{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T18:29:14Z","timestamp":1777573754573,"version":"3.51.4"},"reference-count":111,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,30]],"date-time":"2024-11-30T00:00:00Z","timestamp":1732924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2018YFC1311300"],"award-info":[{"award-number":["2018YFC1311300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070204"],"award-info":[{"award-number":["82070204"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81860080"],"award-info":[{"award-number":["81860080"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170245"],"award-info":[{"award-number":["82170245"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No.U22A20269"],"award-info":[{"award-number":["No.U22A20269"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.ejphar.2024.177101","type":"journal-article","created":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T03:27:57Z","timestamp":1732678077000},"page":"177101","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["RNA binding proteins: Mechanistic considerations and perspectives in controlling cardiovascular diseases"],"prefix":"10.1016","volume":"987","author":[{"given":"Lanlan","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saiyang","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ejphar.2024.177101_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11883-018-0711-4","article-title":"Cardiorespiratory fitness and cardiovascular disease prevention: an update","volume":"20","author":"Al-Mallah","year":"2018","journal-title":"Curr Atheroscler Rep"},{"issue":"17","key":"10.1016\/j.ejphar.2024.177101_bib2","doi-asserted-by":"crossref","first-page":"2917","DOI":"10.1002\/1873-3468.13161","article-title":"Unconventional RNA-binding proteins: an. uncharted zone in RNA biology","volume":"592","author":"Albihlal","year":"2018","journal-title":"FEBS Lett."},{"key":"10.1016\/j.ejphar.2024.177101_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2022.110245","article-title":"G3bp1 - microRNA-1 axis regulates cardiomyocyte hypertrophy","volume":"91","author":"Alikunju","year":"2022","journal-title":"Cell. Signal."},{"issue":"4","key":"10.1016\/j.ejphar.2024.177101_bib4","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1016\/j.bbrc.2015.06.101","article-title":"Cytoplasmic translocation of HuR contributes to angiotensin II induced cardiac fibrosis","volume":"463","author":"Bai","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.ejphar.2024.177101_bib5","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/imr.13025","article-title":"RNA-binding proteins and RNA methylation in myeloid cells","volume":"304","author":"Bataclan","year":"2021","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.ejphar.2024.177101_bib6","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms10127","article-title":"The RNA-binding proteomes from yeast to man harbour conserved enigmRBPs","volume":"6","author":"Beckmann","year":"2015","journal-title":"Nat. Commun."},{"issue":"23","key":"10.1016\/j.ejphar.2024.177101_bib7","doi-asserted-by":"crossref","first-page":"e535","DOI":"10.1161\/CIR.0000000000000450","article-title":"Contributory risk and management of comorbidities of hypertension, obesity, diabetes mellitus, hyperlipidemia, and metabolic syndrome in chronic heart failure: a scientific statement from the American heart association","volume":"134","author":"Bozkurt","year":"2016","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.ejphar.2024.177101_bib8","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1097\/FJC.0000000000001271","article-title":"Dihydroartemisinin attenuates hypoxia-induced pulmonary hypertension through the ELAVL2\/miR-503\/PI3K\/AKT Axis","volume":"80","author":"Cai","year":"2022","journal-title":"J. Cardiovasc. Pharmacol."},{"issue":"10","key":"10.1016\/j.ejphar.2024.177101_bib9","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1161\/CIRCRESAHA.117.311281","article-title":"CELF1 mediates connexin 43 mRNA degradation in dilated cardiomyopathy","volume":"121","author":"Chang","year":"2017","journal-title":"Circ. Res."},{"issue":"5","key":"10.1016\/j.ejphar.2024.177101_bib10","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202002553R","article-title":"CELF1 promotes vascular endothelial growth factor degradation resulting in impaired microvasculature in heart failure","volume":"35","author":"Chang","year":"2021","journal-title":"FASEB J"},{"issue":"20","key":"10.1016\/j.ejphar.2024.177101_bib11","doi-asserted-by":"crossref","first-page":"5135","DOI":"10.1111\/jcmm.17539","article-title":"miR-486 improves fibrotic activity in myocardial infarction by targeting SRSF3\/p21-Mediated cardiac myofibroblast senescence","volume":"26","author":"Chen","year":"2022","journal-title":"J. Cell Mol. Med."