{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T20:32:09Z","timestamp":1783629129429,"version":"3.55.0"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:00:00Z","timestamp":1763510400000},"content-version":"am","delay-in-days":322,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100000278","name":"Department for International Development, UK Government","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000278","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000873","name":"Queen's University Belfast","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000873","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000200","name":"USAID","doi-asserted-by":"publisher","award":["0703-03"],"award-info":[{"award-number":["0703-03"]}],"id":[{"id":"10.13039\/100000200","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007842","name":"Utenriksdepartementet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007842","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.ejphar.2024.177138","type":"journal-article","created":{"date-parts":[[2024,11,17]],"date-time":"2024-11-17T20:36:22Z","timestamp":1731875782000},"page":"177138","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Modified lipoprotein-induced sFlt1 production in human placental trophoblasts is mediated by protein kinase C"],"prefix":"10.1016","volume":"986","author":[{"given":"Rebecca P.","family":"Chow","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7199-0270","authenticated-orcid":false,"given":"Jiawu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanchun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1543-2781","authenticated-orcid":false,"given":"Tim M.","family":"Curtis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy J.","family":"Lyons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2491-4806","authenticated-orcid":false,"given":"Jeremy Y.","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2024.177138_bib1","first-page":"1122","article-title":"Hypertension in pregnancy, report of the American college of obstetricians and gynecologists' task force on hypertension in pregnancy","volume":"122","year":"2013","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.ejphar.2024.177138_bib2","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1161\/HYPERTENSIONAHA.109.136333","article-title":"Activation of proteinase-activated receptor 2 stimulates soluble vascular endothelial growth factor receptor 1 release via epidermal growth factor receptor transactivation in endothelial cells","volume":"55","author":"Al-Ani","year":"2010","journal-title":"Hypertension"},{"key":"10.1016\/j.ejphar.2024.177138_bib3","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1080\/01443615.2016.1269227","article-title":"Increased circulating oxidised low-density lipoprotein and antibodies to oxidised low-density lipoprotein in preeclampsia","volume":"37","author":"Arifin","year":"2017","journal-title":"J. Obstet. Gynaecol."},{"key":"10.1016\/j.ejphar.2024.177138_bib4","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1016\/S0140-6736(07)60712-0","article-title":"Antiplatelet agents for prevention of pre-eclampsia: a meta-analysis of individual patient data","volume":"369","author":"Askie","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.ejphar.2024.177138_bib5","doi-asserted-by":"crossref","first-page":"2200","DOI":"10.1007\/s00125-007-0768-z","article-title":"Oxidised, glycated LDL selectively influences tissue inhibitor of metalloproteinase-3 gene expression and protein production in human retinal capillary pericytes","volume":"50","author":"Barth","year":"2007","journal-title":"Diabetologia"},{"key":"10.1016\/j.ejphar.2024.177138_bib6","doi-asserted-by":"crossref","first-page":"IX","DOI":"10.3109\/10641950109152635","article-title":"The classification and diagnosis of the hypertensive disorders of pregnancy: statement from the International Society for the Study of Hypertension in Pregnancy (ISSHP)","volume":"20","author":"Brown","year":"2001","journal-title":"Hypertens. Pregnancy"},{"key":"10.1016\/j.ejphar.2024.177138_bib7","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1038\/414813a","article-title":"Biochemistry and molecular cell biology of diabetic complications","volume":"414","author":"Brownlee","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2024.177138_bib8","doi-asserted-by":"crossref","first-page":"7847","DOI":"10.1016\/S0021-9258(18)34459-4","article-title":"Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters","volume":"257","author":"Castagna","year":"1982","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2024.177138_bib9","doi-asserted-by":"crossref","first-page":"159","DOI":"10.3109\/10641955.2015.1122035","article-title":"Attenuation of hyperglycemia-induced apoptotic signaling and anti-angiogenic milieu in cultured cytotrophoblast