{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T04:49:20Z","timestamp":1784609360003,"version":"3.55.0"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.ejphar.2024.177075","type":"journal-article","created":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T12:55:09Z","timestamp":1731070509000},"page":"177075","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Proteomic alteration in catalpol treatment of Alzheimer's disease by regulating HSPA5\/ GPX4"],"prefix":"10.1016","volume":"987","author":[{"given":"Leiyu","family":"Tian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaobin","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengzhi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1662-4315","authenticated-orcid":false,"given":"Changhua","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2024.177075_bib1","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s10339-011-0430-z","article-title":"The novel object recognition memory: neurobiology, test procedure, and its modifications","volume":"13","author":"Antunes","year":"2012","journal-title":"Cognit. Process."},{"key":"10.1016\/j.ejphar.2024.177075_bib2","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1038\/s41418-020-00685-9","article-title":"Loss of ferroportin induces memory impairment by promoting ferroptosis in Alzheimer's disease","volume":"28","author":"Bao","year":"2021","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.ejphar.2024.177075_bib3","doi-asserted-by":"crossref","first-page":"9427","DOI":"10.1039\/D3SC02350H","article-title":"A natural polyphenol activates and enhances GPX4 to mitigate amyloid-\u03b2 induced ferroptosis in Alzheimer's disease","volume":"14","author":"Baruah","year":"2023","journal-title":"Chem. Sci."},{"key":"10.1016\/j.ejphar.2024.177075_bib4","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s13195-019-0490-3","article-title":"Exposure to fluoride aggravates the impairment in learning and memory and neuropathological lesions in mice carrying the APP\/PS1 double-transgenic mutation","volume":"11","author":"Cao","year":"2019","journal-title":"Alzheimer's Res. Ther."},{"key":"10.1016\/j.ejphar.2024.177075_bib5","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.redox.2017.10.014","article-title":"Oxidative stress and the amyloid beta peptide in Alzheimer's disease","volume":"14","author":"Cheignon","year":"2018","journal-title":"Redox Biol."},{"key":"10.1016\/j.ejphar.2024.177075_bib6","article-title":"Ferroptosis, a potential therapeutic target in Alzheimer's disease","volume":"9","author":"Chen","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.ejphar.2024.177075_bib7","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.3174\/ajnr.A5143","article-title":"Relationships among Cortical glutathione levels, brain amyloidosis, and memory in healthy older adults investigated in vivo with (1)H-MRS and Pittsburgh compound-B PET","volume":"38","author":"Chiang","year":"2017","journal-title":"AJNR. American journal of neuroradiology"},{"key":"10.1016\/j.ejphar.2024.177075_bib8","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/509282a","article-title":"Policy: NIH to balance sex in cell and animal studies","volume":"509","author":"Clayton","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2024.177075_bib9","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.neulet.2017.12.026","article-title":"Association of GPX1 and GPX4 polymorphisms with episodic memory and Alzheimer's disease","volume":"666","author":"da Rocha","year":"2018","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ejphar.2024.177075_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.pneurobio.2019.101716","article-title":"Revisiting the intersection of amyloid, pathologically modified tau and iron in Alzheimer's disease from a ferroptosis perspective","volume":"184","author":"Derry","year":"2020","journal-title":"Progress in neurobiology"},{"key":"10.1016\/j.ejphar.2024.177075_bib11","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.ejmech.2019.03.009","article-title":"Therapeutic potentials of plant iridoids in Alzheimer's and Parkinson's diseases: a review","volume":"169","author":"Dinda","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejphar.2024.177075_bib12","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.nbd.2018.12.010","article-title":"Cerebrospinal fluid ferritin levels predict brain hypometabolism in people with underlying \u03b2-amyloid pathology","volume":"124","author":"Diouf","year":"2019","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.ejphar.2024.177075_bib13","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.ejphar.2024.177075_bib14","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1007\/s12640-022-00524-4","article-title":"Catalpol ameliorates neurotoxicity in N2a\/APP695swe cells and APP\/PS1 transgenic mice","volume":"40","author":"Du","year":"2022","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.ejphar.2024.177075_bib15","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.redox.2017.01.021","article-title":"Ablation of ferroptosis regulator glutathione peroxidase 4 in forebrain neurons promotes cognitive impairment and neurodegeneration","volume":"12","author":"Hambright","year":"2017","journal-title":"Redox Biol."