{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T18:55:19Z","timestamp":1781204119888,"version":"3.54.1"},"reference-count":65,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.ejphar.2024.177079","type":"journal-article","created":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T17:42:17Z","timestamp":1730396537000},"page":"177079","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["H2S protects rat cerebral ischemia-reperfusion injury by inhibiting expression and activation of hippocampal ROCK2 at the Thr436 and Ser575 sites"],"prefix":"10.1016","volume":"985","author":[{"given":"Fang","family":"Fang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Ning","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei-Jing","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Yue","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Wu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2024.177079_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2021.107848","article-title":"Targeting autophagy in ischemic stroke: from molecular mechanisms to clinical therapeutics","volume":"225","author":"Ajoolabady","year":"2021","journal-title":"Pharmacol. Ther."},{"issue":"6","key":"10.1016\/j.ejphar.2024.177079_bib2","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1111\/bph.12811","article-title":"The role of gasotransmitters NO, H2S and CO in myocardial ischaemia\/reperfusion injury and cardioprotection by preconditioning, postconditioning and remote conditioning","volume":"172","author":"Andreadou","year":"2015","journal-title":"Br. J. Pharmacol."},{"issue":"12","key":"10.1016\/j.ejphar.2024.177079_bib3","doi-asserted-by":"crossref","first-page":"21183","DOI":"10.3390\/molecules191221183","article-title":"Hydrogen sulfide and endothelium-dependent vasorelaxation","volume":"19","author":"Beltowski","year":"2014","journal-title":"Molecules"},{"issue":"5","key":"10.1016\/j.ejphar.2024.177079_bib4","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1681\/ASN.2012030268","article-title":"Cystathionine gamma-lyase protects against renal ischemia\/reperfusion by modulating oxidative stress","volume":"24","author":"Bos","year":"2013","journal-title":"J. Am. Soc. Nephrol."},{"issue":"1","key":"10.1016\/j.ejphar.2024.177079_bib5","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1161\/CIRCULATIONAHA.109.920991","article-title":"Genetic and pharmacologic hydrogen sulfide therapy attenuates ischemia-induced heart failure in mice","volume":"122","author":"Calvert","year":"2010","journal-title":"Circulation"},{"issue":"5","key":"10.1016\/j.ejphar.2024.177079_bib6","first-page":"3789","article-title":"A new hope for a devastating disease: hydrogen sulfide in Parkinson's disease","volume":"55","author":"Cao","year":"2018","journal-title":"Mol. Neurobiol."},{"issue":"1","key":"10.1016\/j.ejphar.2024.177079_bib7","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1152\/physrev.00028.2021","article-title":"Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs","volume":"103","author":"Cirino","year":"2023","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ejphar.2024.177079_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.105119","article-title":"Hydrogen sulfide: an endogenous regulator of the immune system","volume":"161","author":"Dilek","year":"2020","journal-title":"Pharmacol. Res."},{"issue":"1","key":"10.1016\/j.ejphar.2024.177079_bib9","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.bcp.2013.12.013","article-title":"Ischemia\/reperfusion injury: effect of simultaneous inhibition of plasma cascade systems versus specific complement inhibition","volume":"88","author":"Duehrkop","year":"2014","journal-title":"Biochem. Pharmacol."},{"issue":"11","key":"10.1016\/j.ejphar.2024.177079_bib10","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1038\/nm.2507","article-title":"Ischemia and reperfusion--from mechanism to translation","volume":"17","author":"Eltzschig","year":"2011","journal-title":"Nat. Med."},{"issue":"2","key":"10.1016\/j.ejphar.2024.177079_bib11","doi-asserted-by":"crossref","DOI":"10.3390\/ph16020218","article-title":"Protection of HS against hypoxia\/reoxygenation injury in rat hippocampal neurons through inhibiting phosphorylation of ROCK at Thr436 and Ser575","volume":"16","author":"Fang","year":"2023","journal-title":"Pharmaceuticals"},{"issue":"4","key":"10.1016\/j.ejphar.2024.177079_bib12","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/j.ncl.2016.06.013","article-title":"Epidemiology of ischemic stroke","volume":"34","author":"Favate","year":"2016","journal-title":"Neurol. Clin."