cells","volume":"35","author":"Cawyer","year":"2016","journal-title":"Hypertens. Pregnancy"},{"key":"10.1016\/j.ejphar.2024.177138_bib10","doi-asserted-by":"crossref","first-page":"81","DOI":"10.3109\/10641955.2013.837175","article-title":"The association of circulating angiogenic factors and HbA1c with the risk of preeclampsia in women with preexisting diabetes","volume":"33","author":"Cohen","year":"2014","journal-title":"Hypertens. Pregnancy"},{"key":"10.1016\/j.ejphar.2024.177138_bib11","article-title":"Antiplatelet agents for preventing pre-eclampsia and its complications","volume":"CD004659","author":"Duley","year":"2007","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.ejphar.2024.177138_bib12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001425","article-title":"Preeclampsia as a risk factor for diabetes: a population-based cohort study","volume":"10","author":"Feig","year":"2013","journal-title":"PLoS Med."},{"key":"10.1016\/j.ejphar.2024.177138_bib13","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1194\/jlr.M045401","article-title":"Immune complex formation in human diabetic retina enhances toxicity of oxidized LDL towards retinal capillary pericytes","volume":"55","author":"Fu","year":"2014","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.ejphar.2024.177138_bib14","first-page":"421","article-title":"Increased serum oxidized low-density lipoprotein levels in pregnancies complicated by gestational diabetes mellitus","volume":"13","author":"Ghaneei","year":"2015","journal-title":"Iran. J. Reproductive Med."},{"key":"10.1016\/j.ejphar.2024.177138_bib15","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1006\/excr.1993.1139","article-title":"Establishment and characterization of first trimester human trophoblast cells with extended lifespan","volume":"206","author":"Graham","year":"1993","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.ejphar.2024.177138_bib16","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1006\/bbrc.1994.1199","article-title":"Rottlerin, a novel protein kinase inhibitor","volume":"199","author":"Gschwendt","year":"1994","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejphar.2024.177138_bib17","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/S0140-6736(05)60605-8","article-title":"Endothelial-cell permeability and protein kinase C in pre-eclampsia","volume":"351","author":"Haller","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.ejphar.2024.177138_bib18","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1111\/aji.12339","article-title":"Glucose and metformin modulate human first trimester trophoblast function: a model and potential therapy for diabetes-associated uteroplacental insufficiency","volume":"73","author":"Han","year":"2015","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.ejphar.2024.177138_bib19","doi-asserted-by":"crossref","first-page":"695","DOI":"10.7326\/M13-2844","article-title":"Low-dose aspirin for prevention of morbidity and mortality from preeclampsia: a systematic evidence review for the U.S. Preventive Services Task Force","volume":"160","author":"Henderson","year":"2014","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.ejphar.2024.177138_bib20","doi-asserted-by":"crossref","first-page":"3671","DOI":"10.2337\/dc13-0944","article-title":"The role of angiogenic and antiangiogenic factors in the second trimester in the prediction of preeclampsia in pregnant women with type 1 diabetes","volume":"36","author":"Holmes","year":"2013","journal-title":"Diabetes Care"},{"key":"10.1016\/j.ejphar.2024.177138_bib21","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1159\/000261788","article-title":"Protein kinase C-alpha activation induces NF-kB-dependent VCAM-1 expression in cultured human umbilical vein endothelial cells treated with sera from preeclamptic patients","volume":"69","author":"Jiang","year":"2010","journal-title":"Gynecol. Obstet. Invest."},{"key":"10.1016\/j.ejphar.2024.177138_bib22","doi-asserted-by":"crossref","first-page":"e115","DOI":"10.1038\/emm.2014.59","article-title":"Preeclampsia serum-induced collagen I expression and intracellular calcium levels in arterial smooth muscle cells are mediated by the PLC-\u03b31 pathway","volume":"46","author":"Jiang","year":"2014","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.ejphar.2024.177138_bib23","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1002\/jcp.24526","article-title":"Choline inadequacy impairs trophoblast function and vascularization in cultured human placental trophoblasts","volume":"229","author":"Jiang","year":"2014","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.ejphar.2024.177138_bib24","doi-asserted-by":"crossref","first-page":"2664","DOI":"10.1021\/jm950588y","article-title":"(S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16, 21-dimetheno-1H, 13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H)-d ione (LY333531) and related analogues: isozyme selective inhibitors of protein kinase C