{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T18:32:43Z","timestamp":1792607563490,"version":"4.5.0"},"reference-count":162,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T00:00:00Z","timestamp":1728432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023561","name":"Government of Spain Ministry of Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100023561","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.ejphar.2024.177052","type":"journal-article","created":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T01:58:48Z","timestamp":1728525528000},"page":"177052","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["P2X3 and P2X2\/3 receptors inhibition produces a consistent analgesic efficacy: A systematic review and meta-analysis of preclinical studies"],"prefix":"10.1016","volume":"984","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2842-0085","authenticated-orcid":false,"given":"Miguel \u00c1.","family":"Huerta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7223-527X","authenticated-orcid":false,"given":"Daniel","family":"Marcos-Frutos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1239-7960","authenticated-orcid":false,"given":"Javier de la","family":"Nava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0608-8755","authenticated-orcid":false,"given":"Amador","family":"Garc\u00eda-Ramos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9323-7626","authenticated-orcid":false,"given":"Miguel \u00c1ngel","family":"Tejada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5757-9066","authenticated-orcid":false,"given":"Carolina","family":"Roza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2024.177052_bib1","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/0163-7258(94)00048-4","article-title":"Purinoceptors: are there families of P2X and P2Y purinoceptors?","volume":"64","author":"Abbracchio","year":"1994","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.ejphar.2024.177052_bib2","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20010155","article-title":"Overexpression of P2X3 and P2X7 receptors and TRPV1 channels in adrenomedullary chromaffin cells in a rat model of neuropathic pain","volume":"20","author":"Arribas-Bl\u00e1zquez","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2024.177052_bib3","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27041337","article-title":"Synthesis and structure-activity relationship studies of benzimidazole-4,7-dione-based P2X3 receptor antagonists as novel anti-nociceptive agents","volume":"27","author":"Bae","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.ejphar.2024.177052_bib4","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1111\/j.1476-5381.2011.01322.x","article-title":"Characterization of three diaminopyrimidines as potent and selective antagonists of P2X3 and P2X2\/3 receptors with in vivo efficacy in a pain model","volume":"163","author":"Ballini","year":"2011","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2024.177052_bib5","doi-asserted-by":"crossref","first-page":"8139","DOI":"10.1523\/JNEUROSCI.22-18-08139.2002","article-title":"Functional downregulation of P2X3 receptor subunit in rat sensory neurons reveals a significant role in chronic neuropathic and inflammatory pain","volume":"22","author":"Barclay","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2024.177052_bib6","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.cell.2009.09.028","article-title":"Cellular and molecular mechanisms of pain","volume":"139","author":"Basbaum","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.ejphar.2024.177052_bib7","unstructured":"Bayer will discontinue phase II development candidate eliapixant [WWW Document], n.d. URL https:\/\/www.bayer.com\/media\/en-us\/bayer-will-discontinue-phase-ii-development-candidate-eliapixant (accessed 12.24.23)."},{"key":"10.1016\/j.ejphar.2024.177052_bib8","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1111\/bph.13957","article-title":"P2X receptor channels in chronic pain pathways","volume":"175","author":"Bernier","year":"2018","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2024.177052_bib9","first-page":"716","article-title":"Homomeric and heteromeric P2X3 receptors in peripheral sensory neurons","volume":"9","author":"Brederson","year":"2008","journal-title":"Curr Opin Investig Drugs"},{"key":"10.1016\/j.ejphar.2024.177052_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.ynpai.2020.100047","article-title":"The naked mole-rat has a functional purinergic pain pathway despite having a non-functional peptidergic pain pathway","volume":"8","author":"Browe","year":"2020","journal-title":"Neurobiol Pain"},{"key":"10.1016\/j.ejphar.2024.177052_bib11","doi-asserted-by":"crossref","DOI":"10.1177\/2398212818817494","article-title":"Purine and purinergic receptors","volume":"2","author":"Burnstock","year":"2018","journal-title":"Brain Neurosci Adv"},{"key":"10.1016\/j.ejphar.2024.177052_bib12","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/1744-8069-5-69","article-title":"Purinergic mechanosensory transduction and visceral pain","volume":"5","author":"Burnstock","year":"2009","journal-title":"Mol. Pain"},{"key":"10.1016\/j.ejphar.2024.177052_bib13","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/S0165-6147(00)01643-6","article-title":"Purine-mediated signalling in pain and visceral perception","volume":"22","author":"Burnstock","year":"2001","journal-title":"Trends Pharmacol. Sci."},{"issue":"Pt 3","key":"10.1016\/j.ejphar.2024.177052_bib14","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1046\/j.1469-7580.1999.19430335.x","article-title":"Release of vasoactive substances from endothelial cells by shear stress and purinergic mechanosensory transduction","volume":"194","author":"Burnstock","year":"1999","journal-title":"J. Anat."