},{"issue":"1","key":"10.1016\/j.ejphar.2024.177101_bib12","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/s41467-020-20327-5","article-title":"QKI is a critical pre-mRNA alternative splicing regulator of cardiac myofibrillogenesis and contractile function","volume":"12","author":"Chen","year":"2021","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.ejphar.2024.177101_bib13","doi-asserted-by":"crossref","first-page":"5010","DOI":"10.1038\/s41598-024-55804-0","article-title":"Hygrothermal stress increases malignant arrhythmias susceptibility by inhibiting the LKB1-AMPK-Cx43 pathway","volume":"14","author":"Chi","year":"2024","journal-title":"Sci. Rep."},{"issue":"7","key":"10.1016\/j.ejphar.2024.177101_bib14","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2025070118","article-title":"METTL3-dependent N(6)-methyladenosine RNA modification mediates the atherogenic inflammatory cascades in vascular endothelium","volume":"118","author":"Chien","year":"2021","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"11","key":"10.1016\/j.ejphar.2024.177101_bib15","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1161\/CIRCULATIONAHA.119.039596","article-title":"Widespread translational control of fibrosis in the human heart by RNA-binding proteins","volume":"140","author":"Chothani","year":"2019","journal-title":"Circulation"},{"issue":"7","key":"10.1016\/j.ejphar.2024.177101_bib16","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/s41581-020-0278-5","article-title":"Genetics of diabetes mellitus and diabetes complications","volume":"16","author":"Cole","year":"2020","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.ejphar.2024.177101_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.biocel.2020.105907","article-title":"Diabetic endotheliopathy: RNA-binding proteins as new therapeutic targets","volume":"131","author":"Cornelius","year":"2021","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"12","key":"10.1016\/j.ejphar.2024.177101_bib18","doi-asserted-by":"crossref","first-page":"4066","DOI":"10.4049\/jimmunol.1701211","article-title":"Regnase-1 and Roquin nonredundantly regulate Th1 differentiation causing cardiac inflammation and fibrosis","volume":"199","author":"Cui","year":"2017","journal-title":"J. Immunol."},{"issue":"11","key":"10.1016\/j.ejphar.2024.177101_bib19","first-page":"1751","article-title":"RBM20 is a candidate gene for hypertrophic cardiomyopathy","volume":"37","author":"Dai","year":"2021","journal-title":"Can. J. Cardiol."},{"issue":"2_Suppl. l","key":"10.1016\/j.ejphar.2024.177101_bib20","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1177\/2047487319878371","article-title":"Diabetes as a cardiovascular risk factor: an overview of global trends of macro and micro vascular complications","volume":"26","author":"Dal Canto","year":"2019","journal-title":"Eur J Prev Cardiol"},{"issue":"18","key":"10.1016\/j.ejphar.2024.177101_bib21","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202100275","article-title":"Emerging targets in type 2 diabetes and diabetic complications","volume":"8","author":"Demir","year":"2021","journal-title":"Adv. Sci."},{"key":"10.1016\/j.ejphar.2024.177101_bib22","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.intimp.2018.09.023","article-title":"Endothelial HuR deletion reduces the expression of proatherogenic molecules and attenuates atherosclerosis","volume":"65","author":"Fu","year":"2018","journal-title":"Int Immunopharmacol"},{"issue":"6","key":"10.1016\/j.ejphar.2024.177101_bib23","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a037176","article-title":"Formation and growth of cardiac lymphatics during embryonic development, heart regeneration, and disease","volume":"12","author":"Gancz","year":"2020","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"3","key":"10.1016\/j.ejphar.2024.177101_bib24","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/s41576-020-00302-y","article-title":"RNA-binding proteins in human genetic disease","volume":"22","author":"Gebauer","year":"2021","journal-title":"Nat. Rev. Genet."},{"issue":"12","key":"10.1016\/j.ejphar.2024.177101_bib25","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/nrg3813","article-title":"A census of human RNA-binding proteins","volume":"15","author":"Gerstberger","year":"2014","journal-title":"Nat. Rev. Genet."