beta","volume":"39","author":"Jirousek","year":"1996","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejphar.2024.177138_bib25","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.ejogrb.2006.07.046","article-title":"Paraoxonase gene polymorphism, serum lipid, and oxidized low-density lipoprotein in preeclampsia","volume":"133","author":"Kim","year":"2007","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"10.1016\/j.ejphar.2024.177138_bib26","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1189\/jlb.1007691","article-title":"Novel PKC signaling is required for LPS-induced soluble Flt-1 expression in macrophages","volume":"84","author":"Lee","year":"2008","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.ejphar.2024.177138_bib27","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1056\/NEJMoa031884","article-title":"Circulating angiogenic factors and the risk of preeclampsia","volume":"350","author":"Levine","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejphar.2024.177138_bib28","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/0006-2952(93)90541-4","article-title":"Inhibition by Ro 31-8220 of acid secretory activity induced by carbachol indicates a stimulatory role for protein kinase C in the action of muscarinic agonists on isolated rat parietal cells","volume":"46","author":"McKenna","year":"1993","journal-title":"Biochem. Pharmacol."},{"issue":"1","key":"10.1016\/j.ejphar.2024.177138_bib29","doi-asserted-by":"crossref","DOI":"10.1136\/bmjdrc-2020-001696","article-title":"Effects of modified lipoproteins on human trophoblast cells: a role in pre-eclampsia in pregnancies complicated by diabetes","volume":"9","author":"McLeese","year":"2021","journal-title":"BMJ Open Diabetes Res. Care"},{"key":"10.1016\/j.ejphar.2024.177138_bib30","first-page":"359","article-title":"Upregulation of angiogenic factors via protein kinase C and hypoxia-induced factor-1alpha pathways under high-glucose conditions in the placenta","volume":"72","author":"Mitsui","year":"2018","journal-title":"Acta Med. Okayama"},{"key":"10.1016\/j.ejphar.2024.177138_bib31","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1053\/j.ackd.2013.02.003","article-title":"New developments in the pathogenesis of preeclampsia","volume":"20","author":"Naljayan","year":"2013","journal-title":"Adv. Chron. Kidney Dis."},{"key":"10.1016\/j.ejphar.2024.177138_bib32","doi-asserted-by":"crossref","first-page":"R1085","DOI":"10.1152\/ajpregu.00794.2005","article-title":"Increased expression of sFlt-1 in in vivo and in vitro models of human placental hypoxia is mediated by HIF-1","volume":"291","author":"Nevo","year":"2006","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.ejphar.2024.177138_bib33","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0013263","article-title":"Soluble fms-like tyrosine kinase 1 (sFlt1), endoglin and placental growth factor (PlGF) in preeclampsia among high risk pregnancies","volume":"5","author":"Powers","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2024.177138_bib34","doi-asserted-by":"crossref","first-page":"2578","DOI":"10.1016\/j.yexcr.2013.07.005","article-title":"Protein kinase C regulates FLT1 abundance and stimulates its cleavage in vascular endothelial cells with the release of a soluble PlGF\/VEGF antagonist","volume":"319","author":"Raikwar","year":"2013","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.ejphar.2024.177138_bib35","doi-asserted-by":"crossref","first-page":"189","DOI":"10.3109\/10641955.2013.784788","article-title":"Clinical characterization and outcomes of preeclampsia with normal angiogenic profile","volume":"32","author":"Rana","year":"2013","journal-title":"Hypertens. Pregnancy"},{"issue":"Suppl. A","key":"10.1016\/j.ejphar.2024.177138_bib36","doi-asserted-by":"crossref","first-page":"S32","DOI":"10.1016\/j.placenta.2008.11.009","article-title":"The two stage model of preeclampsia: variations on the theme","volume":"30","author":"Roberts","year":"2009","journal-title":"Placenta"},{"key":"10.1016\/j.ejphar.2024.177138_bib37","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1186\/1471-2393-13-240","article-title":"Risk of future cardiovascular disease in women with prior preeclampsia: a focus group study","volume":"13","author":"Seely","year":"2013","journal-title":"BMC Pregnancy Childbirth"},{"key":"10.1016\/j.ejphar.2024.177138_bib38","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1016\/S0006-2952(98)00045-8","article-title":"Induction of apoptosis in glioblastoma cells by inhibition of protein kinase C and its association with the rapid accumulation of p53 and induction of the insulin-like growth factor-1-binding protein-3","volume":"55","author":"Shen","year":"1998","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejphar.2024.177138_bib39","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0112890","article-title":"Protein profiling of preeclampsia placental