{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T08:26:32Z","timestamp":1768811192603,"version":"3.49.0"},"reference-count":80,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007840","name":"Moscow State University of Geodesy and Cartography","doi-asserted-by":"publisher","award":["121032300075-6"],"award-info":[{"award-number":["121032300075-6"]}],"id":[{"id":"10.13039\/501100007840","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000046","name":"National Research Council Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000046","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["22-25-00807"],"award-info":[{"award-number":["22-25-00807"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.ejphar.2024.177068","type":"journal-article","created":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T15:38:34Z","timestamp":1729525114000},"page":"177068","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Antidepressant-like and antistress effects of the ACTH(4\u201310) synthetic analogs Semax and Melanotan II on male rats in a model of chronic unpredictable stress"],"prefix":"10.1016","volume":"984","author":[{"given":"Ludmila S.","family":"Inozemtseva","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4109-7278","authenticated-orcid":false,"given":"Ksenia A.","family":"Yatsenko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalya Yu","family":"Glazova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrey A.","family":"Kamensky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolai F.","family":"Myasoedov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9095-2907","authenticated-orcid":false,"given":"Natalia G.","family":"Levitskaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Igor A.","family":"Grivennikov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3187-6331","authenticated-orcid":false,"given":"Oleg V.","family":"Dolotov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2024.177068_bib1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.neubiorev.2018.12.002","article-title":"Chronic unpredictable mild stress for modeling depression in rodents: meta-analysis of model reliability","volume":"99","author":"Antoniuk","year":"2019","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.ejphar.2024.177068_bib2","first-page":"105","article-title":"Design and investigation of an ACTH(4-10) analogue lacking D-amino acids and hydrophobic radicals","volume":"16","author":"Ashmarin","year":"1995","journal-title":"Neurosci. Res. Commun."},{"key":"10.1016\/j.ejphar.2024.177068_bib3","doi-asserted-by":"crossref","first-page":"2882","DOI":"10.1038\/npp.2016.100","article-title":"ProBDNF signaling regulates depression-like behaviors in rodents under chronic stress","volume":"41","author":"Bai","year":"2016","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.ejphar.2024.177068_bib4","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.brainresrev.2007.04.005","article-title":"The stress system in depression and neurodegeneration: focus on the human hypothalamus","volume":"57","author":"Bao","year":"2008","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.ejphar.2024.177068_bib5","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.neuropharm.2015.10.034","article-title":"Bdnf - a key transducer of antidepressant effects","volume":"102","author":"Bj\u00f6rkholm","year":"2016","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ejphar.2024.177068_bib6","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.physbeh.2013.05.012","article-title":"Factors influencing behavior in the forced swim test","volume":"118","author":"Bogdanova","year":"2013","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.ejphar.2024.177068_bib7","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1172\/JCI113677","article-title":"Multiple feedback regulatory loops upon rat hypothalamic corticotropin-releasing hormone secretion. Potential clinical implications","volume":"82","author":"Calogero","year":"1988","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ejphar.2024.177068_bib8","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/j.cell.2021.01.034","article-title":"Antidepressant drugs act by directly binding to TRKB neurotrophin receptors","volume":"184","author":"Casarotto","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.ejphar.2024.177068_bib9","article-title":"Stress markers for mental states and biotypes of depression and anxiety: a scoping review and preliminary illustrative analysis","volume":"5","author":"Chesnut","year":"2021","journal-title":"Chronic Stress (Thousand Oaks)"},{"key":"10.1016\/j.ejphar.2024.177068_bib10","doi-asserted-by":"crossref","first-page":"647","DOI":"10.3109\/10253890.2011.654370","article-title":"Circadian activity of the hypothalamic-pituitary-adrenal axis is differentially affected in the rat chronic mild stress model of depression","volume":"15","author":"Christiansen","year":"2012","journal-title":"Stress"},{"key":"10.1016\/j.ejphar.2024.177068_bib11","doi-asserted-by":"crossref","first-page":"7777","DOI":"10.3390\/ijms21207777","article-title":"Neurotrophic factor BDNF, physiological functions and therapeutic potential in depression, neurodegeneration and","volume":"21","author":"Colucci-D'Amato","year":"2020","journal-title":"Brain Cancer. Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2024.177068_bib12","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1021\/acschemneuro.7b00042","article-title":"The rodent forced swim test measures stress-coping strategy, not depression-like behavior","volume":"8","author":"Commons","year":"2017","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.ejphar.2024.177068_bib13","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.bbr.2011.01.038","article-title":"Neurochemical, hormonal, and behavioral effects of chronic unpredictable stress in the rat","volume":"220","author":"Cox","year":"2011","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ejphar.2024.177068_bib14","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232214445","article-title":"BDNF as a mediator of antidepressant response: recent advances and lifestyle interactions","volume":"23","author":"Cubillos","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2024.177068_bib15","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.neuroscience.2005.06.068","article-title":"Chronic mild stress impact: are females more vulnerable?","volume":"135","author":"Dalla","year":"2005","journal-title":"Neuroscience"},{"key":"10.1016\/j.ejphar.2024.177068_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2022.109335","article-title":"Role of neurotrophic and growth factors in the rapid and sustained antidepressant actions of ketamine","volume":"224","author":"Deyama","year":"2023","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ejphar.2024.177068_bib17","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.brainres.2006.07.108","article-title":"Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus","volume":"1117","author":"Dolotov","year":"2006","journal-title":"Brain Res."},{"issue":"Suppl. 1","key":"10.1016\/j.ejphar.2024.177068_bib18","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1111\/j.1471-4159.2006.03658.x","article-title":"Semax, an analogue of adrenocorticotropin (4-10), binds specifically and increases levels of brain-derived neurotrophic factor protein in rat basal forebrain","volume":"97","author":"Dolotov","year":"2006","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ejphar.2024.177068_bib19","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1111\/ejn.14630","article-title":"Role of BDNF in the pathophysiology and treatment of depression: activity-dependent effects distinguish rapid-acting antidepressants","volume":"53","author":"Duman","year":"2021","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.ejphar.2024.177068_bib20","doi-asserted-by":"crossref","DOI":"10.3390\/ijms221810054","article-title":"Antistress action of melanocortin derivatives associated with correction of gene expression patterns in the Hippocampus of male rats following acute stress","volume":"22","author":"Filippenkov","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2024.177068_bib21","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/S0896-6273(00)80395-5","article-title":"CREB: a major mediator of neuronal neurotrophin responses","volume":"19","author":"Finkbeiner","year":"1997","journal-title":"Neuron"},{"key":"10.1016\/j.ejphar.2024.177068_bib22","doi-asserted-by":"crossref","first-page":"61","DOI":"10.17116\/jnevro20181183261-68","article-title":"[The efficacy of semax in the tretament of patients at different stages of ischemic stroke]","volume":"118","author":"Gusev","year":"2018","journal-title":"Zh. Nevrol. Psikhiatr. Im. S S Korsakova"},{"key":"10.1016\/j.ejphar.2024.177068_bib23","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.peptides.2005.01.029","article-title":"Melanocortin peptide therapeutics: historical milestones, clinical studies and commercialization","volume":"27","author":"Hadley","year":"2006","journal-title":"Peptides"},{"key":"10.1016\/j.ejphar.2024.177068_bib24","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20194827","article-title":"Selecting an appropriate animal model of depression","volume":"20","author":"Hao","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2024.177068_bib25","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1134\/S0012496606020037","article-title":"Effect of Semax on changes in pain sensitivity and behavior of animals induced by forced swimming","volume":"407","author":"Ivanova","year":"2006","journal-title":"Dokl. Biol. Sci."