},{"issue":"2","key":"10.1016\/j.ejphar.2024.177101_bib26","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.1096\/fj.201901995R","article-title":"Targeting exosome-associated human antigen R attenuates fibrosis and inflammation in diabetic heart","volume":"34","author":"Govindappa","year":"2020","journal-title":"FASEB J"},{"issue":"4","key":"10.1016\/j.ejphar.2024.177101_bib27","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.121541","article-title":"Human antigen R as a therapeutic target in pathological cardiac hypertrophy","volume":"4","author":"Green","year":"2019","journal-title":"JCI Insight"},{"key":"10.1016\/j.ejphar.2024.177101_bib28","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.yjmcc.2022.10.007","article-title":"HuR-dependent expression of Wisp1 is necessary for TGFbeta-induced cardiac myofibroblast activity","volume":"174","author":"Green","year":"2023","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"25","key":"10.1016\/j.ejphar.2024.177101_bib29","doi-asserted-by":"crossref","first-page":"2688","DOI":"10.1056\/NEJMoa062800","article-title":"Electrocardiographic abnormalities and sudden death in myotonic dystrophy type 1","volume":"358","author":"Groh","year":"2008","journal-title":"N. Engl. J. Med."},{"issue":"2","key":"10.1016\/j.ejphar.2024.177101_bib30","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24021283","article-title":"Suppression of RBFox2 by multiple MiRNAs in pressure overload-induced heart failure","volume":"24","author":"Gu","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.ejphar.2024.177101_bib31","doi-asserted-by":"crossref","first-page":"H228","DOI":"10.1152\/ajpheart.00957.2020","article-title":"Adipocyte-specific deletion of HuR induces spontaneous cardiac hypertrophy and fibrosis","volume":"321","author":"Guarnieri","year":"2021","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.ejphar.2024.177101_bib32","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.yjmcc.2014.07.010","article-title":"QKI deficiency promotes FoxO1 mediated nitrosative stress and. endoplasmic reticulum stress contributing to increased vulnerability to ischemic injury in diabetic heart","volume":"75","author":"Guo","year":"2014","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"4","key":"10.1016\/j.ejphar.2024.177101_bib33","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1159\/000335755","article-title":"RNA binding protein QKI inhibits the ischemia\/reperfusion-induced apoptosis in neonatal cardiomyocytes","volume":"28","author":"Guo","year":"2011","journal-title":"Cell. Physiol. Biochem."},{"issue":"2","key":"10.1016\/j.ejphar.2024.177101_bib34","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1161\/CIRCRESAHA.117.311335","article-title":"Quaking inhibits doxorubicin-mediated cardiotoxicity through regulation of cardiac circular RNA expression","volume":"122","author":"Gupta","year":"2018","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2024.177101_bib35","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.yjmcc.2021.04.002","article-title":"Sarcoplasmic reticulum-mitochondria communication; implications for. cardiac arrhythmia","volume":"156","author":"Hamilton","year":"2021","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"24","key":"10.1016\/j.ejphar.2024.177101_bib36","doi-asserted-by":"crossref","first-page":"7282","DOI":"10.7150\/thno.33920","article-title":"LncRNA-Safe contributes to cardiac fibrosis through Safe-Sfrp2-HuR complex in mouse myocardial infarction","volume":"9","author":"Hao","year":"2019","journal-title":"Theranostics"},{"issue":"5","key":"10.1016\/j.ejphar.2024.177101_bib37","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/nrm.2017.130","article-title":"A brave new world of RNA-binding proteins","volume":"19","author":"Hentze","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"5","key":"10.1016\/j.ejphar.2024.177101_bib38","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1093\/cvr\/cvz205","article-title":"HuR regulates phospholamban expression in isoproterenol-induced cardiac remodelling","volume":"116","author":"H","year":"2020","journal-title":"Cardiovasc. Res."},{"issue":"13","key":"10.1016\/j.ejphar.2024.177101_bib39","doi-asserted-by":"crossref","first-page":"6172","DOI":"10.1073\/pnas.1822176116","article-title":"RBFox2-miR-34a-Jph2 axis contributes to cardiac decompensation during heart failure","volume":"116","author":"Hu","year":"2019","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"9","key":"10.1016\/j.ejphar.2024.177101_bib40","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1164\/rccm.202009-3419OC","article-title":"YTHDF1 regulates pulmonary hypertension through translational control of MAGED1","volume":"203","author":"Hu","year":"2021","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"1","key":"10.1016\/j.ejphar.2024.177101_bib41","doi-asserted-by":"crossref","first-page":"5877","DOI":"10.1038\/s41467-022-32982-x","article-title":"Intrinsic myocardial defects underlie an Rbfox-deficient zebrafish model of hypoplastic left heart syndrome","volume":"13","author":"Huang","year":"2022","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.ejphar.2024.177101_bib42","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-74800-8","article-title":"A missense mutation in the RSRSP stretch of Rbm20 causes dilated cardiomyopathy and atrial fibrillation in mice","volume":"10","author":"Ihara","year":"2020","journal-title":"Sci. Rep."