tissues","volume":"9","author":"Shu","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2024.177138_bib40","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.tips.2007.07.003","article-title":"Rottlerin: an inappropriate and ineffective inhibitor of PKCdelta","volume":"28","author":"Soltoff","year":"2007","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.ejphar.2024.177138_bib41","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1681\/ASN.2015020157","article-title":"Removal of soluble fms-like tyrosine kinase-1 by dextran sulfate apheresis in preeclampsia","volume":"27","author":"Thadhani","year":"2016","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.ejphar.2024.177138_bib42","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1161\/CIRCULATIONAHA.111.034793","article-title":"Pilot study of extracorporeal removal of soluble fms-like tyrosine kinase 1 in preeclampsia","volume":"124","author":"Thadhani","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2024.177138_bib43","doi-asserted-by":"crossref","first-page":"15771","DOI":"10.1016\/S0021-9258(18)98476-0","article-title":"The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C","volume":"266","author":"Toullec","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2024.177138_bib44","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1159\/000087205","article-title":"Circulating oxidized low-density lipoprotein and paraoxonase activity in preeclampsia","volume":"60","author":"Uzun","year":"2005","journal-title":"Gynecol. Obstet. Invest."},{"key":"10.1016\/j.ejphar.2024.177138_bib45","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/0014-4827(90)90310-7","article-title":"Modulators of cyclic AMP metabolism induce syncytiotrophoblast formation in vitro","volume":"186","author":"Wice","year":"1990","journal-title":"Exp. Cell Res."},{"issue":"Pt 2","key":"10.1016\/j.ejphar.2024.177138_bib46","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1042\/bj2940335","article-title":"Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C","volume":"294","author":"Wilkinson","year":"1993","journal-title":"Biochem. J."},{"key":"10.1016\/j.ejphar.2024.177138_bib47","doi-asserted-by":"crossref","first-page":"2679","DOI":"10.1167\/iovs.07-1440","article-title":"Intraretinal leakage and oxidation of LDL in diabetic retinopathy","volume":"49","author":"Wu","year":"2008","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.ejphar.2024.177138_bib48","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.1007\/s00125-016-4012-6","article-title":"Extravascular modified lipoproteins: a role in the propagation of diabetic retinopathy in a mouse model of type 1 diabetes","volume":"59","author":"Yu","year":"2016","journal-title":"Diabetologia"},{"issue":"6","key":"10.1016\/j.ejphar.2024.177138_bib49","first-page":"314","article-title":"Modified lipoproteins in diabetic retinopathy: a local action in the retina","volume":"4","author":"Yu","year":"2013","journal-title":"J. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.ejphar.2024.177138_bib50","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1007\/s00125-008-1182-x","article-title":"Anti-angiogenic factors and pre-eclampsia in type 1 diabetic women","volume":"52","author":"Yu","year":"2009","journal-title":"Diabetologia"},{"key":"10.1016\/j.ejphar.2024.177138_bib51","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1159\/000370195","article-title":"Inhibition of lectin-like oxidized low-density lipoprotein receptor 1 protects against plasma\/hypoxia-mediated trophoblast dysfunction associated with preeclampsia","volume":"79","author":"Zhang","year":"2015","journal-title":"Gynecol. Obstet. Invest."},{"key":"10.1016\/j.ejphar.2024.177138_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2020.102813","article-title":"The inhibition of protein kinase C \u03b2 contributes to the pathogenesis of preeclampsia by activating autophagy","volume":"56","author":"Zhao","year":"2020","journal-title":"EBioMedicine"},{"key":"10.1016\/j.ejphar.2024.177138_bib53","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1096\/fba.2020-00057","article-title":"Modelling preeclampsia: a comparative analysis of the common human trophoblast cell lines","volume":"3","author":"Zhao","year":"2021","journal-title":"FASEB Bioadv."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299924008288?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299924008288?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T21:12:44Z","timestamp":1750108364000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299924008288"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":53,"alternative-id":["S0014299924008288"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2024.177138","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Modified lipoprotein-induced sFlt1 production in human placental trophoblasts is mediated by protein kinase C","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2024.177138","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"177138"}}