{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T06:09:21Z","timestamp":1789538961933,"version":"build-2803163510"},"reference-count":87,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004763","name":"Inner Mongolia Autonomous Region Natural Science Foundation","doi-asserted-by":"publisher","award":["2024QN08029"],"award-info":[{"award-number":["2024QN08029"]}],"id":[{"id":"10.13039\/501100004763","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004763","name":"Inner Mongolia Autonomous Region Natural Science Foundation","doi-asserted-by":"publisher","award":["2023MS08052"],"award-info":[{"award-number":["2023MS08052"]}],"id":[{"id":"10.13039\/501100004763","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004763","name":"Inner Mongolia Autonomous Region Natural Science Foundation","doi-asserted-by":"publisher","award":["2021BS08006N"],"award-info":[{"award-number":["2021BS08006N"]}],"id":[{"id":"10.13039\/501100004763","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82160309"],"award-info":[{"award-number":["82160309"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.ejphar.2024.177136","type":"journal-article","created":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T17:07:12Z","timestamp":1731690432000},"page":"177136","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Analysis of how melatonin-upregulated clock genes PER2 and CRY2 alleviate rheumatoid arthritis-associated interstitial lung disease"],"prefix":"10.1016","volume":"986","author":[{"given":"Yinping","family":"Huo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajie","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingle","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiyao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiyang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyan","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongfu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2024.177136_bib1","doi-asserted-by":"crossref","first-page":"2997","DOI":"10.1007\/s00018-014-1579-2","article-title":"Extrapineal melatonin: sources, regulation, and potential functions","volume":"71","author":"Acu\u00f1a-Castroviejo","year":"2014","journal-title":"Cell. Mol. Life Sci. : CMLS"},{"key":"10.1016\/j.ejphar.2024.177136_bib2","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.jconrel.2018.05.035","article-title":"Lipid nanoparticles with minimum burst release of TNF-\u03b1 siRNA show strong activity against rheumatoid arthritis unresponsive to methotrexate","volume":"283","author":"Aldayel","year":"2018","journal-title":"J. Contr. Release : official journal of the Controlled Release Society"},{"key":"10.1016\/j.ejphar.2024.177136_bib3","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1002\/art.27584","article-title":"2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology\/European League against Rheumatism collaborative initiative","volume":"62","author":"Aletaha","year":"2010","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.ejphar.2024.177136_bib4","doi-asserted-by":"crossref","first-page":"3733","DOI":"10.1016\/j.celrep.2018.11.101","article-title":"REV-ERB\u03b1 regulates T(H)17 cell development and autoimmunity","volume":"25","author":"Amir","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.ejphar.2024.177136_bib5","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1136\/jcp.41.4.467","article-title":"Simple method of estimating severity of pulmonary fibrosis on a numerical scale","volume":"41","author":"Ashcroft","year":"1988","journal-title":"Journal of clinical pathology"},{"key":"10.1016\/j.ejphar.2024.177136_bib6","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1007\/s00198-023-06836-1","article-title":"Melatonin and bone-related diseases: an updated mechanistic overview of current evidence and future prospects","volume":"34","author":"Bagherifard","year":"2023","journal-title":"Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA"},{"key":"10.1016\/j.ejphar.2024.177136_bib7","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0140-6736(08)60114-2","article-title":"Glucocorticoid chronotherapy in rheumatoid arthritis","volume":"371","author":"Bijlsma","year":"2008","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.ejphar.2024.177136_bib8","doi-asserted-by":"crossref","first-page":"e25","DOI":"10.1016\/S0140-6736(17)32661-2","article-title":"Nobel Prize awarded for discoveries in circadian rhythm","volume":"390","author":"Burki","year":"2017","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.ejphar.2024.177136_bib9","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2021174118","article-title":"Molecular mechanism of the repressive phase of the mammalian circadian clock","volume":"118","author":"Cao","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejphar.2024.177136_bib10","doi-asserted-by":"crossref","first-page":"18528","DOI":"10.1073\/pnas.1907563116","article-title":"The nuclear receptor REV-ERB\u03b1 modulates Th17 cell-mediated autoimmune disease","volume":"116","author":"Chang","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejphar.2024.177136_bib11","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1016\/j.febslet.2010.03.019","article-title":"Altered circadian rhythm of the clock genes in fibrotic livers induced by carbon tetrachloride","volume":"584","author":"Chen","year":"2010","journal-title":"FEBS Lett."