},{"issue":"25","key":"10.1016\/j.ejphar.2024.177101_bib43","doi-asserted-by":"crossref","first-page":"2996","DOI":"10.1016\/j.jacc.2016.03.590","article-title":"The diagnosis and evaluation of dilated cardiomyopathy","volume":"67","author":"Japp","year":"2016","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ejphar.2024.177101_bib44","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.yjmcc.2020.02.009","article-title":"MicroRNA-31-5p attenuates doxorubicin-induced cardiotoxicity via quaking and circular RNA Pan3","volume":"140","author":"Ji","year":"2020","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"24","key":"10.1016\/j.ejphar.2024.177101_bib45","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1161\/CIR.0000000000001191","article-title":"Novel prediction equations for absolute risk assessment of total cardiovascular disease incorporating cardiovascular-kidney-metabolic health: a scientific statement from the American heart association","volume":"148","author":"Khan","year":"2023","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.ejphar.2024.177101_bib46","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCEP.122.011466","article-title":"Chronic kidney disease induces proarrhythmic remodeling","volume":"16","author":"King","year":"2023","journal-title":"Circ Arrhythm Electrophysiol"},{"issue":"6","key":"10.1016\/j.ejphar.2024.177101_bib47","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1161\/CIRCRESAHA.120.318577","article-title":"The SRSF4-GAS5-glucocorticoid receptor Axis regulates ventricular hypertrophy","volume":"129","author":"Larrasa-Alonso","year":"2021","journal-title":"Circ. Res."},{"issue":"5","key":"10.1016\/j.ejphar.2024.177101_bib48","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1161\/CIRCRESAHA.118.312669","article-title":"Sedentary. Behavior, exercise, and cardiovascular health","volume":"124","author":"Lavie","year":"2019","journal-title":"Circ. Res."},{"issue":"10","key":"10.1016\/j.ejphar.2024.177101_bib49","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1161\/CIRCRESAHA.116.306287","article-title":"Cold-Inducible RNA-binding protein regulates cardiac repolarization by targeting transient outward potassium channels","volume":"116","author":"Li","year":"2015","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2024.177101_bib50","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.matbio.2018.01.013","article-title":"Extracellular matrix remodeling and cardiac fibrosis","volume":"68\u201369","author":"Li","year":"2018","journal-title":"Matrix Biol."},{"issue":"2","key":"10.1016\/j.ejphar.2024.177101_bib51","doi-asserted-by":"crossref","first-page":"9655","DOI":"10.1080\/21655979.2021.1977552","article-title":"RNA binding Motif protein-38 regulates myocardial hypertrophy in LXR-alpha-dependent lipogenesis pathway","volume":"12","author":"Li","year":"2021","journal-title":"Bioengineered"},{"issue":"1","key":"10.1016\/j.ejphar.2024.177101_bib52","doi-asserted-by":"crossref","first-page":"e1565","DOI":"10.1002\/wrna.1565","article-title":"Approaches for measuring the dynamics of RNA-protein interactions","volume":"11","author":"Licatalosi","year":"2020","journal-title":"Wiley Interdiscip Rev RNA"},{"issue":"5","key":"10.1016\/j.ejphar.2024.177101_bib53","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/s41594-018-0054-4","article-title":"Tapping the RNA world for therapeutics","volume":"25","author":"Lieberman","year":"2018","journal-title":"Nat. Struct. Mol. Biol."},{"issue":"6","key":"10.1016\/j.ejphar.2024.177101_bib54","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1161\/CIRCRESAHA.118.314316","article-title":"Nut consumption in relation to cardiovascular disease incidence and mortality among patients with diabetes mellitus","volume":"124","author":"Liu","year":"2019","journal-title":"Circ. Res."},{"issue":"10","key":"10.1016\/j.ejphar.2024.177101_bib55","doi-asserted-by":"crossref","first-page":"4732","DOI":"10.1111\/jcmm.16437","article-title":"Deficiency of cold-inducible RNA-binding protein exacerbated monocrotaline-induced pulmonary artery hypertension through Caveolin1 and CAVIN1","volume":"25","author":"Liu","year":"2021","journal-title":"J. Cell Mol. Med."