},{"key":"10.1016\/j.ejphar.2024.177052_bib15","article-title":"Purinergic nerves","volume":"24","author":"Burnstock","year":"1972","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.ejphar.2024.177052_bib16","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.1016\/j.bmcl.2012.01.124","article-title":"Discovery of P2X3 selective antagonists for the treatment of chronic pain","volume":"22","author":"Cantin","year":"2012","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejphar.2024.177052_bib17","doi-asserted-by":"crossref","first-page":"9075","DOI":"10.1073\/pnas.0901507106","article-title":"Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli","volume":"106","author":"Cavanaugh","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ejphar.2024.177052_bib18","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1097\/WNR.0b013e32801231bf","article-title":"The same dorsal root ganglion neurons innervate uterus and colon in the rat","volume":"18","author":"Chaban","year":"2007","journal-title":"Neuroreport"},{"key":"10.1016\/j.ejphar.2024.177052_bib19","first-page":"553","article-title":"P2X receptors and nociception","volume":"53","author":"Chizh","year":"2001","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.ejphar.2024.177052_bib20","doi-asserted-by":"crossref","first-page":"560","DOI":"10.2174\/1570159X113119990041","article-title":"\u201cBedside-to-Bench\u201d behavioral outcomes in animal models of pain: beyond the evaluation of reflexes","volume":"11","author":"Cobos","year":"2013","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.ejphar.2024.177052_bib21","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/j.celrep.2018.01.006","article-title":"Mechanistic differences in neuropathic pain modalities revealed by correlating behavior with global expression profiling","volume":"22","author":"Cobos","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.ejphar.2024.177052_bib22","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1113\/jphysiol.2005.088435","article-title":"P2X2 knockout mice and P2X2\/P2X3 double knockout mice reveal a role for the P2X2 receptor subunit in mediating multiple sensory effects of ATP","volume":"567","author":"Cockayne","year":"2005","journal-title":"J. Physiol."},{"key":"10.1016\/j.ejphar.2024.177052_bib23","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1038\/35039519","article-title":"Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X3-deficient mice","volume":"407","author":"Cockayne","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2024.177052_bib24","first-page":"ED000142","article-title":"Updated guidance for trusted systematic reviews: a new edition of the Cochrane Handbook for Systematic Reviews of Interventions","volume":"10","author":"Cumpston","year":"2019","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.ejphar.2024.177052_bib25","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-99177-0","article-title":"Eliapixant is a selective P2X3 receptor antagonist for the treatment of disorders associated with hypersensitive nerve fibers","volume":"11","author":"Davenport","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejphar.2024.177052_bib26","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s11302-019-09659-0","article-title":"P2X3 receptors contribute to muscle pain induced by static contraction by a mechanism dependent on neutrophil migration","volume":"15","author":"de Melo Aquino","year":"2019","journal-title":"Purinergic Signal."},{"key":"10.1016\/j.ejphar.2024.177052_bib27","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.ejphar.2010.09.037","article-title":"P2X3 and P2X2\/3 receptors mediate mechanical hyperalgesia induced by bradykinin, but not by pro-inflammatory cytokines, PGE\u2082 or dopamine","volume":"649","author":"de Oliveira Fusaro","year":"2010","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2024.177052_bib28","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0123810","article-title":"P2X3 receptors mediate visceral hypersensitivity during acute chemically-induced colitis and in the post-inflammatory phase via different mechanisms of sensitization","volume":"10","author":"Deiteren","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2024.177052_bib29","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13461","article-title":"Bone marrow-derived mesenchymal stem cells attenuate complete Freund's adjuvant-induced inflammatory pain by inhibiting the expression of P2X3","volume":"56","author":"Deng","year":"2023","journal-title":"Cell Prolif."},{"key":"10.1016\/j.ejphar.2024.177052_bib30","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2017.00284","article-title":"Methods used to evaluate pain behaviors in rodents","volume":"10","author":"Deuis","year":"2017","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.ejphar.2024.177052_bib31","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/6656863","article-title":"Pharmacotherapeutic options for managing neuropathic pain: a systematic review and meta-analysis","volume":"2021","author":"Di Stefano","year":"2021","journal-title":"Pain Res. Manag."},{"key":"10.1016\/j.ejphar.2024.177052_bib32","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0184647","article-title":"P2X3 receptor involvement in endometriosis pain via ERK signaling pathway","volume":"12","author":"Ding","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2024.177052_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113029","article-title":"Association between P2X3 receptors and neuropathic pain: as a potential therapeutic target for therapy","volume":"150","author":"Dong","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ejphar.2024.177052_bib34","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1124\/jpet.106.105890","article-title":"Painful purinergic receptors","volume":"324","author":"Donnelly-Roberts","year":"2008","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.ejphar.2024.177052_bib35","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gnh044","article-title":"siRNA relieves chronic neuropathic pain","volume":"32","author":"Dorn","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ejphar.2024.177052_bib36","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1111\/j.1526-4637.2009.00696.x","article-title":"Pain medicine position paper","volume":"10","author":"Dubois","year":"2009","journal-title":"Pain Med."},{"key":"10.1016\/j.ejphar.2024.177052_bib37","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple, graphical test","volume":"315","author":"Egger","year":"1997","journal-title":"BMJ"},{"key":"10.1016\/j.ejphar.2024.177052_bib38","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2015-010364","article-title":"Prevalence of chronic pain in the UK: a systematic review and meta-analysis of population studies","volume":"6","author":"Fayaz","year":"2016","journal-title":"BMJ Open"},{"key":"10.1016\/j.ejphar.2024.177052_bib39","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/s11302-020-09728-9","article-title":"Electroacupuncture alleviates diabetic neuropathic pain in rats by suppressing P2X3 receptor expression in dorsal root ganglia","volume":"16","author":"Fei","year":"2020","journal-title":"Purinergic Signal."