},{"key":"10.1016\/j.ejphar.2024.177136_bib12","doi-asserted-by":"crossref","first-page":"63","DOI":"10.2353\/ajpath.2009.080430","article-title":"The protective role of Per2 against carbon tetrachloride-induced hepatotoxicity","volume":"174","author":"Chen","year":"2009","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.ejphar.2024.177136_bib13","doi-asserted-by":"crossref","first-page":"867","DOI":"10.3389\/fimmu.2020.00867","article-title":"A pro- and anti-inflammatory Axis modulates the macrophage circadian clock","volume":"11","author":"Chen","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejphar.2024.177136_bib14","doi-asserted-by":"crossref","DOI":"10.3390\/cells10020436","article-title":"Macrophages in lung injury, repair, and fibrosis","volume":"10","author":"Cheng","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.ejphar.2024.177136_bib15","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0929-6646(08)60143-6","article-title":"MMP-9 mRNA as a therapeutic marker in acute and chronic stages of arthritis induced by type II collagen antibody","volume":"107","author":"Chia","year":"2008","journal-title":"Journal of the Formosan Medical Association = Taiwan yi zhi"},{"key":"10.1016\/j.ejphar.2024.177136_bib16","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1002\/art.1780351107","article-title":"Defective hypothalamic response to immune and inflammatory stimuli in patients with rheumatoid arthritis","volume":"35","author":"Chikanza","year":"1992","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.ejphar.2024.177136_bib17","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1089\/ten.teb.2016.0463","article-title":"Collagen membrane and immune response in guided bone regeneration: recent progress and perspectives","volume":"23","author":"Chu","year":"2017","journal-title":"Tissue Eng. B Rev."},{"key":"10.1016\/j.ejphar.2024.177136_bib18","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1210\/er.2018-00084","article-title":"Melatonin as a hormone: new physiological and clinical insights","volume":"39","author":"Cipolla-Neto","year":"2018","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.ejphar.2024.177136_bib19","doi-asserted-by":"crossref","first-page":"R93","DOI":"10.1530\/JME-19-0153","article-title":"Circadian clock genes and the transcriptional architecture of the clock mechanism","volume":"63","author":"Cox","year":"2019","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.ejphar.2024.177136_bib20","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1073\/pnas.1912109117","article-title":"The circadian clock protein REVERB\u03b1 inhibits pulmonary fibrosis development","volume":"117","author":"Cunningham","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejphar.2024.177136_bib21","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.jbspin.2018.09.003","article-title":"Circadian rhythms and rheumatoid arthritis","volume":"86","author":"Cutolo","year":"2019","journal-title":"Joint Bone Spine"},{"key":"10.1016\/j.ejphar.2024.177136_bib22","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.autrev.2005.04.019","article-title":"Altered circadian rhythms in rheumatoid arthritis patients play a role in the disease's symptoms","volume":"4","author":"Cutolo","year":"2005","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.ejphar.2024.177136_bib23","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.clnesp.2023.04.011","article-title":"Melatonin supplementation improves rheumatological disease activity: a systematic review","volume":"55","author":"de Carvalho","year":"2023","journal-title":"Clinical nutrition ESPEN"},{"key":"10.1016\/j.ejphar.2024.177136_bib24","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.phrs.2015.04.012","article-title":"Bleomycin in the setting of lung fibrosis induction: from biological mechanisms to counteractions","volume":"97","author":"Della Latta","year":"2015","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.ejphar.2024.177136_bib25","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24032363","article-title":"Disruption of the expression of the placental clock and melatonin genes in