},{"issue":"23\u201324","key":"10.1016\/j.ejphar.2024.177079_bib13","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1016\/j.lfs.2008.04.005","article-title":"Hydrogen sulfide protects rat lung from ischemia-reperfusion injury","volume":"82","author":"Fu","year":"2008","journal-title":"Life Sci."},{"issue":"3","key":"10.1016\/j.ejphar.2024.177079_bib14","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.neuint.2011.12.014","article-title":"Inhibition of Rho kinase by hydroxyfasudil attenuates brain edema after subarachnoid hemorrhage in rats","volume":"60","author":"Fujii","year":"2012","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.ejphar.2024.177079_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.jneuroim.2020.577284","article-title":"Fasudil inhibits the activation of microglia and astrocytes of transgenic Alzheimer's disease mice via the downregulation of TLR4\/Myd88\/NF-kappaB pathway","volume":"346","author":"Guo","year":"2020","journal-title":"J. Neuroimmunol."},{"issue":"1","key":"10.1016\/j.ejphar.2024.177079_bib16","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/jphp.13178","article-title":"Total flavones of Rhododendron simsii Planch flower protect rat hippocampal neuron from hypoxia-reoxygenation injury via activation of BK(Ca) channel","volume":"72","author":"Guo","year":"2020","journal-title":"J. Pharm. Pharmacol."},{"issue":"11","key":"10.1016\/j.ejphar.2024.177079_bib17","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1038\/nrcardio.2011.85","article-title":"The therapeutic potential of ischemic conditioning: an update","volume":"8","author":"Hausenloy","year":"2011","journal-title":"Nat. Rev. Cardiol."},{"issue":"4","key":"10.1016\/j.ejphar.2024.177079_bib18","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.jstrokecerebrovasdis.2015.11.035","article-title":"Effects of fluoxetine on neural functional prognosis after ischemic stroke: a randomized controlled study in China","volume":"25","author":"He","year":"2016","journal-title":"J. Stroke Cerebrovasc. Dis."},{"issue":"2","key":"10.1016\/j.ejphar.2024.177079_bib19","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1093\/cvr\/26.2.101","article-title":"Reperfusion induced injury: manifestations, mechanisms, and clinical relevance","volume":"26","author":"Hearse","year":"1992","journal-title":"Cardiovasc. Res."},{"issue":"4","key":"10.1016\/j.ejphar.2024.177079_bib20","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1111\/jnc.13688","article-title":"Rho-associated protein kinase 1 (ROCK1) is increased in Alzheimer's disease and ROCK1 depletion reduces amyloid- levels in brain","volume":"138","author":"Henderson","year":"2016","journal-title":"J. Neurochem."},{"issue":"587","key":"10.1016\/j.ejphar.2024.177079_bib21","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aaw9318","article-title":"Pharmacologic inhibition of LIMK1 provides dendritic spine resilience against beta-amyloid","volume":"12","author":"Henderson","year":"2019","journal-title":"Sci. Signal."},{"issue":"8","key":"10.1016\/j.ejphar.2024.177079_bib22","doi-asserted-by":"crossref","first-page":"6117","DOI":"10.1074\/jbc.M110.167239","article-title":"Rho kinase II phosphorylation of the lipoprotein receptor LR11\/SORLA alters amyloid-beta production","volume":"286","author":"Herskowitz","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"49","key":"10.1016\/j.ejphar.2024.177079_bib23","doi-asserted-by":"crossref","first-page":"19086","DOI":"10.1523\/JNEUROSCI.2508-13.2013","article-title":"Pharmacologic inhibition of ROCK2 suppresses amyloid-beta production in an Alzheimer's disease mouse model","volume":"33","author":"Herskowitz","year":"2013","journal-title":"J. Neurosci."},{"issue":"9932","key":"10.1016\/j.ejphar.2024.177079_bib24","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1016\/S0140-6736(14)60107-0","article-title":"Cardiovascular remodelling in coronary artery disease and heart failure","volume":"383","author":"Heusch","year":"2014","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.ejphar.2024.177079_bib25","doi-asserted-by":"crossref","first-page":"439","DOI":"10.31083\/j.jin.2019.04.1163","article-title":"Effects of cellular prion protein on rapid eye movement sleep deprivation-induced spatial memory impairment","volume":"18","author":"Hu","year":"2019","journal-title":"J. Integr. Neurosci."