},{"key":"10.1016\/j.ejphar.2024.177052_bib40","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.neuroscience.2016.01.005","article-title":"Mechanisms mediating nitroglycerin-induced delayed-onset hyperalgesia in the rat","volume":"317","author":"Ferrari","year":"2016","journal-title":"Neuroscience"},{"key":"10.1016\/j.ejphar.2024.177052_bib41","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1126\/science.1118435","article-title":"ATP signaling is crucial for communication from taste buds to gustatory nerves","volume":"310","author":"Finger","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2024.177052_bib42","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S1474-4422(14)70251-0","article-title":"Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis","volume":"14","author":"Finnerup","year":"2015","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.ejphar.2024.177052_bib43","doi-asserted-by":"crossref","DOI":"10.1007\/s11302-021-09831-5","article-title":"Selectivity of the P2X3 receptor antagonist Eliapixant, and its potential use in the treatment of endometriosis","volume":"18","author":"Fletcher","year":"2022","journal-title":"Purinergic Signal."},{"key":"10.1016\/j.ejphar.2024.177052_bib44","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s11302-011-9271-6","article-title":"In pursuit of P2X3 antagonists: novel therapeutics for chronic pain and afferent sensitization","volume":"8","author":"Ford","year":"2012","journal-title":"Purinergic Signal."},{"key":"10.1016\/j.ejphar.2024.177052_bib45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12931-023-02384-8","article-title":"The P2X3 receptor antagonist filapixant in patients with refractory chronic cough: a randomized controlled trial","volume":"24","author":"Friedrich","year":"2023","journal-title":"Respir. Res."},{"key":"10.1016\/j.ejphar.2024.177052_bib46","doi-asserted-by":"crossref","DOI":"10.1186\/1744-8069-2-19","article-title":"Inhibitory role of supraspinal P2X3\/P2X2\/3 subtypes on nociception in rats","volume":"2","author":"Fukui","year":"2006","journal-title":"Mol. Pain"},{"key":"10.1016\/j.ejphar.2024.177052_bib47","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.pupt.2019.03.007","article-title":"BLU-5937: a selective P2X3 antagonist with potent anti-tussive effect and no taste alteration","volume":"56","author":"Garceau","year":"2019","journal-title":"Pulm. Pharmacol. Ther."},{"key":"10.1016\/j.ejphar.2024.177052_bib48","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1111\/j.1476-5381.2010.00796.x","article-title":"AF-353, a novel, potent and orally bioavailable P2X3\/P2X2\/3 receptor antagonist","volume":"160","author":"Gever","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2024.177052_bib49","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s40265-022-01675-6","article-title":"Pharmacologic management of persistent pain in cancer survivors","volume":"82","author":"Glare","year":"2022","journal-title":"Drugs"},{"key":"10.1016\/j.ejphar.2024.177052_bib50","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.613068","article-title":"Intracolonic mustard oil induces visceral pain in mice by TRPA1-dependent and -independent mechanisms: role of tissue injury and P2X receptors","volume":"11","author":"Gonzalez-Cano","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejphar.2024.177052_bib51","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.neubiorev.2020.03.004","article-title":"The search for translational pain outcomes to refine analgesic development: where did we come from and where are we going?","volume":"113","author":"Gonz\u00e1lez-Cano","year":"2020","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.ejphar.2024.177052_bib52","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.neulet.2009.09.015","article-title":"Involvement of enkephalins in the inhibition of osteosarcoma-induced thermal hyperalgesia evoked by the blockade of peripheral P2X3 receptors","volume":"465","author":"Gonz\u00e1lez-Rodr\u00edguez","year":"2009","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ejphar.2024.177052_bib53","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.sjpain.2016.09.011","article-title":"Synergistic combinations of the dual enkephalinase inhibitor PL265 given orally with various analgesic compounds acting on different targets, in a murine model of cancer-induced bone pain","volume":"14","author":"Gonz\u00e1lez-Rodr\u00edguez","year":"2017","journal-title":"Scand J Pain"},{"key":"10.1016\/j.ejphar.2024.177052_bib54","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1002\/ana.21949","article-title":"Novel peptide from spider venom inhibits P2X3 receptors and inflammatory pain","volume":"67","author":"Grishin","year":"2010","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.ejphar.2024.177052_bib55","unstructured":"GSK reaches agreement to acquire late-stage biopharmaceutical company BELLUS Health | GSK [WWW Document], n.d. URL https:\/\/www.gsk.com\/en-gb\/media\/press-releases\/gsk-reaches-agreement-to-acquire-late-stage-biopharmaceutical-company-bellus-health\/#_BRA1 (accessed 12.24.23)."},{"key":"10.1016\/j.ejphar.2024.177052_bib56","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.bone.2018.02.006","article-title":"Antagonists to TRPV1, ASICs and P2X have a potential role to prevent the triggering of regional bone metabolic disorder and pain-like behavior in tail-suspended mice","volume":"110","author":"Hanaka","year":"2018","journal-title":"Bone"},{"key":"10.1016\/j.ejphar.2024.177052_bib57","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.ejphar.2012.05.008","article-title":"Chronic administration of the selective P2X3, P2X2\/3 receptor antagonist, A-317491, transiently attenuates cancer-induced bone pain in mice","volume":"688","author":"Hansen","year":"2012","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2024.177052_bib58","author":"Harrer"},{"key":"10.1016\/j.ejphar.2024.177052_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2020.113482","article-title":"Wnt5b\/Ryk-mediated membrane trafficking of P2X3 receptors contributes to bone cancer pain","volume":"334","author":"He","year":"2020","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.ejphar.2024.177052_bib60","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"Higgins","year":"2003","journal-title":"BMJ"},{"key":"10.1016\/j.ejphar.2024.177052_bib61","doi-asserted-by":"crossref","DOI":"10.1183\/23120541.00007-2023","article-title":"Variability in P2X receptor composition in