preeclampsia","volume":"24","author":"Diallo","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2024.177136_bib26","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1146\/annurev-physiol-021909-135821","article-title":"The mammalian circadian timing system: organization and coordination of central and peripheral clocks","volume":"72","author":"Dibner","year":"2010","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.ejphar.2024.177136_bib27","doi-asserted-by":"crossref","first-page":"E8460","DOI":"10.1073\/pnas.1800431115","article-title":"Circadian clock protein BMAL1 regulates IL-1\u03b2 in macrophages via NRF2","volume":"115","author":"Early","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejphar.2024.177136_bib28","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.immuni.2017.02.006","article-title":"Immunopathogenesis of rheumatoid arthritis","volume":"46","author":"Firestein","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.ejphar.2024.177136_bib29","doi-asserted-by":"crossref","first-page":"640","DOI":"10.3899\/jrheum.121043","article-title":"Mycophenolate mofetil improves lung function in connective tissue disease-associated interstitial lung disease","volume":"40","author":"Fischer","year":"2013","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.ejphar.2024.177136_bib30","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1111\/j.1365-2125.2007.02911.x","article-title":"Inflammatory status and kynurenine metabolism in rheumatoid arthritis treated with melatonin","volume":"64","author":"Forrest","year":"2007","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.ejphar.2024.177136_bib31","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1038\/nm.3599","article-title":"An epithelial circadian clock controls pulmonary inflammation and glucocorticoid action","volume":"20","author":"Gibbs","year":"2014","journal-title":"Nature medicine"},{"key":"10.1016\/j.ejphar.2024.177136_bib32","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1210\/en.2008-0638","article-title":"Circadian timing in the lung; a specific role for bronchiolar epithelial cells","volume":"150","author":"Gibbs","year":"2009","journal-title":"Endocrinology"},{"key":"10.1016\/j.ejphar.2024.177136_bib33","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1073\/pnas.1106750109","article-title":"The nuclear receptor REV-ERB\u03b1 mediates circadian regulation of innate immunity through selective regulation of inflammatory cytokines","volume":"109","author":"Gibbs","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ejphar.2024.177136_bib34","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1008692","article-title":"Loss of FOXM1 in macrophages promotes pulmonary fibrosis by activating p38 MAPK signaling pathway","volume":"16","author":"Goda","year":"2020","journal-title":"PLoS Genet."},{"key":"10.1016\/j.ejphar.2024.177136_bib35","doi-asserted-by":"crossref","DOI":"10.1186\/ar3852","article-title":"Disruption of rhythms of molecular clocks in primary synovial fibroblasts of patients with osteoarthritis and rheumatoid arthritis, role of IL-1\u03b2\/TNF","volume":"14","author":"Haas","year":"2012","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.ejphar.2024.177136_bib36","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1126\/science.1227568","article-title":"JNK expression by macrophages promotes obesity-induced insulin resistance and inflammation","volume":"339","author":"Han","year":"2013","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.ejphar.2024.177136_bib37","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s13075-018-1770-1","article-title":"The circadian regulator Bmal1 in joint mesenchymal cells regulates both joint development and inflammatory arthritis","volume":"21","author":"Hand","year":"2019","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.ejphar.2024.177136_bib38","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.4049\/jimmunol.0903284","article-title":"Mammalian clock gene Cryptochrome regulates arthritis via proinflammatory cytokine TNF-alpha","volume":"184","author":"Hashiramoto","year":"2010","journal-title":"Journal of immunology"},{"key":"10.1016\/j.ejphar.2024.177136_bib39","doi-asserted-by":"crossref","DOI":"10.1136\/rmdopen-2017-000475","article-title":"Relationship between shift work and the onset of rheumatoid arthritis","volume":"3","author":"Hedstr\u00f6m","year":"2017","journal-title":"RMD Open"},{"key":"10.1016\/j.ejphar.2024.177136_bib40","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12560","article-title":"Melatonin attenuates TNF-\u03b1 and IL-1\u03b2 expression in synovial fibroblasts and diminishes cartilage degradation: implications for the treatment of rheumatoid arthritis","volume":"66","author":"Huang","year":"2019","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.ejphar.2024.177136_bib41","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.preteyeres.2005.01.003","article-title":"Circadian