027","article-title":"T cell metabolism: a new perspective on Th17\/Treg cell imbalance in systemic lupus erythematosus","volume":"11","author":"Shan","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejphar.2024.176996_bib82","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115976","article-title":"Polysaccharides regulate Th1\/Th2 balance: a new strategy for tumor immunotherapy","volume":"170","author":"Shang","year":"2024","journal-title":"Biomed. Pharmacother."},{"issue":"6","key":"10.1016\/j.ejphar.2024.176996_bib83","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.14336\/AD.2022.0314","article-title":"CD4+ CTLs act as a key effector population for allograft rejection of MSCs in a donor MHC-II dependent manner in injured liver","volume":"13","author":"Shen","year":"2022","journal-title":"Aging Dis"},{"issue":"1","key":"10.1016\/j.ejphar.2024.176996_bib84","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1186\/s13287-018-1023-x","article-title":"Mesenchymal stem cell transplantation ameliorates Sj\u00f6gren\u2019s syndrome via suppressing IL-12 production by dendritic cells","volume":"9","author":"Shi","year":"2018","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.ejphar.2024.176996_bib85","article-title":"Th17 cells and inflammation in neurological disorders: possible mechanisms of action","volume":"13","author":"Shi","year":"2022","journal-title":"Front. Immunol."},{"issue":"22","key":"10.1016\/j.ejphar.2024.176996_bib86","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232214349","article-title":"Regulatory T-cell enhancement, expression of adhesion molecules, and production of anti-inflammatory factors are differentially modulated by spheroid-cultured mesenchymal stem cells","volume":"23","author":"Silva-Carvalho","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"9","key":"10.1016\/j.ejphar.2024.176996_bib87","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.it.2023.07.005","article-title":"Factors contributing to the potency of CD8+ T cells","volume":"44","author":"Sykulev","year":"2023","journal-title":"Trends Immunol."},{"issue":"1","key":"10.1016\/j.ejphar.2024.176996_bib88","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1186\/s13287-019-1300-3","article-title":"Mechanisms utilized by feline adipose-derived mesenchymal stem cells to inhibit T lymphocyte proliferation","volume":"10","author":"Taechangam","year":"2019","journal-title":"Stem Cell Res. Ther."},{"issue":"1","key":"10.1016\/j.ejphar.2024.176996_bib89","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1186\/s13287-021-02558-5","article-title":"Feline adipose-derived mesenchymal stem cells induce effector phenotype and enhance cytolytic function of CD8+ T cells","volume":"12","author":"Taechangam","year":"2021","journal-title":"Stem Cell Res. Ther."},{"issue":"1","key":"10.1016\/j.ejphar.2024.176996_bib90","doi-asserted-by":"crossref","first-page":"2406","DOI":"10.1038\/s41598-021-81916-y","article-title":"Human amnion-derived mesenchymal stem cells attenuate xenogeneic graft-versus-host disease by preventing T cell activation and proliferation","volume":"11","author":"Tago","year":"2021","journal-title":"Sci. Rep."},{"issue":"7","key":"10.1016\/j.ejphar.2024.176996_bib91","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.3390\/cells9071660","article-title":"Mechanisms behind the immunoregulatory dialogue between mesenchymal stem cells and Th17 Cells","volume":"9","author":"Terraza-Aguirre","year":"2020","journal-title":"Cells"},{"issue":"5","key":"10.1016\/j.ejphar.2024.176996_bib92","doi-asserted-by":"crossref","first-page":"4865","DOI":"10.3390\/ijms24054865","article-title":"Th17\/Treg imbalance: implications in lung inflammatory diseases","volume":"24","author":"Thomas","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.ejphar.2024.176996_bib93","doi-asserted-by":"crossref","first-page":"54","DOI":"10.3390\/cells10010054","article-title":"Role of human mesenchymal stem cells in regenerative therapy","volume":"10","author":"Vasanthan","year":"2020","journal-title":"Cells"},{"issue":"5","key":"10.1016\/j.ejphar.2024.176996_bib94","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1007\/s00296-019-04296-7","article-title":"Secretory factors produced by adipose mesenchymal stem cells downregulate Th17 and increase Treg cells in peripheral blood mononuclear cells from rheumatoid arthritis patients","volume":"39","author":"Vasilev","year":"2019","journal-title":"Rheumatol. Int."},{"key":"10.1016\/j.ejphar.2024.176996_bib95","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.3389\/fimmu.2018.01139","article-title":"A decade of Th9 cells: role of Th9 cells in inflammatory bowel disease","volume":"9","author":"Vyas","year":"2018","journal-title":"Front. Immunol."},{"issue":"7","key":"10.1016\/j.ejphar.2024.176996_bib96","doi-asserted-by":"crossref","first-page":"4212","DOI":"10.1111\/jcmm.15081","article-title":"Different culture method changing CD105 expression in amniotic fluid MSCs without affecting differentiation ability or immune function","volume":"24","author":"Wang","year":"2020","journal-title":"J. Cell Mol. Med."