},{"key":"10.1016\/j.ejphar.2024.177068_bib26","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1002\/(SICI)1520-6769(199609)19:2<115::AID-NRC171>3.0.CO;2-B","article-title":"Synthetic acth analogue semax displays nootropic-like activity in humans","volume":"19","author":"Kaplan","year":"1996","journal-title":"Neurosci. Res. Commun."},{"key":"10.1016\/j.ejphar.2024.177068_bib27","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1146\/annurev.psych.48.1.191","article-title":"The effects of stressful life events on depression","volume":"48","author":"Kessler","year":"1997","journal-title":"Annu. Rev. Psychol."},{"key":"10.1016\/j.ejphar.2024.177068_bib28","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.neulet.2007.12.020","article-title":"Effects of melanotan II, a melanocortin agonist, on grooming and exploration in rats after repeated restraint\/immobilization","volume":"432","author":"Klenerov\u00e1","year":"2008","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ejphar.2024.177068_bib29","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1152\/jn.00359.2015","article-title":"Corticosterone mediates the synaptic and behavioral effects of chronic stress at rat hippocampal temporoammonic synapses","volume":"114","author":"Kvarta","year":"2015","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.ejphar.2024.177068_bib30","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1134\/S1062359010020147","article-title":"Influence of semax on the emotional state of white rats in the norm and against the background of cholecystokinin-tetrapeptide action","volume":"37","author":"Levitskaya","year":"2010","journal-title":"Biol. Bull."},{"key":"10.1016\/j.ejphar.2024.177068_bib31","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1007\/s12264-021-00638-3","article-title":"Major depressive disorder: advances in neuroscience research and translational applications","volume":"37","author":"Li","year":"2021","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.ejphar.2024.177068_bib32","doi-asserted-by":"crossref","first-page":"7863","DOI":"10.1523\/JNEUROSCI.23-21-07863.2003","article-title":"Interaction between alpha-melanocyte-stimulating hormone and corticotropin-releasing hormone in the regulation of feeding and hypothalamo-pituitary-adrenal responses","volume":"23","author":"Lu","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2024.177068_bib33","doi-asserted-by":"crossref","first-page":"4871","DOI":"10.1007\/s12035-021-02470-2","article-title":"Norepinephrine and glucocorticoids modulate chronic unpredictable stress-induced increase in the type 2 CRF and glucocorticoid receptors in brain structures related to the HPA Axis activation","volume":"58","author":"Malta","year":"2021","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.ejphar.2024.177068_bib34","doi-asserted-by":"crossref","first-page":"6664","DOI":"10.3390\/ijms24076664","article-title":"The melanocortin system: a promising target for the development of new antidepressant drugs","volume":"24","author":"Markov","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2024.177068_bib35","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.psyneuen.2017.04.019","article-title":"Systemic N-terminal fragments of adrenocorticotropin reduce inflammation- and stress-induced anhedonia in rats","volume":"82","author":"Markov","year":"2017","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.ejphar.2024.177068_bib36","doi-asserted-by":"crossref","first-page":"101","DOI":"10.3389\/fpsyt.2019.00101","article-title":"Is the HPA Axis as target for depression outdated, or is there a new hope?","volume":"10","author":"Menke","year":"2019","journal-title":"Front. Psychiatr."},{"key":"10.1016\/j.ejphar.2024.177068_bib37","doi-asserted-by":"crossref","DOI":"10.3390\/brainsci11101298","article-title":"HPA Axis in the pathomechanism of depression and schizophrenia: new therapeutic strategies based on its participation","volume":"11","author":"Mikulska","year":"2021","journal-title":"Brain Sci."