clocks, clock networks, arylalkylamine N-acetyltransferase, and melatonin in the retina","volume":"24","author":"Iuvone","year":"2005","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.ejphar.2024.177136_bib42","doi-asserted-by":"crossref","first-page":"3230","DOI":"10.1111\/bph.13898","article-title":"Melatonin in regulation of inflammatory pathways in rheumatoid arthritis and osteoarthritis: involvement of circadian clock genes","volume":"175","author":"Jahanban-Esfahlan","year":"2018","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2024.177136_bib43","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3000303","article-title":"Individual metabolomic signatures of circadian misalignment during simulated night shifts in humans","volume":"17","author":"Kervezee","year":"2019","journal-title":"PLoS Biol."},{"key":"10.1016\/j.ejphar.2024.177136_bib44","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.678457","article-title":"Roles of macrophage polarization and macrophage-derived miRNAs in pulmonary fibrosis","volume":"12","author":"Kishore","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejphar.2024.177136_bib45","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.73976","article-title":"Quantification of protein abundance and interaction defines a mechanism for operation of the circadian clock","volume":"11","author":"Koch","year":"2022","journal-title":"Elife"},{"key":"10.1016\/j.ejphar.2024.177136_bib46","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1111\/j.1365-2125.2008.03181.x","article-title":"Melatonin as an adjuvant therapy in patients with rheumatoid arthritis","volume":"66","author":"Korkmaz","year":"2008","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.ejphar.2024.177136_bib47","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/nrm3758","article-title":"Molecular mechanisms of epithelial-mesenchymal transition","volume":"15","author":"Lamouille","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ejphar.2024.177136_bib48","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1038\/s41401-022-01018-x","article-title":"Melatonin ameliorates bleomycin-induced pulmonary fibrosis via activating NRF2 and inhibiting galectin-3 expression","volume":"44","author":"Lan","year":"2023","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.ejphar.2024.177136_bib49","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S1474-4422(18)30461-7","article-title":"Association between circadian rhythms and neurodegenerative diseases","volume":"18","author":"Leng","year":"2019","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.ejphar.2024.177136_bib50","article-title":"New therapeutic strategies for IPF: based on the \"phagocytosis-secretion-immunization\" network regulation mechanism of pulmonary macrophages","volume":"118","author":"Liu","year":"2019","journal-title":"Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie"},{"key":"10.1016\/j.ejphar.2024.177136_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2022.115073","article-title":"Melatonin regulates the immune response and improves Sj\u00f6gren's syndrome-like symptoms in NOD\/Ltj Mice","volume":"201","author":"Liu","year":"2022","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejphar.2024.177136_bib52","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome biology"},{"key":"10.1016\/j.ejphar.2024.177136_bib53","first-page":"138","article-title":"Diagnostic criteria for idiopathic pulmonary fibrosis: a fleischner society white paper. The lancet","volume":"6","author":"Lynch","year":"2018","journal-title":"Respir. Med."},{"key":"10.1016\/j.ejphar.2024.177136_bib54","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1111\/j.1365-2125.2007.03088.x","article-title":"Melatonin treatment does not improve rheumatoid arthritis","volume":"65","author":"Maestroni","year":"2008","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.ejphar.2024.177136_bib55","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1126\/science.aah4966","article-title":"Immunity around the clock","volume":"354","author":"Man","year":"2016","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.ejphar.2024.177136_bib56","first-page":"7202","article-title":"miR-590-3p mediates melatonin-induced cell apoptosis by targeting septin 7 in the human osteoblast cell line hFOB 1.19","volume":"17","author":"Meng","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.ejphar.2024.177136_bib57","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1146\/annurev-neuro-060909-153128","article-title":"Central and peripheral circadian clocks in mammals","volume":"35","author":"Mohawk","year":"2012","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.ejphar.2024.177136_bib58","doi-asserted-by":"crossref","DOI":"10.1111\/ijcp.14246","article-title":"Effects of melatonin supplementation on serum oxidative stress markers and disease activity in systemic lupus erythematosus patients: a randomised, double-blind, placebo-controlled trial","volume":"75","author":"Nabatian-Asl","year":"2021","journal-title":"Int. J. Clin. Pract."