human taste nerves: implications for treatment of chronic cough","volume":"9","author":"High","year":"2023","journal-title":"ERJ Open Res"},{"key":"10.1016\/j.ejphar.2024.177052_bib62","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0304-3959(01)00469-9","article-title":"ATP responses in human C nociceptors","volume":"98","author":"Hilliges","year":"2002","journal-title":"Pain"},{"key":"10.1016\/j.ejphar.2024.177052_bib63","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.pain.2004.03.043","article-title":"Acidic pH and capsaicin activate mechanosensitive group IV muscle receptors in the rat","volume":"110","author":"Hoheisel","year":"2004","journal-title":"Pain"},{"key":"10.1016\/j.ejphar.2024.177052_bib64","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0304-3959(02)00032-5","article-title":"Analgesic profile of intrathecal P2X3 antisense oligonucleotide treatment in chronic inflammatory and neuropathic pain states in rats","volume":"99","author":"Honore","year":"2002","journal-title":"Pain"},{"key":"10.1016\/j.ejphar.2024.177052_bib65","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2288-14-43","article-title":"SYRCLE's risk of bias tool for animal studies","volume":"14","author":"Hooijmans","year":"2014","journal-title":"BMC Med. Res. Methodol."},{"key":"10.1016\/j.ejphar.2024.177052_bib66","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.pain.2010.03.005","article-title":"Upregulations of P2X(3) and ASIC3 involve in hyperalgesia induced by cisplatin administration in rats","volume":"149","author":"Hori","year":"2010","journal-title":"Pain"},{"key":"10.1016\/j.ejphar.2024.177052_bib67","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.expneurol.2012.02.013","article-title":"P2X3-mediated peripheral sensitization of neuropathic pain in resiniferatoxin-induced neuropathy","volume":"235","author":"Hsieh","year":"2012","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.ejphar.2024.177052_bib68","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.brainresbull.2022.07.006","article-title":"P2X7 receptor in inflammation and pain","volume":"187","author":"Hua","year":"2022","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.ejphar.2024.177052_bib69","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241612987","article-title":"Investigational drugs for the treatment of postherpetic neuralgia: systematic review of randomized controlled trials","volume":"24","author":"Huerta","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2024.177052_bib70","doi-asserted-by":"crossref","DOI":"10.1016\/j.neubiorev.2024.105761","article-title":"Strategies for measuring non-evoked pain in preclinical models of neuropathic pain: systematic review","volume":"163","author":"Huerta","year":"2024","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.ejphar.2024.177052_bib71","doi-asserted-by":"crossref","first-page":"316","DOI":"10.3390\/md21050316","article-title":"Efficacy and security of tetrodotoxin in the treatment of cancer-related pain: systematic review and meta-analysis","volume":"21","author":"Huerta","year":"2023","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.ejphar.2024.177052_bib72","doi-asserted-by":"crossref","first-page":"17179","DOI":"10.1073\/pnas.252537299","article-title":"A-317491, a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2\/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat","volume":"99","author":"Jarvis","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ejphar.2024.177052_bib73","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2020.108356","article-title":"Potentiation of P2X3 receptor mediated currents by endothelin-1 in rat dorsal root ganglion neurons","volume":"181","author":"Jin","year":"2020","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ejphar.2024.177052_bib74","doi-asserted-by":"crossref","first-page":"2841","DOI":"10.2147\/JIR.S315774","article-title":"Acute P38-mediated enhancement of P2X3 receptor currents by TNF-\u03b1 in rat dorsal root ganglion neurons","volume":"14","author":"Jin","year":"2021","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.ejphar.2024.177052_bib75","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1016\/j.jpain.2010.07.002","article-title":"The prevalence of chronic pain in United States adults: results of an Internet-based survey","volume":"11","author":"Johannes","year":"2010","journal-title":"J. Pain"},{"key":"10.1016\/j.ejphar.2024.177052_bib76","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s11302-020-09718-x","article-title":"P2X3 receptors contribute to transition from acute to chronic muscle pain","volume":"16","author":"Jorge","year":"2020","journal-title":"Purinergic Signal."},{"key":"10.1016\/j.ejphar.2024.177052_bib77","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1213\/ANE.0000000000001883","article-title":"Isobolographic analysis of drug combinations with intrathecal BRL52537 (\u03ba-opioid agonist), pregabalin (calcium channel modulator), AF 353 (P2X3 receptor antagonist), and A804598 (P2X7 receptor antagonist) in neuropathic rats","volume":"125","author":"Jung","year":"2017","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.ejphar.2024.177052_bib78","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.1093\/brain\/awq194","article-title":"Systemic blockade of P2X3 and P2X2\/3 receptors attenuates bone cancer pain behaviour in rats","volume":"133","author":"Kaan","year":"2010","journal-title":"Brain"},{"key":"10.1016\/j.ejphar.2024.177052_bib79","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.ejphar.2008.05.011","article-title":"Minodronic acid, a third-generation bisphosphonate, antagonizes purinergic P2X(2\/3) receptor function and exerts an analgesic effect in pain models","volume":"589","author":"Kakimoto","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2024.177052_bib80","doi-asserted-by":"crossref","first-page":"E6297","DOI":"10.1073\/pnas.1704847114","article-title":"Identification of a vesicular ATP release inhibitor for the treatment of neuropathic and inflammatory pain","volume":"114","author":"Kato","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ejphar.2024.177052_bib81","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1177\/1073858404274063","article-title":"P2X receptors: targets for novel analgesics?","volume":"11","author":"Kennedy","year":"2005","journal-title":"Neuroscientist"},{"key":"10.1016\/j.ejphar.2024.177052_bib82","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.neuroscience.2008.02.031","article-title":"Pharmacological characterization and gene expression profiling of an L5\/L6 spinal nerve ligation model for neuropathic pain in mice","volume":"153","author":"Kiso","year":"2008","journal-title":"Neuroscience"},{"key":"10.1016\/j.ejphar.2024.177052_bib83","doi-asserted-by":"crossref","first-page":"530","DOI":"10.3325\/cmj.2016.57.530","article-title":"The role of P2X3 receptors in bilateral masseter muscle allodynia in rats","volume":"57","author":"Kne\u017eevi\u0107","year":"2016","journal-title":"Croat. Med. J."