},{"issue":"6","key":"10.1016\/j.ejphar.2024.177101_bib56","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s13238-018-0578-8","article-title":"RNA binding protein 24 deletion disrupts global alternative splicing and causes dilated cardiomyopathy","volume":"10","author":"Liu","year":"2019","journal-title":"Protein Cell"},{"issue":"12","key":"10.1016\/j.ejphar.2024.177101_bib57","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1007\/s00018-022-04624-4","article-title":"RBM24 controls cardiac QT interval through CaMKIIdelta splicing","volume":"79","author":"Liu","year":"2022","journal-title":"Cell. Mol. Life Sci."},{"issue":"4","key":"10.1016\/j.ejphar.2024.177101_bib58","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/s41419-021-03671-2","article-title":"Smooth muscle-specific HuR knockout induces defective autophagy and atherosclerosis","volume":"12","author":"Liu","year":"2021","journal-title":"Cell Death Dis."},{"issue":"2","key":"10.1016\/j.ejphar.2024.177101_bib59","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.bbagrm.2018.11.006","article-title":"A positive feedback regulation of Heme oxygenase 1 by CELF1 in cardiac myoblast cells","volume":"1862","author":"Liu","year":"2019","journal-title":"Biochim Biophys Acta Gene Regul Mech"},{"issue":"2","key":"10.1016\/j.ejphar.2024.177101_bib60","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24021555","article-title":"Post-transcriptional modification by alternative splicing and pathogenic splicing variants in cardiovascular development and congenital heart defects","volume":"24","author":"Mehta","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.ejphar.2024.177101_bib61","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/s41419-021-04484-z","article-title":"METTL14 suppresses pyroptosis and diabetic cardiomyopathy by downregulating TINCR lncRNA","volume":"13","author":"Meng","year":"2022","journal-title":"Cell Death Dis."},{"issue":"6","key":"10.1016\/j.ejphar.2024.177101_bib62","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/j.devcel.2020.01.037","article-title":"Aberrant expression of a non-muscle RBFOX2 isoform triggers cardiac conduction defects in myotonic dystrophy","volume":"52","author":"Misra","year":"2020","journal-title":"Dev. Cell"},{"issue":"13","key":"10.1016\/j.ejphar.2024.177101_bib63","doi-asserted-by":"crossref","first-page":"3539","DOI":"10.1016\/j.celrep.2018.08.077","article-title":"A splicing-independent function of RBM10 controls specific 3' UTR processing to regulate cardiac hypertrophy","volume":"24","author":"Mohan","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.ejphar.2024.177101_bib64","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/1750-1172-8-97","article-title":"Pulmonary arterial hypertension","volume":"8","author":"Montani","year":"2013","journal-title":"Orphanet J. Rare Dis."},{"issue":"7","key":"10.1016\/j.ejphar.2024.177101_bib65","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23073587","article-title":"Pathophysiology and treatment of diabetic cardiomyopathy and heart failure in patients with diabetes mellitus","volume":"23","author":"Nakamura","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"672","key":"10.1016\/j.ejphar.2024.177101_bib66","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.ade1633","article-title":"Precise genomic editing of pathogenic mutations in RBM20 rescues dilated cardiomyopathy","volume":"14","author":"Nishiyama","year":"2022","journal-title":"Sci. Transl. Med."},{"issue":"10","key":"10.1016\/j.ejphar.2024.177101_bib67","doi-asserted-by":"crossref","first-page":"2200","DOI":"10.1016\/j.celrep.2016.05.002","article-title":"Dysregulation of RBFOX2 is an early event in cardiac pathogenesis of diabetes","volume":"15","author":"Nutter","year":"2016","journal-title":"Cell Rep."},{"issue":"2","key":"10.1016\/j.ejphar.2024.177101_bib68","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1161\/CIRCRESAHA.118.314515","article-title":"Loss of SRSF3 in cardiomyocytes leads to decapping of contraction-related mRNAs and severe systolic dysfunction","volume":"125","author":"Ortiz-S\u00e1nchez","year":"2019","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.ejphar.2024.177101_bib69","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1002\/cbin.11216","article-title":"RNA-binding protein SFPQ cooperates with HDAC1 to suppress CD40 transcription in pulmonary adventitial fibroblasts","volume":"44","author":"Pan","year":"2020","journal-title":"Cell Biol. Int."