},{"key":"10.1016\/j.ejphar.2024.177136_bib59","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/j.1600-079X.2009.00689.x","article-title":"Melatonin inhibits human fibroblast-like synoviocyte proliferation via extracellular signal-regulated protein kinase\/P21(CIP1)\/P27(KIP1) pathways","volume":"47","author":"Nah","year":"2009","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.ejphar.2024.177136_bib60","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/614529","article-title":"Temporal regulation of cytokines by the circadian clock","volume":"2014","author":"Nakao","year":"2014","journal-title":"Journal of immunology research"},{"key":"10.1016\/j.ejphar.2024.177136_bib61","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1164\/rccm.201004-0622OC","article-title":"Rheumatoid arthritis-interstitial lung disease-associated mortality","volume":"183","author":"Olson","year":"2011","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.ejphar.2024.177136_bib62","doi-asserted-by":"crossref","first-page":"96","DOI":"10.3389\/fcimb.2020.00096","article-title":"Circadian regulation of immunity through epigenetic mechanisms","volume":"10","author":"Orozco-Solis","year":"2020","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.ejphar.2024.177136_bib63","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1186\/ar2292","article-title":"Cells of the synovium in rheumatoid arthritis","volume":"9","author":"Otero","year":"2007","journal-title":"Chondrocytes. Arthritis research & therapy"},{"key":"10.1016\/j.ejphar.2024.177136_bib64","doi-asserted-by":"crossref","first-page":"189","DOI":"10.5114\/reum.2017.69779","article-title":"Glucocorticoid management in rheumatoid arthritis: morning or night low dose?","volume":"55","author":"Paolino","year":"2017","journal-title":"Reumatologia"},{"key":"10.1016\/j.ejphar.2024.177136_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102509","article-title":"Inhibition of ferroptosis and iron accumulation alleviates pulmonary fibrosis in a bleomycin model","volume":"57","author":"Pei","year":"2022","journal-title":"Redox Biol."},{"key":"10.1016\/j.ejphar.2024.177136_bib66","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1101\/gad.237081.113","article-title":"The circadian clock regulates rhythmic activation of the NRF2\/glutathione-mediated antioxidant defense pathway to modulate pulmonary fibrosis","volume":"28","author":"Pekovic-Vaughan","year":"2014","journal-title":"Genes & development"},{"key":"10.1016\/j.ejphar.2024.177136_bib67","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/s13073-020-00783-w","article-title":"The murine Microenvironment Cell Population counter method to estimate abundance of tissue-infiltrating immune and stromal cell populations in murine samples using gene expression","volume":"12","author":"Petitprez","year":"2020","journal-title":"Genome Med."},{"key":"10.1016\/j.ejphar.2024.177136_bib68","doi-asserted-by":"crossref","DOI":"10.21769\/BioProtoc.1626","article-title":"Collagen-induced arthritis: a model for murine autoimmune arthritis","volume":"5","author":"Pietrosimone","year":"2015","journal-title":"Bio-protocol"},{"key":"10.1016\/j.ejphar.2024.177136_bib69","doi-asserted-by":"crossref","first-page":"L998","DOI":"10.1152\/ajplung.00304.2017","article-title":"Nintedanib reduces pulmonary fibrosis in a model of rheumatoid arthritis-associated interstitial lung disease","volume":"314","author":"Redente","year":"2018","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.ejphar.2024.177136_bib70","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"key":"10.1016\/j.ejphar.2024.177136_bib71","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/03009742.2011.566433","article-title":"Morning symptoms in rheumatoid arthritis: a defining characteristic and marker of active disease","volume":"125","author":"Sierakowski","year":"2011","journal-title":"Scand. J. Rheumatol. Suppl."