},{"key":"10.1016\/j.ejphar.2024.177075_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2021.112781","article-title":"HA15 alleviates bone loss in ovariectomy-induced osteoporosis by targeting HSPA5","volume":"406","author":"Han","year":"2021","journal-title":"Experimental cell research"},{"key":"10.1016\/j.ejphar.2024.177075_bib17","doi-asserted-by":"crossref","first-page":"491","DOI":"10.3892\/mmr.2015.4496","article-title":"Catalpol preserves neural function and attenuates the pathology of Alzheimer's disease in mice","volume":"13","author":"Huang","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.ejphar.2024.177075_bib18","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1111\/jnc.15519","article-title":"Ferroptosis as a mechanism of neurodegeneration in Alzheimer's disease","volume":"159","author":"Jakaria","year":"2021","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ejphar.2024.177075_bib19","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1042\/EBC20210017","article-title":"Ferroptosis and NRF2: an emerging battlefield in the neurodegeneration of Alzheimer's disease","volume":"65","author":"Lane","year":"2021","journal-title":"Essays Biochem."},{"key":"10.1016\/j.ejphar.2024.177075_bib20","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/nrc3701","article-title":"Glucose-regulated proteins in cancer: molecular mechanisms and therapeutic potential","volume":"14","author":"Lee","year":"2014","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.ejphar.2024.177075_bib21","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1002\/jnr.25033","article-title":"The key roles of organelles and ferroptosis in Alzheimer's disease","volume":"100","author":"Long","year":"2022","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.ejphar.2024.177075_bib22","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.fsi.2019.11.008","article-title":"Integrated dual RNA-seq and dual iTRAQ of infected tissue reveals the functions of a diguanylate cyclase gene of Pseudomonas plecoglossicida in host-pathogen interactions with Epinephelus coioides","volume":"95","author":"Luo","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.ejphar.2024.177075_bib23","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/s00011-022-01547-5","article-title":"The RNA-binding protein SND1 promotes the degradation of GPX4 by destabilizing the HSPA5 mRNA and suppressing HSPA5 expression, promoting ferroptosis in osteoarthritis chondrocytes","volume":"71","author":"Lv","year":"2022","journal-title":"Inflamm. Res. : official journal of the European Histamine Research Society \u2026 [et al."},{"key":"10.1016\/j.ejphar.2024.177075_bib24","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1007\/s10519-014-9667-5","article-title":"Behavioral and pharmacological evaluation of a selectively bred mouse model of home cage hyperactivity","volume":"44","author":"Majdak","year":"2014","journal-title":"Behav. Genet."},{"key":"10.1016\/j.ejphar.2024.177075_bib25","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.biopsych.2015.04.005","article-title":"Brain glutathione levels--a novel biomarker for mild cognitive impairment and Alzheimer's disease","volume":"78","author":"Mandal","year":"2015","journal-title":"Biol. Psychiatr."},{"key":"10.1016\/j.ejphar.2024.177075_bib26","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.arr.2021.101448","article-title":"Effectiveness of caregiver non-pharmacological interventions for behavioural and psychological symptoms of dementia: an updated meta-analysis","volume":"71","author":"Meng","year":"2021","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.ejphar.2024.177075_bib27","doi-asserted-by":"crossref","first-page":"3082","DOI":"10.1039\/D4MH00023D","article-title":"Polycatechols inhibit ferroptosis and modulate tau liquid-liquid phase separation to mitigate Alzheimer's disease","volume":"11","author":"Moorthy","year":"2024","journal-title":"Mater. Horiz."},{"key":"10.1016\/j.ejphar.2024.177075_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103119","article-title":"Hybrid molecules synergistically mitigate ferroptosis and amyloid-associated toxicities in Alzheimer's disease","volume":"71","author":"Padhi","year":"2024","journal-title":"Redox Biol."},{"key":"10.1016\/j.ejphar.2024.177075_bib29","doi-asserted-by":"crossref","first-page":"13657","DOI":"10.1039\/D2SC03932J","article-title":"Multipronged diagnostic and therapeutic strategies for Alzheimer's disease","volume":"13","author":"Ramesh","year":"2022","journal-title":"Chem. Sci."},{"key":"10.1016\/j.ejphar.2024.177075_bib30","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.tips.2023.07.007","article-title":"Therapeutic inhibition of ferroptosis in neurodegenerative disease","volume":"44","author":"Ryan","year":"2023","journal-title":"Trends in pharmacological sciences"},{"key":"10.1016\/j.ejphar.2024.177075_bib31","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.freeradbiomed.2018.09.014","article-title":"Role of GPX4 in ferroptosis and its pharmacological implication","volume":"133","author":"Seibt","year":"2019","journal-title":"Free radical biology & medicine"},{"key":"10.1016\/j.ejphar.2024.177075_bib32","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1159\/000524236","article-title":"Catalpol alleviates isoflurane-induced hippocampal learning and memory dysfunction and neuropathological changes in aged