},{"issue":"3","key":"10.1016\/j.ejphar.2024.177101_bib70","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.118.005371","article-title":"Regional variation in RBM20 causes a highly penetrant arrhythmogenic cardiomyopathy","volume":"12","author":"Parikh","year":"2019","journal-title":"Circ Heart Fail"},{"issue":"1","key":"10.1016\/j.ejphar.2024.177101_bib71","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s13062-022-00346-6","article-title":"LncRNA Airn alleviates diabetic cardiac fibrosis by inhibiting activation of cardiac fibroblasts via a m6A-IMP2-p53 axis","volume":"17","author":"Peng","year":"2022","journal-title":"Biol. Direct"},{"issue":"1","key":"10.1016\/j.ejphar.2024.177101_bib72","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.ijcard.2014.03.088","article-title":"High prevalence of cardiac involvement in patients with myotonic dystrophy type 1: a cross-sectional study","volume":"174","author":"Petri","year":"2014","journal-title":"Int. J. Cardiol."},{"issue":"5","key":"10.1016\/j.ejphar.2024.177101_bib74","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.yjmcc.2012.08.013","article-title":"Heart through participation of FoxO1","volume":"53","author":"Puthanveetil","year":"2012","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"622","key":"10.1016\/j.ejphar.2024.177101_bib75","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abe8952","article-title":"Therapeutic inhibition of RBM20 improves diastolic function in a murine heart failure model and human engineered heart tissue","volume":"13","author":"Radke","year":"2021","journal-title":"Sci. Transl. Med."},{"issue":"5","key":"10.1016\/j.ejphar.2024.177101_bib76","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.143465","article-title":"Reversible cardiac disease features in an inducible CUG repeat RNA-expressing mouse model of myotonic dystrophy","volume":"6","author":"Rao","year":"2021","journal-title":"JCI Insight"},{"issue":"4","key":"10.1016\/j.ejphar.2024.177101_bib77","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1111\/joim.12944","article-title":"Dilated cardiomyopathy: from epidemiologic to genetic phenotypes: a translational review of current literature","volume":"286","author":"Reichart","year":"2019","journal-title":"J. Intern. Med."},{"issue":"4","key":"10.1016\/j.ejphar.2024.177101_bib78","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1161\/CIRCULATIONAHA.122.059346","article-title":"RNA-binding protein LIN28a regulates new myocyte formation in the heart through long noncoding RNA-H19","volume":"147","author":"Rigaud","year":"2023","journal-title":"Circulation"},{"issue":"16","key":"10.1016\/j.ejphar.2024.177101_bib79","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1161\/CIRCULATIONAHA.122.059591","article-title":"HNRNPA2B1: RNA-binding protein that orchestrates smooth muscle cell phenotype in pulmonary arterial hypertension","volume":"146","author":"Ruffenach","year":"2022","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.ejphar.2024.177101_bib80","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/jcpe.13189","article-title":"Periodontitis and cardiovascular diseases: consensus report","volume":"47","author":"Sanz","year":"2020","journal-title":"J. Clin. Periodontol."},{"issue":"11","key":"10.1016\/j.ejphar.2024.177101_bib81","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1038\/s41591-020-1087-x","article-title":"Dysregulated ribonucleoprotein granules promote cardiomyopathy in RBM20 gene-edited pigs","volume":"26","author":"Schneider","year":"2020","journal-title":"Nat Med"},{"issue":"1","key":"10.1016\/j.ejphar.2024.177101_bib82","doi-asserted-by":"crossref","first-page":"e1573","DOI":"10.1002\/wrna.1573","article-title":"The potential of engineered eukaryotic RNA-binding proteins as molecular tools and therapeutics","volume":"11","author":"Shotwell","year":"2020","journal-title":"Wiley Interdiscip Rev RNA"},{"issue":"1","key":"10.1016\/j.ejphar.2024.177101_bib83","doi-asserted-by":"crossref","first-page":"6135","DOI":"10.1038\/s41467-020-19664-2","article-title":"A macrophage-specific lncRNA regulates apoptosis and atherosclerosis by tethering HuR in the nucleus","volume":"11","author":"Simion","year":"2020","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.ejphar.2024.177101_bib84","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1042\/BST20200688","article-title":"The search for RNA-binding proteins: a technical and interdisciplinary challenge","volume":"49","author":"Smith","year":"2021","journal-title":"Biochem. Soc. Trans."