},{"issue":"4","key":"10.1016\/j.ejphar.2024.177079_bib26","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1161\/CIRCRESAHA.113.300987","article-title":"Historical perspective on the pathology of myocardial ischemia\/reperfusion injury","volume":"113","author":"Jennings","year":"2013","journal-title":"Circ. Res."},{"issue":"5","key":"10.1016\/j.ejphar.2024.177079_bib27","doi-asserted-by":"crossref","first-page":"C537","DOI":"10.1152\/ajpcell.00329.2016","article-title":"Vascular biology of hydrogen sulfide","volume":"312","author":"Kanagy","year":"2017","journal-title":"American Journal of Physiology-Cell Physiology"},{"key":"10.1016\/j.ejphar.2024.177079_bib28","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.niox.2014.01.002","article-title":"The physiological role of hydrogen sulfide and beyond","volume":"41","author":"Kimura","year":"2014","journal-title":"Nitric Oxide"},{"issue":"5","key":"10.1016\/j.ejphar.2024.177079_bib29","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2014.191","article-title":"ROCK2 is a major regulator of axonal degeneration, neuronal death and axonal regeneration in the CNS","volume":"5","author":"Koch","year":"2014","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ejphar.2024.177079_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pharmthera.2018.03.008","article-title":"ROCK inhibition in models of neurodegeneration and its potential for clinical translation","volume":"189","author":"Koch","year":"2018","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.ejphar.2024.177079_bib31","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.niox.2013.07.002","article-title":"Hydrogen sulfide chemical biology: pathophysiological roles and detection","volume":"35","author":"Kolluru","year":"2013","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.ejphar.2024.177079_bib32","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.bbrc.2021.06.019","article-title":"PEA prevented early BBB disruption after cerebral ischaemic\/reperfusion (I\/R) injury through regulation of ROCK\/MLC signaling","volume":"566","author":"Kong","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.ejphar.2024.177079_bib33","article-title":"Real-time in vivo two-photon imaging study reveals decreased cerebro-vascular volume and increased blood-brain barrier permeability in chronically stressed mice","volume":"8","author":"Lee","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejphar.2024.177079_bib34","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.niox.2013.07.001","article-title":"Chemical foundations of hydrogen sulfide biology","volume":"35","author":"Li","year":"2013","journal-title":"Nitric Oxide"},{"issue":"21","key":"10.1016\/j.ejphar.2024.177079_bib35","doi-asserted-by":"crossref","first-page":"9644","DOI":"10.7150\/thno.47651","article-title":"HDAC3 inhibition ameliorates ischemia\/reperfusion-induced brain injury by regulating the microglial cGAS-STING pathway","volume":"10","author":"Liao","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.ejphar.2024.177079_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2021.113700","article-title":"Bone marrow mesenchymal stem cell-derived exosomes attenuate cerebral ischemia-reperfusion injury-induced neuroinflammation and pyroptosis by modulating microglia M1\/M2 phenotypes","volume":"341","author":"Liu","year":"2021","journal-title":"Exp. Neurol."},{"issue":"1","key":"10.1016\/j.ejphar.2024.177079_bib37","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-11113-3","article-title":"RhoA-ROCK inhibition reverses synaptic remodeling and motor and cognitive deficits caused by traumatic brain injury","volume":"7","author":"Mulherkar","year":"2017","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.ejphar.2024.177079_bib38","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1136\/jnnp-2016-314814","article-title":"Venous imaging-based biomarkers in acute ischaemic stroke","volume":"88","author":"Munuera","year":"2017","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"issue":"51","key":"10.1016\/j.ejphar.2024.177079_bib39","doi-asserted-by":"crossref","first-page":"21972","DOI":"10.1073\/pnas.0908047106","article-title":"Hydrogen sulfide is an endogenous stimulator of angiogenesis","volume":"106","author":"Papapetropoulos","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"issue":"8","key":"10.1016\/j.ejphar.2024.177079_bib40","article-title":"Role of rho-associated protein kinase inhibition as therapeutic strategy for Parkinson's disease: dopaminergic survival and enhanced mitophagy","volume":"13","author":"Quadir","year":"2021","journal-title":"Cureus"},{"issue":"3","key":"10.1016\/j.ejphar.2024.177079_bib42","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/s10571-016-0379-7","article-title":"Regulation of microglial phagocytosis by RhoA\/ROCK-inhibiting drugs","volume":"37","author":"Scheiblich","year":"2017","journal-title":"Cell. Mol. Neurobiol."