},{"key":"10.1016\/j.ejphar.2024.177068_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2020.104932","article-title":"Memantine treatment exerts an antidepressant-like effect by preventing hippocampal mitochondrial dysfunction and memory impairment via upregulation of CREB\/BDNF signaling in the rat model of chronic unpredictable stress-induced depression","volume":"142","author":"Mishra","year":"2021","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.ejphar.2024.177068_bib39","doi-asserted-by":"crossref","first-page":"2813","DOI":"10.1111\/ejn.15139","article-title":"Forced swim stressor: trends in usage and mechanistic consideration","volume":"55","author":"Molendijk","year":"2022","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.ejphar.2024.177068_bib40","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1080\/00207454.2018.1527328","article-title":"Direct and indirect evidences of BDNF and NGF as key modulators in depression: role of antidepressants treatment","volume":"129","author":"Mondal","year":"2019","journal-title":"Int. J. Neurosci."},{"key":"10.1016\/j.ejphar.2024.177068_bib41","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1210\/endo-77-2-392","article-title":"A \"short\" feedback loop in the control of ACTH secretion","volume":"77","author":"Motta","year":"1965","journal-title":"Endocrinology"},{"key":"10.1016\/j.ejphar.2024.177068_bib42","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1038\/oby.2011.81","article-title":"Melanocortin receptor 4 deficiency affects body weight regulation, grooming behavior, and substrate preference in the rat","volume":"20","author":"Mul","year":"2012","journal-title":"Obesity"},{"key":"10.1016\/j.ejphar.2024.177068_bib43","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2019.00974","article-title":"Cortisol and major depressive disorder\u2014translating findings from humans to animal models and back","volume":"10","author":"Nandam","year":"2020","journal-title":"Front. Psychiatr."},{"key":"10.1016\/j.ejphar.2024.177068_bib44","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1111\/j.1530-0277.2011.01438.x","article-title":"Assessment of voluntary ethanol consumption and the effects of a melanocortin (MC) receptor agonist on ethanol intake in mutant C57BL\/6J mice lacking the MC-4 receptor","volume":"35","author":"Navarro","year":"2011","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.ejphar.2024.177068_bib45","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.3390\/ijms18112312","article-title":"Actions of brain-derived neurotrophic factor and glucocorticoid stress in neurogenesis","volume":"18","author":"Numakawa","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2024.177068_bib46","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1111\/j.1471-4159.2009.06057.x","article-title":"Chronic stress elicits prolonged activation of alpha-MSH secretion and subsequent degeneration of melanotroph","volume":"109","author":"Ogawa","year":"2009","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ejphar.2024.177068_bib47","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1006\/exnr.1997.6500","article-title":"An acid-treatment method for the enhanced detection of GDNF in biological samples","volume":"145","author":"Okragly","year":"1997","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.ejphar.2024.177068_bib48","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.1586","article-title":"Sex differences in hypothalamic-pituitary-adrenal axis regulation after chronic unpredictable stress","volume":"10","author":"Palumbo","year":"2020","journal-title":"Brain and behavior"},{"key":"10.1016\/j.ejphar.2024.177068_bib49","doi-asserted-by":"crossref","first-page":"3923","DOI":"10.1523\/JNEUROSCI.21-11-03923.2001","article-title":"Effects of early visual experience and diurnal rhythms on BDNF mRNA and protein levels in the visual system, hippocampus, and cerebellum","volume":"21","author":"Pollock","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2024.177068_bib50","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0304-3940(91)90912-D","article-title":"Entry of the synthetic ACTH(4-10) analogue into the rat brain following intravenous injection","volume":"127","author":"Potaman","year":"1991","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ejphar.2024.177068_bib51","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1016\/j.neuroscience.2007.03.027","article-title":"Hypothalamus-pituitary-adrenal modifications consequent to chronic stress exposure in an experimental model of depression in rats","volume":"146","author":"Raone","year":"2007","journal-title":"Neuroscience"},{"key":"10.1016\/j.ejphar.2024.177068_bib52","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1523\/JNEUROSCI.5100-09.2010","article-title":"Global deprivation of brain-derived neurotrophic factor in the CNS reveals an area-specific requirement for dendritic growth","volume":"30","author":"Rauskolb","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2024.177068_bib53","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.mce.2016.08.020","article-title":"Pivotal role of median eminence tanycytes for hypothalamic function and