},{"key":"10.1016\/j.ejphar.2024.177136_bib72","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1136\/annrheumdis-2020-217230","article-title":"Mechanisms of progressive fibrosis in connective tissue disease (CTD)-associated interstitial lung diseases (ILDs)","volume":"80","author":"Spagnolo","year":"2021","journal-title":"Annals of the rheumatic diseases"},{"key":"10.1016\/j.ejphar.2024.177136_bib73","doi-asserted-by":"crossref","first-page":"D605","DOI":"10.1093\/nar\/gkaa1074","article-title":"The STRING database in 2021: customizable protein-protein networks, and functional characterization of user-uploaded gene\/measurement sets","volume":"49","author":"Szklarczyk","year":"2021","journal-title":"Nucleic acids research"},{"key":"10.1016\/j.ejphar.2024.177136_bib74","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1254\/jphs.13R06CR","article-title":"Chrono-biology, chrono-pharmacology, and chrono-nutrition","volume":"124","author":"Tahara","year":"2014","journal-title":"Journal of pharmacological sciences"},{"key":"10.1016\/j.ejphar.2024.177136_bib75","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.atherosclerosis.2018.05.046","article-title":"Loss of CLOCK under high glucose upregulates ROCK1-mediated endothelial to mesenchymal transition and aggravates plaque vulnerability","volume":"275","author":"Tang","year":"2018","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.ejphar.2024.177136_bib76","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1111\/ejn.14361","article-title":"Mechanisms of circadian clock interactions with aryl hydrocarbon receptor signalling","volume":"51","author":"Tischkau","year":"2020","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.ejphar.2024.177136_bib77","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12988","article-title":"Circadian clock genes promote glioma progression by affecting tumour immune infiltration and tumour cell proliferation","volume":"54","author":"Wang","year":"2021","journal-title":"Cell Prolif."},{"key":"10.1016\/j.ejphar.2024.177136_bib78","first-page":"1520","article-title":"High resolution computed tomography in early scleroderma lung disease","volume":"18","author":"Warrick","year":"1991","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.ejphar.2024.177136_bib79","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/s41467-017-00462-2","article-title":"Misalignment with the external light environment drives metabolic and cardiac dysfunction","volume":"8","author":"West","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejphar.2024.177136_bib80","series-title":"ggplot2 - Elegant Graphics for Data Analysis, Use R!","author":"Wickham","year":"2009"},{"key":"10.1016\/j.ejphar.2024.177136_bib81","doi-asserted-by":"crossref","DOI":"10.1111\/apha.14028","article-title":"Detecting and exploiting the circadian clock in rheumatoid arthritis","volume":"239","author":"Wilantri","year":"2023","journal-title":"Acta Physiol."},{"key":"10.1016\/j.ejphar.2024.177136_bib82","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1007\/s00296-023-05296-4","article-title":"Association between levels of serotonin, melatonin, cortisol and the clinical condition of patients with rheumatoid arthritis","volume":"43","author":"Wr\u00f3bel","year":"2023","journal-title":"Rheumatol. Int."},{"key":"10.1016\/j.ejphar.2024.177136_bib83","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2021.102866","article-title":"Circadian clock genes as promising therapeutic targets for autoimmune diseases","volume":"20","author":"Xiang","year":"2021","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.ejphar.2024.177136_bib84","doi-asserted-by":"crossref","DOI":"10.1016\/j.micres.2022.127292","article-title":"Acute sleep deprivation exacerbates systemic inflammation and psychiatry disorders through gut microbiota dysbiosis and disruption of circadian rhythms","volume":"268","author":"Yang","year":"2023","journal-title":"Microbiol. Res."},{"key":"10.1016\/j.ejphar.2024.177136_bib85","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/282495","article-title":"Involvement of the circadian rhythm and inflammatory cytokines in the pathogenesis of rheumatoid arthritis","volume":"2014","author":"Yoshida","year":"2014","journal-title":"Journal of immunology research"},{"key":"10.1016\/j.ejphar.2024.177136_bib86","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"OMICS A J. Integr. Biol."},{"key":"10.1016\/j.ejphar.2024.177136_bib87","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cytogfr.2019.07.002","article-title":"Potential role of melatonin in autoimmune diseases","volume":"48","author":"Zhao","year":"2019","journal-title":"Cytokine Growth Factor Rev."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299924008264?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299924008264?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T01:09:51Z","timestamp":1733792991000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299924008264"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":87,"alternative-id":["S0014299924008264"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2024.177136","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Analysis of how melatonin-upregulated clock genes PER2 and CRY2 alleviate rheumatoid arthritis-associated interstitial lung disease","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2024.177136","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"177136"}}