},{"issue":"3","key":"10.1016\/j.ejphar.2024.177079_bib43","first-page":"1452","article-title":"miR-335 promotes stress granule formation to inhibit apoptosis by targeting ROCK2 in acute ischemic stroke","volume":"43","author":"Si","year":"2019","journal-title":"Int. J. Mol. Med."},{"issue":"1","key":"10.1016\/j.ejphar.2024.177079_bib44","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.redox.2012.11.006","article-title":"Redox biology of hydrogen sulfide: implications for physiology, pathophysiology, and pharmacology","volume":"1","author":"Stein","year":"2013","journal-title":"Redox Biol."},{"issue":"1","key":"10.1016\/j.ejphar.2024.177079_bib45","doi-asserted-by":"crossref","first-page":"53","DOI":"10.14336\/AD.2015.1011","article-title":"mHealth for aging China: opportunities and challenges","volume":"7","author":"Sun","year":"2016","journal-title":"Aging Dis"},{"issue":"8","key":"10.1016\/j.ejphar.2024.177079_bib46","doi-asserted-by":"crossref","DOI":"10.3390\/brainsci9080204","article-title":"Pro-nerve growth factor induces activation of RhoA kinase and neuronal cell death","volume":"9","author":"Sycheva","year":"2019","journal-title":"Brain Sci."},{"issue":"2","key":"10.1016\/j.ejphar.2024.177079_bib47","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1111\/j.1440-1681.2007.04799.x","article-title":"Effect of hydrogen sulphide on beta-amyloid-induced damage in PC12 cells","volume":"35","author":"Tang","year":"2008","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"issue":"3","key":"10.1016\/j.ejphar.2024.177079_bib48","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.neures.2010.07.2039","article-title":"Hydrogen sulfide antagonizes homocysteine-induced neurotoxicity in PC12 cells","volume":"68","author":"Tang","year":"2010","journal-title":"Neurosci. Res."},{"issue":"1","key":"10.1016\/j.ejphar.2024.177079_bib49","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.neuint.2012.04.011","article-title":"Hydrogen sulfide prevents formaldehyde-induced neurotoxicity to PC12 cells by attenuation of mitochondrial dysfunction and pro-apoptotic potential","volume":"61","author":"Tang","year":"2012","journal-title":"Neurochem. Int."},{"issue":"1","key":"10.1016\/j.ejphar.2024.177079_bib50","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/ijs.12245","article-title":"Global stroke statistics","volume":"9","author":"Thrift","year":"2014","journal-title":"Int. J. Stroke"},{"key":"10.1016\/j.ejphar.2024.177079_bib51","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3389\/fnmol.2011.00039","article-title":"ROCKing regeneration: rho kinase inhibition as molecular target for neurorestoration","volume":"4","author":"Tonges","year":"2011","journal-title":"Front. Mol. Neurosci."},{"issue":"6","key":"10.1016\/j.ejphar.2024.177079_bib52","doi-asserted-by":"crossref","first-page":"954","DOI":"10.4161\/auto.19927","article-title":"The role of AKT1 and autophagy in the protective effect of hydrogen sulphide against hepatic ischemia\/reperfusion injury in mice","volume":"8","author":"Wang","year":"2012","journal-title":"Autophagy"},{"issue":"3\u20134","key":"10.1016\/j.ejphar.2024.177079_bib53","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1159\/000448712","article-title":"Involvement of hydrogen sulfide in endothelium-derived relaxing factor-mediated responses in rat cerebral arteries","volume":"53","author":"Wang","year":"2016","journal-title":"J. Vasc. Res."},{"issue":"4","key":"10.1016\/j.ejphar.2024.177079_bib54","doi-asserted-by":"crossref","first-page":"383","DOI":"10.4062\/biomolther.2015.180","article-title":"Neuroprotection of dexmedetomidine against cerebral ischemia-reperfusion injury in rats: involved in inhibition of NF-kappaB and inflammation response","volume":"25","author":"Wang","year":"2017","journal-title":"Biomol Ther (Seoul)"},{"key":"10.1016\/j.ejphar.2024.177079_bib55","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.neuroscience.2018.04.045","article-title":"Beta-elemene enhances GAP-43 expression and neurite outgrowth by inhibiting RhoA kinase activation in rats with spinal cord injury","volume":"383","author":"Wang","year":"2018","journal-title":"Neuroscience"},{"issue":"12","key":"10.1016\/j.ejphar.2024.177079_bib56","doi-asserted-by":"crossref","first-page":"2796","DOI":"10.1007\/s11064-019-02903-4","article-title":"Increased