},{"issue":"6","key":"10.1016\/j.ejphar.2024.176996_bib97","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1002\/stem.2795","article-title":"Differentiation of mesenchymal stem cells from human induced pluripotent stem cells results in downregulation of c-Myc and DNA replication pathways with immunomodulation toward CD4 and CD8 cells","volume":"36","author":"Wang","year":"2018","journal-title":"Stem Cell."},{"key":"10.1016\/j.ejphar.2024.176996_bib98","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.840610","article-title":"T cell metabolism in infection","volume":"13","author":"Wik","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejphar.2024.176996_bib99","author":"Wu"},{"issue":"5","key":"10.1016\/j.ejphar.2024.176996_bib100","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1080\/08923973.2022.2077755","article-title":"IL-27 overexpression alleviates inflammatory response in allergic asthma by inhibiting Th9 differentiation and regulating Th1\/Th2 balance","volume":"44","author":"Xiong","year":"2022","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"10.1016\/j.ejphar.2024.176996_bib101","article-title":"Mesenchymal stem cell-secreted TGF-\u03b21 restores Treg\/Th17 skewing induced by lipopolysaccharide and hypoxia challenge via miR-155 suppression","volume":"2022","author":"Xue","year":"2022","journal-title":"Stem Cell. Int."},{"key":"10.1016\/j.ejphar.2024.176996_bib102","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/8813558","article-title":"The function and role of the Th17\/Treg cell balance in inflammatory bowel disease","volume":"2020","author":"Yan","year":"2020","journal-title":"J Immunol Res"},{"issue":"1","key":"10.1016\/j.ejphar.2024.176996_bib103","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.yexcr.2014.03.013","article-title":"Immunomodulation of mesenchymal stromal cells on regulatory T cells and its possible mechanism","volume":"324","author":"Yan","year":"2014","journal-title":"Exp. Cell Res."},{"issue":"1","key":"10.1016\/j.ejphar.2024.176996_bib104","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1177\/0961203317711013","article-title":"Bone marrow-derived mesenchymal stem cells inhibit T follicular helper cell in lupus-prone mice","volume":"27","author":"Yang","year":"2018","journal-title":"Lupus"},{"issue":"3","key":"10.1016\/j.ejphar.2024.176996_bib105","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s00281-019-00733-8","article-title":"The pathogenicity of Th17 cells in autoimmune diseases","volume":"41","author":"Yasuda","year":"2019","journal-title":"Semin. Immunopathol."},{"issue":"1","key":"10.1016\/j.ejphar.2024.176996_bib106","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s13287-022-02735-0","article-title":"Osteogenic differentiation of mesenchymal stem cells promotes c-Jun-dependent secretion of interleukin 8 and mediates the migration and differentiation of CD4+ T cells","volume":"13","author":"Ye","year":"2022","journal-title":"Stem Cell Res. Ther."},{"issue":"1","key":"10.1016\/j.ejphar.2024.176996_bib107","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1186\/s13287-021-02176-1","article-title":"Human fetal liver MSCs are more effective than adult bone marrow MSCs for their immunosuppressive, immunomodulatory, and Foxp3+ T reg induction capacity","volume":"12","author":"Yu","year":"2021","journal-title":"Stem Cell Res. Ther."},{"issue":"1","key":"10.1016\/j.ejphar.2024.176996_bib108","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/s41368-021-00150-4","article-title":"Exosomes derived from 3D-cultured MSCs improve therapeutic effects in periodontitis and experimental colitis and restore the Th17 cell\/Treg balance in inflamed periodontium","volume":"13","author":"Zhang","year":"2021","journal-title":"Int. J. Oral Sci."},{"issue":"1","key":"10.1016\/j.ejphar.2024.176996_bib109","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1186\/s13287-019-1287-9","article-title":"The role of mesenchymal stem cells in hematopoietic stem cell transplantation: prevention and treatment of graft-versus-host disease","volume":"10","author":"Zhao","year":"2019","journal-title":"Stem Cell Res. Ther."},{"issue":"21","key":"10.1016\/j.ejphar.2024.176996_bib110","doi-asserted-by":"crossref","first-page":"8011","DOI":"10.3390\/ijms21218011","article-title":"CD4 T helper cell subsets and related human immunological disorders","volume":"21","author":"Zhu","year":"2020","journal-title":"Int. J. Mol. Sci."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299924006861?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299924006861?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T20:07:08Z","timestamp":1777406828000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299924006861"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":110,"alternative-id":["S0014299924006861"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2024.176996","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mesenchymal stem cells alleviate inflammatory responses through regulation of T-cell subsets","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2024.176996","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"176996"}}