},{"key":"10.1016\/j.ejphar.2024.177052_bib84","doi-asserted-by":"crossref","DOI":"10.1186\/s10194-021-01244-4","article-title":"P2X3 receptor upregulation in trigeminal ganglion neurons through TNF\u03b1 production in macrophages contributes to trigeminal neuropathic pain in rats","volume":"22","author":"Koizumi","year":"2021","journal-title":"J. Headache Pain"},{"key":"10.1016\/j.ejphar.2024.177052_bib85","doi-asserted-by":"crossref","DOI":"10.1186\/s13287-021-02526-z","article-title":"Endometrial stem\/progenitor cells and their roles in immunity, clinical application, and endometriosis","volume":"12","author":"Kong","year":"2021","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.ejphar.2024.177052_bib86","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1007\/s13311-020-00934-2","article-title":"P2X3-Containing receptors as targets for the treatment of chronic pain","volume":"17","author":"Krajewski","year":"2020","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.ejphar.2024.177052_bib87","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.pbb.2013.09.017","article-title":"P2X3 receptors induced inflammatory nociception modulated by TRPA1, 5-HT3 and 5-HT1A receptors","volume":"112","author":"Krimon","year":"2013","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.ejphar.2024.177052_bib88","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.neuroscience.2009.05.069","article-title":"Involvement of prostaglandin F 2 alpha receptor in ATP-induced mechanical allodynia","volume":"163","author":"Kunori","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.ejphar.2024.177052_bib89","doi-asserted-by":"crossref","first-page":"310","DOI":"10.3109\/15360288.2012.736933","article-title":"Chronic diseases in the European union: the prevalence and health cost implications of chronic pain","volume":"26","author":"Leadley","year":"2012","journal-title":"J. Pain Palliat. Care Pharmacother."},{"key":"10.1016\/j.ejphar.2024.177052_bib90","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1038\/377432a0","article-title":"Coexpression of P2X2 and P2X3 receptor subunits can account for ATP-gated currents in sensory neurons","volume":"377","author":"Lewis","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2024.177052_bib91","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1097\/j.pain.0000000000001013","article-title":"Long noncoding RNA MRAK009713 is a novel regulator of neuropathic pain in rats","volume":"158","author":"Li","year":"2017","journal-title":"Pain"},{"key":"10.1016\/j.ejphar.2024.177052_bib92","doi-asserted-by":"crossref","DOI":"10.1152\/ajpheart.00395.2002","article-title":"ATP stimulates chemically sensitive and sensitizes mechanically sensitive afferents","volume":"283","author":"Li","year":"2002","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.ejphar.2024.177052_bib93","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.pbb.2014.10.007","article-title":"Antihyperalgesic effect of 5-HT7 receptor activation on the midbrain periaqueductal gray in a rat model of neuropathic pain","volume":"127","author":"Li","year":"2014","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.ejphar.2024.177052_bib94","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1016\/j.pain.2013.04.022","article-title":"Upregulation of P2X3 receptors by neuronal calcium sensor protein VILIP-1 in dorsal root ganglions contributes to the bone cancer pain in rats","volume":"154","author":"Liu","year":"2013","journal-title":"Pain"},{"key":"10.1016\/j.ejphar.2024.177052_bib95","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.neuroscience.2017.06.036","article-title":"Activation of P2X3 receptors in the cerebrospinal fluid-contacting nucleus neurons reduces formalin-induced pain behavior via PAG in a rat model","volume":"358","author":"Liu","year":"2017","journal-title":"Neuroscience"},{"key":"10.1016\/j.ejphar.2024.177052_bib96","doi-asserted-by":"crossref","DOI":"10.1186\/s12964-020-00621-x","article-title":"Molecular basis of carrageenan-induced cytokines production in macrophages","volume":"18","author":"Lopes","year":"2020","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.ejphar.2024.177052_bib97","first-page":"1","article-title":"Functional coupling of slack channels and P2X3 receptors contributes to neuropathic pain processing","volume":"22","author":"Lu","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2024.177052_bib98","doi-asserted-by":"crossref","DOI":"10.1016\/j.npep.2023.102355","article-title":"Role and therapeutic target of P2X2\/3 receptors in visceral pain","volume":"101","author":"Luo","year":"2023","journal-title":"Neuropeptides"},{"key":"10.1016\/j.ejphar.2024.177052_bib99","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s11302-010-9212-9","article-title":"Estrogen modulation of peripheral pain signal transduction: involvement of P2X(3) receptors","volume":"7","author":"Ma","year":"2011","journal-title":"Purinergic Signal."},{"key":"10.1016\/j.ejphar.2024.177052_bib100","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1515\/mr-2022-0007","article-title":"Spontaneous pain as a challenge of research and management in chronic pain","volume":"2","author":"Ma","year":"2022","journal-title":"Medical Review"},{"key":"10.1016\/j.ejphar.2024.177052_bib101","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1007\/s40265-022-01700-8","article-title":"Gefapixant: first approval","volume":"82","author":"Markham","year":"2022","journal-title":"Drugs"},{"key":"10.1016\/j.ejphar.2024.177052_bib102","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/sj.bjp.0706346","article-title":"Endogenous opioid mechanisms partially mediate P2X3\/P2X2\/3-related antinociception in rat models of inflammatory and chemogenic pain but not neuropathic pain","volume":"146","author":"McGaraughty","year":"2005","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2024.177052_bib103","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1038\/sj.bjp.0705574","article-title":"Effects of