expression of Kv10.2 in the Hippocampus attenuates valproic acid-induced autism-like behaviors in rats","volume":"44","author":"Wang","year":"2019","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.ejphar.2024.177079_bib57","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.saa.2018.11.017","article-title":"A dansyl-appended N-heterocycle for Cu(2+) and S(2-) recognition via a displacement mode","volume":"210","author":"Wang","year":"2019","journal-title":"Spectrochim. Acta Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.ejphar.2024.177079_bib58","article-title":"CSE\/H(2)S ameliorates colitis in mice via protection of enteric glial cells and inhibition of the RhoA\/ROCK pathway","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejphar.2024.177079_bib59","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2022.04.014","article-title":"Hydrogen sulfide alleviates particulate matter-induced emphysema and airway inflammation by suppressing ferroptosis","volume":"186","author":"Wang","year":"2022","journal-title":"Free Radic. Biol. Med."},{"issue":"3","key":"10.1016\/j.ejphar.2024.177079_bib60","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1021\/acschemneuro.8b00533","article-title":"Role of CSE-produced H(2)S on cerebrovascular relaxation via RhoA-ROCK inhibition and cerebral ischemia-reperfusion injury in mice","volume":"10","author":"Wen","year":"2019","journal-title":"ACS Chem. Neurosci."},{"issue":"2","key":"10.1016\/j.ejphar.2024.177079_bib61","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.ijcard.2014.01.068","article-title":"Targeting hydrogen sulfide as a promising therapeutic strategy for atherosclerosis","volume":"172","author":"Xu","year":"2014","journal-title":"Int. J. Cardiol."},{"issue":"1","key":"10.1016\/j.ejphar.2024.177079_bib62","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1089\/ars.2012.5024","article-title":"Hydrogen sulfide treatment promotes glucose uptake by increasing insulin receptor sensitivity and ameliorates kidney lesions in type 2 diabetes","volume":"19","author":"Xue","year":"2013","journal-title":"Antioxidants Redox Signal."},{"issue":"14","key":"10.1016\/j.ejphar.2024.177079_bib63","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27144567","article-title":"Protection against hypoxia-reoxygenation injury of hippocampal neurons by H(2)S via promoting phosphorylation of ROCK(2) at Tyr722 in rat model","volume":"27","author":"Xue","year":"2022","journal-title":"Molecules"},{"issue":"5901","key":"10.1016\/j.ejphar.2024.177079_bib41","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1126\/science.1162667","article-title":"H2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine gamma-lyase","volume":"322","author":"Yang","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2024.177079_bib65","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.brainres.2012.10.046","article-title":"Exogenous hydrogen sulfide protects against global cerebral ischemia\/reperfusion injury via its anti-oxidative, anti-inflammatory and anti-apoptotic effects in rats","volume":"1491","author":"Yin","year":"2013","journal-title":"Brain Res."},{"issue":"4","key":"10.1016\/j.ejphar.2024.177079_bib66","doi-asserted-by":"crossref","first-page":"C720","DOI":"10.1152\/ajpcell.00014.2020","article-title":"3-Mercaptopyruvate sulfurtransferase\/hydrogen sulfide protects cerebral endothelial cells against oxygen-glucose deprivation\/reoxygenation-induced injury via mitoprotection and inhibition of the RhoA\/ROCK pathway","volume":"319","author":"Zhang","year":"2020","journal-title":"Am J Physiol Cell Physiol"}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299924007696?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299924007696?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,8]],"date-time":"2024-12-08T01:28:25Z","timestamp":1733621305000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299924007696"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":65,"alternative-id":["S0014299924007696"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2024.177079","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"H2S protects rat cerebral ischemia-reperfusion injury by inhibiting expression and activation of hippocampal ROCK2 at the Thr436 and Ser575 sites","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2024.177079","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"177079"}}