mice","volume":"29","author":"Shi","year":"2022","journal-title":"Neuroimmunomodulation"},{"key":"10.1016\/j.ejphar.2024.177075_bib33","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.cell.2017.09.021","article-title":"Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease","volume":"171","author":"Stockwell","year":"2017","journal-title":"Cell"},{"issue":"8.31","key":"10.1016\/j.ejphar.2024.177075_bib34","first-page":"31","article-title":"Examining object location and object recognition memory in mice","volume":"69","author":"Vogel-Ciernia","year":"2014","journal-title":"Current protocols in neuroscience"},{"key":"10.1016\/j.ejphar.2024.177075_bib35","article-title":"Iron dyshomeostasis and ferroptosis: a new alzheimer's disease hypothesis?","volume":"14","author":"Wang","year":"2022","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.ejphar.2024.177075_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejcb.2019.151058","article-title":"Mitochondria regulation in ferroptosis","volume":"99","author":"Wang","year":"2020","journal-title":"European journal of cell biology"},{"key":"10.1016\/j.ejphar.2024.177075_bib37","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1016\/j.neuroscience.2009.07.041","article-title":"Catalpol ameliorates beta amyloid-induced degeneration of cholinergic neurons by elevating brain-derived neurotrophic factors","volume":"163","author":"Wang","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.ejphar.2024.177075_bib38","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.molmed.2022.02.003","article-title":"Ferroptosis in Parkinson's disease: glia-neuron crosstalk","volume":"28","author":"Wang","year":"2022","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.ejphar.2024.177075_bib39","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/s41586-019-1426-6","article-title":"Intercellular interaction dictates cancer cell ferroptosis via NF2-YAP signalling","volume":"572","author":"Wu","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2024.177075_bib40","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/j.neuron.2015.02.010","article-title":"Presenilin-1 knockin mice reveal loss-of-function mechanism for familial Alzheimer's disease","volume":"85","author":"Xia","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.ejphar.2024.177075_bib41","doi-asserted-by":"crossref","first-page":"69303","DOI":"10.18632\/oncotarget.17951","article-title":"Catalpol protects synaptic proteins from beta-amyloid induced neuron injury and improves cognitive functions in aged rats","volume":"8","author":"Xia","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.ejphar.2024.177075_bib42","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/cdd.2015.158","article-title":"Ferroptosis: process and function","volume":"23","author":"Xie","year":"2016","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.ejphar.2024.177075_bib43","doi-asserted-by":"crossref","first-page":"690","DOI":"10.3389\/fphar.2020.00690","article-title":"Neuroprotective effect of catalpol via anti-oxidative, anti-inflammatory, and anti-apoptotic mechanisms","volume":"11","author":"Yang","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejphar.2024.177075_bib44","doi-asserted-by":"crossref","first-page":"3763","DOI":"10.1007\/s00213-015-4036-5","article-title":"Inhibition of hyperactivity and impulsivity by carbonic anhydrase inhibitors in spontaneously hypertensive rats, an animal model of ADHD","volume":"232","author":"Yang","year":"2015","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.ejphar.2024.177075_bib45","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.cell.2013.12.010","article-title":"Regulation of ferroptotic cancer cell death by GPX4","volume":"156","author":"Yang","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.ejphar.2024.177075_bib46","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1016\/j.freeradbiomed.2012.02.043","article-title":"Gpx4 ablation in adult mice results in a lethal phenotype accompanied by neuronal loss in brain","volume":"52","author":"Yoo","year":"2012","journal-title":"Free radical biology & medicine"},{"key":"10.1016\/j.ejphar.2024.177075_bib47","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/s41420-022-01173-4","article-title":"Regulating Nrf2-GPx4 axis by bicyclol can prevent ferroptosis in carbon tetrachloride-induced acute liver injury in mice","volume":"8","author":"Zhao","year":"2022","journal-title":"Cell death discovery"},{"key":"10.1016\/j.ejphar.2024.177075_bib48","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1158\/0008-5472.CAN-16-1979","article-title":"HSPA5 regulates ferroptotic cell death in cancer cells","volume":"77","author":"Zhu","year":"2017","journal-title":"Cancer Res."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299924007659?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299924007659?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T17:06:31Z","timestamp":1735319191000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299924007659"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":48,"alternative-id":["S0014299924007659"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2024.177075","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Proteomic alteration in catalpol treatment of Alzheimer's disease by regulating HSPA5\/ GPX4","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2024.177075","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"177075"}}