A-317491, a novel and selective P2X3\/P2X2\/3 receptor antagonist, on neuropathic, inflammatory and chemogenic nociception following intrathecal and intraplantar administration","volume":"140","author":"McGaraughty","year":"2003","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2024.177052_bib104","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s00408-022-00592-5","article-title":"A randomized, double-blind, placebo-controlled, parallel-group phase 2b trial of P2X3 receptor antagonist sivopixant for refractory or unexplained chronic cough","volume":"201","author":"McGarvey","year":"2023","journal-title":"Lung"},{"key":"10.1016\/j.ejphar.2024.177052_bib105","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/S0140-6736(21)02348-5","article-title":"Efficacy and safety of gefapixant, a P2X3 receptor antagonist, in refractory chronic cough and unexplained chronic cough (COUGH-1 and COUGH-2): results from two double-blind, randomised, parallel-group, placebo-controlled, phase 3 trials","volume":"399","author":"McGarvey","year":"2022","journal-title":"Lancet"},{"key":"10.1016\/j.ejphar.2024.177052_bib106","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1002\/jrsm.1411","article-title":"Risk-of-bias VISualization (robvis): an R package and Shiny web app for visualizing risk-of-bias assessments","volume":"12","author":"McGuinness","year":"2021","journal-title":"Res. Synth. Methods"},{"key":"10.1016\/j.ejphar.2024.177052_bib107","first-page":"17","article-title":"Functional anatomy of muscle: muscle, nociceptors and afferent fibers","author":"Mense","year":"2010","journal-title":"Muscle Pain: Understanding the Mechanisms"},{"key":"10.1016\/j.ejphar.2024.177052_bib108","first-page":"214","article-title":"Muscle pain: mechanisms and clinical significance","volume":"105","author":"Mense","year":"2008","journal-title":"Dtsch Arztebl Int"},{"key":"10.1016\/j.ejphar.2024.177052_bib109","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1007\/s40265-022-01780-6","article-title":"Cancer pain treatment strategies in patients with cancer","volume":"82","author":"Mercadante","year":"2022","journal-title":"Drugs"},{"key":"10.1016\/j.ejphar.2024.177052_bib110","doi-asserted-by":"crossref","DOI":"10.1186\/1744-8069-5-47","article-title":"Subtype-specific regulation of P2X3 and P2X2\/3 receptors by phosphoinositides in peripheral nociceptors","volume":"5","author":"Mo","year":"2009","journal-title":"Mol. Pain"},{"key":"10.1016\/j.ejphar.2024.177052_bib111","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/nrn2606","article-title":"Animal models of pain: progress and challenges","volume":"10","author":"Mogil","year":"2009","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.ejphar.2024.177052_bib112","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S1090-3801(02)00096-4","article-title":"Experimental muscle pain and tenderness following infusion of endogenous substances in humans","volume":"7","author":"M\u00f8rk","year":"2003","journal-title":"Eur. J. Pain"},{"key":"10.1016\/j.ejphar.2024.177052_bib113","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1007\/s11302-021-09813-7","article-title":"Recommended tool compounds and drugs for blocking P2X and P2Y receptors","volume":"17","author":"M\u00fcller","year":"2021","journal-title":"Purinergic Signal."},{"key":"10.1016\/j.ejphar.2024.177052_bib114","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00725-2021","article-title":"Randomised trial of the P2X3 receptor antagonist sivopixant for refractory chronic cough","volume":"59","author":"Niimi","year":"2022","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.ejphar.2024.177052_bib115","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1177\/0022034513483770","article-title":"Interaction of IL-1\u03b2 and P2X(3) receptor in pathologic masseter muscle pain","volume":"92","author":"Noma","year":"2013","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.ejphar.2024.177052_bib116","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1113\/jphysiol.2003.048587","article-title":"P2X3 receptors and peripheral pain mechanisms","volume":"554","author":"North","year":"2004","journal-title":"J. Physiol."},{"key":"10.1016\/j.ejphar.2024.177052_bib117","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2022.891759","article-title":"Piezo1-pannexin-1-P2X3 axis in odontoblasts and neurons mediates sensory transduction in dentinal sensitivity","volume":"13","author":"Ohyama","year":"2022","journal-title":"Front. Physiol."},{"key":"10.1016\/j.ejphar.2024.177052_bib118","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.pain.2008.10.024","article-title":"Peripheral mechanisms underlying the essential role of P2X3,2\/3 receptors in the development of inflammatory hyperalgesia","volume":"141","author":"Oliveira","year":"2009","journal-title":"Pain"},{"key":"10.1016\/j.ejphar.2024.177052_bib119","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"10.1016\/j.ejphar.2024.177052_bib120","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abj9954","article-title":"Acute inflammatory response via neutrophil activation protects against the development of chronic pain","volume":"14","author":"Parisien","year":"2022","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.ejphar.2024.177052_bib121","doi-asserted-by":"crossref","first-page":"4544","DOI":"10.1002\/sim.2889","article-title":"Performance of the trim and fill method in the presence of publication bias and between-study heterogeneity","volume":"26","author":"Peters","year":"2007","journal-title":"Stat. Med."},{"key":"10.1016\/j.ejphar.2024.177052_bib122","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.neuropharm.2012.11.011","article-title":"Neuronal P2X3 receptor activation is essential to the hyperalgesia induced by prostaglandins and sympathomimetic amines released during inflammation","volume":"67","author":"Prado","year":"2013","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ejphar.2024.177052_bib123","doi-asserted-by":"crossref","first-page":"51","DOI":"10.11607\/ofph.1459","article-title":"Upregulation of the purinergic receptor subtype P2X3 in the trigeminal ganglion is involved in orofacial pain induced by occlusal interference in rats","volume":"30","author":"Qi","year":"2016","journal-title":"J Oral Facial Pain Headache"},{"key":"10.1016\/j.ejphar.2024.177052_bib124","doi-asserted-by":"crossref","DOI":"10.1016\/j.pupt.2023.102252","article-title":"Safety and efficacy of P2X3 receptor antagonist for the treatment of refractory or unexplained chronic cough: a systematic review and meta-analysis of 11 randomized controlled trials","volume":"83","author":"Ramadan","year":"2023","journal-title":"Pulm. Pharmacol. Ther."