},{"issue":"12","key":"10.1016\/j.ejphar.2024.177101_bib85","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1093\/cvr\/cvz063","article-title":"Therapeutic modulation of RNA-binding protein Rbm38 facilitates re-endothelialization after arterial injury","volume":"115","author":"Sonnenschein","year":"2019","journal-title":"Cardiovasc. Res."},{"issue":"7","key":"10.1016\/j.ejphar.2024.177101_bib86","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.tibs.2020.03.005","article-title":"Global approaches in studying RNA-binding protein interaction networks","volume":"45","author":"Sternburg","year":"2020","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.ejphar.2024.177101_bib87","doi-asserted-by":"crossref","DOI":"10.1016\/j.clim.2022.109176","article-title":"Matr3 reshapes m6A modification complex to alleviate macrophage inflammation during atherosclerosis","volume":"245","author":"Sun","year":"2022","journal-title":"Clin Immunol"},{"issue":"6","key":"10.1016\/j.ejphar.2024.177101_bib88","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s00395-016-0584-z","article-title":"Cross-talk between macrophages and atrial myocytes in atrial fibrillation","volume":"111","author":"Sun","year":"2016","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.ejphar.2024.177101_bib89","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1146\/annurev-physiol-021119-034527","article-title":"Cardiac fibroblast diversity","volume":"82","author":"Tallquist","year":"2020","journal-title":"Annu. Rev. Physiol."},{"issue":"1","key":"10.1016\/j.ejphar.2024.177101_bib90","doi-asserted-by":"crossref","DOI":"10.3390\/genes12010094","article-title":"RBM20-Associated ventricular arrhythmias in a patient with structurally normal heart","volume":"12","author":"Vakhrushev","year":"2021","journal-title":"Genes"},{"issue":"13","key":"10.1016\/j.ejphar.2024.177101_bib91","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1161\/CIRCULATIONAHA.117.031947","article-title":"RBM20 mutations induce an arrhythmogenic dilated cardiomyopathy related to disturbed calcium handling","volume":"138","author":"van den Hoogenhof","year":"2018","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.ejphar.2024.177101_bib92","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2019.165620","article-title":"Genes of the cGMP-PKG-Ca(2+) signaling pathway are alternatively spliced in cardiomyopathy: role of RBFOX2","volume":"1866","author":"Wan","year":"2020","journal-title":"Biochim. Biophys. Acta, Mol. Basis Dis."},{"key":"10.1016\/j.ejphar.2024.177101_bib93","article-title":"Analysis of m(7)G methylation modification patterns and pulmonary vascular immune microenvironment in pulmonary arterial hypertension","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Immunol."},{"issue":"10","key":"10.1016\/j.ejphar.2024.177101_bib94","doi-asserted-by":"crossref","first-page":"2802","DOI":"10.1172\/JCI32308","article-title":"Elevation of RNA-binding protein CUGBP1 is an early event in an inducible heart-specific mouse model of myotonic dystrophy","volume":"117","author":"Wang","year":"2007","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.ejphar.2024.177101_bib95","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1080\/21655979.2021.1918522","article-title":"Fus knockdown inhibits the profibrogenic effect of cardiac fibroblasts induced by angiotensin II through targeting Pax3 thereby regulating TGF-beta1\/Smad pathway","volume":"12","author":"Wang","year":"2021","journal-title":"Bioengineered"},{"key":"10.1016\/j.ejphar.2024.177101_bib96","article-title":"Endothelial dysfunction and diabetic cardiomyopathy","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Endocrinol."},{"issue":"5","key":"10.1016\/j.ejphar.2024.177101_bib97","doi-asserted-by":"crossref","first-page":"L726","DOI":"10.1152\/ajplung.00407.2020","article-title":"Matrix stiffening induces a pathogenic QKI-miR-7-SRSF1 signaling axis in pulmonary arterial endothelial cells","volume":"320","author":"Woodcock","year":"2021","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"issue":"3","key":"10.1016\/j.ejphar.2024.177101_bib98","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1093\/cvr\/cvac080","article-title":"Targeting DNA damage response in cardiovascular diseases: from pathophysiology to therapeutic implications","volume":"119","author":"Wu","year":"2023","journal-title":"Cardiovasc. Res."