neurogenesis","volume":"445","author":"Rizzoti","year":"2017","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.ejphar.2024.177068_bib54","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1177\/0271678X16647739","article-title":"Stress does not increase blood-brain barrier permeability in mice","volume":"36","author":"Roszkowski","year":"2016","journal-title":"J. Cerebr. Blood Flow Metabol. : official journal of the International Society of Cerebral Blood Flow and Metabolism"},{"key":"10.1016\/j.ejphar.2024.177068_bib55","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1111\/j.1365-2826.1995.tb00814.x","article-title":"Evidence for short-loop feedback effects of ACTH on CRF and vasopressin expression in parvocellular neurosecretory neurons","volume":"7","author":"Sawchenko","year":"1995","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.ejphar.2024.177068_bib56","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0304-3940(01)01994-2","article-title":"Rapid induction of neurotrophin mRNAs in rat glial cell cultures by Semax, an adrenocorticotropic hormone analog","volume":"308","author":"Shadrina","year":"2001","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ejphar.2024.177068_bib57","doi-asserted-by":"crossref","first-page":"324","DOI":"10.21307\/ane-2017-031","article-title":"Anhedonia but not passive floating is an indicator of depressive-like behavior in two chronic stress paradigms","volume":"76","author":"Stepanichev","year":"2016","journal-title":"Acta Neurobiol. Exp."},{"key":"10.1016\/j.ejphar.2024.177068_bib58","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1007\/s00213-021-05982-w","article-title":"Chronic mild stress paradigm as a rat model of depression: facts, artifacts, and future perspectives","volume":"239","author":"Strekalova","year":"2022","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.ejphar.2024.177068_bib59","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1210\/endo-118-1-459","article-title":"Inhibitory effect of adrenocorticotropin on corticotropin- releasing factor release from rat hypothalamus in vitro","volume":"118","author":"Suda","year":"1986","journal-title":"Endocrinology"},{"key":"10.1016\/j.ejphar.2024.177068_bib60","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2020.00443","article-title":"Pharmacological treatment of anxiety disorders: the role of the HPA Axis","volume":"11","author":"Tafet","year":"2020","journal-title":"Front. Psychiatr."},{"key":"10.1016\/j.ejphar.2024.177068_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2021.113364","article-title":"Effect of chronically electric foot shock stress on spatial memory and hippocampal blood brain barrier permeability","volume":"410","author":"Taghadosi","year":"2021","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ejphar.2024.177068_bib80","doi-asserted-by":"crossref","first-page":"2689","DOI":"10.1038\/s41380-022-01520-y","article-title":"Dysregulation of adult hippocampal neuroplasticity in major depression: pathogenesis and therapeutic implications","volume":"27","author":"Tartt","year":"2022","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.ejphar.2024.177068_bib62","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0006-8993(03)02683-0","article-title":"Exploring the site of anorectic action of peripherally administered synthetic melanocortin peptide MT-II in rats","volume":"977","author":"Trivedi","year":"2003","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2024.177068_bib63","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1517\/13543784.2014.934805","article-title":"Melanocortin receptor agonists in the treatment of male and female sexual dysfunctions: results from basic research and clinical studies","volume":"23","author":"\u00dcckert","year":"2014","journal-title":"Expet Opin. Invest. Drugs"},{"key":"10.1016\/j.ejphar.2024.177068_bib64","doi-asserted-by":"crossref","first-page":"E965","DOI":"10.1152\/ajpendo.00070.2006","article-title":"Chronic stress induces adrenal hyperplasia and hypertrophy in a subregion-specific manner","volume":"291","author":"Ulrich-Lai","year":"2006","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.ejphar.2024.177068_bib65","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1073\/pnas.82.4.1271","article-title":"NH2-terminal specificity and axonal localization of adrenocorticotropin binding sites in rat median eminence","volume":"82","author":"Van Houten","year":"1985","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ejphar.2024.177068_bib66","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.pnpbp.2017.08.014","article-title":"Sex differences in cardiovascular, neuroendocrine and behavioral changes evoked by chronic stressors in