},{"key":"10.1016\/j.ejphar.2024.177052_bib125","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1111\/bph.14677","article-title":"Action of MK-7264 (gefapixant) at human P2X3 and P2X2\/3 receptors and in vivo efficacy in models of sensitisation","volume":"176","author":"Richards","year":"2019","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2024.177052_bib126","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1038\/s41583-022-00611-7","article-title":"TRP channels: a journey towards a molecular understanding of pain","volume":"23","author":"Rosenbaum","year":"2022","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.ejphar.2024.177052_bib127","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1111\/bph.16003","article-title":"The sigma-1 receptor curtails endogenous opioid analgesia during sensitization of TRPV1 nociceptors","volume":"180","author":"Ruiz-Cantero","year":"2023","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2024.177052_bib128","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.neuroscience.2014.11.020","article-title":"Muscle hyperalgesia induced by peripheral P2X3 receptors is modulated by inflammatory mediators","volume":"285","author":"Schiavuzzo","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.ejphar.2024.177052_bib129","doi-asserted-by":"crossref","first-page":"11890","DOI":"10.1523\/JNEUROSCI.0698-12.2012","article-title":"Differential expression and pharmacology of native P2X receptors in rat and primate sensory neurons","volume":"32","author":"Serrano","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2024.177052_bib130","doi-asserted-by":"crossref","first-page":"12254","DOI":"10.1074\/jbc.M116.722330","article-title":"Modulation of P2X3 and P2X2\/3 receptors by monoclonal antibodies","volume":"291","author":"Shcherbatko","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2024.177052_bib131","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1517\/13543776.16.8.1113","article-title":"P2X receptor ligands and pain","volume":"16","author":"Shieh","year":"2006","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.ejphar.2024.177052_bib132","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1006\/jmcc.1994.1156","article-title":"Relationships between cytosolic [ATP], [ATP]\/[ADP] and ionic fluxes in the perfused rat heart: a 31P, 23Na and 87Rb NMR study","volume":"26","author":"Stewart","year":"1994","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.ejphar.2024.177052_bib133","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2022.108166","article-title":"Treatment of chronic cough: P2X3 receptor antagonists and beyond","volume":"237","author":"Sykes","year":"2022","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.ejphar.2024.177052_bib134","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abj8186","article-title":"Spatial transcriptomics of dorsal root ganglia identifies molecular signatures of human nociceptors","volume":"14","author":"Tavares-Ferreira","year":"2022","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.ejphar.2024.177052_bib135","doi-asserted-by":"crossref","first-page":"6174","DOI":"10.1007\/s12035-016-0146-2","article-title":"P2X3 and P2X2\/3 receptors play a crucial role in articular hyperalgesia development through inflammatory mechanisms in the knee joint experimental synovitis","volume":"54","author":"Teixeira","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.ejphar.2024.177052_bib136","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173054","article-title":"P2X3 and P2X2\/3 receptors activation induces articular hyperalgesia by an indirect sensitization of the primary afferent nociceptor in the rats' knee joint","volume":"879","author":"Teixeira","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2024.177052_bib137","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s11302-022-09861-7","article-title":"Analgesic effect of electroacupuncture on bone cancer pain in rat model: the role of peripheral P2X3 receptor","volume":"19","author":"Tian","year":"2023","journal-title":"Purinergic Signal."},{"key":"10.1016\/j.ejphar.2024.177052_bib138","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1007\/s11302-012-9306-7","article-title":"P2X4 purinoceptor signaling in chronic pain","volume":"8","author":"Trang","year":"2012","journal-title":"Purinergic Signal."},{"key":"10.1016\/j.ejphar.2024.177052_bib139","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms21228512","article-title":"Purinergic signaling in endometriosis-associated pain","volume":"21","author":"Trapero","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2024.177052_bib140","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.jneumeth.2013.09.010","article-title":"Meta-analysis of data from animal studies: a practical guide","volume":"221","author":"Vesterinen","year":"2014","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.ejphar.2024.177052_bib141","doi-asserted-by":"crossref","DOI":"10.1177\/1744806916637704","article-title":"Stable, synthetic analogs of diadenosine tetraphosphate inhibit rat and human P2X3 receptors and inflammatory pain","volume":"12","author":"Viatchenko-Karpinski","year":"2016","journal-title":"Mol. Pain"},{"key":"10.1016\/j.ejphar.2024.177052_bib142","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v036.i03","article-title":"Conducting meta-analyses in R with the metafor package","volume":"36","author":"Viechtbauer","year":"2010","journal-title":"J. Stat. Software"},{"key":"10.1016\/j.ejphar.2024.177052_bib143","doi-asserted-by":"crossref","first-page":"3470","DOI":"10.1046\/j.1460-9568.1998.00355.x","article-title":"P2X3 is expressed by DRG neurons that terminate in inner lamina II","volume":"10","author":"Vulchanova","year":"1998","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.ejphar.2024.177052_bib144","doi-asserted-by":"crossref","DOI":"10.1186\/s12990-015-0012-7","article-title":"Sensitization of P2X3 receptors by cystathionine \u03b2-synthetase mediates persistent pain hypersensitivity in a rat model of lumbar disc herniation","volume":"11","author":"Wang","year":"2015","journal-title":"Mol. Pain"},{"key":"10.1016\/j.ejphar.2024.177052_bib145","doi-asserted-by":"crossref","first-page":"G710","DOI":"10.1152\/ajpgi.00395.2014","article-title":"Adrenergic signaling mediates mechanical hyperalgesia through