},{"issue":"9","key":"10.1016\/j.ejphar.2024.177101_bib99","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/s41570-020-0201-4","article-title":"Inhibition of RNA-binding proteins with small molecules","volume":"4","author":"Wu","year":"2020","journal-title":"Nat. Rev. Chem"},{"issue":"6","key":"10.1016\/j.ejphar.2024.177101_bib100","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1016\/j.hrthm.2019.12.021","article-title":"Cold-inducible RNA-binding protein modulates atrial fibrillation onset by targeting multiple ion channels","volume":"17","author":"Xie","year":"2020","journal-title":"Heart Rhythm"},{"issue":"1","key":"10.1016\/j.ejphar.2024.177101_bib101","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/s12931-021-01728-6","article-title":"The role of RNA m(6)A methylation in the regulation of postnatal hypoxia-induced pulmonary hypertension","volume":"22","author":"Xu","year":"2021","journal-title":"Respir. Res."},{"issue":"2","key":"10.1016\/j.ejphar.2024.177101_bib102","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1111\/jcmm.16177","article-title":"MBNL1 regulates isoproterenol-induced myocardial remodelling in vitro and in vivo","volume":"25","author":"Xu","year":"2021","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.ejphar.2024.177101_bib103","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.2147\/DDDT.S275000","article-title":"PTBP1 targets ILK to regulate the hypoxia-induced phenotypic transformation of pulmonary artery smooth muscle cells","volume":"15","author":"Yan","year":"2021","journal-title":"Drug Des Devel Ther"},{"issue":"1","key":"10.1016\/j.ejphar.2024.177101_bib104","doi-asserted-by":"crossref","first-page":"3812","DOI":"10.1038\/s41467-020-17468-y","article-title":"Targeting QKI-7 in vivo restores endothelial cell function in diabetes","volume":"11","author":"Yang","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejphar.2024.177101_bib105","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.3389\/fphys.2018.01310","article-title":"RBPs play important roles in vascular endothelial dysfunction under diabetic conditions","volume":"9","author":"Yang","year":"2018","journal-title":"Front. Physiol."},{"issue":"14","key":"10.1016\/j.ejphar.2024.177101_bib106","doi-asserted-by":"crossref","first-page":"18238","DOI":"10.18632\/aging.203230","article-title":"Integrated analysis of m(6)A mRNA methylation in rats with monocrotaline-induced pulmonary arterial hypertension","volume":"13","author":"Zeng","year":"2021","journal-title":"Aging (Albany NY)"},{"issue":"11","key":"10.1016\/j.ejphar.2024.177101_bib107","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21113757","article-title":"RNA-binding proteins in pulmonary hypertension","volume":"21","author":"Zhang","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.ejphar.2024.177101_bib108","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1080\/19336950.2018.1499368","article-title":"Mutations in voltage-gated L-type calcium channel: implications in cardiac arrhythmia","volume":"12","author":"Zhang","year":"2018","journal-title":"Channels"},{"key":"10.1016\/j.ejphar.2024.177101_bib109","article-title":"Role of inflammation, immunity, and oxidative stress in hypertension: new insights and potential therapeutic targets","volume":"13","author":"Zhang","year":"2022","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.ejphar.2024.177101_bib110","doi-asserted-by":"crossref","DOI":"10.1111\/sji.12949","article-title":"Cold-inducible RNA-binding protein (CIRP) in inflammatory diseases: molecular insights of its associated signalling pathways","volume":"93","author":"Zhong","year":"2021","journal-title":"Scand. J. Immunol."},{"issue":"7","key":"10.1016\/j.ejphar.2024.177101_bib111","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1016\/j.hrthm.2018.02.018","article-title":"HuR-mediated SCN5A messenger RNA stability reduces arrhythmic risk in heart failure","volume":"15","author":"Zhou","year":"2018","journal-title":"Heart Rhythm"},{"issue":"7","key":"10.1016\/j.ejphar.2024.177101_bib112","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1111\/jcmm.17225","article-title":"IMP3 promotes re-endothelialization after arterial injury via increasing stability of VEGF mRNAhv","volume":"26","author":"Zhou","year":"2022","journal-title":"J. Cell Mol. Med."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001429992400791X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001429992400791X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:20:29Z","timestamp":1777404029000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S001429992400791X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":111,"alternative-id":["S001429992400791X"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2024.177101","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"RNA binding proteins: Mechanistic considerations and perspectives in controlling cardiovascular diseases","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2024.177101","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"177101"}}