rats","volume":"81","author":"Vieira","year":"2018","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.ejphar.2024.177068_bib67","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.ejphar.2019.02.024","article-title":"Molecular aspects of depression: a review from neurobiology to treatment","volume":"851","author":"Villas Boas","year":"2019","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2024.177068_bib68","doi-asserted-by":"crossref","DOI":"10.1016\/j.npep.2022.102247","article-title":"ACTH(6-9)-Pro-Gly-Pro ameliorates anxiety-like and depressive-like behaviour and gut mucosal microbiota composition in rats under conditions of chronic restraint stress","volume":"93","author":"Vorvul","year":"2022","journal-title":"Neuropeptides"},{"key":"10.1016\/j.ejphar.2024.177068_bib69","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1007\/s00726-011-0924-0","article-title":"Comparisons of treatment means when factors do not interact in two-factorial studies","volume":"42","author":"Wei","year":"2012","journal-title":"Amino Acids"},{"key":"10.1016\/j.ejphar.2024.177068_bib70","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0014-2999(99)00298-8","article-title":"Melanocortin receptors: perspectives for novel drugs","volume":"375","author":"Wikberg","year":"1999","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2024.177068_bib71","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s002130050456","article-title":"Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation","volume":"134","author":"Willner","year":"1997","journal-title":"Psychopharmacology (Berl.)."},{"key":"10.1016\/j.ejphar.2024.177068_bib72","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.ynstr.2016.08.002","article-title":"The chronic mild stress (CMS) model of depression: history, evaluation and usage","volume":"6","author":"Willner","year":"2017","journal-title":"Neurobiol Stress"},{"key":"10.1016\/j.ejphar.2024.177068_bib73","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ynstr.2016.08.001","article-title":"Reliability of the chronic mild stress model of depression: a user survey","volume":"6","author":"Willner","year":"2017","journal-title":"Neurobiol Stress"},{"key":"10.1016\/j.ejphar.2024.177068_bib74","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1007\/BF00187257","article-title":"Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant","volume":"93","author":"Willner","year":"1987","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.ejphar.2024.177068_bib75","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.celrep.2014.03.040","article-title":"proBDNF negatively regulates neuronal remodeling, synaptic transmission, and synaptic plasticity in hippocampus","volume":"7","author":"Yang","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.ejphar.2024.177068_bib76","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1134\/S0012496613060161","article-title":"Heptapeptide semax attenuates the effects of chronic unpredictable stress in rats","volume":"453","author":"Yatsenko","year":"2013","journal-title":"Dokl. Biol. Sci."},{"key":"10.1016\/j.ejphar.2024.177068_bib77","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.brainres.2016.03.020","article-title":"Propofol alleviates electroconvulsive shock-induced memory impairment by modulating proBDNF\/mBDNF ratio in depressive rats","volume":"1642","author":"Zhang","year":"2016","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2024.177068_bib78","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.brainres.2010.09.095","article-title":"Chronic antidepressant administration alleviates frontal and hippocampal BDNF deficits in CUMS rat","volume":"1366","author":"Zhang","year":"2010","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2024.177068_bib79","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.pnpbp.2010.04.011","article-title":"Glucocorticoids, cytokines and brain abnormalities in depression","volume":"35","author":"Zunszain","year":"2011","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299924007581?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299924007581?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T01:03:39Z","timestamp":1734570219000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299924007581"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":80,"alternative-id":["S0014299924007581"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2024.177068","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antidepressant-like and antistress effects of the ACTH(4\u201310) synthetic analogs Semax and Melanotan II on male rats in a model of chronic unpredictable stress","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2024.177068","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"177068"}}