activation of P2X3 receptors in primary sensory neurons of rats with chronic pancreatitis","volume":"308","author":"Wang","year":"2015","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.ejphar.2024.177052_bib146","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1002\/jnr.23451","article-title":"Electroacupuncture and A-317491 depress the transmission of pain on primary afferent mediated by the P2X3 receptor in rats with chronic neuropathic pain states","volume":"92","author":"Wang","year":"2014","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.ejphar.2024.177052_bib147","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3009986","article-title":"The nicotinic \u03b16 subunit gene determines variability in chronic pain sensitivity via cross-inhibition of P2X2\/3 receptors","volume":"7","author":"Wieskopf","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.ejphar.2024.177052_bib148","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.ejphar.2004.09.056","article-title":"A-317491, a selective P2X3\/P2X2\/3 receptor antagonist, reverses inflammatory mechanical hyperalgesia through action at peripheral receptors in rats","volume":"504","author":"Wu","year":"2004","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2024.177052_bib149","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1002\/j.1532-2149.2012.00149.x","article-title":"Functional up-regulation of P2X3 receptors in dorsal root ganglion in a rat model of bone cancer pain","volume":"16","author":"Wu","year":"2012","journal-title":"Eur. J. Pain"},{"key":"10.1016\/j.ejphar.2024.177052_bib150","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1097\/j.pain.0000000000002853","article-title":"MiR-1306-3p directly activates P2X3 receptors in primary sensory neurons to induce visceral pain in rats","volume":"164","author":"Wu","year":"2023","journal-title":"Pain"},{"key":"10.1016\/j.ejphar.2024.177052_bib151","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20133248","article-title":"Electroacupuncture stimulation alleviates CFA-induced inflammatory pain via suppressing P2X3 expression","volume":"20","author":"Xiang","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2024.177052_bib152","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.pain.2008.07.006","article-title":"Functional up-regulation of P2X 3 receptors in the chronically compressed dorsal root ganglion","volume":"140","author":"Xiang","year":"2008","journal-title":"Pain"},{"key":"10.1016\/j.ejphar.2024.177052_bib153","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.brainresbull.2017.07.005","article-title":"Inhibitory effects of tetramethylpyrazine on pain transmission of trigeminal neuralgia in CCI-ION rats","volume":"134","author":"Xiong","year":"2017","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.ejphar.2024.177052_bib154","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.jpba.2004.05.013","article-title":"Automated 96-well liquid-liquid back extraction liquid chromatography- tandem mass spectrometry method for the determination of ABT-202 in human plasma","volume":"36","author":"Xu","year":"2004","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.ejphar.2024.177052_bib155","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.neulet.2012.08.067","article-title":"P2X3 receptor mediates ectopic mechanical allodynia with inflamed lower lip in mice","volume":"528","author":"Yasuda","year":"2012","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ejphar.2024.177052_bib156","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/nrd.2017.87","article-title":"Breaking barriers to novel analgesic drug development","volume":"16","author":"Yekkirala","year":"2017","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.ejphar.2024.177052_bib157","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.brainresbull.2017.01.002","article-title":"A317491 relieved HIV gp120-associated neuropathic pain involved in P2X3 receptor in dorsal root ganglia","volume":"130","author":"Yi","year":"2017","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.ejphar.2024.177052_bib158","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1002\/ar.22816","article-title":"Pregabalin alters nociceptive behavior and expression level of P2X3 receptor in the spinal dorsal horn in a rat model induced by chronic compression of the dorsal root ganglion","volume":"296","author":"Yu","year":"2013","journal-title":"Anat. Rec."},{"key":"10.1016\/j.ejphar.2024.177052_bib159","doi-asserted-by":"crossref","first-page":"8171","DOI":"10.2147\/IJN.S146569","article-title":"Effect of A-317491 delivered by glycolipid-like polymer micelles on endometriosis pain","volume":"12","author":"Yuan","year":"2017","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.ejphar.2024.177052_bib160","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/BF03165788","article-title":"The involvement of P2X3 receptors of rat sympathetic ganglia in cardiac nociceptive transmission","volume":"63","author":"Zhang","year":"2007","journal-title":"J. Physiol. Biochem."},{"key":"10.1016\/j.ejphar.2024.177052_bib161","doi-asserted-by":"crossref","first-page":"4272","DOI":"10.2337\/db15-0138","article-title":"Promoted interaction of nuclear factor-\u03bab with demethylated purinergic P2X3 receptor gene contributes to neuropathic pain in rats with diabetes","volume":"64","author":"Zhang","year":"2015","journal-title":"Diabetes"},{"key":"10.1016\/j.ejphar.2024.177052_bib162","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/S0028-3908(99)00145-8","article-title":"Pharmacological comparison of P2X receptors on rat coeliac, mouse coeliac and mouse pelvic ganglion neurons","volume":"39","author":"Zhong","year":"2000","journal-title":"Neuropharmacology"}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299924007428?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299924007428?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T20:03:30Z","timestamp":1734552210000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299924007428"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":162,"alternative-id":["S0014299924007428"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2024.177052","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"P2X3 and P2X2\/3 receptors inhibition produces a consistent analgesic efficacy: A systematic review and meta-analysis of preclinical studies","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2024.177052","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"177052"}}